69 research outputs found
Stress relaxation in the nonequilibrium state of a polymer melt
- Publication venue
- 'Society of Rheology'
- Publication date
- Field of study
Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants
- Author
- A Alkhateeb
- A Franke
- A Gusev
- A Paradisi
- A Taïeb
- AB Lee
- AE Renton
- AH Stegh
- AL Price
- Alain Taïeb
- Albert Wolkerstorfer
- Andreas Overbeck
- Anke Hartmann
- Anne Lienert
- Anthony P Weetman
- BP Fairfax
- C Giambartolomei
- C Praetorius
- D Chang
- D Shlyueva
- D Szklarczyk
- Daniel Yorgov
- David J Gawkrodger
- DL Nicolae
- Dorothy C Bennett
- DS Paul
- E Helen Kemp
- E Melum
- Ele Prans
- ER Gamazon
- F Liu
- F Pan
- G Cavalli
- G Gualco
- G Juyal
- G Laberge
- Genevieve Andersen
- H Guo
- H Mi
- H Nan
- HE Teulings
- HE Teulings
- Henry W Lim
- HK Finucane
- I Ricaño-Ponce
- Igor Korobko
- Iltefat Hamzavi
- J Arloth
- J P Wietze van der Veen
- J Read
- J Reimand
- J Shoag
- J Sun
- Janet Siebert
- Jo Lambert
- JP Higgins
- JP Higgins
- JW Han
- Kelly M Brownson
- Khaled Ezzedine
- Külli Kingo
- L Petukhova
- Li Zhou
- M Hayashi
- M Kellis
- M Visser
- M Wilbe
- Maire Karelson
- Margaret R Wallace
- Markus Böhm
- Mats Olsson
- Mauro Picardo
- MM Ollmann
- N Eriksson
- Nanette B Silverberg
- Nanja van Geel
- O Corradin
- Pamela R Fain
- Paulene J Holland
- PC Dubois
- PK Das
- PK Gregersen
- PS Linsley
- Qing-Sheng Mi
- RA Spritz
- Richard A Spritz
- Roberta Colucci
- Rosalie M Luiten
- S Hou
- S Purcell
- Silvia Moretti
- Songtao Ben
- Stanca A Birlea
- Stephanie A Santorico
- Sulev Kõks
- T Akiyama
- TM Ferrara
- Tracey M Ferrara
- V Plagnol
- W Yang
- Wayne T McCormack
- X Chu
- X Wang
- Y Jin
- Y Jin
- Y Jin
- Y Jin
- Y Jin
- Y Li
- Yan Valle
- YH Lee
- Ying Jin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Vitiligo is an autoimmune disease in which depigmented skin results from the destruction of melanocytes1, with epidemiological association with other autoimmune diseases2. In previous linkage and genome-wide association studies (GWAS1 and GWAS2), we identified 27 vitiligo susceptibility loci in patients of European ancestry. We carried out a third GWAS (GWAS3) in European-ancestry subjects, with augmented GWAS1 and GWAS2 controls, genome-wide imputation, and meta-analysis of all three GWAS, followed by an independent replication. The combined analyses, with 4,680 cases and 39,586 controls, identified 23 new significantly associated loci and 7 suggestive loci. Most encode immune and apoptotic regulators, with some also associated with other autoimmune diseases, as well as several melanocyte regulators. Bioinformatic analyses indicate a predominance of causal regulatory variation, some of which corresponds to expression quantitative trait loci (eQTLs) at these loci. Together, the identified genes provide a framework for the genetic architecture and pathobiology of vitiligo, highlight relationships with other autoimmune diseases and melanoma, and offer potential targets for treatment
Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes
- Author
- A Mari
- A Mari
- A Mari
- A Mari
- A Mari
- A Mari
- A Mari
- A Mari
- Andrea Mari
- B Bode
- D Polidori
- D Polidori
- David Polidori
- E Ferrannini
- E Muscelli
- Ele Ferrannini
- F Lavalle-Gonzalez
- G Schernthaner
- J Radziuk
- J Rosenstock
- JF Yale
- JP Wilding
- K Katsuno
- K Nunoi
- K Stenlöf
- L Rossetti
- RC Loopstra-Masters
- S Jabbour
- S Sha
- S Sha
- SE Inzucchi
- SE Kahn
- WT Cefalu
- Y Liang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Rare and low-frequency coding variants alter human adult height
- Author
- A Boyd
- A Dauber
- A Moayyeri
- AC Karaplis
- Adam E. Locke
- Adam S. Butterworth
- Ailith Pirie
- AL Price
- Albert Vernon Smith
- Alex P. Reiner
- Alex W. Hewitt
- Alexander Teumer
- Aliki-Eleni Farmaki
- Alisa K. Manning
- Alison M. Dunning
- Alison Pattie
- Allan Linneberg
- Amanda J. Cox
- Amber A. Burt
- Andres Metspalu
- Andrew D. Morris
- Andrew P. Morris
- Andrew R. Wood
- Andrew T. Hattersley
- Andries R. Van Der Leij
- André G. Uitterlinden
- Anette Varbo
- Angela L. Mazul
- Aniruddh P. Patel
- Anke Tönjes
- Anna Morgan
- Anne E. Justice
- Anne Tybjaerg-Hansen
- Anne U. Jackson
- Anneke I. den Hollander
- Antonietta Robino
- Anubha Mahajan
- AR Wood
- Artitaya Lophatananon
- Asif Rasheed
- Audrey Y. Chu
- Ayush Giri
- B Pasaniuc
- Bernhard Banas
- Betina H. Thuesen
- Beverley Balkau
- BJ Frey
- BK Bulik-Sullivan
- Bratati Kahali
- Børge G. Nordestgaard
- C Fuchsberger
- C Gyrup
- C Oxvig
- C Sidore
- Carel B. Hoyng
- Carl D. Langefeld
- Carol A. Wang
- Carolina Medina-Gomez
