Resting state network profiles of Alzheimer disease and frontotemporal dementia: A preliminary examination

OBJECTIVES/SPECIFIC AIMS: Recent evidence from resting-state fMRI studies have shown that brain network connectivity is altered in patients with neurodegenerative disorders. However, few studies have examined the complete connectivity patterns of these well-reported RSNs using a whole brain approach and how they compare between dementias. Here, we used advanced connectomic approaches to examine the connectivity of RSNs in Alzheimer disease (AD), Frontotemporal dementia (FTD), and age-matched control participants. METHODS/STUDY POPULATION: In total, 44 participants [27 controls (66.4±7.6 years), 13 AD (68.5.63±13.9 years), 4 FTD (59.575±12.2 years)] from an ongoing study at Indiana University School of Medicine were used. Resting-state fMRI data was processed using an in-house pipeline modeled after Power et al. (2014). Images were parcellated into 278 regions of interest (ROI) based on Shen et al. (2013). Connectivity between each ROI pair was described by Pearson correlation coefficient. Brain regions were grouped into 7 canonical RSNs as described by Yeo et al. (2015). Pearson correlation values were then averaged across pairs of ROIs in each network and averaged across individuals in each group. These values were used to determine relative expression of FC in each RSN (intranetwork) and create RSN profiles for each group. RESULTS/ANTICIPATED RESULTS: Our findings support previous literature which shows that limbic networks are disrupted in FTLD participants compared with AD and age-matched controls. In addition, interactions between different RSNs was also examined and a significant difference between controls and AD subjects was found between FP and DMN RSNs. Similarly, previous literature has reported a disruption between executive (frontoparietal) network and default mode network in AD compared with controls. DISCUSSION/SIGNIFICANCE OF IMPACT: Our approach allows us to create profiles that could help compare intranetwork FC in different neurodegenerative diseases. Future work with expanded samples will help us to draw more substantial conclusions regarding differences, if any, in the connectivity patterns between RSNs in various neurodegenerative diseases

Couleurs de l’architecture

Pour la première fois, le point a été fait sur les connaissances, sur les méthodes d’analyse et d’intervention relatives aux matériaux et couleurs des toitures, façades, huisseries… des palais et villes d’Europe, grâce à la participation d’architectes, de conservateurs, d’historiens, d’historiens de l’art et de restaurateurs. Ce colloque, placé sous le haut patronage de la Direction de l'Architecture et du Patrimoine au Ministère de la Culture et de la Communication, a été réalisé grâce au soutien de l'Union Européenne (programme‑cadre « Culture 2000 »). Consulter le programme complet du colloque. Dix-neuf communications sur vingt-quatre sont publiées ici en texte intégral. Les textes ont été mis en ligne entre 2007 et 2010. This symposium was the first to evaluate our knowledge of materials and colours of roofs, facades and door and window surrounds of the palaces and cities of Europe, and of the various means of analysis and intervention, with the participation of architects, curators, historians, art historians and restorers. The event was held under the high patronage of the Department of Architecture and Heritage at the French Ministry of Culture and Communication, and was made possible thanks to the support of the European Union, as part of the “Culture 2000” programme. See the complete programme of the symposium. Nineteen of the twenty-four conference papers are available here in full text. The papers have been published between 2007 and 2010