Equivalent circuit parameter extraction of low-capacitance high-damping PTs

Existing equivalent circuit extraction techniques are inaccurate for piezoelectric transformers (PTs) with low-input capacitance or high damping. A new method is presented, offering improved accuracy in both damping resistance and resonant frequency extraction compared with state-of-the-art methods. Effectiveness is evaluated on two sample PTs, with the proposed method achieving up to 84% decrease in error compared with previous methods

A grid-based infrastructure for distributed retrieval

In large-scale distributed retrieval, challenges of latency, heterogeneity, and dynamicity emphasise the importance of infrastructural support in reducing the development costs of state-of-the-art solutions. We present a service-based infrastructure for distributed retrieval which blends middleware facilities and a design framework to ‘lift’ the resource sharing approach and the computational services of a European Grid platform into the domain of e-Science applications. In this paper, we give an overview of the DILIGENT Search Framework and illustrate its exploitation in the field of Earth Science

Radiation densitometry in tree-ring analysis: a review and procedure manual

An x-ray densitometry of wood facility is being established by the Environmental Sciences Division, Oak Ridge Natioanl Laboratory (ORNL). The objective is to apply tree-ring data to determine whether or not there is a fertilizer effect on tree growth from increased atmospheric carbon dioxide since the beginning of the industrial era. Intra-ring width and density data, including ring-mass will be detemined from tree-ring samples collected from sites located throughout the United States and Canada. This report is designed as a guide to assist ORNL scientists in building the x-ray densitometry system. The history and development of x-ray densitometry in tree-ring research is examined and x-ray densitometry is compared with other techniques. Relative wood and tree characteristics are described as are environmental and genetic factors affecting tree growth responses. Methods in x-ray densitometry are examined in detail and the techniques used at four operating laboratories are described. Some ways that dendrochronology has been applied in dating, in wood quality, and environmental studies are presented, and a number of tree-ring studies in Canada are described. An annotated bibliography of radiation densitometry in tree-ring analysis and related subjects is included

Fluctuating Nematic Elastomer Membranes: a New Universality Class

We study the flat phase of nematic elastomer membranes with rotational symmetry spontaneously broken by in-plane nematic order. Such state is characterized by a vanishing elastic modulus for simple shear and soft transverse phonons. At harmonic level, in-plane orientational (nematic) order is stable to thermal fluctuations, that lead to short-range in-plane translational (phonon) correlations. To treat thermal fluctuations and relevant elastic nonlinearities, we introduce two generalizations of two-dimensional membranes in a three dimensional space to arbitrary D-dimensional membranes embedded in a d-dimensional space, and analyze their anomalous elasticities in an expansion about D=4. We find a new stable fixed point, that controls long-scale properties of nematic elastomer membranes. It is characterized by singular in-plane elastic moduli that vanish as a power-law eta_lambda=4-D of a relevant inverse length scale (e.g., wavevector) and a finite bending rigidity. Our predictions are asymptotically exact near 4 dimensions.Comment: 18 pages, 4 eps figures. submitted to PR

A synonymous codon variant in two patients with autosomal recessive bestrophinopathy alters in vitro splicing of BEST1

Purpose: Autosomal recessive bestrophinopathy (ARB) is a newly defined retinal dystrophy caused by biallelic mutations in bestrophin-1 (BEST1) and is hypothesized to represent the null bestrophin-1 phenotype in humans. The aim was to determine whether a synonymous BEST1 variant, c.102C>T, identified in two unrelated ARB patients, alters pre-mRNA splicing of the gene. Additionally a detailed phenotypic characterization of this distinctive condition is presented for both patients.Methods: BEST1 was analyzed by direct sequencing. Patients underwent standard ophthalmic assessment. In silico and in vitro analysis using a minigene system was performed to assess whether a synonymous variant identified, c.102C>T p.Gly34Gly, alters pre-mRNA splicing of BEST1.Results: Both ARB patients harbored either proven (patient 1; c.102C>T p.Gly34Gly and c.572T>C p.Leu191Pro) or presumed (patient 2; c.102C>T p.Gly34Gly and c.1470_1471delCA, p.His490GlnfsX24) biallelic mutations in BEST1 and were found to have phenotypes consistent with ARB. In vitro analysis of the synonymous variant, c.102C>T p.Gly34Gly, demonstrated it to introduce a cryptic splice donor site 52 nucleotides upstream of the actual splice donor site.Conclusions: The novel BEST1 variant identified, c.102C>T p.Gly34Gly, alters pre-mRNA splicing in vitro and is potentially pathogenic. In vivo this splicing variant is predicted to lead to the production of an mRNA transcript with a premature termination codon (p.Glu35TrpfsX11) that is predicted to be degraded by NMD

Pulsar Timing and its Application for Navigation and Gravitational Wave Detection

Pulsars are natural cosmic clocks. On long timescales they rival the precision of terrestrial atomic clocks. Using a technique called pulsar timing, the exact measurement of pulse arrival times allows a number of applications, ranging from testing theories of gravity to detecting gravitational waves. Also an external reference system suitable for autonomous space navigation can be defined by pulsars, using them as natural navigation beacons, not unlike the use of GPS satellites for navigation on Earth. By comparing pulse arrival times measured on-board a spacecraft with predicted pulse arrivals at a reference location (e.g. the solar system barycenter), the spacecraft position can be determined autonomously and with high accuracy everywhere in the solar system and beyond. We describe the unique properties of pulsars that suggest that such a navigation system will certainly have its application in future astronautics. We also describe the on-going experiments to use the clock-like nature of pulsars to "construct" a galactic-sized gravitational wave detector for low-frequency (f_GW ~1E-9 - 1E-7 Hz) gravitational waves. We present the current status and provide an outlook for the future.Comment: 30 pages, 9 figures. To appear in Vol 63: High Performance Clocks, Springer Space Science Review

Strong-Field Tests of Gravity Using Pulsars and Black Holes

The sensitivity of the SKA enables a number of tests of theories of gravity. A Galactic Census of pulsars will discover most of the active pulsars in the Galaxy beamed toward us. In this census will almost certainly be pulsar-black hole binaries as well as pulsars orbiting the super-massive black hole in the Galactic centre. These systems are unique in their capability to probe the ultra-strong field limit of relativistic gravity. These measurements can be used to test the Cosmic Censorship Conjecture and the No-Hair theorem. The large number of millisecond pulsars discovered with the SKA will also provide a dense array of precision clocks on the sky. These clocks will act as the multiple arms of a huge gravitational wave detector, which can be used to detect and measure the stochastic cosmological gravitational wave background that is expected from a number of sources.Comment: SKA-Key Science Project, to appear in "Science with the Square Kilometer Array," eds.C. Carilli and S. Rawlings, New Astronomy Reviews (Elsevier: Amsterdam)', 10 pages, 2 figure

Career changers and fast-track induction: teacher perspectives on their early professional development

In this article, the early professional development of mature, early career teachers who entered the profession via an employment-based route to teaching in England is presented and explored from the teachers’ own perspectives. From a larger sample in a longitudinal study, the development of four career changers is traced in detail, using a model of professional learning which highlights teaching and professional skills. There is some evidence that those who undertake the programme experience a smoother induction into teaching than those from more traditional routes, although the internship year itself is challenging and demands a high level of commitment and resilience on the part of the pre-service teachers. Contextual factors, such as school support and learning from experienced teachers, are vital in enabling early professional development and the absence of these can hinder learning and self-confidence. Findings are analysed with reference to the model, as well as research on teachers’ development, within a socio-cultural learning framework. The study makes a valuable contribution to knowledge about the professional development of mature entrants to teaching

Observation of Scaling Violations in Scaled Momentum Distributions at HERA

Charged particle production has been measured in deep inelastic scattering (DIS) events over a large range of $x$ and $Q^2$ using the ZEUS detector. The evolution of the scaled momentum, $x_p$, with $Q^2,$ in the range 10 to 1280 $GeV^2$, has been investigated in the current fragmentation region of the Breit frame. The results show clear evidence, in a single experiment, for scaling violations in scaled momenta as a function of $Q^2$.Comment: 21 pages including 4 figures, to be published in Physics Letters B. Two references adde

D* Production in Deep Inelastic Scattering at HERA

This paper presents measurements of D^{*\pm} production in deep inelastic scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The data have been taken with the ZEUS detector at HERA. The decay channel $D^{*+}\to (D^0 \to K^- \pi^+) \pi^+$ (+ c.c.) has been used in the study. The $e^+p$ cross section for inclusive D^{*\pm} production with $5<Q^2<100 GeV^2$ and $y<0.7$ is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region {$1.3<p_T(D^{*\pm})<9.0$ GeV and $| \eta(D^{*\pm}) |<1.5$}. Differential cross sections as functions of p_T(D^{*\pm}), $\eta(D^{*\pm}), W$ and $Q^2$ are compared with next-to-leading order QCD calculations based on the photon-gluon fusion production mechanism. After an extrapolation of the cross section to the full kinematic region in p_T(D^{*\pm}) and $\eta$(D^{*\pm}), the charm contribution $F_2^{c\bar{c}}(x,Q^2)$ to the proton structure function is determined for Bjorken $x$ between 2 $\cdot$ 10$^{-4}$ and 5 $\cdot$ 10$^{-3}$.Comment: 17 pages including 4 figure