74 research outputs found
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
- Author
- Liza
- - AP-HP) Bertrand Dousset (H\uf4pital Cochin
- - APHP) Anne Thomin (H\uf4pital Trousseau
- - ASST Rhodense) Carlo Corbellin (Ospedale Di Rho
- - NYU Winthrop Hospital) Amir H Sohail (NYU Langone Health
- - Xarxa Assistencial Universit\ue0ria de Manresa) Pablo Collera Ormazabal (Fundaci\uf3 Althaia
- / Columbia University Medical Center) Miriam Callahan (NewYork-Presbyterian
- 3 University Hospital) Bridget Egan (Tallaght
- 4 Lapolla Pierfrancesco
- 5 Spain: Eduardo E Rubio Susana Henriques (Hospital Garcia de Orta).
- 6 G\uf3mez Marcos
- \u2013 IRCCS Francesca Gaino (Humanitas Clinical and Research Center
- \u2013 Italy) 20089 Rozzano (MI)
- \uc1ngel Hern\ue1ndez Bartolom\ue9 Miguel
- A Aaraj Mahmoud
- A Ayeni Funbi
- A Bass Gary
- A Benson Ruth
- A Bozkurt Mehmet
- A Breen Kerry
- A Breen Kerry
- A Breen Kerry
- A Callcut Rachael
- A Chung Eric
- A Coughlin Patrick
- A de Gheldere Charles
- A De Marchi Joshua
- A Elliott Jessie
- A Fahey Brian
- A Griffiths Ewen
- A Griffiths Ewen
- A Griffiths Ewen
- A Guariglia Claudio
- A Hirji Sameer
- A Khalefa Mohamed
- A Marra (Fondazione Policlinico Universitario Agostino Gemelli) Angelo
- A Nguyen (Frankfurt University Hospital Truong
- A Olson (Duke University Medical Center) Steven
- A Raptis Dimitri
- A Rollett Rebecca
- A Saeed Samerah
- A Salama Hiba
- A Salamah Abdulrauf
- A Schnitzbauer Andreas
- A Schnitzbauer Andreas
- A Singh Aminder
- A Stevens Kent
- A Stylianides Nicholas
- A Thaha Mohamed
- A Vega (12 de Octubre University Hospital) Viviana
- A Vivas Alfredo
- A Zappa Marco
- Abate Emmanuele
- Abdalaziz (Gloucestershire Royal Hospital) Hossam
- Abdelkarim Mostafa
- Abdou Hossam
- Aboelkassem-Ibrahim Ahmad
- Abuown Ala
- Acebes-Garcia Fernando
- Acharya Metesh
- Adamina Michel
- Addae-Boateng Emmanuel
- Adolfo Pisanu (Cagliari University Hospital) Mauro Podda
- Aftab Raiyyan
- AG Moir John
- Agarwal Arnav
- AH Ibrahim Mohamed
- Aitken (Queen Elizabeth University Hospital) Emma
- Al-Azzawi Marwa
- Al-Embideen Somya
- Al-Sukaini Ahmad
- Alakaloko Felix
- Alam (Heartlands Hospital) Ruhina
- Alameer Ehab
- Alderson Derek
- Ali Mohamed Ali (Queen Elizabeth Hospital King's Lynn) Inthekab
- Aliyeva (Acibadem Mehmet Ali Aydinlar University Zumrud
- Aljanadi Firas
- Almasri Murad
- Alonso Poza (Hospital Universitario del Sureste) Alfredo
- Alonso-Ortu\uf1o Paula
- Alser Osaid
- Alser Osaid
- Alser Osaid
- Altintoprak (Sakarya University Faculty of Medicine) Fatih
- Amalina Che Bakri Nur
- Amjad Rabbia
- Anania Gabriele
- and Westminster Hospital NHS FT and Imperial College London) Chelsea
- Andabaka Tatjana
- Andrea Pisani Ceretti (ASST Santi Paolo e Carlo) Nicol\uf2 M Mariani
- Angelou Dimitrios
- Anita Volpe (New York Presbyterian Queens) Stephen Merola
- Annamalai Seethalakshmi
- Annessi Valerio
- Anthoney James
- Anuradha R Bhama (Rush University Medical Center) Alfonso Torquati
- Anwar Sibtain
- Aragon-Chamizo Juan
- Ardito Antonella
- Arigoni Michele
- Armao Teodora
- Arminio (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia) Armando
- Armstrong Lara
- Asaad Peter
- Ashcroft James
- Ashmore Christopher
- Asqalan Ahmad
- Asti (IRCCS Policlinico San Donato Emanuele
- Aubry Emmanuelle
- Aytac Erman
- Ayuso-Herrera Esther
- Azerbaijan:Elgun Samadov Joana FF Simoes (Chair). 2 Collaborators: (denotes Local Principal Investigator) Algeria: Faraj S Almaadany (\uc9tablissement Hospitalier Sp\ue9cialis\ue9 en Canc\ue9rologie - Centre Pierre-et- Marie-Curie).
- B Avellana Rocio
- B Catton Andrew
- B Fonsi Giovanni
- B Hing Caroline
- B O'Meara Lindsay
- B Schaffer Kathryn
- B Yousuf (Tobruk Medical Center) Farhat
- B\ue0mbina (Fabrizio Spaziani Hospital Fabrizio
- Bailon-Cuadrado (Hospital Universitario R\uedo Hortega) Martin
- Baldi Caterina
- Baldini Edoardo
- Baldo (Ospedale Santa Corona Stefano
- Ballabio Michele
- Baloyiannis Ioannis
- Baltazar Gerard
- Bandiera Alessandro
- Barlow Emma
- Barmasse (Ospedale Regionale Umberto Parini) Roberto
- Barmpagianni Christina
- Baronio (Policlinico San Pietro) Gianluca
- Barra Fabio
- Bartholomew's Hospital) St
- Bartsch Anne-Marie
- Basgaran Amedra
- Basha Amr
- Bashkirova (North Middlesex University Hospital) Varvara
- Bastazza Marco
- BB Sullivan (The Royal London Hospital) Tom
- Beak Philip
- Belcher Elizabeth
- Belgium: Gabrielle H van Ramshorst Sevda Jafarova (Leyla Medical Center).
- Beltr\ue1n de Heredia Juan
- Belvedere Angela
- Ben\uedtez-Linero Inmaculada
- Benjamin Franklin) Campus
- Bergeat Damien
- Bernasconi Matteo
- Bhalla Ashish
- Bhangu Aneel
- Bianco Federica
- Bisagni Pietro
- BJ Borgstein Alexander
- Blake (Southport and Formby District General Hospital) Iain
- Blanco-Colino Ruth
- Blazquez-Martin (Hospital Principe De Asturias) Alma
- Boal Matthew
- Bologna) Ausl
- Bonavina Giulia
- Bonavina Luigi
- Bond-Smith Giles
- Booth (Freeman Hospital) Karen
- Borges Filipe
- Borghi Felice
- Borja De Lacy (Hospital Clinic Barcelona) F
- Bourke Grainne
- Boyle Emily
- Brachini Gioia
- Brain Jessie
- Brar Amanpreet
- Breckles Lisa
- Brendan L Skelly (Altnagelvin Area Hospital) Catherine Rossborough
- Brianza) Carate
- Brixton Genevieve
- Bruzzaniti Placido
- Bueser Teofila
- Burnside Nathan
- C Bosanquet David
- C Brown (Manchester University NHS Foundation Trust Benjamin
- C De Souza Anthony
- C Glasbey James
- C Glasbey James
- C Hopkins James
- C Lauscher Johannes
- C McIntyre Robert
- C Mckay Siobhan
- C Neary Paul
- C Nugent III William
- C Rodriguez-Sanjuan (Marqu\ue9s de Valdecilla University Hospital) Juan
- C Roslani April
- C Tucker Sarah
- C Velmahos (Massachusetts General Hospital) George
- C Winter Stuart
- Caballero Albert
- Cairo University) Mahmoud MA Elfiky (Kasr Alainy Faculty of Medicine
- Calcerrada-Alises Enrique
- Camacho Fern\ue1ndez-Pacheco (Complejo Hospitalario Universitario Insular-Materno Infantil) Borja
- Camarero Enrique
- Campagnaro Tommaso
- Campanelli Michela
- Candiani Massimo
- Cannoletta (Royal Brompton Hospital) Marina
- Cantalejo-Diaz (Hospital Universitario Miguel Servet) Miguel
- Cao Han
- Capizzi Vita
- Carcano (Ospedale di Circolo Giulio
- Carissimi Francesca
- Carlini Massimo
- Carlos Bernal-Sprekelsen Juan
- Carlos Catal\ue1 Bauset (Consorcio Hospital General Universitario) Juan
- Carlucci Michele
- Carmela Giuffrida Maria
- Carmichael Heather
- Carrasco Milagros
- Carrillo Mariana
- Carvello Michele
- Casati Massimiliano
- Castoro Carlo
- Castro Ruiz Carolina
- Catalan Vanesa
- Catriona R Luney (Nuffield Orthopaedic Centre) Benjamin JF Dean
- Cavaleiro Salom\ue9
- Cellerino Paola
- Center Amsterdam) Cancer
- Centinaio (Ospedale Maggiore di Lodi) Giovanna
- Cernei Cristina
- Cervellera Maurizio
- Chakrabortee Sohini
- Chamberlain Stephanie
- Chan Jeffrey
- Chang Grace
- Chaudhry Daoud
- Chebaro Alexandre
- Chen (Jamaica Hospital) David
- Chetty Govind
- Chia (Royal Derby Hospital) Zoe
- Chiappini Ambra
- Chiarugi (Azienda Ospedaliero Universitaria Pisana) Massimo
- Chidambaram Swathikan
- Chiozza Matteo
- Cholewa Hanna
- Chong (Evelina London Children's Hospital) Clara
- Choolani-Bhojwani Ekta
- Christian Cotsoglou (ASST Vimercate) Stefano Granieri
- Chui Karen
- Chung Choyin
- Cirillo Bruno
- Citterio Davide
- Clermidi Pauline
- Coccolini Federico
- Colletti Gaia
- Compagnoni Bruno
- Concepci\uf3n-Mart\uedn Vanesa
- Confalonieri Marco
- Connolly Hannah
- Conso Christel
- Conti Luigi
- Cooper Zara
- Corral Javier
- Costa Marta
- Costanzi Andrea
- Cox Daniel
- Cozza Valerio
- CR Wormald Justin
- Croatia: Jakov Mihanovic Nicolas Duchateau (Heilig Hart Ziekenhuis Lier).
- CS Clough Ethan
- Cuming Tamzin
- Cuneo)
- Curtis Miles
- Cuschieri Joseph
- D Baron Ryan
- D Bosch Karen
- D Brown Oliver
- D Bueno-Ca\uf1ones Alejandro
- D Cato Liam
- D Drake Thomas
- D Jenkinson Michael
- D Jenkinson Michael
- D Liyanage Aloka S
- D Pinkney Thomas
- D Rajgor Amarkumar
- D Stewart Grant
- D Tebala Giovanni
- D'Agruma Michele
- D'Andrea Giancarlo
- D\uedaz P\ue9rez David
- D\uedaz-Garc\ueda (Hospital Universitario Nuestra Se\uf1ora de Candelaria) Alberto
- Da Roit Anna
- da Saliceto\u201d Patrizio Capelli (Ospedale \u201cG.
- Dare Oliver
- Darko Ebenezer
- Data Monitoring and Ethics Committee: Deborah S Keller H. Hunt Batjer (University of Texas Southwestern).
- Day Andrew
- De Andr\ue9s-Asenjo Beatriz
- de Medicina Facultad
- De Miguel-Ardevines Maria-Carmen
- De Nardi Paola
- De Simone Veronica
- De Toma Giorgio
- Deepti Sinha (University College London Hospital) Nicholas Kalavrezos
- Dehal (Kaiser Permanente Panorama City Medical Center) Ahmed
- Dehart Dustin
- Del Giudice Roberto
- Delgado-Oliver Eduardo
- Denmark: Henry G Smith Bernarda Bakmaz (Zadar General Hospital).
- Denning Max
- Desai Anant
- Desender (Ghent University Hospital) Liesbeth
- Dester (ASST Valcamonica Ospedale di Esine) Sara
- Di Candido Francesca
- Di Chiara Francesco
- Di Franco Gregorio
- Di Giuseppe (Ente Ospedaliero Cantonale del Canton Ticino) Matteo
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Diaz-Pe\uf1a Patricia
- Dieguez Fernandez Beatriz
- Dissemination Committee: Michel Adamina Aneel Bhangu.
- Dolores Del Toro M
- Domodossola
- Doussot Alexandre
- Duff Sarah
- Dunning Joel
- Dunstan Matt
- Duque-Mallen Victoria
- Dziakova Jana
- E Canova Michaela
- e Carle Hospital Chiara Peluso (Santa Croce
- e Carlo ASST Santi Paolo
- E Dawson Brett
- E Dickson Kathryn
- E Hudson Victoria
- E Jenny (Johns Hopkins Hospital) Hillary
- E Lewis Sophia
- E Nita George
- e Oftalmico) Giulio Iacob (Ospedale Fatebenefratelli
- E P\ue9rez-S\ue1nchez Luis
- E Rice Henry
- E Ssentongo Anna
- e Universit\ue1rio de Coimbra) Ana C Almeida (Centro Hospitalar
- E Xyda Souzana
- Edward Fitzgerald J
- EF Abbott Tom
- EF Abbott Tom
- Egan Richard
- Egypt: Mohamed El Kassas University of Copenhagen).
- El Youzouri Hanan
- El-Ali (Queen's Hospital Abess
- Elaine YL Leung (The Pan Birmingham Gynaecological Cancer Centre) Sudha Sundar
- Elfeki Hossam
- Elhadi Muhammed
- Eljareh (Aljalaa Hospital) Mohammed
- Elkadi Hannah
- Elkady Ramy
- Elkhafeefi Fatimah
- Elmore Ugo
- Elmoslemany (The Walton Centre NHS Foundation Trust) Tarek
- EM Bouhuwaish Ahmad
- EM Brathwaite Collin
- Emmerson (North Manchester General Hospital) Oliver
- Enemosah Ibrahim
- English Camilla
- English William
- Ereidge Simon
- Escartin Jorge
- Estaire-Gomez Mercedes
- EuroSurg
- Evans (Queen Elizabeth the Queen Mother Hospital Margate) Jessica
- Exley Rebecca
- F Bath Michael
- F Cunha Miguel
- F Cunha Miguel
- F Davis Niall
- F Ridgway Paul
- Fabbri Nicol\uf3
- Falco Giuseppe
- Familiari Pietro
- Fancellu (Cliniche San Pietro Alessandro
- Fanjul G\uf3mez Mar\ueda
- Farik Shebani
- Farr\ue9 Font Roser
- Farrell Tony
- Fehervari Matyas
- Fell Adam
- Fern\ue1ndez- Mart\uednez Mar\ueda
- Fern\ue1ndez-Gomez Cruzado (Hospital Urduliz) Laura
- Fern\ue1ndez-Mar\uedn Reyes
- Fernandez-Camu\uf1as Angel
- Ferrara)
- Ferrara Francesco
- Ferrari Guglielmo
- Ferrero Simone
- FF Simoes Joana
- FF Simoes Joana
- Findlay Laura
- Fiore Marco
- Fiore Marco
- Fiori Enrico
- FJ Dunne Declan
- Flatman Michael
- Flindall Ian
- Fontana (Vittorio Emanuele Tommaso
- Ford (The Robert Jones and Agnes Hunt Orthopaedic Hospital) David
- Ford Samuel
- Forlani Stefano
- Fr\ue9d\ue9ric Bretagnol (H\uf4pital Louis-Mourier - GHU AP-HP. Nord - Universit\ue9 de Paris) David Moszkowicz
- France: Zaher Lakkis Mohamed Sherief (MISR Cancer Center/MISR International Hospital).
- Francisco de Vitoria Universidad
- Francone Elisa
- Frattaruolo Colomba
- Frio (Institute of Neurological Sciences of Bologna Federico
- Frosinone)
- G Aoun Salah
- G Barranquero Alberto
- G Blazer III Dan
- G Collins Chris
- G Edwards John
- G Edwards John
- G Morton Dion
- G Povey Meical
- G Velopulos Catherine
- G Wade Ryckie
- Gabriel Kinnaman (IU Health Methodist Hospital) Ashley D Meagher
- Gagliano Annalisa
- Gagliardi Filippo
- Gahunia Sukhpreet
- Gala Tanzeela
- Galfrascoli Elisa
- Galimberti Luca
- Galindo Jara (Hospital Universitario de Torrej\uf3n Pablo
- Gallagher Phoebe
- Galleano Raffaele
- Gallo Gaetano
- Gallo Gaetano
- Gallo Gaetano
- Galv\ue1n-P\ue9rez Armando
- Gamal Amira Ibrahim Sallam
- Gammeri Emanuele
- Ganau Mario
- Garc\ue9s-Garc\ueda Ra\ufal
- Garcia Fernandez Andres
- Garcia-Conde Delgado Maria
- Garulli (Ospedale Infermi di Rimini) Gianluca
- Gascon-Ferrer Isabel
- Gattolin (Regina Montis Regalis Hospital Andrea
- Gaujoux Sebastien
- Gentilli Sergio
- Georgiades Fanourios
- Germany: Carsten Kamphues Didier Ollat (Institut Mutualiste Montsouris).
- Gerogiannis (Kingston Hospital NHS Foundation Trust) Ioannis
- Ghanbari (Homerton University Hospital) Amir
- Ghosh Dhruv
- Giacometti Marco
- Giblin Anna-Victoria
- Gilbert (Surrey and Sussex Healthcare NHS Trust) Catherine
- Gim\ue9nez Clara
- Giorgakis Emmanouil
- Gipponi Manuel
- Glen Paul
- GlobalPaedSurg GlobalSurg
- Goatly Giles
- Gobatti (San Carlo Borromeo Hospital Davide
- Godbole Chintamani
- Gohil Kajal
- Gomez-Rosado Juan-Carlos
- Gonullu Emre
- Gonzalez-De Miguel Melania
- Gonzalez-Gonzalez Enrique
- Gordini Luca
- Gracia Isabel
- Gracia-Roche Carlos
- Greece: Konstantinos Bouchagier Markus W L\uf6ffler (University Hospital Tu\u308bingen).
- Green Susanna
- Grivon Manuela
- Grove (Department of Colorectal Surgery Thomas
- Guaglio Marcello
- Guaitoli (Perrino) Eleonora
- Guglielmi Alfredo
- Guha Soumya
- Gustavino (Unit of Obstetrics and Gynecology IRCCS Ospedale Policlinico San Martino Genoa) Claudio
- Guti\ue9rrez Samaniego Mar\ueda
- H Babu Bheemanakone
- H Chowdhury Abeed
- H Davidson Giana
- H Davidson Giana
- H Davidson Giana
- H Elfallal Ahmed
- H Emile Sameh
- H Kirmani Bilal
- H Liu Helen
- H Murphy Suzanne
- H van Ramshorst Gabrielle
- H\uf6lzle Frank
- Habeeb Amir
- Hagger Robert
- Hakmi Hazim
- Halkias Constantine
- Halkias Constantine
- Hampton (Rotherham District General Hospital) Matthew
- Handa Siddhartha
- Haq Iram
- Harky (Liverpool Heart and Chest Hospital) Amer
- Harries (Morriston Hospital Rhiannon
- Harrison Joseph
- Hasan Raashad
- Hawari Mohammad
- Hawkin Paul
- Hebblethwaite Bethany
- Helier University Hospitals NHS Trust) St
- Heritage Emily
- Hernandez Garcia Miguel
- Hernandez-Juara Pilar
- Herrero-Lopez Maria
- Hervieux Erik
- Heyd Bruno
- Higgs Simon
- Hitchman (Hull University Teaching Hospitals NHS Trust) Louise
- Ho Beatrice
- Hogan Aisling
- Hospital of Varese University
- Hospital Universitario del Henares) Miguel Angel Garcia-Ure\uf1a (Universidad Francisco de Vitoria
- Hospital) Atakent
- Hospital) Wythenshawe
- Hossain Tanvir
- Houston Roy
- Hurt Libor
- HV Byrne Matthew
- i Pujol) Alba Zarate (Hospital Germans Trias
- I Roxo (Brigham and Women's Hospital) Vanessa
- I van Berge Henegouwen (Amsterdam UMC Mark
- I Alessandro Di Bartolomeo (Policlinico Umberto
- Iannone Immacolata
- Ibrahim Sherif
- Iovino Domenico
- Ireland: Arnold DK Hill Paraskevi Tourountzi (Kavala General Hospital).
- Isik Arda
- Israel: Oded Zmora Thomas M Aherne (Galway University Hospital).
- Italy: Maurizio Zizzo Nadav Kugler (Shamir Medical Center).
- J Abbott Sarah
- J Baker Olivia
- J Baldwin Alexander
- J Beamish Andrew
- J Carlos William
- J Caruana Edward
- J Caruana Edward
- J Davies Emma
- J Diaz Jose
- J Doe Matthew
- J Eardley Nicola
- J Fern\ue1ndez Antonio
- J G\uf3mez D\uedaz Carlos
- J Hainsworth Alison
- J Hall Bria
- J Holme Thomas
- J Hutchinson Peter
- J Hutchinson Peter
- J Kalkwarf Kyle
- J Lin Daniel
- J Lowery Aoife
- J McCluney Simon
- J Mehigan Brian
- J Mills Sarah
- J Pachl (Birmingham Children's Hospital) Max
- J Rogers Luke
- J Ryan \uc9anna
- J Scurrah Rachel
- J Shackcloth Michael
- J Smart Neil
- J Steinkamp Pieter
- J Tejero-Pintor Francisco
- J Thomas Amy
- J Torres Antonio
- J Warren Oliver
- J Warren Oliver
- J Williams Katherine
- James RW Hall (Stepping Hill Hospital) Claire Hall
- James's Hospital) Conor P Barry (St.
- Jamil Tahir
- Jayaraju (University Hospital of Wales) Ullas
- Jenner Edward
- JG Chase Thomas
- Jha Shane Lester (James Cook University Hospital) Madan
- Jimenez-Higuera Elisa
- Jimeno Jaime
- JM Dunne Naomi
- JM Ferguson Henry
- Jo\ue3o Lima Maria
- Johnstone Jack
- Jones Mark
- Jordan: Mahmoud Al-Masri Gela).
- JS Wall Joshua
- Judkins Nicholas
- JW Wilkin Richard
- K Abou Chaar Mohamad
- K Ambler Graeme
- K Bankhead-Kendall Brittany
- K Bankhead-Kendall Brittany
- K Bankhead-Kendall Brittany
- K Brown Allison
- K Fusai Giuseppe
- K Gill Charn
- K Kamarajah Sivesh
- K Patel Panna
- K Ubhi Harmony
- K Weerasinghe Chamindri
- K\uf6nigsrainer Alfred
- Kalidindi Venugopala
- Kamal Mona
- Kang Chong
- Kara Yasin
- Karam Edward
- Karim Ahmed
- Kashora Florence
- KC Jonker (University Medical Center Groningen (University of Groningen) Pascal
- Kearney (Beaumont Hospital) David
- Khajuria Apoorva
- Khan Azam
- Khan Umul
- Khatri Chetan
- Kinross James
- Kler Aaron
- Klimopoulos (Evangelismos General Hospital) Serafeim
- Kocata\u15f (Kanuni Sultan Suleyman Training and Research Hospital) Ali
- Kolias Angelos
- Kolias Angelos
- Kontovounisios Christos
- Kourdouli (Leicester Royal Infirmary) Amar
- Krishnan Emily
- Kristinsson Sverrir
- Kruijff Schelto
- KS Viswanath Yirupaiahgari
- Kudsk-Iversen S\uf8ren
- Kufeji Dorothy
- Kulkarni Rugved
- Kurihara Hayato
- L Biffl Walter
- L Coleman Natasha
- L Collins Michelle
- L Engel (Temple University Hospital) Jamie
- L Fowler Amy
- L Garcia Galocha Jose
- L Hughes Jane
- L J\uf6nsson (Bispebjerg Hospital Maria
- L Labib Peter
- L Marsh (Scripps Memorial Hospital) Christopher
- L McKevitt Kevin
- L Osorio Alexander
- L Romera Jose
- L Serevina Olivia
- L Venn Mary
- L Venn Mary
- L Venn Mary
- L Wright Franklin
- L Young Alastair
- L\ue1zaro Andr\ue9
- La Torre Filippo
- Laface (Ospedale Vittorio Emanuele III Letizia
- Lami Mariam
- Landaluce-Olavarria Aitor
- Laura Hansen 9
- Lawani Ismail
- Lawday (Southmead Hospital) Samuel
- Lawday Samuel
- Le Roy Bertrand
- Lecco) Asst
- Lecolle Katia
- Lederhuber Hans
- Lederhuber Hans
- Leeds)
- Leicester)
- Leventoglu Sezai
- Li Elizabeth
- Li Elizabeth
- Li Zoe
- Libya: Ghadah Z Alkadeeki Hani Al-Najjar (King Hussein Cancer Center).
- Liew Ignatius
- Ligure (SV) Pietra
- Lima Buarque Igor
- Lisi Giorgio
- Lizzi Vincenzo
- Lo Terence
- Lombardia) Regione
- Lomiento Daniele
- Longhi Marco
- Lopez Antonanzas (Hospital Clinico San Carlos Leyre
- Losada Ruiz Manuel
- Lostis Emilie
- Lostoridis Eftychios
- Loubani Mahmoud
- Lowy- Benoliel Alejandro
- Lucianetti (Papa Giovanni XXIII Hospital) Alessandro
- Luigi MP Marino Cosentino (PO San Filippo Neri - ASL ROMA 1) Andrea Sagnotta
- luis Blas Laina Juan
- Luke Evans (Norfolk and Norwich University Hospital) Mina MG Youssef
- Luke Louis
- Lunevicius Raimundas
- Luraghi Marco
- Lye George
- M Alrahawy (Menofiya University Hospital) Mahmoud
- M Andreani Stefano
- M Ashoush Fouad
- M Bajomo Oreoluwa
- M Blundell Chris
- M Cicerchia Pierfranco
- M Connolly Tara
- M Diez-Alonso Manuel
- M Dur\ue1n-Mu\uf1oz-Cruzado (Hospital Universitario Virgen del Rocio) Virginia
- M Emslie Katy
- M Harrison Ewen
- M Holbrook Charlotte
- M Isolani Simone
- M Keatley James
- M Leite-Moreira Andr\ue9
- M Mithany Reda H
- M Mohan Helen
- M Mohan Helen
- M Monteiro Joana
- M Morgom (Tripoli Central Hospital) Marwa
- M Muguerza Jose
- M Nunes Quentin
- M Nygaard Rachel
- M Omar Aneel Bhangu Omar
- M Philp Matthew
- M Pollok Joerg
- M Rooney Siobhan
- M Sampietro Gianluca
- M Sewards Joseph
- M Tang Alethea
- M Trout Isobel
- M Walters (Harborview Medical Center Andrew
- MA Kaafarani Haytham
- MA Kaafarani Haytham
- MA Kaafarani Haytham
- Maarten van Heinsbergen (VieCuri Medisch Centrum) Joop Konsten
- Mabrouk Islam
- Macchi Alberto
- MacDonald Luisa
- Machairas (Royal Free Hospital) Nikolaos
- Madonini Marco
- Madrid)
- Madrid)
- Magalh\ue3es Maia Mariana
- Magne Augestad Knut
- Magowan Drew
- Maha H Haqqani (Boston Medical Center) Frederick T Drake
- Maisonneuve Emeline
- Majkowska Agata
- Majkowski (Northern General Hospital Lawrence
- Mak (Queen Elizabeth Hospital Birmingham) Jason
- Malabarba Stefano
- Malerba Michele
- Maninder Kalkat 7
- Mannan Syed
- Manson Joanna
- Mansuri Ahmer
- Mantoglu (Sakarya University Research and Educational Hospital) Baris
- Manu Nichola
- Manzoni 56 Via
- Maqsood Afnan
- Marano Alessandra
- Marchbank Adrian
- Marcos-Santos Pablo
- Marinos Kouris (Buckinghamshire Healthcare NHS Trust) Spyros
- Marqueta De Salas Maria
- Marrano Enrico
- Mart\uedn-Rom\ue1n Lorena
- Mart\uednez P\ue9rez Carolina
- Mart\uednez-dePaz Fernando
- Martel Lozano Saida
- Martin (St Mary's Hospital) Guy
- Martin Emmeline
- Martin Janet
- Martin-Albo Lorena
- Martine Uittenbogaart (M\ue1xima Medical Center) Wouter KG Leclercq
- Martinelli Fabio
- Martinez-German Antonio
- Martinez-Pinedo Carlos
- Martins Ricardo
- Marwan Hisham
- Marzi Federica
- MAS Baig Mirza
- Mateos-Sierra (Hospital General Universitario Gregorio Mara\uf1\uf3n) Olga
- Mater Studiorum University of Bologna) Alma
- Mathieu (CHU Besan\ue7on) Pierre
- Matute-Najarro Maria-Soledad
- Maw Andrew
- Mazingi Dennis
- Mazzaferro (Fondazione IRCCS Istituto Nazionale dei Tumori Vincenzo
- McCanny (Antrim Area Hospital) Andrew
- McKenzie Katherine
- McLarty (Northumbria NHS Hospital Trust) Nicola
- McPherson Iain
- Medina Esther
- Mediratta Saniya
- Medone Marzia
- Mehra (Guy's and St Thomas\u2019 NHS Foundation Trust) Gautam
- Mele Simone
- Melero-Cort\ue9s Lidia
- Melody Baeza (Morales Meseguer University Hospital) Jos\ue9 Aguilar
- Mendon\ue7a Ata\uedde Gomes Gustavo
- Mendoza-Moreno Fernando
- Meneghini Simona
- Merate
- Mercante Giuseppe
- Merdrignac (Rennes University Hospital) Aude
- Metallidis Symeon
- Michel (Pinderfields Hospital) Martin
- Migliore Marco
- Milan)
- Milan)
- Milan)
- Miller Douglas
- Minaya- Bravo Ana
- Minaya-Bravo Ana
- Minaya-Bravo Ana
- Minaya-Bravo Ana
- Mingoli Andrea
- Minto Gary
- Mirabella Antonello
- Misra Nikhil
- Mitrasinovic Stefan
- Miu Victor
- Moawad (Royal Victoria Hospital) Nader
- Mochet Sylvie
- Modabber Ali
- Mohammad Adam
- Mohan Midhun
- Moliner-S\ue1nchez Carmen
- Mondov\uec)
- Mongelli Francesco
- Monteleone (Ospedale San Leopoldo Mandic Michela
- Montuori Mauro
- Moore Rachel
- Mora-Guzm\ue1n (Hospital Santa B\ue1rbara) Ismael
- Morales Dieter
- Morales Xavier
- Morelli Luca
- Morelli Lucia
- Morgan Richard
- Morris Chris
- Mortini Pietro
- Mosca Angelo
- Moszkowicz David
- Moszkowicz David
- Motter Dema
- Moug Susan
- Mukherjee Samrat
- Munoz Rivas Ana
- Murcia)
- N Bence Matthew
- N Hopkinson David
- N Mashbari Hassan
- N Mashbari Hassan
- N Mashbari Hassan
- N Naumann David
- N Rao Jagan
- N Townshend David
- N\ufa\uf1ez Jordi
- Najdy Manhal
- Nakas (Glenfield Hospital Apostolos
- Namazov Ilgar
- Naredla Pradyumna
- Nasef Emmhamed
- Nassa Heeam
- Nath Rahul
- Navarro-S\ue1nchez Antonio
- Nazarian (Bupa Cromwell Hospital) Scarlet
- Neal Bhutiani (University of Louisville Hospital and Norton Hospital) Robert CG Martin
- Negri Giampiero
- Nehra Deepika
- Neil-Dwyer Jason
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Neri Jacopo
- Netherlands: Suzanne S Gisbertz Mustafa R Bulugma (Zawia Teaching Hospital). Mexico: Fernando Cordera (ABC Medical Center).
- Newton (Manchester Royal Infirmary) Katy
- Nikaj (Azienda Ospedaliero Universitaria Maggiore della Carit\ue0 Herald
- Niquen Milagros
- Nobile (Azienda Ospedaliera Universitaria Integrata di Verona) Sara
- Nogueiro Jorge
- Nogues Pevidal (Royo Villanova) Ana
- Novara)
- Ntirenganya Faustin
- Nugent Michael
- O Ademuyiwa Adesoji
- O Kavanagh Dara
- O Larkin John
- Oca\uf1a Juan
- of Amsterdam University
- of Ferrara) University
- of Insubria University
- of Milan) University
- of Surgeons in Training (ASiT) Association
- of Surgery) Department
- of Washington) University
- Okafor Barbara U.
- Okechukwu Valentine
- Oliva-Mompean (Hospital Universitario Virgen Macarena) Fernando
- Oliveira Ana
- OM Abdalla Mutwakil
- Omar M Omar
- OO Ayorinde John
- Osagie-Clouard (Epsom &
- Osman (Walsall Manor Hospital) Khabab
- Ottolina Jessica
- Ourieff (Mount Sinai Hospital) Jared
- Outani Oumaima
- Oyewole Bankole
- P Arnaud Alexis
- P Arnaud Alexis
- P Arnaud Alexis
- P Baker Markus
- P Belgaumkar Ajay
- P Boddy Alexander
- P Duffy (Nottingham City Hospital) John
- P Evans Jonathan
- P Hazelton Joshua
- P Jones Andrew
- P Jones Robert
- P Joyce Doireann
- P Kisiel Aaron
- P Pezzuto Anna
- P Singh Rabindra
- P\ue9rez-Gonz\ue1lez Marta
- P\ue9rez-Saborido Baltasar
- Pacheco-Sanchez David
- Padilla-Valverde (Hospital General Universitario De Ciudad Real) David
- Pai (Hammersmith Hospital) Madhava
- Paiella Salvatore
- Paisley (Brighton and Sussex NHS Trust Samuel
- Palermo)
- Palini Gianmarco
- Palmeri Matteo
- Parente Alessandro
- Parlanti Daniele
- Parmar Chetan
- Pascual Angela
- Pata Francesco
- Pata Francesco
- Patel Mahul
- Pathak Abhijit
- Patil Sangram
- Pattyn Piet
- Peckham- Cooper Adam
- Pedram Panahi (University Hospitals Plymouth NHS Trust) Mariam Rela
- Pedrazzani Corrado
- Pellino Gianluca
- Pereira Andr\ue9
- Pereira-Neves Ant\uf3nio
- Perez-Diaz Md
- Perivoliotis (General University Hospital of Larissa) Konstantinos
- Perkins Clare
- Perotto (CHU Saint Etienne) Ornella
- Perra Teresa
- Petrone Patrizio
- Phenix George
- Piacenza)
- Picazo Sara
- Picon-Rodriguez Rafael
- Piloni Martina
- Pingarr\uf3n-Mart\uedn Lorena
- Pinotti Enrico
- Pizzini Paolo
- PM de Vries Jean-Paul
- Pockney Peter
- Podolsky Dina
- Poggioli Gilberto
- Pompili Cecilia
- Pontari Michael
- Porcu Alberto
- Portugal: Hugo Santos-Sousa Pakistan: Mariyah Anwer (Jinnah postgraduate medical center).
- Potter (Royal Bournemouth Hospital) Ryan
- Price Claire
- Prita Daliya 8
- Pruvot (Lille University Hospital) Fran\ue7ois-Ren\ue9
- PTSurg ItSURG
- Pujol-Muncunill Roger
- Puppo Andrea
- Q Mehdi (University of Texas Medical Branch) Mohammad
- Quante Markus
- Quintana-Villamandos Bego\uf1a
- Qureshi Ali
- R Burke Joshua
- R Davidson Brian
- R Dixon Jan
- R Fretwell Kenneth
- R Gujjuri Rohan
- R Gujjuri Rohan
- R Kowal Mikolaj
- R O\u2019Neill John
- R Sarma Diwakar
- R Spalding Duncan
- R Springford Laurie
- Rachel Baumber (Royal National Orthopaedic Hospital) James T Parry
- Radenkovic Dejan
- Rahman Saad (Medway Maritime Hospital) Abdel
- Rakvin Ivan
- Ramallo-Sol\ueds Irene
- Ramcharan Sean
- Ramos Diego
- Ramos-Bonilla Antonio
- Ramos-De la Medina Antonio
- Ramzi Joussi
- Rathinam Sridhar
- Rausa Emanuele
- Ravaioli Matteo
- Ravindran Sharanya
- Raymond (Royal Lancaster Infirmary) Thomas
- Razik Aisha
- Redfern (Furness General Hospital) Jennifer
- Reguera-Rosal Julio
- Rey-Biel Juan
- Rey-Valcarcel Cristina
- RG Sheel Andrea
- Ribolla Marta
- Richards Tomos
- Richmond (University of Maryland Medical Center) Michael
- Righini (Ospedale del Delta Erminio
- Rio-Gomez Javier
- Riuniti Villa Sofia-Cervello Ospedali
- Riyat Harjoat
- Rizvi Sana
- Roberts Keith
- Roberts Matthew
- Robertson (University Hospitals Coventry and Warwickshire) Stuart
- Robertson (University of Arkansas for Medical Sciences) Ronald
- Robin-Valle Alvaro
- Rochon Melissa
- Rojo Mikel
- Rolli Luigi
- Romano Silvio
- Rome)
- Romford)
- Ross Elizabeth
- Ross Howard
- Rottoli Matteo
- Royal Hospital) Princess
- Ruiz (Hospital General Universitario Reina Sof\ueda Miguel
- Ruiz- Grande Fernando
- Ruiz-Martin (Rey Juan Carlos University Hospital) Irene
- Ruiz-Soriano (Hospital Cl\uednico Universitario de Valladolid) Mar\ueda
- Ruzzenente Andrea
- Ryska Ondrej
- S Abdelaal (Alexandria Main University Hospital) Ahmed
- S Al Maadany Faraj
- S Faria Carlos
- S Hammond John
- S Hossain Fahad
- S Jeyaretna Deva
- S Jones Conor
- S Khan (Queen Alexandra Hospital) Jim
- S Moura Francisco
- S Ng-Kamstra Joshua
- S Sica Giuseppe
- S Tamimy Muhammad
- S Wadley Martin
- S\ue1nchez- Arteaga Alejandro
- SA Taher Ahmed
- Saez Carlos
- Sahnan Kapil
- Sahni Arun
- Salim Ali
- Salvia Roberto
- Sammarco Giuseppe
- Sampaio-Alves Mafalda
- San Miguel-Mendez Carlos
- Sanchez del Pueblo Cristina
- Sanchez-Fuentes Maria-Nieves
- Sanchez-Pelaez Daniel
- Sanchez-Perez Coral
- Sanchez-Rubio Maria
- Sancho-Muriel Jorge
- Sanchon Fructuoso Lorena
- Sanders Julie
- Santero-Ramirez Maria-Pilar
- Santora Thomas
- Santoro Antonio
- Santos Irene
- Sapienza Paolo
- Sartarelli (Sant\u2019Orsola Hospital Lodovico
- Sarveswaran Janahan
- Sasia Diego
- Sassari) A. O. U.
- Saudemont Alain
- Saudi-Moro Sef
- Saxena Dolly
- Saxena Shobhit
- Sayasneh Ahmad
- Scalabre Aurelien
- Schache Andrew
- Schiavina Riccardo
- Schineis (Charit\ue9 University Medicine Christian
- Schreckenbach Teresa
- Scorza Antonella
- Scott Lucy
- Seegert (ProMedica Toledo Hospital) Sara
- Seguin-Givelet Agathe
- Senent-Boza Ana
- Serrano Gonz\ue1lez Javier
- Sette Laghi Asst
- Seymour Keith
- Shabana Amanda
- Shah (The Whittington Hospital) Sujay
- Shah Jigar
- Shah Karishma
- Shah Preena
- Shakir Taner
- Shalaby (Mansoura University Hospital) Mostafa
- Shankar (Oxford University Hospitals NHS Foundation Trust Sushma
- Shaw Richard
- Sheffield)
- Shehata Sameh
- Shelley Hwang E.
- Shen Ban Vin
- Shenfine Amy
- Sheridan Kelda
- Sherief Ahmed
- Sherif Mohamed
- Shinkwin Michael
- Shu Sebastian
- Siaw-Acheampong Kwabena
- Sileri (San Raffaele Scientific Institute Pierpaolo
- Singh Abhinav
- Singh Shailendra
- Sinha Sanjay
- Siragusa (Policlinico Tor Vergata Hospital Leandro
- Sivaprakasam Rajesh
- Sivayoganathan Sriharan
- SJ Ledesma Frances
- Smillie Robert
- Smith (Countess of Chester Hospital) Claire
- Smith Andrew
- Smith Christopher
- Sochorova (Royal Liverpool University Hospital) Dana
- Society of Coloproctology (ESCP) European
- Society of Colorectal Surgery (SICCR) Italian
- Soggiu Fiammetta
- Sohrabi (St Bartholomew's Hospital) Catrin
- Sohrabi (Whipps Cross University Hospital) Catrin
- Sohrabi Catrin
- Solari (Royal Gwent Hospital) Francesca
- Solli Piergiorgio
- Soreide Kjetil
- Soto Montesinos Cristina
- SpainSurg
- Spinelli Antonino
- Spinelli Antonino
- Spoletini (Sant'Eugenio Hospital) Domenico
- Spriano Giuseppe
- Sravanam Sanskrithi
- Ssentongo (Pennsylvania State University) Paddy
- Stanger Sophie
- Stavroulias Dionisios
- Steel (Sunderland Royal Hospital) Ben
- Stella Marco
- Stewart Robbie
- Stringer Sally
- Sudan: Osman M Ali Elima P Cagigal- Ortega (Hospital Universitario Severo Ochoa).
- Sulen Nina
- Sundar Sudha
- Sundhu (Aintree University Hospital) Matthew
- Surgical Research Collaborative (ISRC) Irish
- Suri (University of California Davis Health Avni
- Swansea)
- Switzerland: Dimitri Christoforidis Ali A Ali karar (Al-rajhi).
- Syed Arooj
- Szatmary Peter
- T Colonna Emily
- T Enjuto Diego
- T Montella (Azienda Unit\ue0 Sanitaria Locale-IRCCS di Reggio Emilia) Maria
- TA Neely David
- Tabiri Stephen
- Tadross Daniel
- Taglietti Lucio
- Tansey (Princess Alexandra Hospital) Rosamond
- Tartaglia Dario
- Tawheed (Endemic Medicine Department Ahmed
- Tayeh Salim
- Testa Valentina
- Tewari Nilanjana
- Thoenissen Philipp
- Thomas (Worcestershire Acute Hospitals NHS Trust) Kane
- Thrush Jessica
- Tierney Sean
- Tiwari Abhinav
- Tobias Teles (Hospital de Cascais - Dr. Jos\ue9 de Almeida) Pedro A Serralheiro
- Toledo Enrique
- Tonini Valeria
- Torkington Jared
- Torzilli Guido
- Totty Joshua
- Tousidonis Manuel
- Townend Philip
- Townsend Catherine
- Trompeter (St George's Hospital) Alex
- Trotta Francesco
- Truant St\ue9phanie
- Trujillo-D\uedaz Jeancarlos
- Tsoulfas George
- Tsoulfas Georgios
- Turco Celia
- Turkey: Volkan Ozben Georgios Peros (Kantonsspital Winterthur).
- Turrado- Rodriguez Victor
- Turri Giulia
- Tustin (Cumberland Infirmary) Harry
- Tyler Jayne
- Tzedakis Stylianos
- Tzovaras George
- Ullah Ramzan
- Unit\ue0 Sanitaria Locale di Ferrara Azienda
- United Kingdom: Richard J Davies Alp Yildiz (Yildirim Beyazit University Yenimahalle Training and Research Hospital).
- United States: John RT Monson (AdventHealth Orlando) Lavinia Onos (York Teaching Hospitals NHS Trust).
- University Hospitals NHS Trust) Nottingham
- University of Rome) Sapienza
- University) Goethe
- University) Helwan
- Urban (University of Colorado Hospital) Shane
- Urbani (Azienda Ospedaliero Universitaria San'Anna Alessia
- Usai Antonella
- V Bhavaraju Avi
- V Comini Lara
- V Feo Carlo
- V Marino Marco
- V Shaw Abigail
- V\ue1zquez- Fern\ue1ndez Andrea
- Vaccarella (Azienda Ospedaliera Gianpaolo
- Valdes- Hernandez Javier
- Valsecchi Luca
- Vashisht Rajiv
- VCO) Asl
- Venkatesan (Glan Clwyd Hospital) Gowtham
- Vera-Mansilla Cristina
- Vergari (Ospedali Riuniti di Ancona) Roberto
- Vescio (University 'Magna Graecia' of Catanzaro) Giuseppina
- Vidya Raghavan
- Vieira (Centro Hospital Universit\ue1rio S\ue3oJo\ue3o) Paula
- Vijay Vardhini
- Vimalachandran Dale
- Vimalachandran Dale
- Violante Tommaso
- Vovola Fernanda
- Vulliamy Paul
- W Endorf (Hennepin Healthcare) Frederick
- W Etchill Eric
- W L\uf6ffler Markus
- W L\uf6ffler Markus
- Wall Rosemary
- Wallwork Kate
- Ward Alex
- Warwick (University Hospital Southampton) David
- Waseem Saima
- Weaver Helen
- Wells Fiona
- Wen Jiaxin
- West Raha
- Whitehall Emma
- Wild Laura
- Wilkins Alex
- Williams Gethin
- Williams Matthew
- Winnand (University Hospital Aachen) Philipp
- Wong (Addenbrooke's Hospital) Ken
- Worku (Queen\u2019s Medical Centre Dawit
- Wright Naomi
- WS Ho (Leeds Teaching Hospitals NHS Trust Michael
- WT Ngu Albert
- y Cajal) Cristina Cerro (Hospital Universitario Ram\uf3n
- Y Oo (Department of Cardiothoracic Surgery Aung
- y Polit\ue9cnico La Fe) Blas Flor (Hospital Universitario
- Y van der Plas Willemijn
- Yalamanchili Seema
- Yershov (South Warwickshire NHS Foundation Trust) Danylo
- Young Richard
- Yousra Ahmed (Portsmouth Hospital NHS Trust) Simon Toh
- Yurttas Can
- Zadegan Frederic
- Zafar (Northwick Park Hospital) Noman
- Zakaria Rasheed
- Zambon Martina
- Zanini Nicola
- ZE Durst Alexander
- Zerbib Philippe
- Zonta (Ospedale San Biagio Sandro
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- Bülow Robin
- Bülow Robin
- Bürger Christian
- Bÿchel Christian
- Cabrera Yuliana
- Cahn Wiepke
- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
- Carmichael Owen
- Carr Vaughan J
- Carrillo Maria
- Carroll Maria
- Carson Richard E
- Carter Raina
- Casaceli Cynthia
- Casalin Paola
- Caseras Xavier
- Caspell Chelsea
- Caspers Svenja
- Catafau Ana
- Cavalleri Gianpiero L
- Cedarbaum Jesse
- Cellar Janet S
- Celmins Dzintra
- Cendes Fernando
- Chahine Lama
- Chakravarty Mallar
- Chalker Alison
- Chao Steven
- Chen Kewei
- Chen Qiang
- Chertkow Howard
- Cheung Joshua W
- Chiang Gloria
- Ching Christopher R K
- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde Lucía
- Comery Thomas
- Conrad Gary
- Conrod Patricia
- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
- Consortium EPIGEN
- Consortium IMAGEN
- Consortium SYS
- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crawford Karen
- Creech Mary L
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Curran Joanne E
- D'Agostino Daniel
- Daedelow Laura
- Daiello Lori A
- Dale Anders M
- Dale Anders M
- Dalley Jeffrey
- Dalrymple-Alford John C
- Dalvie Shareefa
- Dang Mimi
- Dannlowski Udo
- Darin Abigail
- Davies Gareth E
- Davies Peter
- de Araujo Tânia K
- de Geus Eco J C
- de Zubicaray Greig I
- de Zwarte Sonja M C
- Deary Ian J
- Deary Ian J
- Debette Stephanie
- Debette Stephanie
- Decarli Charles
- DeCarli Charles
- Deeley Cheryl
- Degenhardt Franziska
- Delanty Norman
- DeMarco Kathryn
- den Braber Anouk
- Dennis Michelle F
- Depondt Chantal
- Desrivieres Sylvane
- Desrivières Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doan Nhat Trung
- Doherty Colin P
- Dohm Katharina
- Dolen Sara
- Donohoe Gary
- Donohue Michael
- Doody Rachelle S
- Dooley Eoin
- Doraiswamy P Murali
- Drost Dick
- Duara Ranjan
- Dubow Jordan S
- Dunlop Becky
- Egebjerg Jan
- Ehrlich Stefan
- El Khouli Riham
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espay Alberto
- Espay Kristy
- Espeseth Thomas
- Espiritu Ryan
- Faber Kelley
- Factor Stewart
- Fan Chun Chieh
- Fargher Kristin
- Farlow Martin R
- Fatica Parianne
- Fedko Iryna O
- Feldman Howard
- Fernandez Hubert
- Fernández Guillén
- Figurski Michal
- Filippi Irina
- Fillit Howard
- Fillmer Ariane
- Finger Elizabeth
- Fisher Simon E
- Flashman Laura A
- Fleisher Adam
- Fletcher Evan
- Flor Herta
- Flor Herta
- Foley Sonya F
- Fontaine Deborah
- Fontoura Paulo
- Ford Judith M
- Fornage Myriam
- Fornage Myriam
- Foroud Tatiana
- Foroud Tatiana M
- Forstner Andreas J
- Foster Eric
- Foster Norm
- Fox Nick
- Francks Clyde
- Frank Richard
- Frank Samuel
- Franke Barbara
- Franklin Erin
- Franz Carol E
- Frasier Mark
- Frouin Vincent
- Fröhner Juliane
- Fukunaga Masaki
- Gaikwad Mrunalini
- Galasko Douglas
- Garavan Hugh
- Garijo Daniel
- Garrett Melanie E
- Gauss Katharina
- Ge Tian
- Geldmacher David
- Gessert Devon
- Ghanbari Mohsen
- Giddaluru Sudheer
- Gigliotti Christina
- Gil Yolanda
- Gillespie Nathan A
- Glahn David C
- Gloer Katherine
- Goldman Aaron L
- Goldstein Bonnie S
- Goldstein David B
- Gollub Randy L
- Gowland Penny
- Gowland Penny A
- Grabe Hans J
- Grabe Hans Jörgen
- Grachev Igor D
- Graff-Radford Neill R
- Grasby Katrina L
- Green Davis Robert C
- Green Melissa J
- Green Robert C
- Green Robert C
- Greig-Custo Maria T
- Griffith Randall
- Grimmer Yvonne
- Groenewold Nynke A
- Grossman Hillel
- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gunter Jeff
- Gurholt Tiril P
- Guthrie Stephanie
- Gutman Boris A
- Hake Ann Marie
- Hansell Narelle K
- Hardy Peter
- Hariri Ahmad R
- Harlan Sherry
- Harless Kelly
- Harris Mat
- Harris Mathew A
- Harrison Marc B
- Hart David
- Hartman Catharina A
- Harvey Danielle
- Hashimoto Ryota
- Haswell Courtney C
- Hauser Michael
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- Initiative Alzheimer’s Disease Neuroimaging
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- Iranzo Alex
- Isaacson Stuart
- Isensee Corinna
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- Ittermann Bernd
- Jack Clifford R
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- Jennings Danna
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- Jian Xueqiu
- Jiang Jiyang
- Jicha Greg
- Jimenez Gustavo
- Jockwitz Christiane
- Johnson Kathleen
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- Kataki Maria
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- Kerwin Diana
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- Kielb Stephanie
- Kikuchi Masataka
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- Krämer Bernd
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- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
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- Wang Yunpeng
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- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
- Beckham Jean C.
- Beekman Aartjan T. F.
- Beins Eva C.
- Bellivier Frank
- Bellivier Frank
- Bencko Vladimir
- Bengesser Susanne
- Bergen Andrew W.
- Bergen Andrew W.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Berrettini Wade H.
- Bhushan Sujata
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Binder Elisabeth B.
- Birgegård Andreas
- Birner Armin
- Blackwood Douglas H. R.
- Boden Joseph M.
- Boehm Ilka
- Boehnke Michael
- Boehnke Michael
- Bohus Martin
- Bohus Martin
- Boks Marco P.
- Boks Marco P.
- Boni Claudette
- Boomsma Dorret I.
- Bosch Rosa
- Bosch Rosa
- Boyko Edward
- Braff David L.
- Brandt Harry
- Brandt Harry
- Breeling James
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brewer Jessica V.
- Brophy Mary T.
- Brum Murielle
- Brumpton Ben M.
- Brunkhorst-Kanaan Nathalie
- Bryant Richard
- Bryois Julien
- Bryois Julien
- Bryois Julien
- Budde Monika
- Budde Monika
- Buehren Katharina
- Bulik Cynthia M.
- Bulik Cynthia M.
- Burghardt Roland
- Buttenschøn Henriette N.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D.
- Børglum Anders D.
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- Børte Sigrid
- Cahn Wiepke
- Cai Na
- Cairns Murray
- Campos Adrian I.
- Carlberg Laura
- Carr Vaughan J.
- Carter Bruce W.
- Casas Miguel
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Castelao Enrique
- Catts Stanley
- Cervantes Pablo
- Cervilla Jorge A.
- Chang Kyong-Mi
- Chang Xiao
- Charney Alexander W.
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei J.
- Cho Kelly
- Cho Kelly
- Christensen Jane Hvarregaard
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Clementi Maurizio
- Cohen David
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Colodro-Conde Lucía
- Cone Roger D.
- Connor Todd
- Constans Joseph
- Coombes Brandon
- Coon Hilary
- Corvin Aiden
- Corvin Aiden
- Courtet Philippe
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nicholas
- Craddock Nick
- Craig David
- Crawford Gregory E.
- Crawford Steven
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- Cruceanu Cristiana
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- Cunningham Julie
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- Davies Gail
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- Dellitalia Louis
- Demontis Ditte
- Dennis Michelle F.
- Depaulo J. Raymond
- DePaulo J. Raymond
- der Auwera Sandra Van
- Derks Eske M.
- DeSocio Janiece E.
- Di Florio Arianna
- DiBlasi Emily
- Dick Danielle M.
- Dietl Lydie
- Dikeos Dimitris
- Dikeos Dimitris
- Dina Christian
- Direk Nese
- Djurovic Srdjan
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- Dmitrzak-Weglarz Monika
- Do Nhan
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- Docherty Anna R.
- Dolan Conor V.
- Domenici Enrico
- Domschke Katharina
- Douzenis Athanassios
- Drange Ole Kristian
- Duncan Laramie E.
- Dunn Erin C.
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- Edenberg Howard J.
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- Egberts Karin
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- Elvsåshagen Torbjørn
- Erlangsen Annette
- Escaramís Geòrgia
- Escott-Price Valentina
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- Esko Tõnu
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- Esko Tõnu
- Esko Tõnu
- Espeseth Thomas
- Estivill Xavier
- Etain Bruno
- Fanous Ayman H.
- Farmer Anne
- Favaro Angela
- Fayad Joseph
- Ferentinos Panagiotis
- Fernández-Aranda Fernando
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- Ferrier I. Nicol
- Fichter Manfred M.
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- Gallinger Steven
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- Gawlik Micha
- Gaziano J. Michael
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- Gejman Pablo V.
- Gelernter Joel
- Gelernter Joel
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- Gibson Gretchen
- Giegling Ina
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- Gill Michael
- Giuranna Johanna
- Giusti-Rodríquez Paola
- Gizer Ian R.
- Glatt Stephen J.
- Godschalk Michael
- Goes Fernando S.
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- Gonidakis Fragiskos
- Gordon Scott
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- Grevet Eugenio H.
- Grigoroiu-Serbanescu Maria
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Grove Jakob
- Guillaume Sébastien
- Guo Yiran
- Guo Yiran
- Gupta Samir
- Gutierrez Blanca
- Gutierrez Salvador
- Guzman-Parra Jose
- Guzman-Parra José
- Ha Kyooseob
- Hafferty Jonathan D.
- Hagenaars Saskia P.
- Hakonarson Hakon
- Hakonarson Hakon
- Hall Lynsey S.
- Halmi Katherine A.
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- Hansen Christine Søholm
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- Haraldsson Magnus
- Harley John
- Hartmann Annette
- Harvey Phillip D.
- Hassan Kiadeh Farnush Farhadi
- Hatzikotoulas Konstantinos
- Hauser Elizabeth
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- Hauser Joanna
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- Hautzinger Martin
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- Hebebrand Johannes
- Heilbronner Urs
- Heilmann-Heimbach Stefanie
- Helder Sietske G.
- Hellgren Dennis
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- Henskens Frans
- Herms Stefan
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- Herzog Wolfgang
- Hickie Ian B.
- Hillert Jan
- Hinney Anke
- Hishimoto Akitoyo
- Hoffmann Per
- Hoffmann Per
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- Wade Tracey D.
- Wagner Gudrun
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- Wang Yunpeng
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- Wasserman Danuta
- Watson Hunna J.
- Watson Hunna J.
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- Weickert Thomas W.
- Weickert Thomas W.
- Weinsheimer Shantel Marie
- Weissman Myrna M.
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- Werge Thomas
- Werge Thomas
- Werge Thomas
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- Whitbourne Stacey B.
- Whiteman David C.
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- Whittle Jeffrey
- Whooley Mary
- Wichmann H. Erich
- Widen Elisabeth
- Willemsen Gonneke
- Williams Leanne M.
- Willour Virginia
- Wilson Peter
- Winsvold Bendik S.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Won Hong-Hee
- Woodside D. Blake
- Woodside D. Blake
- Wray Naomi R.
- Wray Naomi R.
- Wray Naomi R.
- Wu Yang
- Xi Hualin S.
- Xi Simon
- Xu Junzhe
- Xu Wei
- Yang Jian
- Yao Shuyang
- Yeh Shing Shing
- Yilmaz Zeynep
- Yilmaz Zeynep
- Young Allan H.
- Young Hannah
- Zablocki Clement J.
- Zai Clement C.
- Zandi Peter P.
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Futao
- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
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Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer’s disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the shape of cortical regions. However, ‘shape connections’ between brain regions are rarely investigated -e.g., how morphological attributes such as cortical thickness and sulcal depth of a specific brain region change in relation to morphological attributes in other regions. To fill this gap, we unprecedentedly design morphological brain multiplexes for late MCI/AD classification. Specifically, we use structural T1-w MRI to define morphological brain networks, each quantifying similarity in morphology between different cortical regions for a specific cortical attribute. Then, we define a brain multiplex where each intra-layer represents the morphological connectivity network of a specific cortical attribute, and each inter-layer encodes the similarity between two consecutive intra-layers. A significant performance gain is achieved when using the multiplex architecture in comparison to other conventional network analysis architectures. We also leverage this architecture to discover morphological connectional biomarkers fingerprinting the difference between late MCI and AD stages, which included the right entorhinal cortex and right caudal middle frontal gyrus
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- Balachandar Rakesh
- Bartha Rob
- Bartzokis George
- Bates Vernice
- Beccera Mauricio
- Beckett Laurel
- Beg Mirza Faisal
- Belden Christine
- Bell Karen
- Bergman Howard
- Bernick Charles
- Black Sandra
- Blank Karen
- Bonakdarpour Borna
- Borges-Neto Salvador
- Borrie Michael
- Brand Connie
- Brewer James
- Brockington John
- Brooks William
- Brosch Jared
- Brown Alice
- Budson Andrew
- Burke Anna
- Burns Jefrey
- Caldwell Curtis
- Capote Horacio
- Carlsson Cynthia
- Carmichael Owen
- Carroll Maria
- Carson Richard
- Carter Raina
- Cellar Janet
- Celmins Dzintra
- Cerbone Brittany
- Chaing Gloria
- Chertkow Howard
- Chowdhury Munir
- Clark David
- Coleman Edward
- Conrad Gary
- Correia Stephen
- Creech Mary
- Dang Mimi
- de Leon Mony
- DeCarli Charles
- deToledo-Morrell Leyla
- Ding Gavin Weiguang
- Dolen Sara
- Doody Rachelle
- Doraiswamy P.
- Duara Ranjan
- Dyck Christopher
- D’Agostino Daniel
- Fargher Kristin
- Farlow Martin
- Fatica Parianne
- Feldman Howard
- Finger Elizabeth
- Flashman Laura
- Fleisher Adam
- Fletcher Evan
- Franklin Erin
- Galvin James
- Garg Pradeep
- Geldmacher David
- Glodzik Lidia
- Goldstein Bonnie
- Gordineer Leslie
- Graf-Radford Neill
- Green Robert
- Greig Maria
- Grifth Randall
- Grossman Hillel
- Hake Ann Marie
- Hardy Peter
- Heidebrink Judith
- Hernando Raymundo
- Herring Scott
- Honig Lawrence
- Hosein Chris
- Hsiung Ging-Yuek Robin
- Hunt Cynthia
- Hynes Mary
- Ismail M.
- Jack Cliford
- Jacobson Sandra
- Jagust William
- Jicha Greg
- Johnson Heather
- Johnson Kathleen
- Johnson Keith
- Johnson Kris
- Johnson Nancy
- Johnson Patricia Lynn
- Johnson Sterling
- Kataki Maria
- Kaye Jefrey
- Kendall Tracy
- Kertesz Andrew
- Kerwin Diana
- Kielb Stephanie
- Killiany Ronald
- Kittur Smita
- Knopman David
- Kowall Neil
- Lah James
- Lane Barton
- Lee T.-Y.
- Lerner Alan
- Levey Allan
- Lin Michael
- Lind Betty
- Lipowski Kristine
- Lord Joanne
- Love Marissa Natelson
- Lu Donghuan
- Lu Po
- MacAvoy Martha
- Maillard Pauline
- Makino Kelly
- Malloy Paul
- Marshall Gad
- Marson Daniel
- Martin Kim
- Mason Sara
- Mathews Dana
- Matthews Brandy
- Mc-Adams-Ortiz Catherine
- Mesulam Marek-Marsel
- Michel Christina
- Miller Bruce
- Mintun Mark
- Mintzer Jacobo
- Mitsis Efe
- Morris John
- Mudge Benita
- Mulnard Ruth
- Munic Donna
- Nguyen Dana
- Norbash Alexander
- Oates Elizabeth
- Obisesan Thomas
- Ogrocki Paula
- Olichney John
- Oliver Angela
- Onyike Chiadi
- Ott Brian
- Parftt Francine
- Pasternack Stephen
- Pawluczyk Sonia
- Pearlson Godfrey
- Perry David
- Petersen Ronald
- Petrella Jefrey
- Pogorelec Dana
- Pomara Nunzio
- Popuri Karteek
- Porsteinsson Anton
- Potkin Steven
- Preda Adrian
- Querfurth Henry
- Quiceno Mary
- Quinn Joseph
- Rachisky Irina
- Rainka Michelle
- Raj Balebail Ashok
- Ravdin Lisa
- Reeder Stephanie
- Relkin Norman
- Reynolds Brigid
- Roberson Erik
- Roberts Peggy
- Rosen Allyson
- Rosen Howard
- Rountree Susan
- Rusinek Henry
- Sabbagh Marwan
- Sadowsky Carl
- Salloway Stephen
- Santi Susan De
- Santulli Robert
- Sarrael Antero
- Saykin Andrew
- Scharre Douglas
- Schneider Lon
- Schneider Stacy
- Seltzer Marc
- Shah Raj
- Shaw Leslie
- Silbert Lisa
- Silverman Daniel
- Sinha Partha
- Sink Kaycee
- Sirrel Sherye
- Smith Amanda
- Smith Charles
- Spann Bryan
- Sperling Reisa
- Spicer Kenneth
- Stefanovic Bojana
- Stern Yaakov
- Swerdlow Russell
- Tariot Pierre
- Tatsuoka Curtis
- Taylor Joy
- Teodoro Liberty
- Thai Gaby
- Tingus Kathleen
- Tinklenberg Jared
- Toga Arthur
- Tremont Geofrey
- Trncic Nadira
- Trojanowki John
- Trost Dick
- Turner Raymond Scott
- Vanderswag Helen
- Varma Pradeep
- Varon Daniel
- Villanueva-Meyer Javier
- Villena Teresa
- Watkins Franklin
- Weiner Michael
- Weintraub Sandra
- Williamson Jef
- Wolday Saba
- Womack Kyle
- Wong Terence
- Woo Ellen
- Wu Chuang-Kuo
- Yesavage Jerome
- Zimmerman Earl
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 30/05/2018
- Field of study
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease where biomarkers for disease based on pathophysiology may be able to provide objective measures for disease diagnosis and staging. Neuroimaging scans acquired from MRI and metabolism images obtained by FDG-PET provide in-vivo measurements of structure and function (glucose metabolism) in a living brain. It is hypothesized that combining multiple different image modalities providing complementary information could help improve early diagnosis of AD. In this paper, we propose a novel deep-learning-based framework to discriminate individuals with AD utilizing a multimodal and multiscale deep neural network. Our method delivers 82.4% accuracy in identifying the individuals with mild cognitive impairment (MCI) who will convert to AD at 3 years prior to conversion (86.4% combined accuracy for conversion within 1–3 years), a 94.23% sensitivity in classifying individuals with clinical diagnosis of probable AD, and a 86.3% specificity in classifying non-demented controls improving upon results in published literature
Recommended from our members
The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum
- Author
- Adeli Anahita
- Aisen Paul
- Albers Colleen S.
- Albert Marilyn
- Allard Joanne
- Ances Beau
- Anderson Karen
- Apostolova Liana
- Ashok Raj Balebail
- Assaly Michele
- Asthana Sanjay
- Bachman David
- Bartha Rob
- Bartzokis George
- Bates Vernice
- Beccera Mauricio
- Beckett Laurel
- Belden Christine M.
- Bell Karen L.
- Bergman Howard
- Bernick Charles
- Black Sandra
- Blank Karen
- Bonakdarpour Borna
- Borges-Neto Salvador
- Borrie Michael
- Brand Connie
- Brewer James
- Brockington John
- Brooks William M.
- Brosch Jared R.
- Brown Alice D.
- Budson Andrew E.
- Burke Anna
- Burns Jeffrey M.
- Caldwell Curtis
- Capote Horacio
- Carlsson Cynthia M.
- Carmichael Owen
- Carroll Maria
- Carson Richard E.
- Carter Raina
- Cellar Janet S.
- Celmins Dzintra
- Cerbone Brittany
- Chaing Gloria
- Chertkow Howard
- Chowdhury Munir
- Clark David
- Coleman Edward
- Conrad Gary
- Correia Stephen
- Creech Mary L.
- Dang Mimi
- de Leon Mony J.
- De Santi Susan
- DeCarli Charles
- deToledo-Morrell Leyla
- Dolen Sara
- Doody Rachelle S.
- Doraiswamy P. Murali
- Duara Ranjan
- D’Agostino Daniel
- Fargher Kristin
- Farlow Martin R.
- Fatica Parianne
- Feldman Howard
- Finger Elizabeth
- Flashman Laura A.
- Fleisher Adam
- Fletcher Evan
- Franklin Erin
- Galvin James E.
- Garg Pradeep
- Geldmacher David
- Glodzik Lidia
- Goldstein Bonnie S.
- Gordineer Leslie
- Graff-Radford Neill R.
- Green Robert C.
- Greig Maria T.
- Griffith Randall
- Grossman Hillel
- Hake Ann Marie
- Hardy Peter
- Heidebrink Judith L.
- Hernando Raymundo
- Herring Scott
- Honig Lawrence S.
- Hosein Chris
- Hunt Cynthia
- Hynes Mary L.
- Ismail M. Saleem
- Jack Clifford R.
- Jacobson Sandra A.
- Jagust William
- Jiang Teng
- Jicha Greg
- Johnson Heather
- Johnson Kathleen
- Johnson Keith A.
- Johnson Kris
- Johnson Nancy
- Johnson Sterling
- Kataki Maria
- Kaye Jeffrey
- Kendall Tracy
- Kertesz Andrew
- Kerwin Diana
- Kielb Stephanie
- Killiany Ronald
- Kittur Smita
- Knopman David
- Kowall Neil
- Lah James J.
- Lane Barton
- Lee T-Y
- Lerner Alan
- Levey Allan I.
- Lin Michael
- Lind Betty
- Lipowski Kristine
- Lord Joanne L.
- Lu Po H.
- Lynn Johnson Patricia
- MacAvoy Martha G.
- Maillard Pauline
- Makino Kelly M.
- Malloy Paul
- Marshall Gad
- Marson Daniel
- Martin Kim
- Mason Sara S.
- Mathews Dana
- Matthews Brandy R.
- Mc-Adams-Ortiz Catherine
- Mesulam Marek-Marsel
- Miao Dan
- Michel Christina A.
- Miller Bruce L.
- Mintun Mark A.
- Mintzer Jacobo
- Mitsis Effie
- Morris John
- Morris John C.
- Mudge Benita
- Mulnard Ruth A.
- Munic Donna
- Natelson Love Marissa
- Nguyen Dana
- Norbash Alexander
- Oates Elizabeth
- Obisesan Thomas O.
- Ogrocki Paula
- Olichney John
- Oliver Angela
- Onyike Chiadi
- Ott Brian R.
- Parfitt Francine
- Pasternack Stephen
- Pawluczyk Sonia
- Pearlson Godfrey D.
- Perry David
- Petersen Ronald
- Petrella Jeffrey R.
- Pogorelec Dana M.
- Pomara Nunzio
- Porsteinsson Anton P.
- Potkin Steven G.
- Preda Adrian
- Querfurth Henry
- Quiceno Mary
- Quinn Joseph
- Rachisky Irina
- Rainka Michelle
- Ravdin Lisa
- Reeder Stephanie
- Relkin Norman
- Reynolds Brigid
- Roberson Erik
- Roberts Peggy
- Robin Hsiung Ging-Yuek
- Rosen Allyson
- Rosen Howard J.
- Rountree Susan
- Rusinek Henry
- Sabbagh Marwan N.
- Sadowsky Carl
- Salloway Stephen
- Santulli Robert B.
- Sarrael Antero
- Saykin Andrew J.
- Scharre Douglas W
- Schneider Lon S.
- Schneider Stacy
- Scott Turner Raymond
- Seltzer Marc
- Shah Raj C.
- Shaw Leslie M.
- Silbert Lisa
- Silverman Daniel H.S.
- Sinha Partha
- Sink Kaycee M.
- Sirrel Sherye A.
- Smith Amanda
- Smith Charles D.
- Spann Bryan M.
- Sperling Reisa A.
- Spicer Kenneth
- Stefanovic Bojana
- Stern Yaakov
- Swerdlow Russell H.
- Tan Chen-Chen
- Tan Lan
- Tan Lin
- Tan Meng-Shan
- Tariot Pierre
- Tatsuoka Curtis
- Taylor Joy L.
- Teodoro Liberty
- Thai Gaby
- Tingus Kathleen
- Tinklenberg Jared
- Toga Arthur W.
- Tremont Geoffrey
- Trncic Nadira
- Trojanowki John Q.
- Trost Dick
- van Dyck Christopher H.
- Vanderswag Helen
- Varma Pradeep
- Varon Daniel
- Villanueva-Meyer Javier
- Villena Teresa
- Wang Hui-Fu
- Watkins Franklin
- Weiner Michael W.
- Weintraub Sandra
- Williamson Jeff D.
- Wolday Saba
- Womack Kyle
- Wong Terence Z.
- Woo Ellen
- Wu Chuang-Kuo
- Xu Wei
- Yesavage Jerome
- Yu Jin-Tai
- Yu Wan-Jiang
- Zhu Xi-Chen
- Zimmerman Earl A.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 02/05/2016
- Field of study
Phosphatidylinositolbinding clathrin assembly protein (PICALM) gene is one novel genetic player associated with late-onset Alzheimer’s disease (LOAD), based on recent genome wide association studies (GWAS). However, how it affects AD occurrence is still unknown. Brain reserve hypothesis highlights the tolerant capacities of brain as a passive means to fight against neurodegenerations. Here, we took the baseline volume and/or thickness of LOAD-associated brain regions as proxies of brain reserve capacities and investigated whether PICALM genetic variations can influence the baseline reserve capacities and the longitudinal atrophy rate of these specific regions using data from Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. In mixed population, we found that brain region significantly affected by PICALM genetic variations was majorly restricted to posterior cingulate. In sub-population analysis, we found that one PICALM variation (C allele of rs642949) was associated with larger baseline thickness of posterior cingulate in health. We found seven variations in health and two variations (rs543293 and rs592297) in individuals with mild cognitive impairment were associated with slower atrophy rate of posterior cingulate. Our study provided preliminary evidences supporting that PICALM variations render protections by facilitating reserve capacities of posterior cingulate in non-demented elderly
Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images
- Author
- Adam Fleisher
- Adam Fleisher
- Adam Schwartz
- Adrian Preda
- Adrian Preda
- Adrian Preda
- Alan Lerner
- Alexander Norbash
- Alice D. Brown
- Allan I. Levey
- Allyson Rosen
- Amanda Smith
- Andrew E. Budson
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew Kertesz
- Andrew Kertesz
- Angela Oliver
- Ann Marie Hake
- Ann Marie Milliken
- Anna Burke
- Ansgar J. Furst
- Antero Sarrael
- Anton P. Porsteinsson
- Anton P. Porsteinsson
- Archana B. Balasubramanian
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Balebail Ashok Raj
- Barton Lane
- Beau Ances
- Becerra Mauricio
- Benita Mudge
- Betty Lind
- Bojana Stefanovic
- Bonnie Goldstein
- Bonnie S. Goldstein
- Borna Bonakdarpour
- Brandy R. Matthews
- Brendan Kelley
- Bret Borowski
- Bret Borowski
- Brian R. Ott
- Brigid Reynolds
- Brigid Reynolds
- Bruce L. Miller
- Bryan M. Spann
- Carl Sadowsky
- Carl Sadowsky
- Chad Ward
- Charles Bernick
- Charles D. Smith
- Charles DeCArli
- Charles DeCarli
- Chet Mathis
- Chiadi Onyike
- Chris Hosein
- Christine M. Belden
- Christopher H. van Dyck
- Christopher M. Clark
- Chuang-Kuo Wu
- Chunren Lai
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Colleen S. Albers
- Congling Wu
- Connie Brand
- Crawford Karen
- Curtis Caldwell
- Curtis Tatsuoka
- Cynthia M. Carlsson
- Dana Mathews
- Dana Nguyen
- Dana Nguyen
- Dana Nguyen
- Daniel D'Agostino
- Daniel H.S. Silverman
- Daniel Marson
- Daniel Varon
- Danielle Harvey
- Danielle Harvey
- Danielle Harvey
- David A. Wolk
- David Bachman
- David Clark
- David Geldmacher
- David Holtzman
- David Jones
- David Knopman
- David Perry
- David Perry
- Davis Melissa
- Debra Fleischman
- Devon Gessert
- Diana Kerwin
- Dick Drost
- Dick Trost
- Dino Massoglia
- Donna M. Simpson
- Donna Munic
- Douglas W. Scharre
- Dzintra Celmins
- Earl A. Zimmerman
- Edward Coleman
- Effie Mitsis
- Elaine R. Peskind
- Elizabeth Finger
- Elizabeth Finger
- Elizabeth Oates
- Ellen Woo
- Emily Rogalski
- Eric C. Petrie
- Eric M. Reiman
- Eric M. Reiman
- Erik Roberson
- Erin Franklin
- Erin Franklin
- Erin Householder
- Evan Fletcher
- Finley Shannon
- Francine Parfitt
- Franklin Watkins
- Franz Hefti
- Friedl Karl
- Gad Marshall
- Gad Marshall
- Gaikwad Mrunalini
- Gail Li
- Gary Conrad
- Geoffrey Tremont
- George Bartzokis
- Gessert Devon
- Ging-Yuek Robin Hsiung
- Gloria Chiang
- Gloria Chiang
- Godfrey D. Pearlson
- Gordineer Leslie
- Greg Jicha
- Greg Sorensen
- Guiyin Cen
- Gus Jiminez
- Gus Jiminez
- Hayes Jacqueline
- Helen Vanderswag
- Helen Vanderswag
- Hillel Grossman
- Horacio Capote
- Howard Bergman
- Howard Chertkow
- Howard Feldman
- Howard Fillit
- Howard J. Rosen
- Howard Rosen
- Hristina Koleva
- Hyungsub Shim
- Irina Rachinsky
- Irina Rachisky
- Iris Sim
- J. Jay Fruehling
- Jacobo Mintzer
- Jacobo Mintzer
- James Brewer
- James Brewer
- James J. Lah
- Janet S. Cellar
- Jared R. Brosch
- Jared Tinklenberg
- Jason H. Karlawish
- Javier Villanueva-Meyer
- Jeff D. Williamson
- Jeff Gunter
- Jeff Gunter
- Jeffrey Kaye
- Jeffrey M. Burns
- Jeffrey R. Petrella
- Jeffrey R. Petrella
- Jennifer Mason
- Jerome A. Yesavage
- Jerome Yesavage
- Joanne Allard
- Joanne Allard
- Joanne L. Lord
- John Brockington
- John C. Morris
- John C. Morris
- John C. Morris
- John C. Morris
- John Hsiao
- John Morris
- John Olichney
- John Q. Trojanowki
- John Q. Trojanowki
- John Q. Trojanowki
- John Q. Trojanowki
- John Rogers
- Jordan Grafman
- Joseph Quinn
- Joy L. Taylor
- Joy L. Taylor
- Judith L. Heidebrink
- Kantarci Kejal
- Karen Anderson
- Karen Blank
- Karen Crawford
- Karen Ekstam Smith
- Karen L. Bell
- Karen L. Bell
- Kathleen Johnson
- Kathleen Tingus
- Kaycee M. Sink
- Keith A. Johnson
- Keith A. Johnson
- Kejal Kantarci
- Kelley Faber
- Kelley Faber
- Kelly Behan
- Kelly M. Makino
- Kenneth Spicer
- Kewei Chen
- Kewei Chen
- Ki Won Nam
- Kim Martin
- Kim Poki-Walker
- Kimberly S. Martin
- Konstantinos Arfanakis
- Kris Johnson
- Kristin Fargher
- Kristine Lipowski
- Kwangsik Nho
- Kwangsik Nho
- Kyle Womack
- Laura A. Flashman
- Laurel Beckett
- Laurel Beckett
- Lawrence S. Honig
- Lawrence S. Honig
- Lean Thal
- Leon Thal
- Leslie M. Shaw
- Leslie M. Shaw
- Leslie M. Shaw
- Leslie M. Shaw
- Lew Kuller
- Leyla deToledo-Morrell
- Li Shen
- Li Shen
- Liana Apostolova
- Liberty Teodoro
- Lisa Ravdin
- Lisa Ravdin
- Lisa Silbert
- Lisa Taylor-Reinwald
- Lon S. Schneider
- Lon S. Schneider
- Lori A. Daiello
- M. Marcel Mesulam
- M. Saleem Ismail
- Magdalena Korecka
- Magdalena Korecka
- Marc Raichle
- Marc Seltzer
- Marek-Marsel Mesulam
- Maria Carrillo
- Maria Carroll
- Maria Kataki
- Maria T Greig
- Maria T. Greig-Custo
- Marilyn Albert
- Marilyn Albert
- Marissa Natelson Love
- Mark A. Mintun
- Martha G. MacAvoy
- Martin R. Farlow
- Martin Sadowski
- Marwan N. Sabbagh
- Marwan N. Sabbagh
- Mary L. Creech
- Mary L. Hynes
- Mary Quiceno
- MaryAnn Oakley
- Matt Senjem
- Matt Senjem
- Matthew Bernstein
- Matthew Bernstein
- Mauricio Becerra
- Michael Borrie
- Michael Donohue
- Michael Donohue
- Michael Donohue
- Michael Donohue
- Michael Lin
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael Weiner
- Michael Weiner
- Michael Weiner
- Michal Figurski
- Michal Figurski
- Michele Assaly
- Michelle Rainka
- Mimi Dang
- Mohammed O. Sheikh
- Munir Chowdhury
- Nadira Trncic
- Nancy Johnson
- Neil Buckholtz
- Neil Kowall
- Neill R Graff-Radford
- Neu Scott
- Nick Fox
- Nigel J. Cairns
- Nigel J. Cairns
- Norbert Schuff
- Norm Foster
- Norm Foster
- Norman Relkin
- Norman Relkin
- Nunzio Pomara
- Olga Brawman-Mintzer
- Olga James
- Oscar L. Lopez
- Owen Carmichael
- P. Murali Doraiswamy
- P. Murali Doraiswamy
- Parianne Fatica
- Partha Sinha
- Patricia Lynn Johnson
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Malloy
- Paul Thompson
- Paula Ogrocki
- Pauline Maillard
- Peter Davies
- Peter Hardy
- Peter J. Snyder
- Peter Snyder
- Pierre Tariot
- Po H. Lu
- Pradeep Garg
- Pradeep Varma
- Prashanthi Vemuri
- Rachelle S. Doody
- Raina Carter
- Raj C. Shah
- Raj C. Shah
- Randall Griffith
- Ranjan Duara
- Ranjan Duara
- Raymond Scott Turner
- Raymond Scott Turner
- Raymundo Hernando
- Reisa A. Sperling
- Reisa A. Sperling
- Richard E. Carson
- Richard Frank
- Rob Bartha
- Robert A. Koeppe
- Robert A. Koeppe
- Robert B. Santulli
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Ronald G. Thomas
- Ronald G. Thomas
- Ronald Killiany
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Rosemary Morrison
- Russell H. Swerdlow
- Saba Wolday
- Saba Wolday
- Salvador Borges-Neto
- Sandra A. Jacobson
- Sandra A. Jacobson
- Sandra Black
- Sandra Harding
- Sandra Weintraub
- Sanjay Asthana
- Sara Dolen
- Sara S. Mason
- Sarah Walter
- Scott Herring
- Scott Neu
- Shengwen Guo
- Sherye A. Sirrel
- Sherye A. Sirrel
- Smita Kittur
- Sonia Pawluczyk
- Sonia Pawluczyk
- Stacy Schneider
- Stephanie Kielb
- Stephanie Reeder
- Stephen Correia
- Stephen Pasternack
- Stephen Pasternak
- Stephen Salloway
- Sterling C. Johnson
- Sterling Johnson
- Steven Chao
- Steven E. Arnold
- Steven G. Potkin
- Steven G. Potkin
- Steven G. Potkin
- Steven Paul
- Steven Paul
- Steven Potkin
- Steven Potkin
- Sungeun Kim
- Sungeun Kim
- Susan K. Schultz
- Susan Landau
- Susan Landau
- Susan Landau
- Susan Rountree
- T-Y Lee
- Tamie Sather
- Tamie Sather
- Tatiana M. Foroud
- Tatiana M. Foroud
- Terence Z. Wong
- Teresa Villena
- Teresa Villena
- The Alzheimer's Disease Neuroimaging Initiative
- Thomas Neylan
- Thomas Neylan
- Thomas O. Obisesan
- Thomas O. Obisesan
- Tom Montine
- Tom Montine
- Ulysse Anaztasia
- Valory Pavlik
- Vernice Bates
- Vesna Sossi
- Victoria Shibley
- Virginia Lee
- Virginia Lee
- Walter Martinez
- Ward Chad
- Warren Barker
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William M. Brooks
- William Potter
- William Potter
- Yaakov Stern
- Yaakov Stern
- Zaven Khachaturian
- Zaven Khachaturian
- Zaven Khachaturian
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/05/2017
- Field of study
Neuroimaging measurements derived from magnetic resonance imaging provide important information required for detecting changes related to the progression of mild cognitive impairment (MCI). Cortical features and changes play a crucial role in revealing unique anatomical patterns of brain regions, and further differentiate MCI patients from normal states. Four cortical features, namely, gray matter volume, cortical thickness, surface area, and mean curvature, were explored for discriminative analysis among three groups including the stable MCI (sMCI), the converted MCI (cMCI), and the normal control (NC) groups. In this study, 158 subjects (72 NC, 46 sMCI, and 40 cMCI) were selected from the Alzheimer's Disease Neuroimaging Initiative. A sparse-constrained regression model based on the l2-1-norm was introduced to reduce the feature dimensionality and retrieve essential features for the discrimination of the three groups by using a support vector machine (SVM). An optimized strategy of feature addition based on the weight of each feature was adopted for the SVM classifier in order to achieve the best classification performance. The baseline cortical features combined with the longitudinal measurements for 2 years of follow-up data yielded prominent classification results. In particular, the cortical thickness produced a classification with 98.84% accuracy, 97.5% sensitivity, and 100% specificity for the sMCI–cMCI comparison; 92.37% accuracy, 84.78% sensitivity, and 97.22% specificity for the cMCI–NC comparison; and 93.75% accuracy, 92.5% sensitivity, and 94.44% specificity for the sMCI–NC comparison. The best performances obtained by the SVM classifier using the essential features were 5–40% more than those using all of the retained features. The feasibility of the cortical features for the recognition of anatomical patterns was certified; thus, the proposed method has the potential to improve the clinical diagnosis of sub-types of MCI and predict the risk of its conversion to Alzheimer's disease
Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients
- Author
- Adam Fleisher
- Adam Fleisher
- Adam Schwartz
- Adrian Preda
- Adrian Preda
- Adrian Preda
- Alan Lerner
- Alexander Norbash
- Alice D. Brown
- Allan I. Levey
- Allyson Rosen
- Alzheimer's Disease Neuroimaging Initiative
- Amanda Smith
- Andrew E. Budson
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew Kertesz
- Andrew Kertesz
- Angela Oliver
- Ann Marie Hake
- Ann Marie Milliken
- Anna Burke
- Ansgar J. Furst
- Antero Sarrael
- Anton P. Porsteinsson
- Anton P. Porsteinsson
- Archana B. Balasubramanian
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Balebail Ashok Raj
- Barton Lane
- Beau Ances
- Becerra Mauricio
- Benita Mudge
- Betty Lind
- Bojana Stefanovic
- Bonnie Goldstein
- Bonnie S. Goldstein
- Borna Bonakdarpour
- Brandy R. Matthews
- Brendan Kelley
- Bret Borowski
- Bret Borowski
- Bret Borowski
- Brian R. Ott
- Brigid Reynolds
- Brigid Reynolds
- Bruce L. Miller
- Bryan M. Spann
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- Tamie Sather
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- Tatiana M. Foroud
- Tatiana M. Foroud
- Terence Z. Wong
- Teresa Villena
- Teresa Villena
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- Thomas Neylan
- Thomas O. Obisesan
- Thomas O. Obisesan
- Tom Montine
- Tom Montine
- Ulysse Anaztasia
- Valory Pavlik
- Vernice Bates
- Vesna Sossi
- Victoria Shibley
- Virginia Lee
- Virginia Lee
- Walter Martinez
- Ward Chad
- Warren Barker
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William M. Brooks
- William Potter
- William Potter
- Yaakov Stern
- Yaakov Stern
- Yiu Ho Au
- Yuliana Cabrera
- Yun Zhou
- Yun Zhou
- Zaven Khachaturian
- Zaven Khachaturian
- Zaven Khachaturian
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/05/2019
- Field of study
Recent developments of tau Positron Emission Tomography (PET) allows assessment of regional neurofibrillary tangles (NFTs) deposition in human brain. Among the tau PET molecular probes, 18F-AV1451 is characterized by high selectivity for pathologic tau aggregates over amyloid plaques, limited non-specific binding in white and gray matter, and confined off-target binding. The objectives of the study are (1) to quantitatively characterize regional brain tau deposition measured by 18F-AV1451 PET in cognitively normal older adults (CN), mild cognitive impairment (MCI), and AD participants; (2) to evaluate the correlations between cerebrospinal fluid (CSF) biomarkers or Mini-Mental State Examination (MMSE) and 18F-AV1451 PET standardized uptake value ratio (SUVR); and (3) to evaluate the partial volume effects on 18F-AV1451 brain uptake.Methods: The study included total 115 participants (CN = 49, MCI = 58, and AD = 8) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Preprocessed 18F-AV1451 PET images, structural MRIs, and demographic and clinical assessments were downloaded from the ADNI database. A reblurred Van Cittertiteration method was used for voxelwise partial volume correction (PVC) on PET images. Structural MRIs were used for PET spatial normalization and region of interest (ROI) definition in standard space. The parametric images of 18F-AV1451 SUVR relative to cerebellum were calculated. The ROI SUVR measurements from PVC and non-PVC SUVR images were compared. The correlation between ROI 18F-AV1451 SUVR and the measurements of MMSE, CSF total tau (t-tau), and phosphorylated tau (p-tau) were also assessed.Results:18F-AV1451 prominently specific binding was found in the amygdala, entorhinal cortex, parahippocampus, fusiform, posterior cingulate, temporal, parietal, and frontal brain regions. Most regional SUVRs showed significantly higher uptake of 18F-AV1451 in AD than MCI and CN participants. SUVRs of small regions like amygdala, entorhinal cortex and parahippocampus were statistically improved by PVC in all groups (p < 0.01). Although there was an increasing tendency of 18F-AV-1451 SUVRs in MCI group compared with CN group, no significant difference of 18F-AV1451 deposition was found between CN and MCI brains with or without PVC (p > 0.05). Declined MMSE score was observed with increasing 18F-AV1451 binding in amygdala, entorhinal cortex, parahippocampus, and fusiform. CSF p-tau was positively correlated with 18F-AV1451 deposition. PVC improved the results of 18F-AV-1451 tau deposition and correlation studies in small brain regions.Conclusion: The typical deposition of 18F-AV1451 tau PET imaging in AD brain was found in amygdala, entorhinal cortex, fusiform and parahippocampus, and these regions were strongly associated with cognitive impairment and CSF biomarkers. Although more deposition was observed in MCI group, the 18F-AV-1451 PET imaging could not differentiate the MCI patients from CN population. More tau deposition related to decreased MMSE score and increased level of CSF p-tau, especially in ROIs of amygdala, entorhinal cortex and parahippocampus. PVC did improve the results of tau deposition and correlation studies in small brain regions and suggest to be routinely used in 18F-AV1451 tau PET quantification
Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.
- Author
- Ahmed Munaza
- Aitken Stuart
- Aitman Timothy
- Akawi Nadia
- Al Turki Saeed
- Alachkar Hana
- Ali Sonia
- Allen Hana Lango
- Allen Louise
- Allsup David
- Alvi Mohsan
- Ambegaonkar Gautum
- Ambridge Kirsty
- Anderson Carl
- Anderson Julie
- Anjum Uruj
- Anney Richard
- Antony Dinu
- Antrobus Richard
- Archer Hayley
- Armstrong Ruth
- Armstrong Ruth
- Arno Gavin
- Artigas Maria Soler
- Arumugakani Gururaj
- Ashford Sofie
- Astle William
- Attwood Antony
- Austin Steve
- Awada Jana
- Ayub Muhammad
- Bacchelli Chiara
- Bakchoul Tamam
- Balasubramaniam Senduran
- Balasubramanian Meena
- Banka Siddharth
- Baralle Diana
- Bariana Tadbir K.
- Barnicoat Angela
- Barrett Daniel M.
- Barrett Jeffrey C.
- Barrett Jeffrey C.
- Barroso Inês
- Batstone Paul
- Baty David
- Baxendale Helen
- Bayzetinova Tanya
- Beales Phil
- Bennett Chris
- Bennett David
- Bentham Jamie
- Berg Jonathan
- Bernhard Birgitta
- Bethune Claire
- Bevan A. Paul
- Bhattacharya Shoumo
- Bibi Shahnaz
- Birney Ewan
- Bitner-Glindzicz Maria
- Bitner-Glindzicz Maria
- Blackwood Douglas
- Blair Edward
- Bleda Marta
- Blyth Moira
- Bobrow Martin
- Bochukova Elena
- Boggard Harm
- Bohanna David
- Bolton Patrick
- Bolton-Maggs Paula
- Booth Claire
- Bounds Rebecca
- Bourdon Louise
- Bourn David
- Boustred Chris
- Bradley John R.
- Bradley Lisa
- Brady Angela
- Brady Angie
- Breen Gerome
- Brent Simon
- Brewer Carole
- Brown Matthew
- Browning Michael
- Brunstrom Kate
- Bryant Emily
- Bryson Christine
- Bunyan David J.
- Burn John
- Burns Siobhan
- Calissano Mattia
- Calleja Paul
- Canham Natalie
- Canham Natalie
- Carmichael Jenny
- Carss Keren
- Carss Keren
- Carss Keren J.
- Carvill Gemma L.
- Castle Bruce
- Caulfield Mark
- Chalmers Elizabeth
- Chandler Kate
- Chandra Anita
- Chatterjee Krishna
- Chatzimichali Elena
- Chen Lu
- Chinnery Patrick
- Chitre Manali
- Church Colin
- Ciampi Antonio
- Cilliers Deirdre
- Cirak Sebhattin
- Clapham Peter
- Clarke Angus
- Clasper Susan
- Clayton Stephen
- Clayton-Smith Jill
- Clayton-Smith Jill
- Clement Emma
- Clement Gail
- Clements-Brod Naomi
- Clowes Virginia
- Clowes Virginia
- Coates Andrea
- Coates Guy
- Coghlan Gerry
- Cole Trevor
- Colgiu Irina
- Collier David
- Collins Amanda
- Collins Peter
- Collinson Morag N.
- Connell Fiona
- Cooper Nichola
- Cooper Nicola
- Cosgrove Catherine
- Cox Helen
- Cox Tony
- Craddock Nick
- Creaser-Myers Amanda
- Cresswell Lara
- Crooks Lucy
- Cross Gareth
- Cross J. Helen
- Crow Yanick
- Curran Sarah
- Curtis David
- D?Alessandro Mariella
- Dabir Tabib
- DaCosta Rosa
- Daly Allan
- Daugherty Louise
- Davidson Rosemarie
- Davies Sally
- Davies Sophie
- Davis John
- Day Ian N.M.
- Day-Williams Aaron
- de Vries Dylan
- De Vries Minka
- Dean John
- Debelle Geoff D.
- Deegan Patrick
- Deevi Sri V.V.
- Deshpande Charu
- Deshpande Charu
- Devlin Gemma
- Devlin Lisa
- Dewhurst Eleanor
- Dixit Abhijit
- Dobbie Angus
- Doffinger Rainer
- Donaldson Alan
- Donnai Dian
- Donnelly Carina
- Donnelly Deirdre
- Dormand Natalie
- Douglas Angela
- Douzgou Sofia
- Down Thomas
- Drewe Elizabeth
- Du Yuanping
- Duncan Alexis
- Dunham Ian
- Eason Jacqueline
- Edgar David
- Edkins Sarah
- Egner William
- Ellard Sian
- Ellis Ian
- Ellis Peter
- Elmslie Frances
- Erber Wendy N.
- Erwood Marie
- Evans David
- Evans Karenza
- Everest Sarah
- Everington Tamara
- Faroogi Sadaf
- Fatemifar Ghazaleh
- Favier Remi
- Fendick Tina
- Firth Helen
- Firth Helen V.
- Fisher Richard
- Fitzgerald Tomas W.
- FitzPatrick David R.
- Fitzpatrick David R.
- Fletcher Debra
- Flicek Paul
- Flinter Frances
- Flinter Frances
- Flyod James
- Foley A. Reghan
- Foulds Nicola
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- Franklin Christopher S.
- Frary Amy
- Freson Kathleen
- Fry Andrew
- Fryer Alan
- Furie Bruce
- Furnell Abigail
- Futema Marta
- Gale Daniel
- Gallagher Louise
- Gardham Alice
- Gardiner Carol
- Gattens Michael
- Gaunt Lorraine
- Geihs Matthias
- Geschwind Daniel
- Ghali Neeti
- Ghali Neeti
- Ghataorhe Pavandeep K.
- Ghurye Rohit
- Gibbons Richard
- Gibbs Simon
- Gill Harinder
- Gilmour Kimberley
- Gissen Paul
- Goddard Sarah
- Gomez Keith
- Goodship Judith
- Gordins Pavel
- Gorman Kathleen M.
- Goudie David
- Gray Emma
- Green Andrew
- Greene Daniel
- Greene Philip
- Greenhalgh Alan
- Greenhalgh Lynn
- Greinacher Andreas
- Gribble Susan
- Griffin Heather
- Grigoriadou Sofia
- Grozeva Detelina
- Gräf Stefan
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- Gurling Hugh
- Haack Tobias B.
- Hackett Scott
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- Harrison Lucy
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- Hart Deborah
- Hawkins Rose
- Hayman Grant
- He Liu
- Heemskerk Johan W.M.
- Hellens Stephen
- Henderson Alex
- Henderson Robert
- Hendricks Audrey
- Hensiek Anke
- Henskens Yvonne
- Herwadkar Archana
- Hewitt Sarah
- Hildyard Lucy
- Hobson Emma
- Holden Simon
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- Holder Muriel
- Holder Muriel
- Holder Susan
- Holder Susan
- Hollingsworth Georgina
- Holmans Peter
- Homfray Tessa
- Howie Bryan
- Hu Fengyuan
- Huang Liren
- Hubbard Tim
- Huissoon Aarnoud
- Humbert Marc
- Humphreys Mervyn
- Humphries Steve E.
- Hurles Matthew E.
- Hurles Matthew E.
- Hurst Jane
- Hurst Jane
- Hutton Ben
- Hysi Pirro
- Ingram Stuart
- Iotchkova Valentina
- Irving Melita
- Islam Lily
- Jackson Andrew
- Jackson David K.
- James Roger
- Jamshidi Yalda
- Jan-Kamsteeg Eric
- Jarvis Joanna
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- Jing Tian
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- Jolles Stephen
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- Jones Wendy D.
- Josifova Dragana
- Josifova Dragana
- Joss Shelagh
- Joyce Chris
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- Kaplanis Joanna
- Kaye Jane
- Kazembe Sandra
- Kazmi Rashid
- Keane Thomas
- Keeling David
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- Kelly Anne M.
- Kelsell Rosemary
- Kemp John
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- Keogh Julia
- Kerr Bronwyn
- Kiely David
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- King Mary D.
- Kingston Helen
- Kingston Nathalie
- Kini Usha
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- Kirby Gail
- Kirk Claire
- Kivuva Emma
- Kolb-Kokocinski Anja
- Koziell Ania
- Kraus Alison
- Krishnakumar Deepa
- Krishnappa Netravathi
- Kuijpers Taco W.
- Kumar Dhavendra
- Kumar V. K. Ajith
- Kumararatne Dinakantha
- Kurian Manju
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- Lachance Genevieve
- Lachlan Katherine
- Laffan Michael A.
- Lam Wayne
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- Lampe Anne
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- Lawrie Allan
- Lawson Daniel
- Lear Sara
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- Lees Melissa
- Lees Melissa
- Lek Monkol
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- Li Rui
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- Lin Hong
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- Longhurst Hilary
- Longman Cheryl
- Lopes Margarida
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- Lowther Gordon
- Lynch Sally A.
- Lönnqvist Jouko
- MacArthur Daniel
- Machado Rajiv
- Mackenzie Rob
- MacLaren Robert
- Magee Alex
- Maher Eamonn
- Maher Eamonn R.
- Maher Eddy
- Maimaris Jesmeen
- Male Alison
- Mangles Sarah
- Manson Ania
- Mansour Sahar
- Mapeta Rutendo
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- Markus Hugh S.
- Martin Jennifer
- Martin Katherine
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- Maslen John
- Mason Laura E.
- Massimo Mangino
- Mathias Mary
- Mathieson Iain
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- McCullagh Gary
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- McGuffin Peter
- McIntosh Andrew
- McJannet Coleen
- McKay Kirsten
- McKechanie Andrew G.
- McKee Shane
- McMullan Dominic J.
- McNerlan Susan
- McQuillin Andrew
- McRae Jeremy F.
- McTague Amy
- McWilliam Catherine
- Meacham Stuart
- Meehan Sharon
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- Megy Karyn
- Mehta Sarju
- Mehta Sarju
- Metcalfe Kay
- Metrustry Sarah
- Meyer Esther
- Michaelides Michel
- Middleton Anna
- Miedzybrodzka Zosia
- Miles Emma
- Millar Carolyn M.
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- Mitchison Hannah
- Moayyeri Alireza
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- Moledina Shahin
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- Morton Jenny
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- Murphy Helen
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- O'Shea Rosie
- Ogilvie Caroline
- Oksenhendler Eric
- Ong Kai-Ren
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- Oualkacha Karim
- Ouwehand Willem H.
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- Pridham Abigail
- Prigmore Elena
- Procter Annie
- Purnell Hellen
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- Raymond Lucy
- Raymond Lucy
- Rehnstrom Karola
- Rehnström Karola
- Reich Adi
- Reid Evan
- Rhodes Christopher J.
- Rice Debbie
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- Vijayarangakannan Parthiban
- Vijayarangakannan Parthiban
- Visscher Peter M.
- Vogt Julie
- Vogt Julie
- von Ziegenweldt Julie
- Vonk Noordegraaf Anton
- Wain Louise V.
- Wakeling Emma
- Wakeling Emma
- Wallwark Sarah
- Walters James T.R.
- Wang Guangbiao
- Wang Jun
- Wang Yu
- Wanjiku Ivy
- Ward Kirsten
- Warner Timothy Q.
- Wassmer Evangeline
- Wassmer Evangeline
- Waters Jonathon
- Watkins Hugh
- Weber Astrid
- Webster Andrew
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- Wellesley Diana
- Westbury Sarah
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- Whitehorn Deborah
- Whyte Tamieka
- Widaa Sara
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- Wilkins Martin
- Wilkinson Emily
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- Williams Hywel
- Williams Nicola
- Williamson Catherine
- Williamson Kathleen A.
- Wilson Crispian
- Wilson Louise
- Wong Kim
- Woods Geoff
- Woods Geoffrey
- Wort John
- Wragg Christopher
- Wright Caroline F.
- Wright Michael
- Xu ChangJiang
- Yang Jian
- Yates Laura
- Yau Michael
- Yeatman Nigel
- Yong Patrick
- Young Tim
- Yu Ping
- Zhang Fend
- Zhang Pingbo
- Publication venue
- AJHG
- Publication date
- 01/01/2019
- Field of study
The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)
Search for single production of vector-like quarks decaying into Wb in pp collisions at s=8 TeV with the ATLAS detector
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- Abbott Brad
- Abdallah Jalal
- Abdinov Ovsat
- Abeloos Baptiste
- Aben Rosemarie
- Abolins Maris
- AbouZeid Ossama
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby Sami
- Adamczyk Leszek
- Adams David
- Adelman Jahred
- Adomeit Stefanie
- Adye Tim
- Affolder Tony
- Agatonovic-Jovin Tatjana
- Agricola Johannes
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- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akerstedt Henrik
- Akimov Andrei
- Alberghi Gian Luigi
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- Oliveira Damazio Denis
- Olszewski Andrzej
- Olszowska Jolanta
- Onofre António
- Onogi Kouta
- Onyisi Peter
- Oram Christophe
- Oreglia Mark
- Oren Yona
- Orestano Domizia
- Orlando Nicola
- Orr Robert
- Osculati Bianca
- Ospanov Rustem
- Otero y Garzon Gustavo
- Otono Hidetoshi
- Ouchrif Mohamed
- Ould-Saada Farid
- Ouraou Ahmimed
- Oussoren Koen Piete
- Ouyang Qun
- Ovcharova Ana
- Owen Mark
- Owen Rhys Edwar
- Ozcan Veysi Erkc
- Ozturk Nurcan
- Pachal Katherine
- Pacheco Pages Andres
- Padilla Aranda Cristobal
- Pagan Griso Simone
- Pagáčová Martina
- Paige Frank
- Pais Preema
- Pajchel Katarina
- Palacino Gabriel
- Palestini Sandro
- Palka Marek
- Pallin Dominique
- Palma Alberto
- Panagiotopoulou Evgenia
- Pandini Carlo Enri
- Panduro Vazquez William
- Pani Priscilla
- Panitkin Sergey
- Pantea Dan
- Paolozzi Lorenzo
- Papadopoulou Theodora
- Papageorgiou Konstantin
- Paramonov Alexander
- Paredes Hernandez Daniela
- Parker Kerry Ann
- Parker Michael An
- Parodi Fabrizio
- Parsons John
- Parzefall Ulrich
- Pascuzzi Vincent
- Pasqualucci Enrico
- Passaggio Stefano
- Pastore Fernanda
- Pastore Francesca
- Pataraia Sophio
- Patel Nikhul
- Pater Joleen
- Pauly Thilo
- Pearce James
- Pearson Benjamin
- Pedersen Lars Eghol
- Pedersen Maiken
- Pedraza Lopez Sebastian
- Pedro Rute
- Peleganchuk Sergey
- Pelikan Daniel
- Penc Ondrej
- Peng Cong
- Peng Haiping
- Penning Bjoern
- Penwell John
- Perepelitsa Dennis
- Perez Codina Estel
- Perini Laura
- Pernegger Heinz
- Perrella Sabrina
- Peschke Richard
- Peshekhonov Vladimir
- Peters Krisztian
- Peters Yvonne
- Petersen Brian
- Petersen Troels
- Petit Elisabeth
- Petridis Andreas
- Petridou Chariclia
- Petroff Pierre
- Petrolo Emilio
- Petrucci Fabrizio
- Pettersson Nora Emili
- Peyaud Alan
- Pezoa Raquel
- Phillips Peter Will
- Piacquadio Giacinto
- Pianori Elisabetta
- Picazio Attilio
- Piccaro Elisa
- Piccinini Maurizio
- Pickering Mark Andre
- Piegaia Ricardo
- Pilcher James
- Pilkington Andrew
- Pin Arnaud Wil
- Pina João Anto
- Pinamonti Michele
- Pinfold James
- Pingel Almut
- Pires Sylvestre
- Pirumov Hayk
- Pitt Michael
- Plazak Lukas
- Pleier Marc-Andre
- Pleskot Vojtech
- Plotnikova Elena
- Plucinski Pawel
- Pluth Daniel
- Poettgen Ruth
- Poggioli Luc
- Pohl David-leon
- Polesello Giacomo
- Poley Anne-luise
- Policicchio Antonio
- Polifka Richard
- Polini Alessandro
- Pollard Christophe
- Polychronakos Venetios
- Pommès Kathy
- Pontecorvo Ludovico
- Pope Bernard
- Popeneciu Gabriel Al
- Popovic Dragan
- Poppleton Alan
- Pospisil Stanislav
- Potamianos Karolos
- Potrap Igor
- Potter Christina
- Potter Christophe
- Poulard Gilbert
- Poveda Joaquin
- Pozdnyakov Valery
- Pozo Astigarraga Mikel Euke
- Pralavorio Pascal
- Pranko Aliaksandr
- Prell Soeren
- Price Darren
- Price Lawrence
- Primavera Margherita
- Prince Sebastien
- Proissl Manuel
- Prokofiev Kirill
- Prokoshin Fedor
- Protopapadaki Eftychia-s
- Protopopescu Serban
- Proudfoot James
- Przybycien Mariusz
- Puddu Daniele
- Puldon David
- Purohit Milind
- Puzo Patrick
- Pásztor Gabriella
- Qian Jianming
- Qin Gang
- Qin Yang
- Quadt Arnulf
- Quarrie David
- Quayle William
- Queitsch-Maitland Michaela
- Quilty Donnchadha
- Raddum Silje
- Radeka Veljko
- Radescu Voica
- Radhakrishnan Sooraj Kri
- Radloff Peter
- Rados Pere
- Ragusa Francesco
- Rahal Ghita
- Rajagopalan Srinivasan
- Rammensee Michael
- Rangel-Smith Camila
- Rauscher Felix
- Rave Stefan
- Ravenscroft Thomas
- Raymond Michel
- Read Alexander
- Readioff Nathan Pet
- Rebuzzi Daniela
- Redelbach Andreas
- Redlinger George
- Reece Ryan
- Reeves Kendall
- Rehnisch Laura
- Reichert Joseph
- Reisin Hernan
- Rembser Christoph
- Ren Huan
- Rescigno Marco
- Resconi Silvia
- Rezanova Olga
- Reznicek Pavel
- Rezvani Reyhaneh
- Richter Robert
- Richter Stefan
- Richter-Was Elzbieta
- Ricken Oliver
- Ridel Melissa
- Rieck Patrick
- Riegel Christian
- Rieger Julia
- Rifki Othmane
- Rijssenbeek Michael
- Rimoldi Adele
- Rinaldi Lorenzo
- Ristić Branislav
- Ritsch Elmar
- Riu Imma
- Rizatdinova Flera
- Rizvi Eram
- Robertson Steven
- Robichaud-Veronneau Andree
- Robinson Dave
- Robinson James
- Robson Aidan
- Roda Chiara
- Rodina Yulia
- Rodriguez Perez Andrea
- Roe Shaun
- Rogan Christophe
- Romaniouk Anatoli
- Romano Saez Silvestre
- Romano Marino
- Romero Adam Elena
- Rompotis Nikolaos
- Ronzani Manfredi
- Roos Lydia
- Ros Eduardo
- Rosati Stefano
- Rosbach Kilian
- Rose Peyton
- Rosenthal Oliver
- Rossetti Valerio
- Rossi Elvira
- Rossi Leonardo P
- Rosten Jonatan
- Rosten Rachel
- Rotaru Marina
- Roth Itamar
- Rothberg Joseph
- Rousseau David
- Royon Christophe
- Rozanov Alexandre
- Rozen Yoram
- Ruan Xifeng
- Rubbo Francesco
- Rubinskiy Igor
- Rud Viacheslav
- Rudolph Matthew Sc
- Ruiz-Martinez Aranzazu
- Rurikova Zuzana
- Rusakovich Nikolai
- Ruschke Alexander
- Russell Heather
- Rutherfoord John
- Ruthmann Nils
- Ryabov Yury
- Rybar Martin
- Rybkin Grigori
- Ryder Nick
- Ryzhov Andrey
- Røhne Ole
- Rühr Frederik
- Saavedra Aldo
- Sabato Gabriele
- Sacerdoti Sabrina
- Sadrozinski Hartmut
- Sadykov Renat
- Safai Tehrani Francesco
- Saha Puja
- Sahinsoy Merve
- Saimpert Matthias
- Saito Tomoyuki
- Sakamoto Hiroshi
- Sakurai Yuki
- Salamanna Giuseppe
- Salamon Andrea
- Salazar Loyola Javier Est
- Salek David
- Sales De Bruin Pedro Henr
- Salihagic Denis
- Salnikov Andrei
- Salt José
- Salvatore Daniela
- Salvatore Pasquale F
- Salvucci Antonio
- Salzburger Andreas
- Sammel Dirk
- Sampsonidis Dimitrios
- Sanchez Martinez Victoria
- Sanchez Arturo
- Sandaker Heidi
- Sandbach Ruth Laura
- Sander Heinz Geor
- Sanders Michiel
- Sandhoff Marisa
- Sandoval Carlos
- Sandstroem Rikard
- Sankey Dave
- Sannino Mario
- Sansoni Andrea
- Santiago Cerqueira Augusto
- Santoni Claudio
- Santonico Rinaldo
- Santos Helena
- Santoyo Castillo Itzebelt
- Sapp Kevin
- Sapronov Andrey
- Saraiva João
- Sarrazin Bjorn
- Sasaki Osamu
- Sasaki Yuichi
- Sato Koji
- Sauvage Gilles
- Sauvan Emmanuel
- Savage Graham
- Savard Pierre
- Sawyer Craig
- Sawyer Lee
- Saxon James
- Sbarra Carla
- Sbrizzi Antonio
- Scanlon Tim
- Scannicchio Diana
- Scarcella Mark
- Scarfone Valerio
- Schaarschmidt Jana
- Schacht Peter
- Schaefer Douglas
- Schaefer Ralph
- Schaeffer Jan
- Schaepe Steffen
- Schaetzel Sebastian
- Schaffer Arthur
- Schaile Dorothee
- Schamberger R Dean
- Scharf Veit
- Schegelsky Valery
- Scheirich Daniel
- Schernau Michael
- Schiavi Carlo
- Schillo Christian
- Schioppa Marco
- Schlenker Stefan
- Schmieden Kristof
- Schmitt Christian
- Schmitt Sebastian
- Schmitt Stefan
- Schmitz Simon
- Schneider Basil
- Schnellbach Yan Jie
- Schnoor Ulrike
- Schoeffel Laurent
- Schoening Andre
- Schoenrock Bradley Da
- Schopf Elisabeth
- Schorlemmer Andre Luka
- Schott Matthias
- Schouten Doug
- Schovancova Jaroslava
- Schramm Steven
- Schreyer Manuel
- Schuh Natascha
- Schultens Martin Joh
- Schultz-Coulon Hans-Chris
- Schulz Holger
- Schumacher Markus
- Schumm Bruce
- Schune Philippe
- Schwanenberger Christian
- Schwartzman Ariel
- Schwarz Thomas And
- Schwegler Philipp
- Schweiger Hansdieter
- Schwemling Philippe
- Schwienhorst Reinhard
- Schwindling Jerome
- Schwindt Thomas
- Schäfer Uli
- Sciolla Gabriella
- Scuri Fabrizio
- Scutti Federico
- Searcy Jacob
- Seema Pienpen
- Seidel Sally
- Seiden Abraham
- Seifert Frank
- Seixas José
- Sekhniaidze Givi
- Sekhon Karishma
- Sekula Stephen
- Seliverstov Dmitry
- Semprini-Cesari Nicola
- Serfon Cedric
- Serin Laurent
- Serkin Leonid
- Sessa Marco
- Seuster Rolf
- Severini Horst
- Sfiligoj Tina
- Sforza Federico
- Sfyrla Anna
- Shabalina Elizaveta
- Shaikh Nabila Wah
- Shan Lianyou
- Shang Ruo-yu
- Shank James
- Shapiro Marjorie
- Shatalov Pavel
- Shaw Kate
- Shaw Savanna Ma
- Shcherbakova Anna
- Shehu Ciwake Yus
- Sherwood Peter
- Shi Liaoshan
- Shimizu Shima
- Shimmin Chase Owen
- Shimojima Makoto
- Shiyakova Mariya
- Shmeleva Alevtina
- Shoaleh Saadi Diane
- Shochet Mel
- Shojaii Seyedruhol
- Shrestha Suyog
- Shulga Evgeny
- Shupe Michael
- Sicho Petr
- Sidebo Per Edvin
- Sidiropoulou Ourania
- Sidorov Dmitri
- Sidoti Antonio
- Siegert Frank
- Sijacki Djordje
- Silva José
- Silverstein Samuel
- Simak Vladislav
- Simard Olivier
- Simic Ljiljana
- Simion Stefan
- Simioni Eduard
- Simmons Brinick
- Simon Dorian
- Simon Manuel
- Sinervo Pekka
- Sinev Nikolai
- Sioli Maximilian
- Siragusa Giovanni
- Sivoklokov Serguei
- Sjursen Therese
- Sjölin Jörgen
- Skinner Malcolm Br
- Skottowe Hugh Phili
- Skubic Patrick
- Slater Mark
- Slavicek Tomas
- Slawinska Magdalena
- Sliwa Krzysztof
- Smakhtin Vladimir
- Smart Ben
- Smestad Lillian
- Smirnov Sergei
- Smirnov Yury
- Smirnova Lidia
- Smirnova Oxana
- Smith Matthew
- Smith Russell
- Smizanska Maria
- Smolek Karel
- Snesarev Andrei
- Snidero Giacomo
- Snyder Scott
- Sobie Randall
- Socher Felix
- Soffer Abner
- Soh Dart-yin
- Sokhrannyi Grygorii
- Solans Sanchez Carlos
- Solar Michael
- Soldatov Evgeny
- Soldevila Urmila
- Solodkov Alexander
- Soloshenko Alexei
- Solovyanov Oleg
- Solovyev Victor
- Sommer Philip
- Song Hong Ye
- Soni Nitesh
- Sood Alexander
- Sopczak Andre
- Sopko Vit
- Sorin Veronica
- Sosa David
- Sotiropoulou Calliope L
- Soualah Rachik
- Soukharev Andrey
- South David
- Sowden Benjamin
- Spagnolo Stefania
- Spalla Margherita
- Spangenberg Martin
- Spanò Francesco
- Sperlich Dennis
- Spettel Fabian
- Spighi Roberto
- Spigo Giancarlo
- Spiller Laurence A
- Spousta Martin
- St Denis Richard Da
- Stabile Alberto
- Staerz Steffen
- Stahlman Jonathan
- Stamen Rainer
- Stamm Soren
- Stanecka Ewa
- Stanek Robert
- Stanescu Cristian
- Stanescu-Bellu Madalina
- Stanitzki Marcel Mic
- Stapnes Steinar
- Starchenko Evgeny
- Stark Giordon
- Stark Jan
- Staroba Pavel
- Starovoitov Pavel
- Staszewski Rafal
- Steinberg Peter
- Stelzer Bernd
- Stelzer Harald Joe
- Stelzer-Chilton Oliver
- Stenzel Hasko
- Stewart Graeme
- Stillings Jan Andre
- Stockton Mark
- Stoebe Michael
- Stoicea Gabriel
- Stolte Philipp
- Stonjek Stefan
- Stradling Alden
- Straessner Arno
- Stramaglia Maria Elen
- Strandberg Jonas
- Strandberg Sara
- Strandlie Are
- Strauss Michael
- Strizenec Pavol
- Strom David
- Stroynowski Ryszard
- Strubig Antonia
- Ströhmer Raimund
- Stucci Stefania A
- Stugu Bjarne
- Styles Nicholas A
- Su Dong
- Su Jun
- Subramaniam Rajivaloch
- Suchek Stanislav
- Sugaya Yorihito
- Suk Michal
- Sulin Vladimir
- Sultansoy Saleh
- Sumida Toshi
- Sun Siyuan
- Sun Xiaohu
- Sundermann Jan Erik
- Suruliz Kerim
- Susinno Giancarlo
- Sutton Mark
- Suzuki Shota
- Svatos Michal
- Swiatlowski Maximilian
- Sykora Ivan
- Sykora Tomas
- Sánchez Javier
- Ta Duc
- Taccini Cecilia
- Tackmann Kerstin
- Taenzer Joe
- Taffard Anyes
- Tafirout Reda
- Taiblum Nimrod
- Takai Helio
- Takashima Ryuichi
- Takeda Hiroshi
- Takeshita Tohru
- Takubo Yosuke
- Talby Mossadek
- Talyshev Alexey
- Tam Jason
- Tan Kong Guan
- Tanaka Junichi
- Tanaka Reisaburo
- Tanaka Shuji
- Tannenwald Benjamin B
- Tapia Araya Sebastian
- Tapprogge Stefan
- Tarem Shlomit
- Tartarelli Giuseppe F
- Tas Petr
- Tasevsky Marek
- Tashiro Takuya
- Tassi Enrico
- Tavares Delgado Ademar
- Tayalati Yahya
- Taylor Aaron
- Taylor Geoffrey
- Taylor Pierre Tho
- Taylor Wendy
- Teischinger Florian Al
- Teixeira-Dias Pedro
- Temming Kim Katrin
- Temple Darren
- Ten Kate Herman
- Teng Ping-Kun
- Teoh Jia Jian
- Tepel Fabian-Phi
- Terada Susumu
- Terashi Koji
- Terron Juan
- Terzo Stefano
- Testa Marianna
- Teuscher Richard
- Theveneaux-Pelzer Timothée
- Thomas Juergen
- Thomas-Wilsker Joshuha
- Thompson Emily
- Thompson Paul
- Thompson Ray
- Thompson Stan
- Thomsen Lotte Ansg
- Thomson Evelyn
- Thomson Mark
- Tibbetts Mark James
- Ticse Torres Royer Edso
- Tikhomirov Vladimir
- Tikhonov Yury
- Timoshenko Sergey
- Tiouchichine Elodie
- Tipton Paul
- Tisserant Sylvain
- Todome Kazuki
- Todorov Theodore
- Todorova-Nova Sharka
- Tojo Junji
- Tokushuku Katsuo
- Tokár Stanislav
- Tolley Emma
- Tomlinson Lee
- Tomoto Makoto
- Tompkins Lauren
- Toms Konstantin
- Tong Baojia(Ton
- Torrence Eric
- Torres Heberth
- Torró Pastor Emma
- Toth Jozsef
- Touchard Francois
- Tovey Daniel
- Trefzger Thomas
- Tremblet Louis
- Tricoli Alessandro
- Trigger Isabel Mar
- Trincaz-Duvoid Sophie
- Tripiana Martin
- Trischuk William
- Trocmé Benjamin
- Trofymov Artur
- Troncon Clara
- Trottier-McDonald Michel
- Trovatelli Monica
- Truong Loan
- Trzebinski Maciej
- Trzupek Adam
- Tseng Jeffrey
- Tsiareshka Pavel
- Tsipolitis Georgios
- Tsirintanis Nikolaos
- Tsiskaridze Shota
- Tsiskaridze Vakhtang
- Tskhadadze Edisher
- Tsui Ka Ming
- Tsukerman Ilya
- Tsulaia Vakhtang
- Tsuno Soshi
- Tsybychev Dmitri
- Tudorache Alexandra
- Tudorache Valentina
- Tuna Alexander
- Tupputi Salvatore
- Turchikhin Semen
- Turecek Daniel
- Turgeman Daniel
- Turra Ruggero
- Turvey Andrew Joh
- Tuts Michael
- Tylmad Maja
- Tyndel Mike
- Ueda Ikuo
- Ueno Ryuichi
- Ughetto Michael
- Ukegawa Fumihiko
- Unal Guillaume
- Undrus Alexander
- Unel Gokhan
- Ungaro Francesca
- Unno Yoshinobu
- Unverdorben Christophe
- Urban Jozef
- Urquijo Phillip
- Urrejola Pedro
- Usai Giulio
- Usanova Anna
- Vacavant Laurent
- Vacek Vaclav
- Vachon Brigitte
- Valderanis Chrysostom
- Valencic Nika
- Valentinetti Sara
- Valero Alberto
- Valery Loic
- Valkar Stefan
- Vallecorsa Sofia
- Valls Ferrer Juan Anton
- Van Den Wollenberg Wouter
- Van Der Deijl Pieter
- van der Geer Rogier
- van der Graaf Harry
- van Eldik Niels
- van Gemmeren Peter
- Van Nieuwkoop Jacobus
- van Vulpen Ivo
- van Woerden Marius Cor
- Vanadia Marco
- Vandelli Wainer
- Vanguri Rami
- Vaniachine Alexandre
- Vardanyan Gagik
- Vari Riccardo
- Varnes Erich
- Varol Tulin
- Varouchas Dimitris
- Vartapetian Armen
- Varvell Kevin
- Vazeille Francois
- Vazquez Schroeder Tamara
- Veatch Jason
- Veloce Laurelle M
- Veloso Filipe
- Veneziano Stefano
- Ventura Andrea
- Venturi Manuela
- Venturi Nicola
- Venturini Alessio
- Vercesi Valerio
- Verducci Monica
- Verkerke Wouter
- Vermeulen Jos
- Vest Anja
- Vetterli Michel
- Viazlo Oleksandr
- Vichou Irene
- Vickey Boeriu Oana Elena
- Vickey Trevor
- Viehhauser Georg
- Viel Simon
- Vigne Ralph
- Villa Mauro
- Villaplana Perez Miguel
- Vilucchi Elisabetta
- Vincter Manuella
- Vinogradov Vladimir
- Vivarelli Iacopo
- Vlachos Sotirios
- Vladoiu Dan
- Vlasak Michal
- Vogel Marcelo
- Vokac Petr
- Volpi Guido
- Volpi Matteo
- von der Schmitt Hans
- von Toerne Eckhard
- Vorobel Vit
- Vorobev Konstantin
- Vos Marcel
- Voss Rudiger
- Vossebeld Joost
- Vranjes Milosavljevic Marija
- Vranjes Nenad
- Vrba Vaclav
- Vreeswijk Marcel
- Vuillermet Raphael
- Vukotic Ilija
- Vykydal Zdenek
- Wagner Peter
- Wagner Wolfgang
- Wahlberg Hernan
- Wahrmund Sebastian
- Wakabayashi Jun
- Walder James
- Walker Rodney
- Walkowiak Wolfgang
- Wallangen Veronica
- Wang Chao
- Wang Fuquan
- Wang Haichen
- Wang Hulin
- Wang Jike
- Wang Jin
- Wang Kuhan
- Wang Rui
- Wang Song-Ming
- Wang Tan
- Wang Tingting
- Wang Xiaoxiao
- Wanotayaroj Chaowaroj
- Warburton Andreas
- Ward Patricia
- Wardrope David Robe
- Washbrook Andrew
- Watkins Peter
- Watson Alan
- Watson Ian
- Watson Miriam
- Watts Gordon
- Watts Stephen
- Waugh Ben
- Webb Samuel
- Weber Michele
- Weber Stefan Wol
- Webster Jordan S
- Weidberg Anthony
- Weinert Benjamin
- Weingarten Jens
- Weiser Christian
- Weits Hartger
- Wells Phillippa
- Wenaus Torre
- Wengler Thorsten
- Wenig Siegfried
- Wermes Norbert
- Werner Matthias
- Werner Per
- Wessels Martin
- Wetter Jeffrey
- Whalen Kathleen
- Wharton Andrew Mar
- White Andrew
- White Martin
- White Ryan
- White Sebastian
- Whiteson Daniel
- Wickens Fred
- Wiedenmann Werner
- Wielers Monika
- Wienemann Peter
- Wiglesworth Craig
- Wiik-Fuchs Liv Antje
- Wildauer Andreas
- Wilkens Henric Geo
- Williams Hugh
- Williams Sarah
- Willis Christophe
- Willocq Stephane
- Wilson John
- Wingerter-Seez Isabelle
- Winklmeier Frank
- Winter Benedict T
- Wittgen Matthias
- Wittkowski Josephine
- Wollstadt Simon Jako
- Wolter Marcin Wla
- Wolters Helmut
- Wosiek Barbara
- Wotschack Jorg
- Woudstra Martin
- Wozniak Krzysztof
- Wu Mengqing
- Wu Miles
- Wu Sau Lan
- Wu Xin
- Wu Yusheng
- Wyatt Terry Rich
- Wynne Benjamin
- Xella Stefania
- Xu Da
- Xu Lailin
- Yabsley Bruce
- Yacoob Sahal
- Yakabe Ryota
- Yamaguchi Daiki
- Yamaguchi Yohei
- Yamamoto Akira
- Yamamoto Shimpei
- Yamanaka Takashi
- Yamauchi Katsuya
- Yamazaki Yuji
- Yan Zhen
- Yang Haijun
- Yang Hongtao
- Yang Yi
- Yang Zongchang
- Yao Weiming
- Yap Yee Chinn
- Yasu Yoshiji
- Yatsenko Elena
- Yau Wong Kaven Henr
- Ye Jingbo
- Ye Shuwei
- Yeletskikh Ivan
- Yen Andy L
- Yildirim Eda
- Yorita Kohei
- Yoshida Rikutaro
- Yoshihara Keisuke
- Young Charles
- Young Christophe
- Youssef Saul
- Yu David Ren-
- Yu Jaehoon
- Yu Jiaming
- Yu Jie
- Yuan Li
- Yuen Stephanie
- Yusuff Imran
- Zabinski Bartlomiej
- Zaidan Remi
- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanello Lucia
- Zanzi Daniele
- Zeitnitz Christian
- Zeman Martin
- Zemla Andrzej
- Zeng Jian Cong
- Zeng Qi
- Zengel Keith
- Zenin Oleg
- Zerwas Dirk
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhong Jiahang
- Zhou Bing
- Zhou Chen
- Zhou Lei
- Zhou Li
- Zhou Mingliang
- Zhou Ning
- Zhu Cheng Guan
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- zur Nedden Martin
- Zurzolo Giovanni
- Zwalinski Lukasz
- Åkesson Torsten Pa
- Åsman Barbro
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/08/2016
- Field of study
- …