89 research outputs found
The Role of Laypersons in the Closing of Residential Real Estate Transactions: North Carolina\u27s New Approach
- Author
- Publication venue
- Carolina Law Scholarship Repository
- Publication date
- 01/04/2003
- Field of study
The Role of Laypersons in the Closing of Residential Real Estate Transactions: North Carolina\u27s New Approach
- Author
- Publication venue
- Carolina Law Scholarship Repository
- Publication date
- 01/04/2003
- Field of study
A randomized controlled trial of vitamin D dosing strategies after acute hip fracture: No advantage of loading doses over daily supplementation
- Author
- A Scillitani
- Alexandra Papaioannou
- B Dawson-Hughes
- B Dawson-Hughes
- BM Tang
- C Simonelli
- CF Pieper
- CJ Bacon
- Courtney C Kennedy
- DA Hanley
- David A Hanley
- E Romagnoli
- George Ioannidis
- H Bischoff-Ferrari
- HA Bischoff
- HA Bischoff-Ferrari
- HA Bischoff-Ferrari
- HA Bischoff-Ferrari
- HA Bischoff-Ferrari
- HA Bischoff-Ferrari
- HA Bischoff-Ferrari
- HA Bischoff-Ferrari
- HM Trang
- JA Kanis
- Janet Pritchard
- Jonathan D Adachi
- Justin DeBeer
- KF Schulz
- KL Hackman
- KM Sanders
- LA Armas
- Leonardo Farrauto
- Lora Giangregorio
- M Di Monaco
- ME Charlson
- MF Holick
- P Lips
- R Przybelski
- RH Harwood
- S Adami
- S Bakhtiyarova
- S Ish-Shalom
- SJ Gallacher
- SR Mastaglia
- T Beringer
- T Pekkarinen
- V Chel
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
A communal catalogue reveals Earth’s multiscale microbial diversity
- Author
- Thompson L R
- Sanders Jon G
- McDonald Daniel
- Amir Amnon
- Ladau Joshua
- Locey Kenneth J
- Prill Robert J
- Tripathi Anupriya
- Gibbons Sean M
- Ackermann Gail
- Navas-Molina Jose A
- Janssen Stefan
- Kopylova Evguenia
- Vázquez-Baeza Yoshiki
- González Antonio
- Morton James T
- Mirarab Siavash
- Zech Xu Zhenjiang
- Jiang Lingjing
- Haroon Mohamed F
- Kanbar Jad
- Zhu Qiyun
- Jin Song Se
- Kosciolek Tomasz
- Bokulich Nicholas A
- Lefler Joshua
- Brislawn Colin J
- Humphrey Gregory
- Owens Sarah M
- Hampton-Marcell Jarrad
- Berg-Lyons Donna
- McKenzie Valerie
- Fierer Noah
- Fuhrman Jed A
- Clauset Aaron
- Stevens Rick L
- Shade Ashley
- Pollard Katherine S
- Goodwin Kelly D
- Jansson Janet K
- Gilbert Jack A
- Knight Rob
- Rivera Jose L Agosto
- Al-Moosawi Lisa
- Alverdy John
- Amato Katherine R
- Andras Jason
- Angenent Largus T
- Antonopoulos Dionysios A
- Apprill Amy
- Armitage David
- Ballantine Kate
- Bárta Jirˇí
- Baum Julia K
- Berry Allison
- Bhatnagar Ashish
- Bhatnagar Monica
- Biddle Jennifer F
- Bittner Lucie
- Boldgiv Bazartseren
- Bottos Eric
- Boyer Donal M
- Braun Josephine
- Brazelton William
- Brearley Francis Q
- Campbell Alexandra H
- Caporaso J Gregory
- Cardona Cesar
- Carroll JoLynn
- Cary S Craig
- Casper Brenda B
- Charles Trevor C
- Chu Haiyan
- Claar Danielle C
- Clark Robert G
- Clayton Jonathan B
- Clemente Jose C
- Cochran Alyssa
- Coleman Maureen L
- Collins Gavin
- Colwell Rita R
- Contreras Mónica
- Crary Benjamin B
- Creer Simon
- Cristol Daniel A
- Crump Byron C
- Cui Duoying
- Daly Sarah E
- Davalos Liliana
- Dawson Russell D
- Defazio Jennifer
- Delsuc Frédéric
- Dionisi Hebe M
- Dominguez-Bello Maria Gloria