- Caroline Hayward
- Carsten A. Böger
- Cecilia M. Lindgren
- Charles Kooperberg
- Chris J. Packard
- Christopher P. Nelson
- CJ Willer
- Claudia Langenberg
- Claudia Schurmann
- Claus Oxvig
- Colin N. A. Palmer
- Cora E. Lewis
- Cornelia M. van Duijn
- Craig E. Pennell
- Cramer Christensen
- Cristen J. Willer
- D Lamparter
- Dajiang J. Liu
- Daniel I. Chasman
- Daniel R. Witte
- Danielle Posthuma
- Danish Saleheen
- David A. Mackey
- David J. Carey
- David Lamparter
- Deborah J. Thompson
- Dennis O. Mook-Kanamori
- Dermot F. Reilly
- Dewan S. Alam
- Diego Vozzi
- Digna R. Velez Edwards
- DJ Liu
- Dominique Arveiler
- Donald W. Bowden
- Douglas F. Easton
- Eirini Marouli
- Ele Ferrannini
- Eleftheria Zeggini
- Elizabeth K. Speliotes
- Ellen W. Demerath
- Emanuele Di Angelantonio
- Emil V. Appel
- Emmanouil Tsafantakis
- Eric B. Larson
- Eric Boerwinkle
- Erik Ingelsson
- Erwin P. Bottinger
- Ethan M. Lange
- Eva Albrecht
- Evangelos Evangelou
- F Danjou
- Feijie Wang
- Fernando Rivadeneira
- Folkert W. Asselbergs
- Fotios Drenos
- Francis S. Collins
- Frank Kee
- Fredrik Karpe
- Frida Renström
- G. Kees Hovingh
- Gabriel Cuellar-Partida
- Gail Davies
- Gail P. Jarvik
- Gaëlle Marenne
- George Dedoussis
- Gerard Pasterkamp
- Gerard Tromp
- Gerome Breen
- Gert J. de Borst
- Gina M. Peloso
- Giorgia Girotto
- Goncalo Abecasis
- Gorm B. Jensen
- Gudmar Thorleifsson
- Guillaume Lettre
- GV Kryukov
- H Ito
- H Lango Allen
- Hanieh Yaghootkar
- He Zheng
- Heather M. Highland
- Heather M. Stringham
- Heikki Oksa
- Heiner Boeing
- Helen R. Warren
- Helena Kuivaniemi
- Henrik Vestergaard
- Hidetoshi Kitajima
- Honghuang Lin
- HS Wei
- Huaixing Li
- I-Te Lee
- Ian Ford
- Ian J. Deary
- Igor Rudan
- Ilaria Gandin
- Ingrid B. Borecki
- Ioanna Ntalla
- Iris M. Heid
- Ivan Brandslund
- J Flannick
- J Gudmundsson
- J Mastaitis
- J Yang
- J Yang
- J Yang
- J. Wouter Jukema
- JA Tennessen
- Jaakko Kaprio
- Jaakko Tuomilehto
- Jaana Lindström
- James A. Perry
- James G. Wilson
- James P. Cook
- Jan-Håkan Jansson
- Janie Corley
- Jaspal S. Kooner
- Jean Ferrieres
- Jean-Claude Tardif
- Jeffrey R. O'Connel
- Jennifer A. Smith
- Jennifer Kriebel
- Jennifer Wessel
- Jerome I Rotter
- Jessica D. Faul
- Jessica van Setten
- Jette Bork-Jensen
- JI Goldstein
- Jian'an Luan
- Jie Yao
- Jin Li
- Jing Hua Zhao
- Joanna M. M. Howson
- Joe G. Dennis
- Joel N. Hirschhorn
- Johanna Kuusisto
- John C. Chambers
- John D. Rioux
- John Danesh
- John M. Starr
- John R. B. Perry
- Jonathan Marten
- Jonathan P. Tyrer
- Jordi Corominas Galbany
- Jose C. Florez
- Jukka Kontto
- Jussi Hernesniemi
- K Silventoinen
- Karen L. Mohlke
- Kari E. North
- Kari Stefansson
- Karina Meidtner
- Katharine R. Owen
- Katherine E. Tansey
- Katherine S. Ruth
- Kathleen E. Stirrups
- Kathleen Mullan Harris
- Katja K. Aben
- Kauko Heikkilä
- Ken Sin Lo
- Kent D. Taylor
- Kerrin S. Small
- Kevin Sandow
- Kirsten B. Kluivers
- Kjell Nikus
- Kristian Hveem
- Kristin L. Young
- Kristine H. Allin
- Lambertus A. Kiemeney
- Lars Lind
- Laura M. Yerges-Armstrong
- Lawrence F. Bielak
- Leen M. ‘t Hart
- Leo-Pekka Lyytikäinen
- Leslie A. Lange
- Li-An Lin
- Lia E. Bang
- Liang He
- Linda Broer
- Linda S. Adair
- Loes M. Olde Loohuis
- Lori L. Bonnycastle
- Lorraine Southam
- Lynne J. Hocking
- M Nikpay
- M. Arfan Ikram
- Maggie C. Y. Ng
- Manuel A. Rivas
- Marcelo P. Segura-Lepe
- Marco M. Ferrario
- Maria Karaleftheri
- Mariaelisa Graff
- Marianne Benn
- Marit E. Jørgensen
- Marjanka K. Schmidt
- Mark C. H. de Groot
- Mark I. McCarthy
- Mark J. Caulfield
- Mark Walker
- Markku Laakso
- Markus Perola
- Martina La Bianca
- Martina Müller-Nurasyid
- Mary F. Feitosa
- Massimiliano Cocca
- Mathias Gorski
- Matt Neville
- Matthew Allison
- Matthias B. Schulze
- Matthias Blüher
- Matthias Nauck
- MB Lanktree
- MC Wu
- Megan L. Grove
- Mengmeng Du
- Mette Hollensted
- Michael Boehnke
- Michael O. Woods
- Michael Stumvoll
- Michiel L. Bots
- Mika Kähönen
- Mike A. Nalls
- Min A. Jhun
- ML Grove
- MR Jepsen
- MT Overgaard
- Murray H. Brilliant
- Myriam Fornage
- NA Sims
- Nancy L. Heard-Costa
- Natasja M. van Schoor
- Naveed Sattar
- NB Schwartz
- Neil Robertson
- Nicholas G. D. Masca
- Nicholas G. Martin
- Nicholas J. Wareham
- Niels Grarup
- Nilesh J. Samani
- O Zuk
- Oddgeir L. Holmen
- Olli T. Raitakari
- Olov Rolandsson
- Oluf Pedersen
- Ozren Polasek
- Pamela A. F. Madden
- Pamela J. Schreiner
- Pang Yao
- Panos Deloukas
- Paolo Gasparini
- Patricia B. Munroe
- Patrick T. Ellinor
- Paul Elliott
- Paul I. W. de Bakker
- Paul L. Auer
- Paul L. Huang
- Paul M. Ridker
- Paul Mitchell
- Paul W. Franks
- Peggy L. Peissig
- Pekka Jousilahti
- Penny Gordon-Larsen
- Peter Kovacs
- Philippe Amouyel
- Pia R. Kamstrup
- Pirjo Komulainen
- Poorva Mudgal
- PR Loh
- Praveen Surendran
- Pål R. Njølstad
- RA Fisher
- Rainer Rauramaa
- Rajiv Chowdhury
- Rebecca S. Fine
- Renske Keeman
- René S. Kahn
- Renée de Mutsert
- Robert A. Scott
- Robin Young
- Roel A. Ophoff
- Rohit Varma
- RS Fehrmann
- Rudolf Uher
- Ruifang Li-Gao
- Ruth Frikke-Schmidt
- Ruth J. F. Loos
- S Feng
- Sailaja Vedantam
- Sander W. van der Laan
- Sandosh Padmanabhan
- Sara M. Willems
- Satu Männistö
- Scott D. Gordon
- Sekar Kathiresan
- Sharon L. R. Kardia
- Sheila Ulivi
- Shuai Wang
- Shuang Feng
- Simon de Denus
- Sina Rüeger
- Sita H. Vermeulen
- SM Purcell
- Stavroula Kanoni
- Stefan Gustafsson
- Stefan Johansson
- Stella Trompet
- Steven A. Lubitz
- Sune F. Nielsen
- Suthesh Sivapalaratnam
- Svati Shah
- Sven Bergmann
- Sébastien Küry
- T Wakahara
- Tamara B. Harris
- Tapani Ebeling
- Terho Lehtimäki
- Tessel E. Galesloot
- TH Pers
- Thomas F. Vogt
- Thomas Kocher
- Thomas N. Person
- Thomas W. Winkler
- Tibor V. Varga
- Timo A. Lakka
- Timothy D. Spector
- Timothy M. Frayling
- Todd L. Edwards
- Torben Hansen
- Torben Jørgensen
- Troels R. Kjaer
- Tugce Karaderi
- Tune H. Pers
- TW Winkler
- Tõnu Esko
- Unnur Thorsteinsdottir
- V Steinthorsdottir
- Valgerdur Steinthorsdottir
- Valérie Turcot
- Veikko Salomaa
- Veronique Vitart
- Vilmantas Giedraitis
- Vilmundur Gudnason
- Wei Gan
- Wei Zhao
- Wei Zhao
- Wei Zhou
- Weihua Zhang
- Xiaowei Zhan
- Xiuqing Guo
- Xu Lin
- Xuejuan Jiang
- Xueling Sim
- Y Kawano
- Y Takeuchi
- Yadav Sapkota
- Yeheng Liu
- Yii-Der Ida Chen
- Ying Wu
- Yingchang Lu
- Yiqin Wang
- Yongmei Liu
- Yucheng Jia
- Zoltán Kutalik
- Øyvind Helgeland
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/12/2016
- Field of study
Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome - wide association studies . Here , we report 83 height - associated coding variants with lower minor allele frequenc ies ( range of 0.1 - 4.8% ) and effects of up to 2 16 cm /allele ( e.g. in IHH , STC2 , AR and CRISPLD2 ) , >10 times the average effect of common variants . In functional follow - up studies, rare height - increasing alleles of STC2 (+1 - 2 cm/allele) compromise d proteolytic inhibition of PAPP - A and increased cleavage of IGFBP - 4 in vitro , resulting in higher bioavailability of insulin - like growth factors . The se 83 height - associated variants overlap genes mutated in monogenic growth disorders and highlight new biological candidates ( e.g. ADAMTS3, IL11RA, NOX4 ) and pathways ( e.g . proteoglycan/ glycosaminoglycan synthesis ) involved in growth . Our results demonstrate that sufficiently large sample sizes can uncover rare and low - frequency variants of moderate to large effect associated with polygenic human phenotypes , and that these variants implicate relevant genes and pathways
The trans-ancestral genomic architecture of glycemic traits
- Author
- Abecasis Gonçalo R
- Adair Linda S
- Aguilar-Salinas Carlos Alberto
- Ahluwalia Tarunveer S
- Alarcón-Riquelme Marta E
- Amin Najaf
- An Ping
- Anasanti Mila D
- Appel Emil VR
- Arzumanyan Zorayr
- Astrup Arne
- Aviles-Santa Larissa
- Bakker Stephan JL
- Baldassarre Damiano
- Barroso Inês
- Becker Diane M
- Beekman Marian
- Beilin Lawrence J
- Bergman Richard N
- Bergmann Sven
- Bertoni Alain
- Bielak Lawrence F
- Bisgaard Hans
- Black Corri
- Blüher Matthias
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L
- Boomsma DI
- Bornstein Stefan R
- Bottinger Erwin P
- Boutin Thibaud S
- Bowden Donald W
- Brody Jennifer A
- Buchanan Thomas A
- Burtt Noël P
- Böhm Bernhard O
- Bønnelykke Klaus
- Cabrera Claudia P
- Cade Brian E
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Canouil Mickaël
- Caulfield Mark J
- Chai Jin Fang
- Chai Xiaoran
- Chambers John C
- Chan Kei Hang Katie
- Chang Li-Ching
- Chang Yi Cheng
- Chasman Daniel I
- Chen Brian H
- Chen Chien-Hsiun
- Chen Ji
- Chen Yii-Der Ida
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Chiu Yen-Feng
- Chu Audrey Y
- Claringbould Annique
- Collins Francis S
- Corbin Laura J
- Correa Adolfo
- Cucca Francesco
- de Geus Eco JC
- de Haan Hugoline G
- de Silva H Janaka
- Dedoussis George
- Dehghan Abbas
- Delgado Graciela E
- Demirkan Ayse
- Du Shufa
- Duan Qing
- Dupuis Josée
- Eiriksdottir Gudny
- Elmståhl Sölve
- Engmann Jorgen
- Evans Michele K
- Farmaki Aliki Eleni
- Fatumo Segun A
- Ferrannini Ele
- Ferrucci Luigi
- Florez Jose C
- Franks Paul W
- Frayling Timothy M
- Froguel Philippe
- Frånberg Mattias
- Fuchsberger Christian
- Gao Yutang
- Gayán Javier
- Gigante Bruna
- Giulianini Franco
- Gjesing Anette P
- Gloyn Anna L
- Goel Anuj
- Gong Jung Ho
- Goodarzi Mark O
- Gordon-Larsen Penny
- Grallert Harald
- Grarup Niels
- Grimsgaard Sameline
- Groop Leif
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson Stefan
- Hai Yang
- Hamsten Anders
- Han Sohee
- Hansen Torben
- Hartman Catharina A
- Hartwig Fernando P
- Hayward Caroline
- He Jing
- Heckbert Susan R
- Heianza Yoriko
- Heikkinen Jani
- Herder Christian
- Hicks Andrew A
- Hong Jaeyoung
- Horikoshi Momoko
- Horta Bernardo L
- Hottenga Jouke-Jan
- Hsieh Chang-Hsun
- Hsueh Willa A
- Huang Tao
- Huang Wei
- Huerta-Chagoya Alicia
- Huo Shaofeng
- Hwang Mi Yeong
- Ichihara Sahoko
- Igase Michiya
- Ikram M Arfan
- Ingelsson Erik
- James Pankow S
- Jarvelin Marjo-Ritta
- Jensen Richard A
- Johnson W Craig
- Jonas Jost B
- Joshi Peter K
- Jukema J Wouter
- Jørgensen Marit E
- Kaakinen Marika A
- Kaleebu Pontiano
- Kalyani Rita R
- Kandeel Fouad R
- Kaplan Robert
- Kardia Sharon LR
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Keinanen-Kiukaanniemi Sirkka M
- Kentistou Katherine A
- Khor Chiea Chuen
- Kiess Wieland
- Kim Bong-Jo
- Kim Young Jin
- Kivimaki Mika
- Kleber Marcus E
- Koistinen Heikki A
- Kolcic Ivana
- Kooner Ishminder K
- Kooner Jaspal S
- Kovacs Peter
- Kuh Diana
- Kumari Meena
- Kutalik Zoltan
- Kuulasmaa Teemu
- Kuusisto Johanna
- Körner Antje
- Laakso Markku
- Lai Shuiqing
- Lakka Timo A
- Lam Kelvin
- Lange Leslie A
- Langefeld Carl D
- Langenberg Claudia
- Launer Lenore J
- Lauzon Marie
- Lawlor Deborah A
- Leander Karin
- Lee Nanette R
- Lemaitre Rozenn N
- Leong Aaron
- Li Honglan
- Li Huaixing
- Li Man
- Li-Gao Ruifang
- Lifelines Cohort Study
- Ligthart Symen
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lindgren Cecilia
- Lindström Jaana
- Linneberg Allan
- Liu Ching-Ti
- Liu Jianjun
- Liu Jun
- Liu Simin
- Loh Marie
- Long Jirong
- Loos Ruth JF
- Lorenzo Carlos
- Louie Tin
- Luan Jian'an
- Lyssenko Valeriya
- Läll Kristi
- Magnusson Patrik KE
- Mahajan Anubha
- Mangino Massimo
- Marenne Gaëlle
- Marzi Carola
- Matsubara Tatsuaki
- Matsuda Fumihiko
- McCarthy Mark I
- Meigs James B
- Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)
- Metspalu Andres
- Mingrone Geltrude
- Mohlke Karen L
- Montasser May E
- Mooijaart Simon
- Mook-Kanamori Dennis O
- Moon Sanghoon
- Moreno-Macias Hortensia
- Mori Trevor A
- Morris Andrew P
- Munroe Patricia B
- Mägi Reedik
- März Winfried
- Nabika Toru
- Nadkarni Girish N
- Nadler Jerry L
- Nag Abhishek
- Nakatochi Masahiro
- Ndungu Anne
- Nelis Mari
- Nelson Sarah C
- Neville Matt J
- Njølstad Inger
- Noce Damia
- Nolte Ilja M
- Noordam Raymond
- Norris Jill M
- North Kari E
- O'Connell Jeffrey R
- Ohyagi Yasumasa
- Oldehinkel Albertine J
- Ong Ken K
- Padmanabhan Sandosh
- Palmer Colin NA
- Palmer Nicholette D
- Parker Stephen CJ
- Pedersen Oluf
- Pennell Craig E
- Peters Annette
- Peyser Patricia A
- Pistis Giorgio
- Polasek Ozren
- Porteous David J
- Pramstaller Peter P
- Preuss Michael
- Prokopenko Inga
- Province Michael A
- Psaty Bruce M
- Qi Lu
- Qi Qibin
- Raffel Leslie J
- Raffield Laura
- Rasmussen-Torvik Laura J
- Raulerson Chelsea K
- Rauramaa Rainer
- Raven Dennis
- Ray Debashree
- Redline Susan
- Reilly Dermot F
- Reiner Alex
- Rich Stephen S
- Ridker Paul M
- Rivideneira Fernando
- Robertson Neil R
- Rohde Rebecca
- Roll Kathryn
- Rosendaal Frits R
- Rotter Jerome I
- Rudan Igor
- Rueedi Rico
- Ryan Kathleen
- Rybin Denis
- Saaristo Timo E
- Sabanayagam Charumathi
- Sandhu Manjinder
- Sandow Kevin
- Sanna Serena
- Saramies Jouko
- Sattar Naveed
- Saxena Richa
- Schneiderman Neil
- Schraut Katharina E
- Schurmann Claudia
- Schwarz Peter
- Schürmann Annette
- Scott Laura J
- Scott Robert A
- Selvin Elizabeth
- Sennblad Bengt
- Setoh Kazuya
- Sever Peter
- Shi Jinxiu
- Shu Xiao-Ou
- Sim Xueling
- Slagboom P Eline
- Small Kerrin S
- Smith Albert V
- Smith Blair H
- Snieder Harold
- Sofer Tamar
- Southam Lorraine
- Sparsø Thomas
- Spector Tim D
- Spracklen Cassandra N
- Stanton Alice
- Steves Claire J
- Stewart Isobel D
- Strawbridge Rona J
- Stringham Heather M
- Stumvoll Michael
- Sun Liang
- Sørensen Thorkild IA
- Tabara Yasuharu
- Tai E Shyong
- Takeuchi Fumihiko
- Tan Jingyi
- Taylor Kent D
- Teslovich Tanya M
- Thuesen Betina
- Timmers Paul RHJ
- Timpson Nicholas J
- Tremoli Elena
- Trompet Stella
- Tsai Michael Y
- Tuomilehto Jaakko
- Tusie Teresa
- Tönjes Anke
- Uitterlinden Andre
- Uusitupa Matti
- van Dam Rob M
- van den Akker Erik
- van der Harst Pim
- van der Most Peter J
- van Duijn Cornelia
- van Heemst Diana
- van Hylckama Vlieg Astrid
- van Vliet-Ostaptchouk Jana V
- Vangipurapu Jagadish
- Varshney Arushi
- Verweij Niek
- Vestergaard Henrik
- Vitart Veronique
- Vogel Mandy
- Vollenweider Peter
- Vrijkotte Tanja GM
- Waage Johannes
- Wagenknecht Lynne E
- Walker Mark
- Wang Carol A
- Wang Chaolong
- Wang Heming
- Wang Nan
- Wang Tao
- Wang Ya X
- Wang Yujie
- Wareham Nick J
- Warren Helen R
- Watanabe Richard M
- Watkins Hugh
- Wei Wen B
- Wen Wanqing
- Wheeler Eleanor
- Wickremasinghe Ananda R
- Willems van Dijk Ko
- Willems Sara M
- Willemsen Gonneke
- Wilsgaard Tom
- Wilson James F
- Wong Andrew
- Wong Tien-Yin
- Wood Andrew R
- Wu Jer-Yuarn
- Wu Peitao
- Wu Ying
- Xiang Anny H
- Xie Tian
- Yanek Lisa R
- Yao Jie
- Yengo Loïc
- Yokota Mitsuhiro
- Zafarmand Mohammad Hadi
- Zeggini Eleftheria
- Zemunik Tatijana
- Zhang Weihua
- Zhang Xiaoshuai
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zonderman Alan B
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution. A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Peer reviewe
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
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- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
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- Casas Juan P
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- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
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- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
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- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
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- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
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- d'Adamo Pio
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- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
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- de Andrade Mariza
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- Denniff Matthew
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- Deshmukh Harshal
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- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
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- Dupuis Josee
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- Egan Josephine
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- El Mokhtari NourEddine
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- Ernst Florian
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- Estrada Karol
- Eury Elodie
- Evangelou Evangelos
- Evans Alun
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- Fagerholm Emma
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- Ferreira Teresa
- Ferreli Liana
- Ferrières Jean
- Ferrucci Luigi
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- Folkersen Lasse
- Folsom Aaron R
- Fontanillas Pierre
- Ford Ian
- Fornage Myriam
- Foroud Tatiana
- Forouhi Nita G
- Forrester Terrence
- Forsblom Carol
- Foster Meredith C
- Fowke Jay
- Fowkes F Gerald R
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- Franceschini Nora
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- Franke Andre
- Franke Lude
- Franks Paul W
- Frants Rune
- Fraser Ross M
- Frayling Timothy M
- Freedman Barry I
- Freimer Nelson B
- Freitag Daniel F
- Friedrich Nele
- Froguel Philippe
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- Fuchsberger Christian
- Galan Pilar
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- Geller Frank
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- Gigante Bruna
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- Giroux Sylvie
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- Glenn Kim
- Glorioso Nicola
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- Godson Catherine
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- Goessling Wolfram
- Golay Alain
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- Goltzman David
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- González-Macías Jesús
- Goodall Alison H
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- Goodloe Robert
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- Grabe Hans-Jörgen
- Graff Misa
- Grallert Harald
- Grammer Tanja B
- Gravito Martha L
- Greenwood Celia M T
- Grewal Jagvir
- Grimsby Jonna
- Grobbee Diederick E
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- Gräßler Jürgen
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- Gudnason Vilmundur
- Guiducci Candace
- Guo Qun
- Guo Xiuqing
- Gurdasani Deepti
- Gustafsson Stefan
- Gyllensten Ulf
- Gyllensten Ulf B
- Hadjadj Samy
- Hadley David
- Haessler Jeff
- Hager Jörg
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- Haines Jonathan
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- Haller Toomas
- Hallmans Goran
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- Hamsten Anders
- Han Bok-Ghee
- Hankinson Susan E
- Hanson Robert L
- Hardy Rebecca
- Haritunians Talin
- Harjutsalo Valma
- Harris Tamara
- Hartikainen Anna-Liisa
- Hartman Catharina A
- Hass Merli
- Hassanali Neelam
- Hassinen Maija
- Hastie Nicholas D
- Hastie Nick
- Hattersley Andrew T
- Haun Margot
- Havulinna Aki S
- Hayward Caroline
- Hazen Stanley L
- He Bing
- He Chunyan
- Heard-Costa Nancy L
- Heath Andrew C
- Heath Simon
- Heckbert Susan R
- Hedblad Bo
- Hedman Åsa K
- Heid Iris M
- Heikkilä Kauko
- Heikkilä Outi
- Heiss Gerardo
- Heliövaara Markku
- Helmer Catherine
- Helmer Quinta
- Henders Anjali K
- Henderson Brian
- Hengstenberg Christian
- Henneman Peter
- Hercberg Serge
- Herder Christian
- Hernandez Dena
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- Herrera Lizbeth
- Herzig Karl-Heinz
- Hicks Andrew A
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- Higashio Julia
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- Hilton Gina
- Hindorff Lucia
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- Ho Weang K
- Hocking Lynne J
- Hoffmann Wolfgang
- Hofman Albert
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- Holm Hilma
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- Horikoshi Momoko
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- Hottenga Jouke-Jan
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- Howard Philip
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- Imboden Medea
- Ingelsson Erik
- Ingle Catherine
- Ingvarsson Thorvaldur
- Ioannidis John P A
- Iribarren Carlos
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- Ittermann Till
- Iwai Naoharu
- Jackson Anne U
- Jackson Rebecca
- Jacobs Gunnar
- Jafar Tazeen H
- James Alan L
- Jameson Karen A
- Jang Yangsoo
- Janipalli Charles S
- Jansen Hanneke
- Janssens A Cecile J W
- Jarvelin Marjo-Riitta
- Jeff Janina
- Jenny Nancy
- Johannsdottir Hrefna
- Johansen Berit
- Johansson Ingegerd
- Johansson Åsa
- Johnson Andrew
- Johnson Louise
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- Jones Michelle R
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- Jukema J Wouter
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- Kahali Bratati
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- Moilanen Leena
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- Monroe Kristine
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- Pankow James
- Papamarkou Theodore
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- Parts Leopold
- Parving Hans-Henrik
- Paré Guillaume
- Pasko Dorota
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- Patsy Bruce
- Pattaro Cristian
- Paulweber Bernhard
- Peacock Munro
- Pechlivanis Sonali
- Peden John F
- Pedersen Nancy L
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- Peltonen Leena
- Pendergrass Sarah
- Pennell Craig E
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- Peters Annette
- Peters Marjolein J
- Peters Ulrike
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- Pettersson-Kymmer Ulrika
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- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso Inês
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
- Boehnke Mike
- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
- Bumpstead Suzannah
- Burnett Mary Susan
- Burtt Noisël P.
- Busonero Fabio
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Cappuccio Francesco P.
- Cardiogenics [Unknown]
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Cavalcanti-Proença Christine
- Chambers John C.
- Chanock Stephen J.
- Charpentier Guillaume
- Chasman Daniel I.
- Chatterjee Nilanjan
- Chen Chih Mei
- Chen Han
- Chen Li
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Codd Veryan
- Coin Lachlan
- Collins Francis S.
- Collins Rory
- Connell John
- Cooper Cyrus C.
- Cooper Matthew N.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Cupples L. Adrienne
- Daly Mark J.
- Danesh John
- Davies Robert W.
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- de Faire Ulf
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- den Heijer Martin
- Dennison Elaine M.
- Dermitzakis Emmanouil T.
- Devaney Joseph M.
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S.
- Dina Christian
- Dixon Anna L.
