472 research outputs found

    Radium isotopes and radon-222 as tracers of sediment-water interaction in Arctic coastal and lacustrine environments

    Get PDF
    Submitted in partial fulfillment of the requirements for the degree of Master of Science in Chemical Oceanography at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution September 2020.Arctic marine and lacustrine systems are experiencing rapid warming due to climate change. These changes are especially important at the interface between sediments and surface waters because they are hotspots for biogeochemical transformations such as redox reactions, nutrient consumption and regeneration, organic matter leaching and degradation, and mineral weathering. Radium isotopes (223Ra, 224Ra, 226Ra, 228Ra) and radon-222, naturally occurring radioactive isotopes produced in sediments, are well-suited as tracers of nutrients, trace metals, and organic matter cycling processes at the sediment-water interface. In this thesis, I have applied radon-222 and the quartet of radium isotopes to study fundamental processes in subarctic lakes and on the Arctic continental shelf. First, radon-222 is used to quantify groundwater discharge into a shallow, tundra lake on the Yukon-Kuskokwim Delta in Alaska in summer of 2017. Radon-derived groundwater fluxes were then paired with methane (CH4) measurements to determine delivery rates of methane into the lake via groundwater. Groundwater CH4 fluxes significantly exceeded diffusive air-water fluxes from the lake to the atmosphere, suggesting that groundwater is an important source of CH4 to Arctic lakes and may drive observed CH4 emissions. Higher CH4 emissions were observed compared to those reported previously in high latitude lakes, like due to higher CH4 concentrations in groundwater. These findings indicate that deltaic lakes across warmer permafrost regions may act as important hotspots for methane release across Arctic landscapes. Then, the quartet of radium isotopes is used to study the impacts of storms and sea ice formation as drivers of sediment-water interaction on the Alaskan Beaufort shelf. The timeseries presented in this study is among the first to document the combined physical and chemical signals of winter water formation in the Beaufort Sea, made possible by repeat occupations of the central Beaufort shelf. Radium measurements are combined with inorganic nitrogen and hydrographic measurements to elucidate the episodic behavior of winter water formation and its ability to drive exchange with bottom sediments during freeze-up.Financial support for Chapter 2 was funded by National Science Foundation awards OCE-1458305 to M.A.C., 1561437 to S.M.N, J.D.S., and R.M.H and 1624927 to S.M.N., P.J.M. and R.M.H. The work completed for Chapter 3 was funded by the Montrym Fund at the Massachusetts Institute of Technology, the Academic Programs Office at Woods Hole Oceanographic Institution, and the NSF Arctic GEOTRACES (OCE-1458305), Pacific GEOTRACES (OCE-1736277), and Arctic Observing Network programs (OPP-1733564)

    Observational and modeling evidence of seasonal trends in sediment-derived material inputs to the Chukchi Sea

    Get PDF
    Author Posting. © American Geophysical Union, 2020. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 125(5), (2020): e2019JC016007, doi:10.1029/2019JC016007.Benthic inputs of nutrients help support primary production in the Chukchi Sea and produce nutrient‐rich water masses that ventilate the halocline of the western Arctic Ocean. However, the complex biological and redox cycling of nutrients and trace metals make it difficult to directly monitor their benthic fluxes. In this study, we use radium‐228, which is a soluble radionuclide produced in sediments, and a numerical model of an inert, generic sediment‐derived tracer to study variability in sediment inputs to the Chukchi Sea. The 228Ra observations and modeling results are in general agreement and provide evidence of strong benthic inputs to the southern Chukchi Sea during the winter, while the northern shelf receives higher concentrations of sediment‐sourced materials in the spring and summer due to continued sediment‐water exchange as the water mass traverses the shelf. The highest tracer concentrations are observed near the shelfbreak and southeast of Hanna Shoal, a region known for high biological productivity and enhanced benthic biomass.This study presents data from multiple Arctic expeditions over the past two decades, and we are indebted to the captains, crews, and scientific parties that made this data collection possible. This work was funded by NSF awards OCE‐1458305 to M. Charette, OCE‐1458424 to W. Moore, OCE‐1434085 to D. Kadko, PLR‐1504333 to R. Pickart, and OPP‐1822334 to M. Spall. Funding was also provided by National Oceanic and Atmospheric Administration Grant NA14‐OAR4320158 to R. Pickart. L. Kipp was supported by an Ocean Frontier Institute Postdoctoral Fellowship. Radium data used in this manuscript are available in Table S1.2020-10-2

    Using radon to quantify groundwater discharge and methane fluxes to a shallow, tundra lake on the Yukon-Kuskokwim Delta, Alaska

    Get PDF
    Northern lakes are a source of greenhouse gases to the atmosphere and contribute substantially to the global carbon budget. However, the sources of methane (CH4) to northern lakes are poorly constrained limiting our ability to the assess impacts of future Arctic change. Here we present measurements of the natural groundwater tracer, radon, and CH4 in a shallow lake on the Yukon-Kuskokwim Delta, AK and quantify groundwater discharge rates and fluxes of groundwater-derived CH4. We found that groundwater was significantly enriched (2000%) in radon and CH4 relative to lake water. Using a mass balance approach, we calculated average groundwater fluxes of 1.2 ± 0.6 and 4.3 ± 2.0 cm day−1, respectively as conservative and upper limit estimates. Groundwater CH4 fluxes were 7—24 mmol m−2 day−1 and significantly exceeded diffusive air–water CH4 fluxes (1.3–2.3 mmol m−2 day−1) from the lake to the atmosphere, suggesting that groundwater is an important source of CH4 to Arctic lakes and may drive observed CH4 emissions. Isotopic signatures of CH4 were depleted in groundwaters, consistent with microbial production. Higher methane concentrations in groundwater compared to other high latitude lakes were likely the source of the comparatively higher CH4 diffusive fluxes, as compared to those reported previously in high latitude lakes. These findings indicate that deltaic lakes across warmer permafrost regions may act as important hotspots for CH4 release across Arctic landscapes

    Exome-wide association study to identify rare variants influencing COVID-19 outcomes : Results from the Host Genetics Initiative

    Get PDF
    Publisher Copyright: Copyright: © 2022 Butler-Laporte et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare variants may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome and whole-genome sequencing from 21 cohorts across 12 countries and performed rare variant exome-wide burden analyses for COVID-19 outcomes. In an analysis of 5,085 severe disease cases and 571,737 controls, we observed that carrying a rare deleterious variant in the SARS-CoV-2 sensor toll-like receptor TLR7 (on chromosome X) was associated with a 5.3-fold increase in severe disease (95% CI: 2.75–10.05, p = 5.41x10-7). This association was consistent across sexes. These results further support TLR7 as a genetic determinant of severe disease and suggest that larger studies on rare variants influencing COVID-19 outcomes could provide additional insights.Peer reviewe

    Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative

    Get PDF

    Search for stop and higgsino production using diphoton Higgs boson decays

    Get PDF
    Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass

    Severe early onset preeclampsia: short and long term clinical, psychosocial and biochemical aspects

    Get PDF
    Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance. This thesis opens with a review of the literature on identifiable risk factors of preeclampsia

    Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

    Get PDF
    A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

    Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

    Get PDF
    A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

    Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

    Get PDF
    Peer reviewe
    corecore