- Dowell Robin
- Dubinsky Eric A
- Dunn Peter O
- Ercolini Danilo
- Espinoza Robert E
- Ezenwa Vanessa
- Fenner Nathalie
- Findlay Helen S
- Fleming Irma D
- Fogliano Vincenzo
- Forsman Anna
- Freeman Chris
- Friedman Elliot S
- Galindo Giancarlo
- Garcia Liza
- Garcia-Amado Maria Alexandra
- Garshelis David
- Gasser Robin B
- Gerdts Gunnar
- Gibson Molly K
- Gifford Isaac
- Gill Ryan T
- Giray Tugrul
- Gittel Antje
- Golyshin Peter
- Gong Donglai
- Grossart Hans-Peter
- Guyton Kristina
- Haig Sarah-Jane
- Hale Vanessa
- Hall Ross Stephen
- Hallam Steven J
- Handley Kim M
- Hasan Nur A
- Haydon Shane R
- Hickman Jonathan E
- Hidalgo Glida
- Hofmockel Kirsten S
- Hooker Jeff
- Hulth Stefan
- Hultman Jenni
- Hyde Embriette
- Ibáñez-Álamo Juan Diego
- Jastrow Julie D
- Jex Aaron R
- Johnson L Scott
- Johnston Eric R
- Joseph Stephen
- Jurburg Stephanie D
- Jurelevicius Diogo
- Karlsson Anders
- Karlsson Roger
- Kauppinen Seth
- Kellogg Colleen T E
- Kennedy Suzanne J
- Kerkhof Lee J
- King Gary M
- Kling George W
- Koehler Anson V
- Krezalek Monika
- Kueneman Jordan
- Lamendella Regina
- Landon Emily M
- Lane-deGraaf Kelly
- LaRoche Julie
- Larsen Peter
- Laverock Bonnie
- Lax Simon
- Lentino Miguel
- Levin Iris I
- Liancourt Pierre
- Liang Wenju
- Linz Alexandra M
- Lipson David A
- Liu Yongqin
- Lladser Manuel E
- Lozada Mariana
- Spirito Catherine M
- MacCormack Walter P
- MacRae-Crerar Aurora
- Magris Magda
- Martín-Platero Antonio M
- Martín-Vivaldi Manuel
- Martínez L Margarita
- Martínez-Bueno Manuel
- Marzinelli Ezequiel M
- Mason Olivia U
- Mayer Gregory D
- McDevitt-Irwin Jamie M
- McDonald James E
- McGuire Krista L
- McMahon Katherine D
- McMinds Ryan
- Medina Mónica
- Mendelson Joseph R
- Metcalf Jessica L
- Meyer Folker
- Michelangeli Fabian
- Miller Kim
- Mills David A
- Minich Jeremiah
- Mocali Stefano
- Moitinho-Silva Lucas
- Moore Anni
- Morgan-Kiss Rachael M
- Munroe Paul
- Myrold David
- Neufeld Josh D
- Ni Yingying
- Nicol Graeme W
- Nielsen Shaun
- Nissimov Jozef I
- Niu Kefeng
- Nolan Matthew J
- Noyce Karen
- O’Brien Sarah L
- Okamoto Noriko
- Orlando Ludovic
- Castellano Yadira Ortiz
- Osuolale Olayinka
- Oswald Wyatt
- Parnell Jacob
- Peralta-Sánchez
- Juan M
- Petraitis Peter
- Pfister Catherine
- Pilon-Smits Elizabeth
- Piombino Paola
- Pointing Stephen B
- Pollock F Joseph
- Potter Caitlin
- Prithiviraj Bharath
- Quince Christopher
- Rani Asha
- Ranjan Ravi
- Rao Subramanya
- Rees Andrew P
- Richardson Miles
- Riebesell Ulf
- Robinson Carol
- Rockne Karl J
- Rodriguezl Selena Marie
- Rohwer Forest
- Roundstone Wayne
- Safran Rebecca J
- Sangwan Naseer
- Sanz Virginia
- Schrenk Matthew
- Schrenzel Mark D
- Scott Nicole M
- Seger Rita L
- Seguin-Orlando Andaine
- Seldin Lucy
- Seyler Lauren M
- Shakhsheer Baddr
- Sheets Gabriela M
- Shen Congcong
- Shi Yu
- Shin Hakdong
- Shogan Benjamin D
- Shutler Dave
- Siegel Jeffrey
- Simmons Steve
- Sjöling Sara
- Smith Daniel P
- Soler Juan J
- Sperling Martin
- Steinberg Peter D
- Stephens Brent
- Stevens Melita A
- Taghavi Safiyh
- Tai Vera
- Tait Karen
- Tan Chia L
- Tas Neslihan
- Taylor D Lee
- Thomas Torsten
- Timling Ina
- Turner Benjamin L
