576 research outputs found
Te-doped MoV-Oxide (M1 phase) for ethane ODH. The role of tellurium on morphology, thermal stability and catalytic behaviour
[EN] Undoped and Te-doped MoV-Oxide (M1 phase) catalysts have been prepared hydrothermally (Te/Mo ratio in the synthesis gel from 0 to 0.17; and heat-treated at 400 or 600ºC in N2 atmosphere), characterized by several physicochemical techniques and tested in the oxidative dehydrogenation (ODH) of ethane. The morphology and microporosity of the catalysts, the nature of V-species on the catalyst surface and the catalytic performance strongly depend on the composition and the heat-treatment temperature. When calcined at 400ºC, the selectivity to ethylene decreases when the amount of tellurium increases, whereas when heat treated at 600ºC, the selectivity to ethylene increases when the Te-loading increases. These trends have been explained on the basis of the good correlation between selectivity to ethylene and the concentration of V4+ species on the surface of catalysts, in which the most selective catalyst is that prepared with a Te/Mo ratio of 0.17 and heat-treated at 600ºC.The authors would like to thank the Spanish Ministry of Economy and Competitiveness for funding the projects (MINECO/FEDER) : CRTl2018-099668-B-C21, PID2019-106662RBC44, MAT2017-84118- C2-1-R and SEV-2016-0683. A.A. acknowledges Severo Ochoa Excellence Program for his fellowship (BES-2017-080329) . Authors would also like to acknowledge the "A -Team" of the ITQ (Dr. Miguel Palomino, Dr. Susana Valencia and Prof. Fernando Rey) for their assistance in the performance of the adsorption experiments.De Arriba-Mateos, A.; Solsona, B.; Garcia-Gonzalez, E.; Concepción Heydorn, P.; López Nieto, JM. (2022). Te-doped MoV-Oxide (M1 phase) for ethane ODH. The role of tellurium on
morphology, thermal stability and catalytic behaviour. Applied Catalysis A General. 643:1-13. https://doi.org/10.1016/j.apcata.2022.11878011364
Patient Journey Mapping in human-centered design: a critical review
Recent studies indicate that a positive Patient eXperience (PX) leads to a faster patient recovery, greater safety and lower costs for the healthcare system. Therefore, PX design is fundamental for hospitals service delivery. The Patient Journey Map (PJM) is a healthcar-specific tool that goes beyond the static view of other Human-Centered Design (HCD) methods by illustrating the relationship between the patient and the service organization as dynamic, ubiquitous and chronological within the system. The literature suggests that the PJM tool has the potential of PX explicit understanding; however, the way of mapping it is diverse, variable and subjective depending on the investigation. This article identifies, through a systematic search, investigations that use the PJM method with a HCD approach. Then, performs a critical analysis based on eleven items that critically review: (1) the nature of mapped information; (2) the purpose of its usage; and (3) the ease of use. As a result, a standardized, structured and reproducible PJM model is proposed that combines all these variables.Una eXperiencia de Paciente (PX) positiva conlleva una recuperación del paciente más rápida, mayor seguridad y menores costos para el sistema de salud, por ello constituye un aspecto fundamental para diseñar nuevos servicios hospitalarios. El Patient Journey Map (PJM) es una herramienta específica para el sector de la salud que va más allá de la vista estática de otros métodos del diseño centrado en las personas (HCD) al ilustrar la relación entre el usuario y la organización de servicios de forma dinámica, ubicua y cronológica. La literatura sugiere que la herramienta PJM alberga potencial para la comprensión explícita de la PX. Sin embargo, la aplicación del PJM es diversa, variable y subjetiva en función del equipo de investigación. Este artículo identifica a través de una búsqueda sistemática investigaciones que emplean el método PJM, a continuación, realiza un análisis crítico en base a once ítems que evalúan: (1) la tipología de información mostrada; (2) el uso que los equipos de diseño implicados hacen de la herramienta; y (3) su facilidad de uso. Como resultado, se propone un modelo estandarizado, estructurado y reproducible del PJM que aúne todas estas variables
Un lugar concreto desde el que vivir, mirar y pensar el mundo (educativo)
Editorial de presentación del Volumen 2 número 1 de Márgenes, Revista de Educación de la Universidad de Málaga. Quinto número de la revista, compuesto por un total de 17 textos, distribuidos en las diferentes secciones. Se trata de un número de carácter ecléctico en el que continuamos ofreciendo contenidos fieles a las premisas y los pilares educativos con los que partíamos
The polygenic basis of relapse after a first episode of schizophrenia
Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRS-EA, showed both a lower risk (OR=0.29, 95% CI [0.11–0.73]) and a later onset of relapse (30.96± 1.74 vs. 23.12± 1.14 months, p=0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse
Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications
Inherited retinal diseases (IRDs), defined by dysfunction or progressive loss of photoreceptors, are disorders characterized by elevated heterogeneity, both at the clinical and genetic levels. Our main goal was to address the genetic landscape of IRD in the largest cohort of Spanish patients reported to date. A retrospective hospital-based cross-sectional study was carried out on 6089 IRD affected individuals (from 4403 unrelated families), referred for genetic testing from all the Spanish autonomous communities. Clinical, demographic and familiar data were collected from each patient, including family pedigree, age of appearance of visual symptoms, presence of any systemic findings and geographical origin. Genetic studies were performed to the 3951 families with available DNA using different molecular techniques. Overall, 53.2% (2100/3951) of the studied families were genetically characterized, and 1549 different likely causative variants in 142 genes were identified. The most common phenotype encountered is retinitis pigmentosa (RP) (55.6% of families, 2447/4403). The most recurrently mutated genes were PRPH2, ABCA4 and RS1 in autosomal dominant (AD), autosomal recessive (AR) and X-linked (XL) NON-RP cases, respectively; RHO, USH2A and RPGR in AD, AR and XL for non-syndromic RP; and USH2A and MYO7A in syndromic IRD. Pathogenic variants c.3386G > T (p.Arg1129Leu) in ABCA4 and c.2276G > T (p.Cys759Phe) in USH2A were the most frequent variants identified. Our study provides the general landscape for IRD in Spain, reporting the largest cohort ever presented. Our results have important implications for genetic diagnosis, counselling and new therapeutic strategies to both the Spanish population and other related populations.This work was supported by the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Health (FIS; PI16/00425 and PI19/00321), Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER, 06/07/0036), IIS-FJD BioBank (PT13/0010/0012), Comunidad de Madrid (CAM, RAREGenomics Project, B2017/BMD-3721), European Regional Development Fund (FEDER), the Organización Nacional de Ciegos Españoles (ONCE), Fundación Ramón Areces, Fundación Conchita Rábago and the University Chair UAM-IIS-FJD of Genomic Medicine. Irene Perea-Romero is supported by a PhD fellowship from the predoctoral Program from ISCIII (FI17/00192). Ionut F. Iancu is supported by a grant from the Comunidad de Madrid (CAM, PEJ-2017-AI/BMD7256). Marta del Pozo-Valero is supported by a PhD grant from the Fundación Conchita Rábago. Berta Almoguera is supported by a Juan Rodes program from ISCIII (JR17/00020). Pablo Minguez is supported by a Miguel Servet program from ISCIII (CP16/00116). Marta Corton is supported by a Miguel Servet program from ISCIII (CPII17/00006). The funders played no role in study design, data collection, data analysis, manuscript preparation and/or publication decisions
Mapping disparities in education across low- and middle-income countries
Analyses of the proportions of individuals who have completed key levels of schooling across all low- and middle-income countries from 2000 to 2017 reveal inequalities across countries as well as within populations. Educational attainment is an important social determinant of maternal, newborn, and child health(1-3). As a tool for promoting gender equity, it has gained increasing traction in popular media, international aid strategies, and global agenda-setting(4-6). The global health agenda is increasingly focused on evidence of precision public health, which illustrates the subnational distribution of disease and illness(7,8); however, an agenda focused on future equity must integrate comparable evidence on the distribution of social determinants of health(9-11). Here we expand on the available precision SDG evidence by estimating the subnational distribution of educational attainment, including the proportions of individuals who have completed key levels of schooling, across all low- and middle-income countries from 2000 to 2017. Previous analyses have focused on geographical disparities in average attainment across Africa or for specific countries, but-to our knowledge-no analysis has examined the subnational proportions of individuals who completed specific levels of education across all low- and middle-income countries(12-14). By geolocating subnational data for more than 184 million person-years across 528 data sources, we precisely identify inequalities across geography as well as within populations.Peer reviewe
Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC
Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe
Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions
We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe
Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV
Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe
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