243 research outputs found
Incretins in patients with rheumatoid arthritis
- Author
- Alejandra González-Delgado
- AN Burska
- Antonia M. de Vera-González
- B Kreymann
- Beatriz Tejera-Segura
- Begoña Ubilla
- C Muscat
- CF Deacon
- CP Chung
- D Aletaha
- D Aletaha
- D Shahin
- ER DeLong
- G Montagna La
- GC Weir
- H Tilg
- H Ulusoy
- I Ferraz Amaro
- I Ferraz-Amaro
- I Ferraz-Amaro
- Iván Ferraz-Amaro
- J Dupre
- JA Miranda-Filloy
- JC Levy
- JL Hernandez
- JM Olmos
- José L. Hernández
- José M. Olmos
- JS Smolen
- L Sromova
- LA Rodriguez
- M Grujic
- MA González-Gay
- María Jesús Domínguez-Luis
- Miguel A. González-Gay
- ML Prevoo
- OJ Cordero
- ON Pamuk
- PH Dessein
- R Mentlein
- Raquel López-Mejías
- S Calanna
- T Pina
- T Pincus
- TM Wallace
- W Kim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Background: The precise mechanism linking systemic inflammation with insulin resistance (IR) in rheumatoid arthritis (RA) remains elusive. In the present study, we determined whether the incretin-insulin axis and incretin effect are disrupted in patients with RA and if they are related to the IR found in these patients. Methods: We conducted a cross-sectional study that encompassed 361 subjects without diabetes, 151 patients with RA, and 210 sex-matched control subjects. Insulin, C-peptide, glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), dipeptidyl peptidase 4 (DPP-4) soluble form, and IR indexes by homeostatic model assessment (HOMA2) were assessed. A multivariable analysis adjusted for IR-related factors was performed. Additionally, ten patients and ten control subjects underwent a 566-kcal meal test so that we could further study the postprandial differences of these molecules between patients and control subjects. Results: Insulin, C-peptide, and HOMA2-IR indexes were higher in patients than in control subjects. This was also the case for GLP-1 (0.49 ± 1.28 vs. 0.71 ± 0.22 ng/ml, p = 0.000) and GIP (0.37 ± 0.40 vs. 1.78 ± 0.51 ng/ml, p = 0.000). These differences remained significant after multivariable adjustment including glucocorticoid intake. Disease Activity Score in 28 joints with erythrocyte sedimentation rate (? coefficient 46, 95% CI 6?87, p = 0.026) and Clinical Disease Activity Index (? coefficient 7.74, 95% CI 1.29?14.20, p = 0.019) were associated with DPP-4 serum levels. GLP-1 positively correlated with ?-cell function (HOMA2 of ?-cell production calculated with C-peptide) in patients but not in control subjects (interaction p = 0.003). The meal test in patients with RA revealed a higher total and late response AUC for glucose response, a later maximal response of C-peptide, and a flatter curve in GIP response. Conclusions: The incretin-insulin axis, both during fasting and postprandial, is impaired in patients with RA.This work was supported by grants from the Spanish Ministry of Health,
Subdirección General de Evaluación y Fomento de la Investigación, Plan
Estatal de Investigación Científica y Técnica y de Innovación 2013–2016
Instituto de Salud Carlos III [ISCIII] PI14/00394) and by the Fondo Europeo de
Desarrollo Regional (FEDER) (to IFA). The research of MAGG was supported
by European Union FEDER funds and by the “Fondo de Investigación
Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, and PI15/00525) of the
Instituto de Salud Carlos III (ISCIII; Spanish Health Ministry). The research of
MAGG was also partially supported by RETICS Programs RD12/0009 (RIER)
and RD12/0009/0013 from the ISCIII (Spanish Health Ministry)
Cross-country discrepancies on public understanding of stress concepts: evidence for stress-management psychoeducational programs
- Author
- A Angold
- A Monat
- Aline Talita Santos
- BJ Lohman
- BS McEwen
- BV Lewenstein
- CL Donovan
- D Edwards
- DD Troutt
- Eliane Corrêa Chaves
- Estela Ferraz Bianchi
- GC Patton
- GC Patton
- Instituto Brasileiro de Geografia e Estatística (IBGE)
- J Gaab
- J Gaab
- J Illes
- J Ziman
- JJ Hudziak
- JK Sheffield
- JN Souza-Talarico
- JP Jamieson
- JP Jamieson
- Juliana Nery Souza-Talarico
- JW Mason
- KM Richardson
- LR Murphy
- MD Seery
- ML Andersen
- ML Beltzer
- N Humphrey
- Nathalie Wan
