Isothermal Elastohydrodynamic Lubrication Analysis of Heavily Loaded Hypoid Gear Pairs

A numerical model able to predict the pressure distribution and the film thickness in heavily loaded elliptical EHL contacts is developed and presented in this study. The operating conditions, such as the contact load and the velocities of the mating surfaces, are representative of the corresponding conditions present in automotive differential hypoid gear pair units. The EHL solver presented is able to predict the minimum and central film thickness of the lubricating oil as well as the pressure distribution assuming isothermal and Newtonian conditions. Results are presented for a full quasi-static meshing cycle. A comparison between the numerically calculated values of the central and the minimum film thickness is performed against the corresponding values produced using the Chittenden-Dowson formula. A very good agreement is observed between the values of the central film thickness. However, it is shown that the minimum film thickness values using the Chittenden-Dowson formula can deviate up to 40% compared with the corresponding values which are calculated numerically

Film Thickness Investigation in Heavily Loaded Hypoid Gear Pair Elastohydrodynamic Conjunctions

Introduction: Hypoid gear pairs are some of the most highly loaded components of the differential unit in modern automobiles. Prediction of wear rate and generated friction require determination of lubricant film thickness. However, only very few investigations have addressed the issue of thin elastohydrodynamic films in hypoid gear pairs. The main reason for dearth of analysis in this regard has been the need for accurate determination of transient contact geometry and kinematics of interacting surfaces throughout a typical meshing cycle. Furthermore, combined gear dynamics and lubrication analysis of any pairs of simultaneous meshing teeth pairs is required. Simon [1] was among the first to deal with these issues. He used Tooth Contact Analysis (TCA) in order to calculate the instantaneous contact geometry and load for any teeth pair during their meshing cycle. However, in his study, the load carried by the hypoid pair was quite low, making the application of the results limited and not entirely suitable for real life operating conditions of typical hypoid gear pairs of vehicular differentials, which is of interest in the current paper. Xu and Kahraman [2] performed numerical prediction of power losses and consequently the film thickness for highly loaded hypoid gear pairs. However, in their study only the one-dimensional Reynolds equation was employed. Consequently, the effect of lubricant side leakage in the passage through the contact was ignored. A more recent study by Mohammadpour et al. [3] employed realistic gear geometry data (through the use of TCA) for calculation of film thickness time history through mesh. The two-dimensional Reynolds equation, accounting for the side leakage of the lubricant, was solved numerically. It was shown that the side leakage component of the entraining velocity can significantly influence the film thickness. With regard to hypoid gear dynamics, several studies should be mentioned. Wang and Lim [4] studied the dynamic response of hypoid gear pairs under the influence of time varying meshing stiffness. Yang and Lim [5] created a model able to predict the dynamic response of a hypoid gear pair by taking into account the lateral translations of their shafts due to the compliance of the supporting bearings. Karagiannis et al. [6-7] studied the dynamics of automotive differential hypoid gear pairs by taking into account the velocity dependent resistive torque at the gear caused by aerodynamic drag and tyre-road rolling resistance. The study integrated the gear dynamics with the generated viscous and boundary conjunctional friction

Induction of humoral immune response to multiple recombinant Rhipicephalus appendiculatus antigens and their effect on tick feeding success and pathogen transmission

BACKGROUND: Rhipicephalus appendiculatus is the primary vector of Theileria parva, the etiological agent of East Coast fever (ECF), a devastating disease of cattle in sub-Saharan Africa. We hypothesized that a vaccine targeting tick proteins that are involved in attachment and feeding might affect feeding success and possibly reduce tick-borne transmission of T. parva. Here we report the evaluation of a multivalent vaccine cocktail of tick antigens for their ability to reduce R. appendiculatus feeding success and possibly reduce tick-transmission of T. parva in a natural host-tick-parasite challenge model. METHODS: Cattle were inoculated with a multivalent antigen cocktail containing recombinant tick protective antigen subolesin as well as two additional R. appendiculatus saliva antigens: the cement protein TRP64, and three different histamine binding proteins. The cocktail also contained the T. parva sporozoite antigen p67C. The effect of vaccination on the feeding success of nymphal and adult R. appendiculatus ticks was evaluated together with the effect on transmission of T. parva using a tick challenge model. RESULTS: To our knowledge, this is the first evaluation of the anti-tick effects of these antigens in the natural host-tick-parasite combination. In spite of evidence of strong immune responses to all of the antigens in the cocktail, vaccination with this combination of tick and parasite antigens did not appear to effect tick feeding success or reduce transmission of T. parva. CONCLUSION: The results of this study highlight the importance of early evaluation of anti-tick vaccine candidates in biologically relevant challenge systems using the natural tick-host-parasite combination

Theory of quasi-spherical accretion in X-ray pulsars

A theoretical model for quasi-spherical subsonic accretion onto slowly rotating magnetized neutron stars is constructed. In this model the accreting matter subsonically settles down onto the rotating magnetosphere forming an extended quasi-static shell. This shell mediates the angular momentum removal from the rotating neutron star magnetosphere during spin-down episodes by large-scale convective motions. The accretion rate through the shell is determined by the ability of the plasma to enter the magnetosphere. The settling regime of accretion can be realized for moderate accretion rates $\dot M< \dot M_*\simeq 4\times 10^{16}$ g/s. At higher accretion rates a free-fall gap above the neutron star magnetosphere appears due to rapid Compton cooling, and accretion becomes highly non-stationary. From observations of the spin-up/spin-down rates (the angular rotation frequency derivative $\dot \omega^*$, and $\partial\dot\omega^*/\partial\dot M$ near the torque reversal) of X-ray pulsars with known orbital periods, it is possible to determine the main dimensionless parameters of the model, as well as to estimate the magnetic field of the neutron star. We illustrate the model by determining these parameters for three wind-fed X-ray pulsars GX 301-2, Vela X-1, and GX 1+4. The model explains both the spin-up/spin-down of the pulsar frequency on large time-scales and the irregular short-term frequency fluctuations, which can correlate or anti-correlate with the X-ray flux fluctuations in different systems. It is shown that in real pulsars an almost iso-angular-momentum rotation law with $\omega \sim 1/R^2$, due to strongly anisotropic radial turbulent motions sustained by large-scale convection, is preferred.Comment: 48 pages, 4 figures, accepted for publication in MNRA

Profiling microRNAs in individuals at risk of progression to rheumatoid arthritis

Background: Individuals at risk of rheumatoid arthritis (RA) demonstrate systemic autoimmunity in the form of anti-citrullinated peptide antibodies (ACPA). MicroRNAs (miRNAs) are implicated in established RA. This study aimed to (1) compare miRNA expression between healthy individuals and those at risk of and those that develop RA, (2) evaluate the change in expression of miRNA from "at-risk" to early RA and (3) explore whether these miRNAs could inform a signature predictive of progression from "at-risk" to RA. Methods: We performed global profiling of 754 miRNAs per patient on a matched serum sample cohort of 12 anti-cyclic citrullinated peptide (CCP) + "at-risk" individuals that progressed to RA. Each individual had a serum sample from baseline and at time of detection of synovitis, forming the matched element. Healthy controls were also studied. miRNAs with a fold difference/fold change of four in expression level met our primary criterion for selection as candidate miRNAs. Validation of the miRNAs of interest was conducted using custom miRNA array cards on matched samples (baseline and follow up) in 24 CCP+ individuals; 12 RA progressors and 12 RA non-progressors. Results: We report on the first study to use matched serum samples and a comprehensive miRNA array approach to identify in particular, three miRNAs (miR-22, miR-486-3p, and miR-382) associated with progression from systemic autoimmunity to RA inflammation. MiR-22 demonstrated significant fold difference between progressors and non-progressors indicating a potential biomarker role for at-risk individuals. Conclusions: This first study using a cohort with matched serum samples provides important mechanistic insights in the transition from systemic autoimmunity to inflammatory disease for future investigation, and with further evaluation, might also serve as a predictive biomarker

Reframing conservation physiology to be more inclusive, integrative, relevant and forward-looking: Reflections and a horizon scan

Applying physiological tools, knowledge and concepts to understand conservation problems (i.e. conservation physiology) has becomecommonplace and confers an ability to understand mechanistic processes,develop predictive models and identify cause-and-effect relationships. Conservation physiology is making contributions to conservation solutions; the number of \u27success stories\u27 is growing, but there remain unexplored opportunities for which conservation physiology shows immense promise and has the potential to contribute to major advances in protecting and restoring biodiversity. Here, we consider howconservation physiology has evolved with a focus on reframing the discipline to be more inclusive and integrative.Using a \u27horizon scan\u27,we further exploreways in which conservation physiology can be more relevant to pressing conservation issues of today (e.g. addressing the Sustainable Development Goals; delivering science to support the UN Decade on Ecosystem Restoration), aswell as more forward-looking to inform emerging issues and policies for tomorrow. Our horizon scan provides evidence that, as the discipline of conservation physiology continues to mature, it provides a wealth of opportunities to promote integration, inclusivity and forward-thinking goals that contribute to achieving conservation gains. To advance environmentalmanagementand ecosystemrestoration,we need to ensure that the underlying science (such as that generated by conservation physiology) is relevant with accompanying messaging that is straightforward and accessible to end users

One hundred research questions in conservation physiology for generating actionable evidence to inform conservation policy and practice