- Urich Tim
- Ursell Luke K
- van der Lelie Daniel
- Van Treuren William
- van Zwieten Lukas
- Vargas-Robles Daniela
- Thurber Rebecca Vega
- Vitaglione Paola
- Walker Donald A
- Walters William A
- Wang Shi
- Wang Tao
- Weaver Tom
- Webster Nicole S
- Wehrle Beck
- Weisenhorn Pamela
- Weiss Sophie
- Werner Jeffrey J
- West Kristin
- Whitehead Andrew
- Whitehead Susan R
- Whittingham Linda A
- Willerslev Eske
- Williams Allison E
- Wood Stephen A
- Woodhams Douglas C
- Yang Yeqin
- Zaneveld Jesse
- Zarraonaindia Iratxe
- Zhang Qikun
- Zhao Hongxia
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 22/09/2000
- Field of study
Our growing awareness of the microbial world’s importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth’s microbial diversity
A communal catalogue reveals Earth's multiscale microbial diversity
- Author
- Aaron Clauset
- Aaron R. Jex
- Alexandra H. Campbell
- Alexandra M. Linz
- Allison Berry
- Allison E. Williams
- Alyssa Cochran
- Amnon Amir
- Amy Apprill
- Andaine Seguin-Orlando
- Anders Karlsson
- Andrew P. Rees
- Andrew Whitehead
- Anna Forsman
- Anni Moore
- Anson V. Koehler
- Antje Gittel
- Antonio González
- Antonio M. Martín-Platero
- Anupriya Tripathi
- Asha Rani
- Ashish Bhatnagar
- Ashley Shade
- Aurora MacRae-Crerar
- Baddr Shakhsheer
- Bazartseren Boldgiv
- Beck Wehrle
- Benjamin B. Crary
- Benjamin D. Shogan
- Benjamin L. Turner
- Bharath Prithiviraj
- Bonnie Laverock
- Brenda B. Casper
- Brent Stephens
- Byron C. Crump
- Caitlin Potter
- Carol Robinson
- Catherine M. Spirito
- Catherine Pfister
- Cesar Cardona
- Chia L. Tan
- Chris Freeman
- Christopher Quince
- Colin J. Brislawn
- Colleen T. E. Kellogg
- Congcong Shen
- D. Lee Taylor
- Daniel A. Cristol
- Daniel McDonald
- Daniel P. Smith
- Daniel van der Lelie
- Daniela Vargas-Robles
- Danielle C. Claar
- Danilo Ercolini
- Dave Shutler
- David A. Lipson
- David A. Mills
- David Armitage
- David Garshelis
- David Myrold
- Diogo Jurelevicius
- Dionysios A. Antonopoulos
- Donal M. Boyer
- Donald A. Walker
- Donglai Gong
- Donna Berg-Lyons
- Douglas C. Woodhams
- Duoying Cui
- Elizabeth Pilon-Smits
- Elliot S. Friedman
- Embriette Hyde
- Emily M. Landon
- Eric A. Dubinsky
- Eric Bottos
- Eric R. Johnston
- Eske Willerslev
- Evguenia Kopylova
- Ezequiel M. Marzinelli
- F. Joseph Pollock
- Fabian Michelangeli
- Folker Meyer
- Forest Rohwer
- Francis Q. Brearley
- Frédéric Delsuc
- Gabriela M. Sheets
- Gail Ackermann
- Gary M. King
- Gavin Collins
- George W. Kling
- Giancarlo Galindo
- Glida Hidalgo
- Graeme W. Nicol
- Gregory D. Mayer
- Gregory Humphrey
- Gunnar Gerdts
- Haiyan Chu
- Hakdong Shin
- Hans-Peter Grossart
- Hebe M. Dionisi
- Helen S. Findlay
- Hongxia Zhao
- Ina Timling
- Iratxe Zarraonaindia
- Iris I. Levin
- Irma D. Fleming
- Isaac Gifford
- J. Gregory Caporaso
- Jack A. Gilbert
- Jacob Parnell
- Jad Kanbar
- James E. McDonald
- James T. Morton
- Jamie M. McDevitt-Irwin
- Janet K. Jansson
- Jarrad Hampton-Marcell
- Jason Andras
- Jed A. Fuhrman
- Jeff Hooker
- Jeffrey J. Werner
- Jeffrey Siegel
- Jenni Hultman
- Jennifer Defazio
- Jennifer F. Biddle
- Jeremiah Minich
- Jesse Zaneveld
- Jessica L. Metcalf
- Jirˇí Bárta