- National Science Board
- P Barrett
- Patrícia Paes Araujo Fialho
- Paulo Caramelli
- RM Rapee
- RM Sapolsky
- RS Lazarus
- Sheila Santos
- SJ Lupien
- SJ Lupien
- SJ Lupien
- SJ Lupien
- SJ Lupien
- SJ Lupien
- Sonia J Lupien
- SS Dickerson
- SS Macintyre
- WF Stewart
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Risk factors for low birthweight in the public-hospitals at Peshawar, NWFP-Pakistan
- Author
- A Field
- A Malamitsi-Puchner
- A Rahman
- CA Northrop-Clewes
- CJ Machado
- D Allison Paul
- DG Kleinbaum
- DV Mavalankar
- EM Ferraz
- FF Fikree
- FW Lone
- G Dunn
- GC Smith
- HP Sachdev
- I Kuvacic
- I Naheed
- J Valero De Bernabé
- JB Borja
- JC Grant
- K Pahari
- KE Pickett
- Kenneth McKelvie
- L Andersson
- Linda Mason
- M de Onis
- M Hussain
- M Hynes
- M Yaqoob
- MM Honeyman
- MM Khan
- MS Kramer
- MS Kramer
- N Khan
- N Rehan
- P Peduzzi
- P Steer
- PA King
- Paulo JG Lisboa
- PIHS
- Population Council
- R Hussain
- RL Williams
- Roger Payne
- RS Najmi
- RW Payne
- S Aziz
- S Khan
- S Saleem
- SA Karim
- Sareer Badshah
- T McGinn
- V Patel
- Z Parveen
- ZA Bhutta
- ZA Sathar
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
The Vascular Impairment of Cognition Classification Consensus Study
- Author
- Akinyemi R
- Altieri M
- Arana E
- Baiyewu O
- Baldereschi M
- Barroso-Ribal J
- Bastos-Leite AJ
- Ben-Shlomo Y
- Benisty S
- Bertolucci PH
- Biessels GJ
- Black S
- Bocti C
- Brucki S
- Börjesson-Hanson A
- Calatayud T
- Caltagirone C
- Caramelli P
- Caravaglios G
- Chen C
- Coen RF
- Cruz-Jentoft AJ
- de Leeuw FE
- de Toledo Ferraz Alves TC
- DeCarli C
- den Heijer T
- Deramecourt V
- Di Carlo A
- DI Piero V
- Engelborghs S
- Englund E
- Erkinjuntti T
- Exalto LG
- Firmino H
- Ford GA
- Fukui T
- Fulop T
- Gainotti G
- Galluzzi S
- Guo Q
- Hauw J
- Hogan DB
- Hokkanen L
- Hsiung GR
- Ihara M
- Ikram MK
- Jokinen H
- Kalaria RN
- Kandiah N
- Kappelle LJ
- Kehoe PG
- Kim SY
- Kirk A
- Korczyn AD
- Kruglov LS
- Lafosse C
- Laukka EJ
- Leach L
- Lenoir H
- Logroscino G
- Love S
- López-Pousa S
- Martinez-Lage P
- Massano J
- Mataro M
- Mecocci P
- Mizuno T
- Moretti DV
- O'Brien J
- Ogunniyi A
- Padovani A
- Pantoni L
- Pasquier F
- Passmore AP
- Prins ND
- Qiu C
- Richard E
- Robillard A
- Roman GC
- Sachdev P
- Sachdev P
- Sahlas DJ
- Schmand B
- Skoog I
- Skrobot OA
- Sundar U
- Szczudlik A
- Tian J
- Tsatali M
- Tsolaki M
- van den Berg E
- van der Flier WM
- Verdelho A
- Viitanen M
- Wallin A
- Publication venue
- Publication date
- 01/06/2017
- Field of study
Introduction: Numerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none have been universally accepted. These criteria have not been readily comparable, impacting on clinical diagnosis rates and in turn prevalence estimates, research, and treatment. / Methods: The Vascular Impairment of Cognition Classification Consensus Study (VICCCS) involved participants (81% academic researchers) from 27 countries in an online Delphi consensus study. Participants reviewed previously proposed concepts to develop new guidelines. / Results: VICCCS had a mean of 122 (98–153) respondents across the study and a 67% threshold to represent consensus. VICCCS redefined VCI including classification of mild and major forms of VCI and subtypes. It proposes new standardized VCI-associated terminology and future research priorities to address gaps in current knowledge. / Discussion: VICCCS proposes a consensus-based updated conceptualization of VCI intended to facilitate standardization in research
Epidemiological and clinical characteristics of injuries among adolescents attended at an emergency service in the city of Ribeirão Preto, São Paulo
- Author
- Ballesteros MF
- Barbosa HSC
- Blanck D
- Caixera CR
- Carvalho MFPP
- Carver A
- D'Ippolito A
- Danseco ER
- Emery CA
- Franciozi CES
- Gaspar VL
- Grossman DC
- Hedström EM
- Irwin CE Jr
- Irwin CE Jr
- Ivan Savioli Ferraz
- Karla Ishikawa
- Krug EG
- Letícia Graziela Bachette
- Luiz Antonio Del Ciampo
- Maria Tazima
- Martins CBG
- Mathers CD
- Mesquita Filho M
- Patton GC
- Pinheiro Dantas MM
- Rodrigo Paixão
- Santos JLG
- Scheidt PC
- Sleet DA
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2012