Environmental change and biodiversity loss are but two of the complex challenges facing conservation practitioners and policy makers. Relevant and robust scientific knowledge is critical for providing decision-makers with the actionable evidence needed to inform conservation decisions. In the Anthropocene, science that leads to meaningful improvements in biodiversity conservation, restoration and management is desperately needed. Conservation Physiology has emerged as a discipline that is well-positioned to identify the mechanisms underpinning population declines, predict responses to environmental change and test different in situ and ex situ conservation interventions for diverse taxa and ecosystems. Here we present a consensus list of 10 priority research themes. Within each theme we identify specific research questions (100 in total), answers to which will address conservation problems and should improve the management of biological resources. The themes frame a set of research questions related to the following: (i) adaptation and phenotypic plasticity; (ii) human-induced environmental change; (iii) human-wildlife interactions; (iv) invasive species; (v) methods, biomarkers and monitoring; (vi) policy, engagement and communication; (vii) pollution; (viii) restoration actions; (ix) threatened species; and (x) urban systems. The themes and questions will hopefully guide and inspire researchers while also helping to demonstrate to practitioners and policy makers the many ways in which physiology can help to support their decisions

The [OIII] emission line luminosity function of optically selected type-2 AGN from zCOSMOS

We present a catalog of 213 type-2 AGN selected from the zCOSMOS survey. The selected sample covers a wide redshift range (0.15<z<0.92) and is deeper than any other previous study, encompassing the luminosity range 10^{5.5} < Lsun< L[OIII] < 10^{9.1} Lsun. We explore the intrinsic properties of these AGN and the relation to their X-ray emission (derived from the XMM-COSMOS observations). We study their evolution by computing the [OIII]5007A line luminosity function (LF) and we constrain the fraction of obscured AGN as a function of luminosity and redshift. The sample was selected on the basis of the optical emission line ratios, after applying a cut to the signal-to-noise ratio (S/N) of the relevant lines. We used the standard diagnostic diagrams [OIII]/Hbeta versus [NII]/Halpha and ([OIII]/Hbeta versus [SII]/Halpha) to isolate AGN in the redshift range 0.15<z<0.45 and the diagnostic diagram [OIII]/Hbeta versus [OII]/Hbeta to extend the selection to higher redshift (0.5<z<0.92). Combining our sample with one drawn from SDSS, we found that the best description of the evolution of type-2 AGN is a luminosity-dependent density evolution model. Moreover, using the type-1 AGN LF we were able to constrain the fraction of type-2 AGN to the total (type-1 + type-2) AGN population. We found that the type-2 fraction decreases with luminosity, in agreement with the most recent results, and shows signs of a slight increase with redshift. However, the trend with luminosity is visible only after combining the SDSS+zCOSMOS samples. From the COSMOS data points alone, the type-2 fraction seems to be quite constant with luminosity.Comment: 20 pages, 11 figures, accepted for publication in Astronomy and Astrophysic

The VVDS type-1 AGN sample: The faint end of the luminosity function

In a previous paper (Gavignaud et al. 2006), we presented the type-1 Active Galactic Nuclei (AGN) sample obtained from the first epoch data of the VIMOS-VLT Deep Survey (VVDS). The sample consists of 130 faint, broad-line AGN with redshift up to z=5 and 17.5< I <24.0, selected on the basis of their spectra. In this paper we present the measurement of the Optical Luminosity Function up to z=3.6 derived from this sample, we compare our results with previous results from brighter samples both at low and at high redshift. Our data, more than one magnitude fainter than previous optical surveys, allow us to constrain the faint part of the luminosity function up to high redshift. By combining our faint VVDS sample with the large sample of bright AGN extracted from the SDSS DR3 (Richards et al., 2006b) and testing a number of different evolutionary models, we find that the model which better represents the combined luminosity functions, over a wide range of redshift and luminosity, is a luminosity dependent density evolution (LDDE) model, similar to those derived from the major X-surveys. Such a parameterization allows the redshift of the AGN space density peak to change as a function of luminosity and explains the excess of faint AGN that we find at 1.0< z <1.5. On the basis of this model we find, for the first time from the analysis of optically selected samples, that the peak of the AGN space density shifts significantly towards lower redshift going to lower luminosity objects. This result, already found in a number of X-ray selected samples of AGN, is consistent with a scenario of "AGN cosmic downsizing", in which the density of more luminous AGN, possibly associated to more massive black holes, peaks earlier in the history of the Universe, than that of low luminosity ones.Comment: 13 pages, 10 figures, submitted to A&

On Switch-Reference Phenomena in Kolyma Yukaghir

「環太平洋の言語」成果報告書A2-002ELPR publication series A2-00