- John Alverdy
- JoLynn Carroll
- Jon G. Sanders
- Jonathan B. Clayton
- Jonathan E. Hickman
- Jordan Kueneman
- Jose A. Navas-Molina
- Jose C. Clemente
- Jose L. Agosto Rivera
- Joseph R. Mendelson
- Josephine Braun
- Josh D. Neufeld
- Joshua Ladau
- Joshua Lefler
- Jozef I. Nissimov
- Juan Diego Ibáñez-Álamo
- Juan J. Soler
- Juan M. Peralta-Sánchez
- Julia K. Baum
- Julie D. Jastrow
- Julie LaRoche
- Karen Noyce
- Karen Tait
- Karl J. Rockne
- Kate Ballantine
- Katherine D. McMahon
- Katherine R. Amato
- Katherine S. Pollard
- Kefeng Niu
- Kelly D. Goodwin
- Kelly Lane-deGraaf
- Kenneth J. Locey
- Kim M. Handley
- Kim Miller
- Kirsten S. Hofmockel
- Krista L. McGuire
- Kristin West
- Kristina Guyton
- L. Margarita Martínez
- L. Scott Johnson
- Largus T. Angenent
- Lauren M. Seyler
- Lee J. Kerkhof
- Liliana Davalos
- Linda A. Whittingham
- Lingjing Jiang
- Lisa Al-Moosawi
- Liza Garcia
- Lucas Moitinho-Silva
- Lucie Bittner
- Lucy Seldin
- Ludovic Orlando
- Lukas van Zwieten
- Luke K. Ursell
- Luke R. Thompson
- Magda Magris
- Manuel E. Lladser
- Manuel Martín-Vivaldi
- Manuel Martínez-Bueno
- Maria Alexandra Garcia-Amado
- Maria Gloria Dominguez-Bello
- Mariana Lozada
- Mark D. Schrenzel
- Martin Sperling
- Matthew J. Nolan
- Matthew Schrenk
- Maureen L. Coleman
- Melita A. Stevens
- Miguel Lentino
- Miles Richardson
- Mohamed F. Haroon
- Molly K. Gibson
- Monica Bhatnagar
- Monika Krezalek
- Mónica Contreras
- Mónica Medina
- Naseer Sangwan
- Nathalie Fenner
- Neslihan Tas¸
- Nicholas A. Bokulich
- Nicole M. Scott
- Nicole S. Webster
- Noah Fierer
- Noriko Okamoto
- null null
- Nur A. Hasan
- Olayinka Osuolale
- Olivia U. Mason
- Pamela Weisenhorn
- Paola Piombino
- Paola Vitaglione
- Paul Munroe
- Peter D. Steinberg
- Peter Golyshin
- Peter Larsen
- Peter O. Dunn
- Peter Petraitis
- Pierre Liancourt
- Qikun Zhang
- Qiyun Zhu
- Rachael M. Morgan-Kiss
- Ravi Ranjan
- Rebecca J. Safran
- Rebecca Vega Thurber
- Regina Lamendella
- Rick L. Stevens
- Rita L. Seger
- Rita R. Colwell
- Rob Knight
- Robert E. Espinoza
- Robert G. Clark
- Robert J. Prill
- Robin B. Gasser
- Robin Dowell
- Roger Karlsson
- Ross Stephen Hall
- Russell D. Dawson
- Ryan McMinds
- Ryan T. Gill
- S. Craig Cary
- Safiyh Taghavi
- Sara Sjöling
- Sarah E. Daly
- Sarah L. O’Brien
- Sarah M. Owens
- Sarah-Jane Haig
- Se Jin Song
- Sean M. Gibbons
- Selena Marie Rodriguezl
- Seth Kauppinen
- Shane R. Haydon
- Shaun Nielsen
- Shi Wang
- Siavash Mirarab
- Simon Creer
- Simon Lax
- Sophie Weiss
- Stefan Hulth
- Stefan Janssen
- Stefano Mocali
- Stephanie D. Jurburg
- Stephen A. Wood
- Stephen B. Pointing
- Stephen Joseph
- Steve Simmons
- Steven J. Hallam
- Subramanya Rao
- Susan R. Whitehead
- Suzanne J. Kennedy
- Tao Wang
- Tim Urich
- Tom Weaver
- Tomasz Kosciolek
- Torsten Thomas
- Trevor C. Charles
- Tugrul Giray
- Ulf Riebesell
- Valerie McKenzie
- Vanessa Ezenwa
- Vanessa Hale
- Vera Tai
- Vincenzo Fogliano
- Virginia Sanz
- Walter P. MacCormack
- Wayne Roundstone
- Wenju Liang
- William A. Walters
- William Brazelton
- William Van Treuren
- Wyatt Oswald
- Yadira Ortiz Castellano
- Yeqin Yang
- Yingying Ni
- Yongqin Liu
- Yoshiki Vázquez-Baeza
- Yu Shi
- Zhenjiang Zech Xu
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth's microbial diversity.Peer reviewe
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
- C Adams
- C Ahmed
- C Almaden-Boyle
- C Ashbrook-Raby
- C Basikolo
- C Battle
- C Beazley
- C Beith
- C Borra
- C Brandwood
- C Brantwood
- C Burnett
- C Castro Delgado
- C Clark
- C Clulow
- C Collins
- C Cruz
- C Davis
- C Demetriou
- C Dennis
- C Dexter
- C Downes
- C Dunmore
- C Eastgate
- C Eckbad
- C Finch
- C Gibson
- C Gorman
- C Hays
- C Hewitt
- C Holl
- C Howcroft
- C Humphrey
- C Jackson
- C Jardine
- C Jennings
- C Jones
- C Kaye
- C Lynch
- C Lyons
- C McCulloch
- C McParland
- C McParland
- C Murphy
- C Parmar
- C Pawley
- C Phillips
- C Phillips
- C Pothecary
- C Pothecary
- C Prendergast
- C Price
- C Rishton
- C Sell
- C Shovelton
- C Sicat
- C Stuart
- C Summers
- C Swan
- C Thompson
- C Thorpe
- C Tibke
- C Tierney
- C Vigurs
- C Wells
- C Whitton
- C Whyte
- C Wrey Brown
- Cameron J Fairfield
- Carmelo Piscopo
- Carmen Marciano
- Caroline Abernathy
- Carrol Gamble
- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
- D Bakthavatsalam
- D Banach
- D Baptista
- D Bell
- D Branney
- D Brealey
- D Brealey
- D Butcher
- D Butcher
- D Childs
- D Clarke
- D Collier
- D Collier
- D Cristiano
- D Dawson
- D Donaldson
- D Duffin
- D Fottrell-Gould
- D Golden
- D Griffin
- D Hamilton
- D Hawcutt
- D Hope
- D Horner
- D Kallon
- D Kaye
- D Kelly
- D Loader
- D Lomas
- D Martin
- D McGlynn
- D McLaughlanv
- D Melia
- D Menzies
- D Mullan
- D Pogson
- D Potla
- D Potoczna
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- D Salutous
- D Salutous
- D Scaletta
- D Shaw
- D Skinner
- D Smyth
- D Strachan
- D Tetla
- D Thornton
- D Trodd
- D Vedage
- D Walker
- D Warren
- D Williams
- D Wood
- D Wright
- Daniela Francisci
- Daniella Coker
- Danilo Tacconi
- David A van Heel
- David Bennet
- David L Robertson
- David Stuart
- Dawn Law
- Debby Bogaert
- Derek Murphy
- Domenico A Coviello
- E Abaleke
- E Allan
- E Anastasescu
- E Andrews
- E Apetri
- E B Jude
- E Beech
- E Beranova
- E Bevan
- E Black
- E Brinkworth
- E Collins
- E Combes
- E Davies
- E Dobson
- E Dooks
- E Fisher
- E Gendall
- E Goff
- E Goodwin
- E Gordon
- E Heeney
- E Horsley
- E Hughes
- E Johnson
- E Knights
- E Lee
- E London
- E Maccacari
- E Massey
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- S Siddiqui
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- S Stone
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- Samreen Ijaz
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- Serafina Valente
- Serena Ludovisi
- Sergio Daga
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- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
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- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
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- T Newman
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- T Smith
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- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
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- V Lake
- V Linnett
- V Martinson
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- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
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- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
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- Zhao Jun
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- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise Børresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
- Arif O Harmanci
- Arindam Maitra
- Armando Lopez-Guillermo
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- Sheila M Reynolds
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- Sheng-Ben Liang
- Shengjie Gao
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- Shinichi Mizuno
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- Shogo Yamamoto
- Shona MacRae
- Shriram G Bhosle
- Shuai Ding
- Shumpei Ishikawa
- Shun-Ichi Ariizumi
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- Sinisa Ivkovic
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- Solomon I Shorser
- Sonia Grimaldi
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- Stefan M Pfister
- Stefan Schreiber
- Stefania Tommasi
- Stefano Barbi
- Stefano Serra
- Stephan H Bernhart
- Stephan Ossowski
- Stephan Ossowski
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- Stephan Wolf
- Stephanie Sungalee
- Stephen B Baylin
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- Sultan T Al-Sedairy
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- Susan Bullman
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- Suyash S Shringarpure
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- Takafumi N Yamaguchi
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- Xiuqing Zhang
- Xiuqing Zheng
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- Xuanping Zhang
- Xuemei Luo
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- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Abrams J.
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- Redknap I.
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- Uriel Alison
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- Woodhead L.
- Woodward Z.
- Wooldridge G.
- Woollen L.
- Wootton D.
- Worton S.
- Wren L.
- Wright F.
- Wright R.
- Wubetu J.
- Xavier B.
- Yaqoob N.
- Yasmin S.
- Yates Bryan
- Yates T.
- Yelnoorkar F.
- Yeoh A.
- Younes Ibrahim A.
- Young L.
- Yu C.
- Zaki K.
- Zammit-Mangion M.
- Zayed M.
- Zhu D.
- Zia M.
- Zitter L.
- Zuhra N.
- Zullo C.
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Pediatric Return Appointment Adherence for Child Welfare-Involved Children in Los Angeles California
- Author
- A Schoetzau
- American Academy of Pediatrics
- Andrea K. Kennedy
- B Davidson-Arad
- C Glisson
- Caitlin Smith
- Child Welfare League of America
- CT Rust
- DM Rubin
- EM Specht
- G Flores
- H Ringeisen
- Janet S. Arnold-Clark
- Janet U. Schneiderman
- Jorge Fuentes
- JU Schneiderman
- JU Schneiderman
- K Dawson
- LK Leslie
- LM Sanders
- MP Celano
- MP Celano
- R Andrews
- R Raghavan
- RL Hansen
- S Sawyer
- S Yang
- SH Jee
- SM Horwitz
- SS Chipungu
- SW Downs
- V Pesata
- W Hamilton
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …