Diferencias en las respuestas fisiológicas entre triatletas masculinos y femeninos

The current study focused on the differences between male and female non-professional triathletes during a maximal incremental test on the cycle ergometer, as well as, the cycle and run portion of a simulated sprint triathlon. In addition, this research analysed the during association between cycle ergometer maximal incremental test and simulated race variables. Fourteen recreational triathletes, 8 female (35.0 ± 8.1 years; 166.8 ± 7.2  cm; 69.4 ± 14.6 kg; 24.7 ± 3.2 kg.m-2) and 6 male (47.7 ± 14.3 years; 179.9 ± 8.6  cm; 77.8 ± 5.8  kg; 24.0 ± 1.3 kg.m-2) performed a maximal incremental test and a simulated sprint triathlon race (20 km cycle and 5 km run).  No significant differences were found during maximal testing between groups, however, males obtained higher VO2max, Pmax, PVT1, PVT2 and VO2VT2 (p > 0.05, ES = -0.8 to -1.9, large) values than females. No differences between gender were observed during 5 km running during the simulated triathlon. Average and maximal speed (p < 0.05 y p < 0.01, ES = -1.3- -4.1, large) and average and maximal power) (p < 0.01, ES = -2.4- -2.8, alto) during the 20-km cycling were significantly lower in the female group, whereas, time to complete the 20 km (p < 0.01, ES = 1.6, alto) was significantly longer than the male triathletes. Male triathletes who obtained greater values during the maximal test, presented a superior 20km cycling performance. Females who presented larger values during the maximal test accomplished superior performances during both cycling and running simulated tests. These results suggest that recreational male triathletes may present a greater performance during maximal cycle ergometer test and during 20 km cycling simulation than female and the association between a maximal incremental test and simulated triathlon performances might depend on the triathlete’s gender. Los objetivos de este estudio fueron analizar las diferencias entre triatletas masculinos y femeninos amateurs en el rendimiento en un test incremental máximo y en una competición simulada y describir si existe asociación entre el rendimiento en el test máximo incremental y la prueba simulada de competición. Un total de catorce triatletas recreacionales, 8 mujeres (35,0 8,1  años; 166,8 7,2  cm; 69,4 14,6 kg; 24,7 3,2 kg.m-2) y 6 hombres (47,7 14,3  años; 179,9 8,6  cm; 77,8 5,8  kg; 24,0 1,3 kg.m-2) realizaron un test incremental máximo y en una competición simulada (20 km bici y 5 km carrera a pie). A pesar de que no se observaron diferencias significativas entre el grupo masculino y femenino en el test máximo incremental, a efectos prácticos, el grupo masculino obtuvo valores mayores para VO2max, Pmax, PVT1, PVT2 y VO2VT2 (p > 0,05, ES = -0,8 a -1.9, alto). Con respecto a la competición simulada, si bien no se obtuvieron diferencias en función de sexo en los 5 km de carrera, el grupo femenino obtuvo valores significativamente inferiores para las variables velocidad (media y máxima) (p < 0,05 y p < 0,01, ES = -1,3- -4,1, alto) y potencia (media y máxima) (p < 0,01, ES = -2.4- -2.8, alto) durante los 20 km de ciclismo, así como un tiempo de ejecución del sector ciclista significativamente mayor que el grupo masculino (p < 0,01, ES = 1,6, alto).  Por otro lado, un mejor rendimiento durante el test máximo incremental se asoció a un mejor rendimiento durante los 20 km de ciclismo en el grupo masculino (r = 0,848, p < 0,05), mientras que en el grupo femenino se asoció tanto a los 20 km en bici como a los 5 km corriendo (r = -0,714 a -0,822, p < 0,05). Los resultados obtenidos en el estudio ponen de manifiesto que los triatletas masculinos tienen un mejor rendimiento en un test incremental máximo y en el sector bici en una competición simulada y que la asociación entre el rendimiento en un test incremental y el rendimiento en los sectores de la prueba simulada depende del sexo

Small vessel disease and dietary salt intake: cross sectional study and systematic review

Background: Higher dietary salt intake increases the risk of stroke and may increase white matter hyperintensity (WMH) volume. We hypothesized that a long-term higher salt intake may be associated with other features of small vessel disease (SVD). Methods: We recruited consecutive patients with mild stroke presenting to the Lothian regional stroke service. We performed brain magnetic resonance imaging, obtained a basic dietary salt history, and measured the urinary sodium/creatinine ratio. We also carried out a systematic review to put the study in the context of other studies in the field. Results: We recruited 250 patients, 112 with lacunar stroke and 138 with cortical stroke, with a median age of 67.5 years. After adjustment for risk factors, including age and hypertension, patients who had not reduced their salt intake in the long term were more likely to have lacunar stroke (odds ratio [OR], 1.90; 95% confidence interval [CI], 1.10-3.29), lacune(s) (OR, 2.06; 95% CI, 1.09-3.99), microbleed(s) (OR, 3.4; 95% CI, 1.54, 8.21), severe WMHs (OR, 2.45; 95% CI 1.34-4.57), and worse SVD scores (OR, 2.17; 95% CI, 1.22-3.9). There was limited association between SVD and current salt intake or urinary sodium/creatinine ratio. Our systematic review found no previously published studies of dietary salt and SVD. Conclusion: The association between dietary salt and background SVD is a promising indication of a potential neglected contributory factor for SVD. These results should be replicated in larger, long-term studies using the recognized gold-standard measures of dietary sodium

Associations of autozygosity with a broad range of human phenotypes

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (F-ROH) for >1.4 million individuals, we show that F-ROH is significantly associated (p <0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: F-ROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of F-ROH are confirmed within full-sibling pairs, where the variation in F-ROH is independent of all environmental confounding.Peer reviewe

Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3b

We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC-2020 March 27 17:00 UTC). We conduct two independent searches: A generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate. © 2022. The Author(s). Published by the American Astronomical Society

Narrowband Searches for Continuous and Long-duration Transient Gravitational Waves from Known Pulsars in the LIGO-Virgo Third Observing Run

Isolated neutron stars that are asymmetric with respect to their spin axis are possible sources of detectable continuous gravitational waves. This paper presents a fully coherent search for such signals from eighteen pulsars in data from LIGO and Virgo's third observing run (O3). For known pulsars, efficient and sensitive matched-filter searches can be carried out if one assumes the gravitational radiation is phase-locked to the electromagnetic emission. In the search presented here, we relax this assumption and allow both the frequency and the time derivative of the frequency of the gravitational waves to vary in a small range around those inferred from electromagnetic observations. We find no evidence for continuous gravitational waves, and set upper limits on the strain amplitude for each target. These limits are more constraining for seven of the targets than the spin-down limit defined by ascribing all rotational energy loss to gravitational radiation. In an additional search, we look in O3 data for long-duration (hours-months) transient gravitational waves in the aftermath of pulsar glitches for six targets with a total of nine glitches. We report two marginal outliers from this search, but find no clear evidence for such emission either. The resulting duration-dependent strain upper limits do not surpass indirect energy constraints for any of these targets. © 2022. The Author(s). Published by the American Astronomical Society

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362