3,014 research outputs found
Entanglement-free Heisenberg-limited phase estimation
Measurement underpins all quantitative science. A key example is the
measurement of optical phase, used in length metrology and many other
applications. Advances in precision measurement have consistently led to
important scientific discoveries. At the fundamental level, measurement
precision is limited by the number N of quantum resources (such as photons)
that are used. Standard measurement schemes, using each resource independently,
lead to a phase uncertainty that scales as 1/sqrt(N) - known as the standard
quantum limit. However, it has long been conjectured that it should be possible
to achieve a precision limited only by the Heisenberg uncertainty principle,
dramatically improving the scaling to 1/N. It is commonly thought that
achieving this improvement requires the use of exotic quantum entangled states,
such as the NOON state. These states are extremely difficult to generate.
Measurement schemes with counted photons or ions have been performed with N <=
6, but few have surpassed the standard quantum limit and none have shown
Heisenberg-limited scaling. Here we demonstrate experimentally a
Heisenberg-limited phase estimation procedure. We replace entangled input
states with multiple applications of the phase shift on unentangled
single-photon states. We generalize Kitaev's phase estimation algorithm using
adaptive measurement theory to achieve a standard deviation scaling at the
Heisenberg limit. For the largest number of resources used (N = 378), we
estimate an unknown phase with a variance more than 10 dB below the standard
quantum limit; achieving this variance would require more than 4,000 resources
using standard interferometry. Our results represent a drastic reduction in the
complexity of achieving quantum-enhanced measurement precision.Comment: Published in Nature. This is the final versio
Dietary soy and meat proteins induce distinct physiological and gene expression changes in rats
This study reports on a comprehensive comparison of the effects of soy and meat proteins given at the recommended level on physiological markers of metabolic syndrome and the hepatic transcriptome. Male rats were fed semi-synthetic diets for 1 wk that differed only regarding protein source, with casein serving as reference. Body weight gain and adipose tissue mass were significantly reduced by soy but not meat proteins. The insulin resistance index was improved by soy, and to a lesser extent by meat proteins. Liver triacylglycerol contents were reduced by both protein sources, which coincided with increased plasma triacylglycerol concentrations. Both soy and meat proteins changed plasma amino acid patterns. The expression of 1571 and 1369 genes were altered by soy and meat proteins respectively. Functional classification revealed that lipid, energy and amino acid metabolic pathways, as well as insulin signaling pathways were regulated differently by soy and meat proteins. Several transcriptional regulators, including NFE2L2, ATF4, Srebf1 and Rictor were identified as potential key upstream regulators. These results suggest that soy and meat proteins induce distinct physiological and gene expression responses in rats and provide novel evidence and suggestions for the health effects of different protein sources in human diets
Heralded Noiseless Amplification of a Photon Polarization Qubit
Non-deterministic noiseless amplification of a single mode can circumvent the
unique challenges to amplifying a quantum signal, such as the no-cloning
theorem, and the minimum noise cost for deterministic quantum state
amplification. However, existing devices are not suitable for amplifying the
fundamental optical quantum information carrier, a qubit coherently encoded
across two optical modes. Here, we construct a coherent two-mode amplifier, to
demonstrate the first heralded noiseless linear amplification of a qubit
encoded in the polarization state of a single photon. In doing so, we increase
the transmission fidelity of a realistic qubit channel by up to a factor of
five. Qubit amplifiers promise to extend the range of secure quantum
communication and other quantum information science and technology protocols.Comment: 6 pages, 3 figure
Ab-initio Quantum Enhanced Optical Phase Estimation Using Real-time Feedback Control
Optical phase estimation is a vital measurement primitive that is used to
perform accurate measurements of various physical quantities like length,
velocity and displacements. The precision of such measurements can be largely
enhanced by the use of entangled or squeezed states of light as demonstrated in
a variety of different optical systems. Most of these accounts however deal
with the measurement of a very small shift of an already known phase, which is
in stark contrast to ab-initio phase estimation where the initial phase is
unknown. Here we report on the realization of a quantum enhanced and fully
deterministic phase estimation protocol based on real-time feedback control.
Using robust squeezed states of light combined with a real-time Bayesian
estimation feedback algorithm, we demonstrate deterministic phase estimation
with a precision beyond the quantum shot noise limit. The demonstrated protocol
opens up new opportunities for quantum microscopy, quantum metrology and
quantum information processing.Comment: 5 figure
General framework for estimating the ultimate precision limit in noisy quantum-enhanced metrology
The estimation of parameters characterizing dynamical processes is central to
science and technology. The estimation error changes with the number N of
resources employed in the experiment (which could quantify, for instance, the
number of probes or the probing energy). Typically, it scales as 1/N^(1/2).
Quantum strategies may improve the precision, for noiseless processes, by an
extra factor 1/N^(1/2). For noisy processes, it is not known in general if and
when this improvement can be achieved. Here we propose a general framework for
obtaining attainable and useful lower bounds for the ultimate limit of
precision in noisy systems. We apply this bound to lossy optical interferometry
and atomic spectroscopy in the presence of dephasing, showing that it captures
the main features of the transition from the 1/N to the 1/N^(1/2) behaviour as
N increases, independently of the initial state of the probes, and even with
use of adaptive feedback.Comment: Published in Nature Physics. This is the revised submitted version.
The supplementary material can be found at
http://www.nature.com/nphys/journal/v7/n5/extref/nphys1958-s1.pd
Get Organised: The 'Do's' Preceding Successful Field Research
There is no shortage in the political science literature on field research regarding issues of research design, methodology, and data evaluation. Yet, the practical and organisational intricacies that precede successful fieldwork are frequently overlooked. This lack of methodical advice may be due to the impression that field research is highly contextual, and so case-specific that general guidelines, which apply to all field research endeavours alike, are inconceivable. While we acknowledge the organisational complexity of field research, we disagree with the notion that the preparatory dimension of fieldwork is by necessity unique for every undertaking. Rather, recommendations for common challenges that occur during the preparation and organisation phase of a field trip can be identified and formulated. Consequently, we present and discuss ten organisational ?do's? preceding successful field research. Current graduate students and future field researchers will regard these ten pointers as useful hints in the organisation of their own endeavour. While the list is by no means exhaustive, the ten recommendations will lower the organisational entry costs of aspiring field researchers, and enable them to hit the ground running when arriving in the field
Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme
Although catalytic mechanisms in natural enzymes are well understood, achieving the diverse palette of reaction chemistries in re-engineered native proteins has proved challenging. Wholesale modification of natural enzymes is potentially compromised by their intrinsic complexity, which often obscures the underlying principles governing biocatalytic efficiency. The maquette approach can circumvent this complexity by combining a robust de novo designed chassis with a design process that avoids atomistic mimicry of natural proteins. Here, we apply this method to the construction of a highly efficient, promiscuous, and thermostable artificial enzyme that catalyzes a diverse array of substrate oxidations coupled to the reduction of H2O2. The maquette exhibits kinetics that match and even surpass those of certain natural peroxidases, retains its activity at elevated temperature and in the presence of organic solvents, and provides a simple platform for interrogating catalytic intermediates common to natural heme-containing enzymes
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Trust in financial services: the influence of demographics and dispositional characteristics
So far, very little attention has been paid to examining consumer perceptions of trust from an interdisciplinary perspective. The purpose of this study is to examine how consumer trusting belief and disposition to trust within the financial services sector vary on the basis of individual demographic differences in trust. The research provides new insights into how consumers with higher dispositional trust have higher institutional trust and higher trusting belief and how consumers’ trusting belief significantly differs according to their demographic background in terms of age, marital status, ethnicity and gross annual income. The findings offer useful insights for the managers in financial institutions to carefully consider the impact of the influence of these individual differences on consumer behaviour in order to serve the needs of consumers in their target market and be able to design financial products and develop trust building strategies to attract and retain them. They also call for the action of the regulators and the financial institutions to play their part in building strong institutional systems that contribute to engendering higher levels of consumer trust
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