- Field of study
Ressonância magnética na mielopatia associada ao HTLV-I: Leucoencefalopatia e atrofia medular
- Author
- Alberto Alain Gabbai
- Alcindor F
- Ana Claudia Ferraz
- Andrade ASF
- Araújo AQC
- Berger JR
- Braffman BH
- Carpenter MG
- Cruickshank JR
- Farmer JA
- Fazekas F
- Francis GS
- Gabbai AA
- George AE
- George AE
- Gerard G
- Godoy AJ
- Hara Y
- Kermode AG
- Kira J
- Kirkpatrick JB
- Kuroda Y
- Kuroda Y
- Kurtzke JF
- Lasserve ET
- Miller DH
- Muniz MR
- Nakagawa M
- Newton M
- Nitamar Abdala
- Offenbacher H
- Ogata A
- Osame M
- Poser C
- Rao KCVG
- Roberto Gomes Nogueira
- Roman GC
- Rudge P
- Sheremata WA
- Vernant JC
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/1997
- Field of study
Thyroid nodules and differentiated thyroid cancer: update on the Brazilian consensus
- Author
- Akslen LA
- Albino CC
- Alexander EK
- Alexander EK
- Ana Luiza Maia
- Anil C
- Arslan N
- Bachelot A
- Barbaro D
- Baudin E
- Bernier MO
- Biondi B
- Biscolla RP
- Boelaert K
- Boldarine VT
- Bonnema SJ
- Cabanillas ME
- Cappelli C
- Castagna MG
- Castro MR
- Chammas MC
- Chiu AC
- Chow SM
- Chung J
- Cibas ES
- Coelho SM
- Cooper DS
- Davies L
- Durante C
- Dutenhefner SE
- Elisei R
- Eustatia-Rutten CF
- Farooki A
- Ferraz C
- Filetti S
- Filho JG
- Gisah A. Carvalho
- Graf H
- Grebe SK
- Guth S
- Hans Graf
- Hay ID
- Hay ID
- Hay ID
- Haymart MR
- Hegedus L
- Hegedus L
- Heilo A
- Ho AL
- Hong DS
- Hovens GC
- Hugo J
- Ibrahimpasic T
- Iervasi A
- Ito Y
- Ito Y
- Jennings A
- Jonklaas J
- Joo JY
- Kendler DB
- Kim WG
- Kim WG
- King AD
- Klubo-Gwiezdzinska J
- Koike E
- Kouvaraki MA
- Kwak JY
- Laura S. Ward
- Leboulleux S
- Leboulleux S
- Leboulleux S
- Lundgren CI
- Luster M
- Léa Maria Z. Maciel
- Maciel RM
- Maciel RM
- Maia FF
- Mallick U
- Marqusee E
- Martins de Almeida JF
- Martins-Filho R
- Matos PS
- Matos PS
- Mazzaferri EL
- Mazzaferri EL
- McCaffrey JC
- McWilliams RR
- Mestman JH
- Momesso DP
- Moon HJ
- Moosa M
- Morris LF
- Mário Vaisman
- Nascimento C
- Niccoli P
- Nikiforov YE
- Nixon IJ
- Oliver C
- Pacini F
- Pacini F
- Padovani RP
- Papi G
- Peccin S
- Pedro Weslley Rosário
- Rago T
- Randolph GW
- Raza SN
- Rosario PW
- Rosario PW
- Rosario PW
- Rosario PW
- Rosario PW
- Rosario PW
- Rosario PW
- Rosario PW
- Rosário P
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rosário PW
- Rubino C
- Rui M. B. Maciel
- Russ G
- Saleh HA
- Sawka AM
- Schlumberger M
- Schlumberger M
- Schlumberger M
- Schlumberger MJ
- Schneider TC
- Schrut GC
- Schuff KG
- Sdano MT
- Shambaugh GE 3rd
- Shen R
- Shen Y
- Sherman SI
- Shimamoto K
- Shoup M
- Soelberg KK
- Souza Rosário PW
- Souza Rosário PW
- Souza Rosário PW
- Sugitani I
- Tala H
- Tan GH
- Taylor T
- Teixeira G
- Tomimori EK
- Toubeau M
- Tronko MD
- Tunbridge WM
- Tuttle RM
- Uchino S
- Vaisman A
- Vaisman F
- Vaisman F
- Valadão MM
- Vander JB
- Veiga LH
- Vitale G
- Vriens D
- Wada N
- Wong CK
- Yamazaki CA
- Yousef A
- Zanella AB
- Zettinig G
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Combined measurement of differential and total cross sections in the H → γγ and the H → ZZ* → 4ℓ decay channels at s=13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- Abouzeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Gonzalez B
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aperio Bella L
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Armbruster AJ
- Armitage LJ
- Armstrong A
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asimakopoulou EM
- Asquith L
- Assamagan K
- Astalos R
- Atkin RJ
- Atkinson M
- Atlas Collaboration
- Atlay NB
- Augsten K
- Avolio G
- Avramidou R
- Axen B
- Ayoub MK
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
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- Bagnaia P
- Bahmani M
- Bahrasemani H
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- Baines JT
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- Bakalis C
- Baker OK
- Bakker PJ
- Bakshi Gupta D
- Baldin EM
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- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
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- Barnea R
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
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- Barranco Navarro L
- Barreiro Guimarães Da Costa J
- Barreiro F
- Bartoldus R
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- Bartos P
- Basalaev A
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- Beattie MD
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- Bednyakov VA
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- Caloba LP
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- Calvet D
- Calvet S
- Calvet TP
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- Capeans Garrido MDM
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- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- Elsevier
- Publication date
- 01/01/2018
- Field of study
A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ*(→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0−5.9 +6.0 (stat.) −3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions
Search for High-Mass Resonances Decaying to τν in pp Collisions at √s=13 TeV with the ATLAS Detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
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- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
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- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen H Meyer
- zur Nedden M
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2018
- Field of study
A search for high-mass resonances decaying to τν using proton-proton collisions at √s=13 TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb−1. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible τν production cross section. Heavy W′ bosons with masses less than 3.7 TeV in the sequential standard model and masses less than 2.2–3.8 TeV depending on the coupling in the nonuniversal G(221) model are excluded at the 95% credibility level
Search for the direct production of charginos and neutralinos in final states with tau leptons in √s=13 TeV collisions with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
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- Agatonovic-Jovin T
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
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- Aielli G
- Akatsuka S
- Akerstedt H
- Akesson TPA
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- Akimov AV
- Albergh GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt SC
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
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- Ali B
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- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
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- De la Torre H
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- Yildirim E
- Yildiz H Duran
- Yorita K
- Yoshihara K
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- Zhemchugov A
- Zhou B
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- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
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- zur Nedden M
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of 36.1 fb−1, recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13TeV.Nosignificant deviation from the expected Standard Model background is observed. Limits are derived in scenarios of ˜χ+1 ˜χ−1 pair production and of ˜χ±1 ˜χ02 and ˜χ+1 ˜χ−1 production in simplified models where the neutralinos and charginos decay solely via intermediate left-handed staus and tau sneutrinos, and the mass of the ˜ τL state is set to be halfway between the masses of the ˜χ±1 and the ˜χ01. Chargino masses up to 630 GeV are excluded at 95% confidence level in the scenario of direct production of ˜χ+1 ˜χ−1 for a massless ˜χ01. Common ˜χ±1 and ˜χ02 masses up to 760 GeV are excluded in the case of production of ˜χ±1 ˜χ02 and ˜χ+1 ˜χ−1 assuming a massless ˜χ01. Exclusion limits for additional benchmark scenarios with large and small mass-splitting between the ˜χ±1 and the ˜χ01 are also studied by varying the ˜ τL mass between the masses of the ˜χ±1 and the ˜χ01
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