66 research outputs found
Research poster: From lab to basin scale: A Look at changes in evaporative and transpirative processes in arid and semi-arid shallow groundwater systems
Research poste
Quantum computation on a 19-qubit wide 2d nearest neighbour qubit array
In this paper, we explore the relationship between the width of a qubit
lattice constrained in one dimension and physical thresholds for scalable,
fault-tolerant quantum computation. To circumvent the traditionally low
thresholds of small fixed-width arrays, we deliberately engineer an error bias
at the lowest level of encoding using the surface code. We then address this
engineered bias at a higher level of encoding using a lattice-surgery surface
code bus that exploits this bias, or a repetition code to make logical qubits
with unbiased errors out of biased surface code qubits. Arbitrarily low error
rates can then be reached by further concatenating with other codes, such as
Steane [[7,1,3]] code and the [[15,7,3]] CSS code. This enables a scalable
fixed-width quantum computing architecture on a square qubit lattice that is
only 19 qubits wide, given physical qubits with an error rate of . This potentially eases engineering issues in systems with fine qubit
pitches, such as quantum dots in silicon or gallium arsenide.Comment: 34 pages, 19 figure
Concurrent panel session 1: Environmental sustainability and Las Vegas
Moderator: Dr. Stan Smith, UNLV School of Life Sciences Scribe: Crystal Jackson, UNLV Department of Sociology Conference white paper & Full summary of panel session, 6 page
Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development
Mood stabilising drugs such as lithium (LiCl) and valproic acid (VPA) are the first line agents for treating conditions such as Bipolar disorder and Epilepsy. However, these drugs have potential developmental effects that are not fully understood. This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. Treatment with VPA and LiCl resulted in the differential expression of 331 and 164 genes respectively. In the subset of VPA targeted genes, 114 were downregulated whilst 217 genes were upregulated. In the subset of LiCl targeted genes, 73 were downregulated and 91 were upregulated. Gene ontology (GO) term enrichment analysis was used to highlight the most relevant GO terms associated with a given gene list following toxin exposure. In addition, in order to phenotypically anchor the gene expression data, changes in the heterogeneity of cell subtype populations and cell cycle phase were monitored using flow cytometry. Whilst LiCl exposure did not significantly alter the proportion of cells expressing markers for stem cells/undifferentiated cells (Oct4, SSEA4), neurons (Neurofilament M), astrocytes (GFAP) or cell cycle phase, the drug caused a 1.4-fold increase in total cell number. In contrast, exposure to VPA resulted in significant upregulation of Oct4, SSEA, Neurofilament M and GFAP with significant decreases in both G2/M phase cells and cell number. This neurosphere model might provide the basis of a human-based cellular approach for the regulatory exploration of developmental impact of potential toxic chemicals
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points
Sequence diversity and differential expression of major phenylpropanoid-flavonoid biosynthetic genes among three mango varieties
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