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The impact of satellite derived land surface temperatures on numerical weather predication analyses and forecasts
Land surface temperature (LST) observations from a variety of satellite instruments operating in the infrared have been compared to estimates of surface temperature from the Met Office operational numerical weather prediction (NWP) model. The comparisons show that during the day the NWP model can under predict the surface temperature by up to 10 K in certain regions such as the Sahel and Southern Africa. By contrast at night the differences are generally smaller. Matchups have also been performed between satellite LSTs and observations from an in situ radiometer located in Southern England within a region of mixed land use. These matchups demonstrate good agreement at night and suggest that the satellite uncertainties in LST are less than 2 K. The Met Office surface analysis scheme has been adapted to utilize nighttime LST observations. Experiments using these analyses in an NWP model have shown a benefit to the resulting forecasts of near surface air temperature, particularly over Africa
Constraining gravity at the largest scales through CMB lensing and galaxy velocities
We demonstrate a new method to constrain gravity on the largest cosmological
scales by combining measurements of cosmic microwave background (CMB) lensing
and the galaxy velocity field. is a statistic, constructed from a
gravitational lensing tracer and a measure of velocities such as redshift-space
distortions (RSD), that can discriminate between gravity models while being
independent of clustering bias and . While traditionally, the lensing
field for has been probed through galaxy lensing, CMB lensing has been
proposed as a more robust tracer of the lensing field for at higher
redshifts while avoiding intrinsic alignments. We perform the largest-scale
measurement of ever, up to 150 Mpc/, by cross-correlating the Planck
CMB lensing map with the Sloan Digital Sky Survey III (SDSS-III) CMASS galaxy
sample and combining this with our measurement of the CMASS auto-power spectrum
and the RSD parameter . We report (stat)
(sys), a measurement in tension with the general relativity
prediction at a level of 2.6. Note that our measurement deviates
from GR only at scales greater than 80 Mpc/, scales which have not been
probed by previous tests. Upcoming surveys, which will provide an
order-of-magnitude reduction in statistical errors, can significantly constrain
alternative gravity models when combined with better control of systematics.Comment: 12 pages, 11 figures, matches published version in MNRAS, minor edit
FIGO consensus guidelines on intrapartum fetal monitoring: Intermittent auscultation
Intermittent auscultation is the technique used to listen to the fetal heart rate (FHR) for short periods of time without a display of the resulting pattern. Whether it is used for intrapartum fetal monitoring in low-risk women or for all cases in settings where there are no available alternatives, all healthcare professionals attending labor and delivery need to be skilled at performing intermittent auscultation, interpreting its findings, and taking appropriate action. The main aim of this chapter is to describe the tools and techniques for intermittent auscultation in labor
Observation of an Excited Bc+ State
Using pp collision data corresponding to an integrated luminosity of 8.5 fb-1 recorded by the LHCb experiment at center-of-mass energies of s=7, 8, and 13 TeV, the observation of an excited Bc+ state in the Bc+π+π- invariant-mass spectrum is reported. The observed peak has a mass of 6841.2±0.6(stat)±0.1(syst)±0.8(Bc+) MeV/c2, where the last uncertainty is due to the limited knowledge of the Bc+ mass. It is consistent with expectations of the Bc∗(2S31)+ state reconstructed without the low-energy photon from the Bc∗(1S31)+→Bc+γ decay following Bc∗(2S31)+→Bc∗(1S31)+π+π-. A second state is seen with a global (local) statistical significance of 2.2σ (3.2σ) and a mass of 6872.1±1.3(stat)±0.1(syst)±0.8(Bc+) MeV/c2, and is consistent with the Bc(2S10)+ state. These mass measurements are the most precise to date
Bose-Einstein correlations of same-sign charged pions in the forward region in pp collisions at √s=7 TeV
Bose-Einstein correlations of same-sign charged pions, produced in protonproton collisions at a 7 TeV centre-of-mass energy, are studied using a data sample collected
by the LHCb experiment. The signature for Bose-Einstein correlations is observed in the
form of an enhancement of pairs of like-sign charged pions with small four-momentum
difference squared. The charged-particle multiplicity dependence of the Bose-Einstein correlation parameters describing the correlation strength and the size of the emitting source
is investigated, determining both the correlation radius and the chaoticity parameter. The
measured correlation radius is found to increase as a function of increasing charged-particle
multiplicity, while the chaoticity parameter is seen to decreas
Measurement of the inelastic pp cross-section at a centre-of-mass energy of 13TeV
The cross-section for inelastic proton-proton collisions at a centre-of-mass energy of 13TeV is measured with the LHCb detector. The fiducial cross-section for inelastic interactions producing at least one prompt long-lived charged particle with momentum p > 2 GeV/c in the pseudorapidity range 2 < η < 5 is determined to be ϭ acc = 62:2 ± 0:2 ± 2:5mb. The first uncertainty is the intrinsic systematic uncertainty of the measurement, the second is due to the uncertainty on the integrated luminosity. The statistical uncertainty is negligible. Extrapolation to full phase space yields the total inelastic proton-proton cross-section ϭ inel = 75:4 ± 3:0 ± 4:5mb, where the first uncertainty is experimental and the second due to the extrapolation. An updated value of the inelastic cross-section at a centre-of-mass energy of 7TeV is also reported
An immunohistochemical perspective of PPARβ and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours
Peroxisome proliferator-activated receptor β (PPARβ) is a member of the nuclear hormone receptor family and is a ligand-activated transcription factor with few known molecular targets including 3-phosphoinositide-dependent protein kinase 1(PDK1). In view of the association of PPARβ and PDK1 with cancer, we have examined the expression of PPARβ and PDK1 in normal ovaries and different histological grades of ovarian tumours. Normal ovaries, benign, borderline, grades 1, 2 and 3 ovarian tumours of serous, muciuous, endometrioid, clear cell and mixed subtypes were analysed by immunohistochemistry for PPARβ and PDK1 expression. All normal ovarian tissues, benign, borderline and grade 1 tumours showed PPARβ staining localised in the epithelium and stroma. Staining was predominantly nuclear, but some degree of cytoplasmic staining was also evident. Approximately 20% of grades 2 and 3 tumours lacked PPARβ staining, whereas the rest displayed some degree of nuclear and cytoplasmic staining of the scattered epithelium and stroma. The extent of epithelial and stromal PPARβ staining was significantly different among the normal and the histological grades of tumours (χ2=59.25, d.f.=25, P<0.001; χ2=64.48, d.f.=25, P<0.001). Significantly different staining of PPARβ was observed in the epithelium and stroma of benign and borderline tumours compared with grades 1, 2 and 3 tumours (χ2=11.28, d.f.=4, P<0.05; χ2=16.15, d.f.=4, P<0.005). In contrast, PDK1 immunostaining was absent in 9 out of 10 normal ovaries. Weak staining for PDK1 was observed in one normal ovary and 40% of benign ovarian tumours. All borderline and malignant ovarian tumours showed positive cytoplasmic and membrane PDK1 staining. Staining of PDK1 was confined to the epithelium and the blood vessels, and no apparent staining of the stroma was evident. Significantly different PDK1 staining was observed between the benign/borderline and malignant ovarian tumours (χ2=22.45, d.f.=5, P<0.001). In some borderline and high-grade tumours, staining of the reactive stroma was also evident. Our results suggest that unlike the colon, the endometrial, head and neck carcinomas, overexpression of PPARβ does not occur in ovarian tumours. However, overexpression of PDK1 was evident in borderline and low- to high-grade ovarian tumours and is consistent with its known role in tumorigenesis
Phamacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer
Defining biomarkers that predict therapeutic effects and adverse events is a crucial mandate to guide patient selection for personalized cancer treatments. In the present study, we applied a pharmacometabolomics approach to identify biomarkers potentially associated with pathological complete response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer patients. Based on histological response the 34 patients enrolled in the study were subdivided into two groups: good responders (n = 15) and poor responders (n = 19). The pre-treatment serum targeted metabolomics profile of all patients were analyzed by liquid chromatography tandem mass spectrometry and the differences in the metabolomics profile between the two groups was investigated by multivariate partial least squares discrimination analysis. The most relevant metabolites that differentiate the two groups of patients were spermidine and tryptophan. The Good responders showed higher levels of spermidine and lower amounts of tryptophan compared with the poor responders (p < 0.001, q < 0.05). The serum level of these two metabolites identified patients who achieved a pathological complete response with a sensitivity of 90% [0.79-1.00] and a specificity of 0.87% [0.67-1.00]. These preliminary results support the role played by the individual patients' metabolism in determining the response to cancer treatments and may be a useful tool to select patients that are more likely to benefit from the trastuzumab-paclitaxel treatment
Envenomations by Bothrops and Crotalus Snakes Induce the Release of Mitochondrial Alarmins
Skeletal muscle necrosis is a common manifestation of viperid snakebite envenomations. Venoms from snakes of the genus Bothrops, such as that of B. asper, induce muscle tissue damage at the site of venom injection, provoking severe local pathology which often results in permanent sequelae. In contrast, the venom of the South American rattlesnake Crotalus durissus terrificus, induces a clinical picture of systemic myotoxicity, i.e., rhabdomyolysis, together with neurotoxicity. It is known that molecules released from damaged muscle might act as ‘danger’ signals. These are known as ‘alarmins’, and contribute to the inflammatory reaction by activating the innate immune system. Here we show that the venoms of B. asper and C. d. terrificus release the mitochondrial markers mtDNA (from the matrix) and cytochrome c (Cyt c) from the intermembrane space, from ex vivo mouse tibialis anterior muscles. Cyt c was released to a similar extent by the two venoms whereas B. asper venom induced the release of higher amounts of mtDNA, thus reflecting hitherto some differences in their pathological action on muscle mitochondria. At variance, injection of these venoms in mice resulted in a different time-course of mtDNA release, with B. asper venom inducing an early onset increment in plasma levels and C. d. terrificus venom provoking a delayed release. We suggest that the release of mitochondrial ‘alarmins’ might contribute to the local and systemic inflammatory events characteristic of snakebite envenomations
Testing the inverse-Compton catastrophe scenario in the intra-day variable blazar S5 0716+71. I. Simultaneous broadband observations during November 2003
Some intra-day variable, compact extra-galactic radio sources show brightness
temperatures severely exceeding 10^{12} K, the limit set by catastrophic
inverse-Compton (IC) cooling in sources of incoherent synchrotron radiation.
The violation of the IC limit, possible under non-stationary conditions, would
lead to IC avalanches in the soft-gamma-ray energy band during transient
periods. For the first time, broadband signatures of possible IC catastrophes
were searched for in S5 0716+71. A multifrequency observing campaign targetting
S5 0716+71 was carried out in November 2003 under the framework of the European
Network for the Investigation of Galactic nuclei through Multifrequency
Analysis (ENIGMA) together with a campaign by the Whole Earth Blazar Telescope
(WEBT), involving a pointing by the soft-gamma-ray satellite INTEGRAL, optical,
near-infrared, sub-millimeter, millimeter, radio, and Very Long Baseline Array
(VLBA) monitoring. S5 0716+71 was very bright at radio frequencies and in a
rather faint optical state during the INTEGRAL pointing; significant inter-day
and low intra-day variability was recorded in the radio regime, while typical
fast variability features were observed in the optical band. No correlation was
found between the radio and optical emission. The source was not detected by
INTEGRAL, neither by the X-ray monitor JEM-X nor by the gamma-ray imager ISGRI,
but upper limits to the source emission in the 3-200 keV energy band were
estimated. A brightness temperature Tb>2.1x10^{14} K was inferred from the
radio variability, but no corresponding signatures of IC avalanches were
recorded at higher energies. The absence of IC-catastrophe signatures provides
either a lower limit delta>8 to the Doppler factor affecting the radio emission
or strong constraints for modelling of the Compton catastrophes in S5 0716+71.Comment: 15 pages, 3 EPS figures, 3 tables, to appear in A&
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