- Do Ron
- Doering Angela
- Doney Alex S F
- Donnelly Peter
- Dorret I Boomsma
- Duan Jubao
- Dupuis Josée
- Durbin Richard
- Ebrahim Shah
- Eifert Sandra
- Eiriksdottir Gudny
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
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- Eriksson Per
- Esko Tõnu
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- Estrada Karol
- Eury Elodie
- Facheris Maurizio F.
- Farooqi I. Sadaf
- Farrall Martin
- Feitosa Mary F.
- Felix Stephan B.
- Ferrannini Ele
- Ferreir Teresa
- Ferreira Teresa
- Fischer Marcus
- Fischer-Posovszky Pamela
- Fisher Eva
- Florez Jose C.
- Folkersen Lasse
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- Forsen Tom J.
- Fox Caroline S.
- Franklin Christopher S.
- Franzosi Maria Grazia
- Frayling Timothy M.
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- Goddard Michael E.
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- Grallert Harald
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- Gretarsdottir Solveig
- Griffin Simon
- Groop Leif
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- Groves Christopher J.
- Grundberg Elin
- Gräßler Jürgen
- Grönberg Henrik
- Gu Harvest
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gustafsso Stefan
- Gustafsson Stefan
- Gyllensten Ulf
- Hadjadj Samy
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- Halperin Eran
- Hammond Christopher J.
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- Hamsten Anders
- Han Chen
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- Hartikainen Anna Liisa
- Hassanali Neelam
- Hattersley Andrew T.
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- Hitman Graham A.
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- Jameson Karen A.
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- Jarick Ivonne
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- Jewell Elizabeth
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- Jones Gregory T.
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- Jukema J. Wouter
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- Kilpeläine Tuomas O.
- Kilpeläinen Tuomas O
- Kinnunen Leena
- Klopp Norman
- Knowles Joshua W.
- Kolcic Ivana
- Kolovou Genovefa
- Kong Augustine
- Kooner Angad S.
- Kooner Jaspal S.
- Koskinen Seppo
- Kovacs Peter
- Kraft Peter
- Krude Heiko
- Kutalik Zoltán
- Kuulasmaa Teemu
- Kuusisto Johanna
- Kvaløy Kirsti
- Kyriakou Theodosios
- Kähönen Mika
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laitinen Jaana
- Lambrechts Diether
- Lamina Claudia
- Langenberg Claudia
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- Lantieri Olivier
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- Leander Karin
- Lecoeur Cecile
- Lehtimäki Terho
- Lettre Guillaume
- Levinson Douglas F.
- Li Man
- Li Mingyao
- Li Shengxu
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- Lieb Wolfgang
- Lieverse Aloysius
- Lind Lars
- Lindgre Cecilia M.
- Lindgren Cecilia M.
- Linksted Pamela
- Liu Jianjun
- Lokki Marja Liisa
- Loley Christina
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- Lotery Andrew J.
- Lua Jian'an
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- Ludwig Barbara
- Lyssenko Valeriya
- Macciardi Fabio
- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
- Mannila Maria Nastase
- Manning Alisa K.
- Mannucci Pier M.
- Manunta Paolo
- Maouche Seraya
- Marek Diana
- Marre Michel
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- McKnight Barbara
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
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- Metspalu Andres
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- Münzel Thomas
- Nahrstaedt Janja
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- Parts Leopold
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- Rasheed Asif
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Rayner N. William
- Rayner Nigel W.
- Reilly Muredach P.
- Reinehr Thomas
- Rice Catherine
- Ridderstråel Martin
- Ridderstråle Martin
- Ridker Paul M.
- Rief Winfried
- Ripatti Samuli
- Rissanen Aila
- Rivadeneira Fernando
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
- Rosendaal Frits R.
- Rubin Diana
- Rudan Igor
- Ruokonen Aimo
- Rust Stephan
- Rybin Denis
- Rzehak Peter
- Ríos Manuel Serrano
- Sabater-Lleal Maria
- Saleheen Danish
- Salomaa Veikko
- Samad Adbus
- Samani Nilesh
- Sampietro M. Lourdes
- Sampson Michael J.
- Samuel Maria
- Sanders Alan R.
- Sandholt Camilla
- Sandhu Manj S.
- Sandhu Manjinder S.
- Sanna Serena
- Saramies Jouko
- Savolainen Markku J.
- Saxena Richa
- Sayer Avan A.
- Schadt Eric
- Scherag Andre
- Scherag Susann
- Schillert Arne
- Schipf Sabine
- Schlessinger David
- Schreiber Stefan
- Schrezenmeir Jürgen
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- Schwarz Peter E H
- Schäfer Arne
- Scott James
- Scott Laura J.
- Seedorf Udo
- Segrè Ayellet V.
- Sehmi Joban
- Sekowska Magdalena
- Sennblad Bengt
- Shah Nabi
- Shaun Purcell
- Shi Jianxin
- Shields Beverley M.
- Shrader Peter
- Shuldiner Alan R.
- Sigurdsson Gunnar
- Sijbrands Eric
- Silander Kaisa
- Silveira Angela
- Sinisalo Juha
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Sleight Peter
- Small Kerrin
- Smit Jan H.
- Smith Albert
- Smith George Davey
- Smith Tamara B.
- Snoep Jaapjan D.
- Soranzo Nicole
- Sovio Ulla
- Sparsø Thomas
- Spector Timothy D.
- Speliote Elizabeth K.
- Speliotes Elizabeth K
- Spertus John A.
- Stancakova Alena
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdotti Valgerdur
- Steinthorsdottir Valgerdur
- Stephens Jonathan
- Stewart Alexandre F R
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Strawbridge Rona
- Stringha Heather M.
- Stringham Heather M.
- Stumvoll Michael
- Sun Qi
- Surakka Ida
- Surdulescu Gabriela
- Swift Amy J.
- Syvänen Ann Christine
- Tammesoo Mari Liis
- Taneera Jalal
- Tang W. H Wilson
- Tardif Jean Claude
- Teder-Laving Maris
- Tennstedt Stephanie
- Terho Lehtimäki
- Teslovich Tanya M.
- Thiering Elisabeth
- Thompson John R.
- Thomson Brian
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsso Gudmar
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Timpson Nicholas J.
- Tognoni Gianni
- Tomaszewski Maciej
- Travers Mary
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Turrini Fabiola
- Tyrer Jonathan P.
- Tzenova Bell Jordana
- Tönjes Anke
- Uda Manuela
- Uitterlinden Andre
- Uitterlinden Andre G.
- Uitterlinden André
- Valle Timo T.
- van Dam Rob M.
- van Duijn Cornelia M.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Meurs Joyce B.
- van Ommen Gert Jan
- van Rij Andre M.
- van Vliet Jana V
- van Vliet-Ostaptchouk Jana V.
- van Wingerden Sophie
- van't Hooft Ferdinand
- Vatin Vincent
- Vedanta Sailaja
- Vedantam Sailaja
- Viikari Jorma
- Visscher Peter M.
- Visvikis-Siest Sophie
- Vitart Veronique
- Vogel Carla I G
- Voight Benjamin F.
- Wabitsch Martin
- Waeber Gérard
- Waite Lindsay L.
- Walker Mark
- Wallaschofski Henri
- Walter G. Bragi
- Wareham Nicholas J.
- Wareham Nick J.
- Watanabe Richard M.
- Watkins Hugh
- Weedo Michael N.
- Weedon Michael N.
- Welch Ryan
- Wells George A.
- Weyan Robert J.
- Weyant Robert J
- Wheele Eleanor
- Wheeler Eleanor
- White Charles C.
- Wichmann H. Erich
- Widen Elisabeth
- Wiegand Susanna
- Wijmenga Cisca
- Wiklund Fredrik
- Wild Philipp S.
- Wild Sarah H.
- Wilk Alicja
- Wille Cristen J.
- Willemsen Gonneke
- Willenborg Christina
- Willer Cristen J.
- Wilson James F.
- Winkle Thomas W.
- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Öhrvik John
- Östenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
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- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
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- Baron Laurent
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- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
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- Chen Ray
- Chen Shu
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- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
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- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
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- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
- Cockrell Raynard
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- Cofield Jackie
- Coggill Penelope
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- Collings Simon
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- Comstock Robin
- Cong Bin
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- Connolly Anthony
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- Considine Tony
- Constance Doug
- Cook April
- Cook Leanna
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- Copeland Alex
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- Davis Matthew
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- Dawoe Tenzin
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- Gyaltsen Kunsang
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- Görlich Yvonne
- Ha Chi
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- Hamilton Matt
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- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
- Han Shunsheng
- Han Xurong
- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
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- Hashimoto Wakako
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- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
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- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
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- Hillyard Guy
- Hines Sandra
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- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
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- Hogues Marilyn E.
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- Ishikawa Sabine K.
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- Yano Candance
- Yao Zhijian
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- Ye Chen
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- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
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- Zhang Bo
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- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
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- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Limpet feeding rate and the consistency of physiological response to temperature
- Author
- A Zeileis
- Andrew Clarke
- BW Alto
- C Mora
- C-H Lai
- Chien-Hsiang Lai
- CL Prosser
- CL Waller
- CR Boyden
- D Sanchez-Fernandez
- E Pennisi
- ELE Sinclair
- HO Pörtner
- HO Pörtner
- HO Pörtner
- J Davenport
- J Richard
- J-F Grenon
- JF Gillooly
- JM Sunday
- JP Barry
- JS Terblanche
- KDT Nguyen
- KJ Gaston
- KJ Liddiard
- Koh Siang Tan
- Lloyd S. Peck
- LS Peck
- LS Peck
- LS Peck
- LS Peck
- LS Peck
- M Kearney
- Michael A. S. Thorne
- MJ Angilletta
- P Calosi
- PL Horn
- PW Hochachka
- RB Huey
- RD Sagarin
- SA Morley
- SA Morley
- SA Morley
- Simon A. Morley
- SL Chown
- TD Clark
- WJ Davis
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts
- Author
- A Fagot-Campagna
- A Flaviani Di
- A Gautier
- A Mari
- A Mari
- AD Baron
- AD Liese
- AE Pontiroli
- AL Gloyn
- Andrea Natali
- AW Drong
- B Antuna-Puente
- Beverley Balkau
- C Rask-Madsen
- CL Craig
- Céline Lange
- D Conen
- DR Matthews
- DT Villareal
- DZ Cherney
- E Cauter Van
- E Ferrannini
- Ele Ferrannini
- EV Galkina
- F Bonnet
- F Bonnet
- F Bonnet
- Fabrice Bonnet
- GB Ehret
- GC Mistry
- I Vauhkonen
- J Arnlov
- J He
- JB Meigs
- JC Florez
- JC Florez
- JK Bower
- JL Chiasson
- John Petrie
- JV Bjornholt
- KA Britton
- L Monnier
- Loïc Yengo
- Martine Laville
- Michel Marre
- Olivier Lantieri
- P Xun
- P Yerram
- Philippe Froguel
- RC Bonadonna
- Ronan Roussel
- S Cauchi
- S Frontoni
- S Koren
- S O’Rahilly
- SA Hills
- SM Haffner
- SR Srinivasan
- Stéphane Cauchi
- T Heise
- TW Gress
- V Gupta
- V Lyssenko
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …