Nutrition for the ageing brain: towards evidence for an optimal diet

As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains however elusive. Considering the limits of existing preventive methods, there is a desire to develop effective and safe strategies. Growing preclinical and clinical research in healthy individuals or at the early stage of cognitive decline has demonstrated the beneficial impact of nutrition on cognitive functions. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). The latest scientific advances specific to how dietary nutrients and non-nutrient may affect cognitive ageing are presented. Furthermore, several key points related to mechanisms contributing to brain ageing, pathological conditions affecting brain function, and brain biomarkers are also discussed. Overall, findings are inconsistent and fragmented and more research is warranted to determine the underlying mechanisms and to establish dose-response relationships for optimal brain maintenance in different population subgroups. Such approaches are likely to provide the necessary evidence to develop research portfolios that will inform about new dietary recommendations on how to prevent cognitive decline

Building Inventory and Refurbishment Scenario Database Development for Switzerland

© 2017, Yale University. Material usage and the related embodied environmental impact have grown in significance in the built environment. Therefore, cities and governments need to develop strategies to reduce both the consumption of resources during usage phase as well as the embodied impact of the current building stock. This article proposes a new component-based building inventory database as a basis to develop such strategies using building stock modeling. The developed database clusters the building stock according to building typology (single-family houses, multifamily houses, and office buildings), age, and the main construction systems of the different building components. Based on the component makeup, it lists the necessary material input and waste output for different refurbishment options for each building component. The advantages of the proposed database structure are shown based on two applications for the developed database for Switzerland. The component-based database allows optimization of refurbishment strategies not only from an energetic perspective, but also with respect to materials, both on the input (sourcing of materials) and the output (waste streams) level. The database structure makes it possible to continuously extend the data set by adding new refurbishment options or add data such as component-specific lifetimes, costs, or labor intensities of the refurbishment options. In combination with an aligned economic model, this would give an even more holistic view, impact, and feasibility of different refurbishment scenarios both in environmental and economic terms