26 research outputs found
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
- Author
- A Doria
- A Patel
- A Tirosh
- Abbas Dehghan
- AJ Myers
- AL Dixon
- Alan F Wright
- Alan R Shuldiner
- Albert Hofman
- Alex Doney
- Alisa K Manning
- Amanda Elliott
- Amanda J Bennett
- Amy Swift
- Amélie Bonnefond
- Andreas F H Pfeiffer
- Andrew A Hicks
- Andrew D Morris
- Andrew P Morris
- Andrew Singleton
- Andrew T Hattersley
- Andrew Walley
- André G Uitterlinden
- Angela Silveira
- Anke Tönjes
- Ann-Christine Syvänen
- Anna L Gloyn
- Anna-Liisa Hartikainen
- Anne U Jackson
- Anneli Pouta
- Annelli Sandbaek
- Annette C Fedson
- Antje Fischer-Rosinsky
- Antti Jula
- Anuj Goel
- Aroon D Hingorani
- Avan Aihie Sayer
- B Devlin
- B Lukowiak
- B Peter-Riesch
- B Servin
- Barbara Thorand
- Beatrice Knight
- Ben A Oostra
- Benjamin F Voight
- Beverley Balkau
- Beverley Shields
- Björn Zethelius
- Bo Isomaa
- Braxton D Mitchell
- Bruce M Psaty
- C Gieger
- C Newton-Cheh
- C Sabatti
- Carina Zabena
- Caroline Hayward
- Caroline S Fox
- Cecilia M Lindgren
- Christa Meisinger
- Christian Dina
- Christian Gieger
- Christian Herder
- Christine Cavalcanti-Proença
- Christopher J Groves
- Christopher S Franklin
- CJ Willer
- Claudia Langenberg
- Colin N A Palmer
- Cristian Pattaro
- Cyrus Cooper
- Cécile Lecoeur
- D Keane
- Daniel Pearson
- Danielle Posthuma
- David M Nathan
- David Melzer
- David Meyre
- David R Hillman
- Debbie A Lawlor
- Denis Rybin
- Dhiraj Varma
- Diana B. Petitti
- Diana Zelenika
- DJ Drucker
- DR Clemmons
- DR Matthews
- Eco J C de Geus
- EE Schadt
- Eleanor Wheeler
- Eleftheria Zeggini
- Eric Boerwinkle
- Eric Brunner
- Eric J G Sijbrands
- Erik Ingelsson
- Felicity Payne
- Fernando Rivadeneira
- Frank B Hu
- François Pattou
- Fredrik Karpe
- G Bragi Walters
- G Mark Lathrop
- G Waeber
- Gabe Crawford
- GC Weir
- George Davey Smith
- George V Dedoussis
- Ghislain Rocheleau
- Giuseppe Paolisso
- Gonneke Willemsen
- Gordon H Williams
- Guangju Zhai
- Gudmar Thorleifsson
- Guillaume Charpentier
- Gunnar Sigurðsson
- Gérard Waeber
- Göran Hallmans
- H Erich Wichmann
- Harald Grallert
- Harry Campbell
- Heather M Stringham
- Holly Syddall
- Hugh Watkins
- I Pe'er
- I Prokopenko
- I Prokopenko
- Ian N M Day
- Igor Rudan
- Inga Prokopenko
- Ingrid B Borecki
- Irene Pichler
- J Marchini
- J Rung
- Jaakko Kaprio
- James F Wilson
- James S Pankow
- Jaqueline C M Witteman
- Jarred B McAteer
- JB Meigs
- JC Florez
- JD Brunzell
- Jean Tichet
- Jeffrey O'Connell
- Jennie Hui
- Jerome Delplanque
- Jian'an Luan
- Jing Hua Zhao
- JJ Song
- Joachim Spranger
- Joe Hung
- Johanna Kuusisto
- John F Peden
- John P Beilby
- John R B Perry
- John W G Yarnell
- Josephine M Egan
- Joshua Randall
- Josée Dupuis
- Jouke Jan Hottenga
- JP Higgins
- JP Ioannidis
- Jürgen Graessler
- K Kume
- K Warton
- K Yamagata
- K-H Song
- Kaisa Silander
- Kenneth Rice
- Kijoung Song
- Kim L Ward
- Kirsten Ohm Kyvik
- KK Ray
- Knut Borch-Johnsen
- Ko Willems van Dijk
- Kristin Ardlie
- L Schaeffer
- Lachlan J M Coin
- Laila Simpson
- Lars Lind
- Laura Crisponi
- Laura J McCulloch
- Laura J Scott
- Lori L Bonnycastle
- Lu Qi
- Lyle J Palmer
- M Carola Zillikens
- M Coutinho
- M Orho-Melander
- M Prentki
- M Vaxillaire
- Man Li
- Mandy van Hoek
- Manjinder Sandhu
- Manuel Serrano-Ríos
- Marco Orrù
- Maria Grazia Franzosi
- Marika Kaakinen
- Marilyn Cornelis
- Mario A Morken
- Mark O Goodarzi
- Markku Laakso
- Markus Perola
- María Teresa Martínez-Larrad
- Massimo Mangino
- Matthew J Neville
- Matthew N Cooper
- Meena Kumari
- Michael A Province
- Michael J Sampson
- Michael Marmot
- Michael N Weedon
- Michael R Erdos
- Michael Roden
- Michael Stumvoll
- Mika Kivimaki
- MN Weedon
- MT Guillam
- Murielle Bochud
- N Bouatia-Naji
- N Bouatia-Naji
- N Mitro
- Nabila Bouatia-Naji
- Nancy L Pedersen
- Naomi Hammond
- Narisu Narisu
- Neelam Hassanali
- Nicholas J Timpson
- Nicholas L Smith
- Nicole L Glazer
- Nicole Soranzo
- Nicole Vogelzangs
- Niels Grarup
- Nigel W Rayner
- Nita G Forouhi
- NL Beer
- Olivier Le Bacquer
- Olov Rolandsson
- Oluf Pedersen
- Ozren Polasek
- P Rorsman
- Patrik K E Magnusson
- Pau Navarro
- Paul Elliott
- Paul R V Johnson
- Paul Scheet
- Paul W Franks
- PC Ng
- PD Thomas
- Peter Chines
- Peter Henneman
- Peter J Wagner
- Peter Kovacs
- Peter Paul Pramstaller
- Peter Schwarz
- Peter Shrader
- Philip Barter
- Pierre Meneton
- Pilar Galan
- Ping An
- Praveen Sethupathy
- R Santer
- Rafn Benediktsson
- RD Rudic
- Reedik Mägi
- Rhian Gwilliam
- Richa Saxena
- RN Bergman
- Robert Clarke
- Robert Mahley
- Rosa Maria Roccasecca
- RR Holman
- Rune Frants
- Ruth J F Loos
- Ruth McPherson
- Ruth Pakyz
- S Genuth
- S Kathiresan
- S Nejentsev
- S Raychaudhuri
- S Sunyaev
- SA McCarroll
- Samuli Ripatti
- Samy Hadjadj
- Sarah H Wild
- Scott Grundy
- Seppo Koskinen
- Serena Sanna
- Serge Hercberg
- Shah Ebrahim
- Silvia Naitza
- Simon C Heath
- Simon C Potter
- Sophie Visvikis-Siest
- Stavroula Kanoni
- Stefan R Bornstein
- Stephen J Sharp
- Steven A McCarroll
- Sutapa Mukherjee
- Suzannah J Bumpstead
- Sven Bergmann
- T Fukada
- T Sparsø
- Taina Lajunen
- Thomas Illig
- Thomas Sparsø
- Tiinamaija Tuomi
- Toby Johnson
- Torben Hansen
- Torben Jørgensen
- Toshiko Tanaka
- Udo Seedorf
- Ulf Gyllensten
- Ulla Sovio
- V Lyssenko
- V Senée
- Valeriya Lyssenko
- Valgerdur Steinthorsdottir
- Veikko Salomaa
- Veronique Vitart
- W H Linda Kao
- W-M Chen
- Wolfgang Rathmann
- Xijing Han
- Y Antero Kesaniemi
- Y Li
- Y-S Kim
- Yavuz Ariyurek
- Yii-Der Ida Chen
- Yoav Ben-Shlomo
- YS Aulchenko
- YS Aulchenko
- Yun Li
- Yvonne Böttcher
- Publication venue
- Nature Research
- Publication date
- 14/10/2009
- Field of study
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes
Genetic determinants of the ankle-brachial index: A meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium
- Author
- Allison Matthew A.
- Boerwinkle Eric
- Coassin Stefan
- Crawford Dana C.
- Criqui Michael H.
- Cupples L. Adrienne
- Eraso Luis H.
- Ferguson Jane F.
- Franceschini Nora
- Ganesh Santhi K.
- Gibson Quince
- Haun Margot
- Heiss Gerardo
- Hwang Shih-Jen
- Jacobs David R.
- Kaplan Robert C.
- Lamina Claudia
- Li Mingyao
- McDermott Mary M.
- Mehra Reena
- Meisinger Christa
- Mukamal Kenneth J.
- Nambi Vijay
- O’Connell Jeffrey R.
- Papanicolaou George J.
- Redline Susan
- Rotter Jerome I.
- Taylor Herman A.
- van der Harst Pim
- Waite Lindsay L.
- Wassel Christina L.
- Yanek Lisa R.
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Candidate gene association studies for peripheral artery disease (PAD), including subclinical disease assessed with the ankle-brachial index (ABI), have been limited by the modest number of genes examined. We conducted a two stage meta-analysis of ~50,000 SNPs across ~2100 candidate genes to identify genetic variants for ABI
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1
- Author
- Abecasis Gonçalo R.
- Absher Devin
- Adrienne Cupples L.
- Aherrahrou Zouhair
- Allayee Hooman
- Allione Alessandra
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Angelica Merlini Pier
- Ardissino Diego
- Ardlie Kristin
- Assimes Themistocles L.
- Aulchenko Yurii S.
- Baas Annette F.
- Badger Stephen A.
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Bandinelli Stefania
- Barbalic Maja
- Barnes Timothy A.
- Barroso Inês
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Benediktsson Rafn
- Bengtsson Boström Kristina
- Bennett Amanda J.
- Berger Klaus
- Berglund Göran
- Bergman Richard N.
- Bingham Sheila A.
- Bis Joshua C.
- Blagieva Roza
- Blair Ross D.
- Blankenberg Stefan
- Blankensteijn Jan D.
- Bochud Murielle
- Boehm Bernhard O.
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Bots Michiel L.
- Bown Matthew J.
- Bradley Declan T.
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris
- Bumpstead Suzannah
- Burnand Kevin
- Burton Paul R.
- Burtt Noël P.
- Buysschaert Ian
- Cambien Francois
- Campbell Harry
- Carlquist John F.
- Cauchi Stephane
- Caulfield Mark
- Chambers John C.
- Charpentier Guillaume
- Chen Li
- Child Anne H.
- Chines Peter S.
- Cichon Sven
- Clarke Robert
- Clough Rachel E.
- Cockerill Gillian
- Codd Veryan
- Coin Lachlan
- Connell John M.
- Cornelis Marilyn
- Couper David J.
- Crawford Gabe
- Crawford Gabriel J.
- Daly Mark J.
- Davies Robert W.
- de Faire Ulf
- de Graaf Jacqueline
- de Jong Paul E.
- Dedoussis George
- Dehghan Abbas
- Deloukas Panos
- Demissie Serkalem
- Devaney Joseph M.
- Di Gregorio Alessandra
- Diemert Patrick
- Dina Christian
- Do Ron
- Doering Angela
- Dominiczak Anna
- Doney Alex S. F.
- Dupuis Josée
- Döring Angela
- Dörr Marcus
- Edkins Sarah
- Eifert Sandra
- El Mokhtari Nour Eddine
- Elliott Amanda L.
- Elliott Katherine S.
- Elliott Katherine S.
- Elliott Paul
- Ellis Stephen G.
- Elosua Roberto
- Engert James C.
- Epstein Stephen E.
- Erdmann Jeanette
- Erdos Michael R.
- Eriksson Per
- Ernst Florian
- Eyheramendy Susana
- Farrall Martin
- Felix Stephan B.
- Ferreira Teresa
- Ferrucci Luigi
- Fischer Marcus
- Florez Jose C.
- Folkersen Lasse
- Folsom Aaron R.
- Forouhi Nita G.
- Fox Caroline S.
- Franco-Cereceda Anders
- Franklin Christopher S.
- Frayling Timothy M.
- Freimer Nelson B.
- Freyer Jennifer
- Frikke-Schmidt Ruth
- Froguel Philippe
- Futers Simon
- Galan Pilar
- Ganser Martha
- Gateva Vesela
- Gerry Hill B.
- Gieger Christian
- Gigante Bruna
- Girelli Domenico
- Gloyn Anna L.
- Goel Anuj
- Golledge Jonathan
- Goodall Alison H.
- Grallert Harald
- Grarup Niels
- Green Todd
- Gretarsdottir Solveig
- Griffin Simon
- Grobbee Diederick E.
- Groop Leif
- Groves Christopher J.
- Guarrera Simonetta
- Gudnason Vilmundur
- Guiducci Candace
- Gulcher Jeffrey R.
- Gut Ivo G.
- Gwilliam Rhian
- Gyllensten Ulf
- Hadjadj Samy
- Hadley David
- Hafez Hany
- Hall Alistair S.
- Halperin Eran
- Hammond Naomi
- Hamsten Anders
- Hansen Torben
- Harrison Seamus C.
- Hartikainen Anna-Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Hazen Stanley L.
- Heath Simon C.
- Hengstenberg Christian
- Hercberg Serge
- Herder Christian
- Hide Winston A.
- Hill Andrew A.
- Hitman Graham A.
- Hofman Albert
- Hofmann Oliver M.
- Holm Hilma
- Homuth Georg
- Horne Benjamin D.
- Hu Frank B.
- Hua Zhao Jing
- Hughes Anne E.
- Humphries Steve E.
- Hunt Sarah E.
- Hunter David J.
- Huth Cornelia
- Hveem Kristian
- Illig Thomas
- Iribarren Carlos
- Isomaa Bo
- Jackson Anne U.
- Jarvelin Marjo-Riitta
- Johnson Anne
- Johnson Paul R. V.
- Johnson Toby
- Jones Gregory T.
- Jousilahti Pekka
- Jørgensen Torben
- Kaiser Michael A.
- Kao Wen H. L.
- Kaplan Lee M.
- Kastelein John J. P.
- Kathiresan Sekar
- Khaw Kay-Tee
- Kiemeney Lambertus A.
- Klopp Norman
- Knowles Joshua W.
- Kolovou Genovefa
- Kong Augustine
- Kooner Jaspal S.
- Kraft Peter
- Kuusisto Johanna
- König Inke R.
- Laakso Markku
- Laaksonen Reijo
- Laan Maris
- Lakatta Edward G.
- Lambrechts Diether
- Langenberg Claudia
- Lauritzen Torsten
- Leander Karin
- Lettre Guillaume
- Lewis David R.
- Li Mingyao
- Lieb Wolfgang
- Lieverse Aloysius
- Lim Noha
- Lindgren Cecilia M.
- Lindholt Jes S.
- Loley Christina
- Loos Ruth J. F.
- Lorbeer Roberto
- Lotery Andrew J.
- Lourdes Sampietro M.
- Luan Jian'an
- Luben Robert N.
- Lucas Gavin
- Lyssenko Valeriya
- Mannucci Pier M.
- Maouche Seraya
- Mark Lathrop G.
- Marre Michel
- Marrugat Jaume
- Martinelli Nicola
- Matthiasson Stefan E.
- Matthijs Boekholdt S.
- Matullo Giuseppe
- McArdle Wendy L.
- McCarroll Steve A.
- McCarthy Mark I.
- McCulloch Laura J.
- McKeown Pascal P.
- McNoe Les A.
- McPherson Ruth
- Meigs James B.
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Meneton Pierre
- Merriman Tony R.
- Midthjell Kristian
- Mohlke Karen L.
- Mooser Vincent
- Morgan Thomas
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Muhlestein Joseph B.
- Munroe Patricia B.
- Musunuru Kiran
- März Winfried
- Mühleisen Thomas W.
- Münzel Thomas
- Nahrstaedt Janja
- Naik Dilip K.
- Najjar Samer S.
- Narisu Narisu
- Navarro Pau
- Navis Gerjan
- Nelson Christopher P.
- Newhouse Stephen J.
- Newton-Cheh Christopher
- Nilsson Peter
- Norman Paul E.
- Numans Mattijs E.
- Nöthen Markus M.
- O'Donnell Christopher J.
- O'Reilly Paul F.
- Olivieri Oliviero
- Onland-Moret N. Charlotte
- Org Elin
- Orho-Melander Marju
- Ouwehand Willem H.
- Owen Katharine R.
- Palmen Jutta
- Palmer Colin N. A.
- Panico Salvatore
- Pankow James S.
- Papadakis Konstantinos
- Patel Riyaz S.
- Patterson Chris C.
- Payne Felicity
- Peden John F.
- Pedersen Oluf
- Peltonen Leena
- Perola Markus
- Perry John R. B.
- Peters Annette
- Petersen Ann-Kristin
- Peyvandi Flora
- Pfeufer Arne
- Platou Carl
- Polidoro Silvia
- Potter Simon
- Pouta Anneli
- Powell Janet T.
- Pramstaller Peter P.
- Preuss Michael
- Proença Christine
- Prokopenko Inga
- Qi Lu
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed A.
- Rader Daniel J.
- Rallidis Loukianos S.
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Reffelmann Thorsten
- Refstrup Mette
- Reilly Muredach P.
- Rettig Rainer
- Ricceri Fulvio
- Rice Catherine
- Roberts Robert
- Robertson Neil R.
- Rocheleau Ghislain
- Roden Michael
- Romanazzi Valeria
- Rosendaal Frits R.
- Rubin Diana
- Rudan Igor
- Sacerdote Carlotta
- Salomaa Veikko
- Samani Nilesh J.
- Sampson Michael J.
- Sandhu Manjinder S.
- Sanna Serena
- Saxena Richa
- Sayers Robert D.
- Schadt Eric
- Scheet Paul
- Schillert Arne
- Schlessinger David
- Schreiber Stefan
- Schrezenmeir Jürgen
- Schunkert Heribert
- Schwartz Stephen M.
- Schäfer Arne
- Scott D Julian A.
- Scott Laura J.
- Scuteri Angelo
- Seedorf Udo
- Segrè Ayellet V.
- Shields Beverley M.
- Shrader Peter
- Sigurdsson Gunnar
- Sijbrands Eric
- Siscovick David S.
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Sladek Rob
- Smith Alberto
- Smith Andrew J.
- Smith Tamara B.
- Snieder Harold
- Snoep Jaapjan D.
- Sohrabi Soroush
- Song Kijoung
- Soranzo Nicole
- Sparsø Thomas
- Spector Tim D.
- Spertus John A.
- Stark Klaus
- Stefansson Kari
- Stein Lincoln D.
- Steinthorsdottir Valgerdur
- Stewart Alexandre F. R.
- Stirrups Kathy
- Stoll Monika
- Strachan David P.
- Strassburger Klaus
- Stringham Heather M.
- Subirana Isaac
- Sun Qi
- Susan Burnett Mary
- Swift Amy J.
- Sylvius Nicolas
- Syvänen Ann-Christine
- Tanaka Toshiko
- Teijink Joep A. W.
- Tennstedt Stephanie
- Teumer Alexander
- Thompson John R.
- Thompson Matthew M.
- Thomson Ian A.
- Thorand Barbara
- Thorgeirsson Gudmundur
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Tobin Martin D.
- Tognoni Giovanni
- Tomaszewski Maciej
- Topless Ruth
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tybjærg-Hansen Anne
- Uda Manuela
- Uiterwaal Cuno S.
- Uitterlinden Andre
- Uitterlinden Andre G.
- Valle Timo T.
- van Bockxmeer Frank M.
- van Dam Rob M.
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- van Haeften Timon W.
- van Herpt Thijs
- van Hoek Mandy
- van Rij Andre
- van Rij Andre M.
- van Vliet-Ostaptchouk Jana V.
- Vasudevan Thodur M.
- Vicky Phillips L.
- Vineis Paolo
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Waeber Gerard
- Wain Louise V.
- Walker Mark
- Wallace Chris
- Waltham Matthew
- Wareham Nicholas J.
- Watanabe Richard M.
- Waterworth Dawn M.
- Watkins Hugh
- Webster John
- Weedon Michael N.
- Welch Ryan P.
- Wells George A.
- Wichmann H-Erich
- Wijmenga Cisca
- Wild John B.
- Wild Philipp S.
- Willenborg Christina
- Willer Cristen J.
- William Rayner N.
- Williams Frances M.
- Wilson Tang W. H.
- Wilson James F.
- Witteman Jaqueline C. M.
- Wouter Jukema J.
- Wright Benjamin J.
- Wu Guanming
- Ye Shu
- Yu Grace
- Yuan Xin
- Zeggini Eleftheria
- Zelenika Diana
- Zeller Tanja
- Zhai Guangju
- Zhang Feng
- Ziegler Andreas
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10-5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1 × 10-5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 × 10-10, odds ratio 1.15 [1.10-1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04-1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
- Author
- Abecasis Goncalo
- Abecasis Gonçalo R.
- Aben Katja K.
- Absher Devin
- Aherrahrou Zouhair
- Ahlqvist Emma
- Ahmadi Kourosh
- Ahmed Nabeel
- Alavere Helene
- Alibrandi Maria T S
- Allayee Hooman
- Almgren Peter
- Altshuler David
- Amin Najaf
- Anand Sonia S.
- Andersen Karl
- Anderson Jeffrey L.
- Ardissino Diego
- Ardlie Kristin
- Armitage Jane
- Arnold Alice M.
- Aspelund Thor
- Assimes Themistocles L.
- Assmann Gerd
- Atwood Larry D.
- Aulchenko Yurii S.
- Azhar Muhammad
- Balkau Beverley
- Ball Stephen G.
- Balmforth Anthony J.
- Barbalic Maja
- Barker Adam
- Barker David J P
- Barlassina Christina
- Barlera Simona
- Barnes Daniel
- Barnes Timothy A.
- Barrett Amy
- Barroso H
- Barroso Inês
- Bataille Veronique
- Becker Diane M.
- Becker Lewis C.
- Beckmann Jacques S.
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Berger Klaus
- Bergman Richard N.
- Bergmann Sven
- Bernd Sonja I.
- Berndt Sonja I
- Biebermann Heike
- Bis Joshua C.
- Blagieva Roza
- Blakemore Alexandra I F
- Blankenberg Stefan
- Boehm Bernhard O.
- Boehnke Michael
- Boehnke Mike
- Boeing Heiner
- Boekholdt S. Matthijs
- Boerwinkle Eric
- Boes Tanja
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bornstein Stefan R.
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowman Louise
- Bragi Walters G.
- Braund Peter S.
- Bravenboer Bert
- Brown Morris J.
- Buchanan Thomas A.
- Bumpstead Suzannah
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- Griffin Simon
- Groop Leif
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- Grundberg Elin
- Gräßler Jürgen
- Grönberg Henrik
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- Guiducci Candace
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- Gustafsso Stefan
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- Gyllensten Ulf
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- Hattersley Andrew T.
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- Hitman Graham A.
- Hoesel Volker
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- Jukema J. Wouter
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- Kanoni Stavroula
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- Macciardi Fabio
- MAGIC [Unknown]
- Makrilakis Konstantinos
- Mallick Nadeem
- Mangino Massimo
- Mannila Maria Nastase
- Manning Alisa K.
- Mannucci Pier M.
- Manunta Paolo
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- O'Rahilly Steve
- Offer Alison
- Ohlsson Claes
- Ohrvik John
- Olivieri Oliviero
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- Parts Leopold
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- Sladek Rob
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- Wild Sarah H.
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- Willemsen Gonneke
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- Winkler Thomas W
- Witte Daniel R.
- Witteman Jacqueline
- Witteman Jacqueline C.
- Witteman Jaqueline C M
- Woo Andrew R.
- Wood Andrew R
- Workalemah Tsegaselassie
- Workalemahu Tsegaselassie
- Wright Alan F.
- Wright Benjamin J.
- Wu Guanming
- Xie Weijia
- Xu Jianfeng
- Yang Jian
- Yang Tsun Po
- Ye Shu
- Zabena Carina
- Zaidi Moazzam
- Zaman Khan Shah
- Zeggini Eleftheria
- Zeller Tanja
- Zethelius Björn
- Zgaga Lina
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Ziegler Andreas
- Zillikens M. Carola
- Zitting Paavo
- Zondervan Krina T.
- Öhrvik John
- Östenson Claes Göran
- Publication venue
- Diabetes
- Publication date
- 01/01/2011
- Field of study
OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
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- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
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- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
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- Chasman Dan
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- Chen Constance
- Chen Han
- Chen Ida
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- Chen Ming-Huei
- Chen Wei
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- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
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- Chouraki Vincent
- Christiansen Claus
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- Cimponeriu Dan
- Ciullo Marina
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- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
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- Coresh Josef
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- Curhan Gary
- d'Adamo Pio
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- Dailiana Zoe
- Danesh John
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- Viigimaa Margus
- Viikari Jorma
- Vinay D G
- Vineis Paolo
- Vink Jacqueline M
- Virtamo Jarmo
- Visscher Peter M
- Visser Jenny A
- Vitart Veronique
- Vohl Marie-Claude
- Voight Benjamin F
- Volcik Kelly A
- Vollenweider Peter
- Vonk Judith M
- Voorhuis Marlies
- Völker Uwe
- Völzke Henry
- Wadén Johan
- Waeber Gerard
- Waeber Gérard
- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
- Wain Louise V
- Wainwright Nicholas
- Waite Lindsay L
- Walker Mark
- Wallace Leanne
- Wallaschofski Henri
- Wallentin Lars
- Wang Hansong
- Wang Jie Jin
- Wang Thomas J
- Wang Xiaoling
- Wareham Nicholas
- Wareham Nick J
- Warrington Nicole M
- Watanabe Richard M
- Waterworth Dawn
- Watkins Hugh
- Weder Alan B
- Weedon Michael N
- Welch Ryan P
- Wells George A
- Wennauer Roman
- Westra Harm-Jan
- Wheeler Eleanor
- Wheeler Heather E
- Whincup Peter H
- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
- Wild Philipp S
- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
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- Bach Phil
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- Baertsch Robert
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- Bajorek Eva
- Baker Andrew
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- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
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- Banerjee Ruby
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- Bao Qiyu
- Bao Weidong
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- Barbe Valérie
- Bardill Simon
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- Barker Darren
- Barker Gary
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- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
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- Bituin Aleksandr
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- Hubbard Timothy
- Huber James W.
- Huckle Elizabeth
- Hue Heather
- Hughes Jaime
- Hughes Jennifer
- Hughes Lee
- Hughes-Hull Hillary
- Hull Louisa
- Hulme Bill
- Hulyk Steven
- Hume Jennifer
- Hummeric Holger
- Humphray Sean
- Humphries David
- Humphries Matthew
- Hunt Adrienne
- Hunt Michael
- Hunt Paul
- Hunt Sarah
- Hunter Giselle
- Hunter Rov, II
- Hupman Matt
- Huynh Sandy
- Hyde David
- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
- Ingram Drew
- Inoue Shuuji
- Isak Amber
- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
- Isozaki Emi
- Israni Sanjay
- Ito Fumiaki
- Ito Noriko
- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
- Iwatsu Mikiko
- Iyer Vivek
- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
- Jacintho Mark
- Jackson Laronda R.
- Jackson Terri
- Jacob Leni Susan
- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
- Jeffery Kim
- Jeffrey Colin
- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
- Jia Xingchang
- Jiang Lu
- Jiang Yanrui
- Jiang Ziyou
- Jimenez Alberto
- Jin Jian
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- Johansen Tina
- Johnson Bennie
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- Jones Micheil
- Jones Myrna D.
- Jones Steven
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- Karunaratne Kanchi
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- Keefe Damian
- Keen Gifford
- Keenan Stephen
- Kegelmeyer Laura
- Kegg Lisa
- Kelley Simon
- Kells Cristyn
- Kelly Shayna P.
- Kelly Susan H.
- Kershaw Joanna
- Kettleborough Ross
- Keys David
- Khan Arsi
- Khan Umer F.
- Khan Ziad Mohid
- Khine Susu
- Khurama Divya
- Kidd Cathy
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- Kohlberg Sara
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- Kong Yi
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- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
- Kudoh Jun
- Kuehl Jennifer
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- Lam Edward
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- Lamar Betty
- Lambart Christine
- Lamble Ralph
- Lamerdin Jane E.
- Lander Eric S.
- Landers Tom
- Langford Cordelia
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- Lao Victoria
- Lapidus Alla
- Larke Ben
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- Lei Meng
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- Levan Jaclyn M.
- Leversha Margaret
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- Lewis Doreen
- Lewis Ernest K.
- Lewis Keith
- Lewis Lakeshia C.
- Lewis Lora R.
- Lewis Tammy
- Leyba Tina
- Li Changfeng
- Li Chenji
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- Li Gang
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- Li Zhangwan
- Lieuallen Kim
- Lightning Julia
- Lim Meng K.
- Lindblad-Toh Kerstin
- Lindo Ken
- Lindquist K.
- Lindsay Sarah
- Lindstrom Kirsten
- LIne Matthew
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- Liu Zhanwei
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- Llewellyn-Silva Crystal
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- Lock Victoria
- Lock William
- Lodziak Anne
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- Longden Ian
- Longmire Johnathan L.
- Lopez Frederick
- Lopez John
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- Loraine Howard
- Lord Rachel
- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
- Loveland Jane
- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
- Lu Tao
- Lu Xiuhua
- Lu Yongxiang
- Lu Yontao T.
- Lu Yue
- Lucas Robert
- Lucas Susan
- Lucier Alice
- Lucier Raymond L.
- Ludeman Thom
- Lui Annie
- Lundgren Lyndsey
- Luo Chunqing
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- Lv Gang
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- Lynch Daniel
- Löhnert Tschong-Hun
- Ma Cheng
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- Maas Jason
- Mabbitt Richard
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- Machrus Migdad
- Macht Madison
- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
- Maglott Donna
- Maheshwari Manjula
- Mahindartne Mathew
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- Mahnke Ryan
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- Malfatti Stephanie
- Malloy Kevin
- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
- Manohar Chitra
- Mapua Patricia
- Marabella Dick
- Mardis Elaine R.
- Mareth David
- Mariano Marisa
- Marinelli Lisa
- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
- Marroquin Christian
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- Martinez Diego
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- Maslen Gareth
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- Matsushita Yoshitaka
- Matthews Charles D.
- Matthews Lucy
- Matthews Nick
- Matthews Paul
- Matthews Sterling D.
- Mauceli Evan
- Maunes Cynthia
- Maupin Rachel
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- Maynard Madalynne
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- McLean James
- McLellan Michael D.
- McLeod Michael P.
- McMurdo John
- McMurray Amanda
- McMurray Des
- McMurray Kimberly
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- McPherson John
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- Meidi Patrick
- Meier Elke
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- Meneus Louis
- Meng Shanshan
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- Mercer Simon
- Merritt Christina E.
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- Metzker Michael Lee
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- Miah Asab
- Michaelis Evelyn
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- Mieczkowski Carl
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- Mihalkanin Danielle
- Mihova Tanya
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- Miner Sheri
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- Minja Emmanuel
- Minoshima Shinsei
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- Morgan Margaret B.
- Morita Hiroko
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- Mullenger Ian
- Mullikin Jim
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- Mundt Mark O.
- Mungall Andy
- Munidasa Mala
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- Munson Glen
- Murakami Katsuhiko
- Murayama Yuji
- Murnane Clare
- Murphy Matthew B.
- Murphy Michael
- Murray Christine
- Murray Debra Dianne
- Murray Jennifer
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- Muzny Donna Marie
- Myers Alison
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- Nagao Syunsuke
- Nagaraja R.
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- Nelson Joanne
- Nelson Kathryn
- Nelson Ward
- Nesbitt Ryan
- Neunkirch Jennifer
- Newes Christian
- Newman April
- Ng Bee
- Ng Terrance
- Ngo Robin Ngoc
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- Nguyen Lisa
- Nguyen Minh
- Nguyen Na
- Nguyen Natalie M.
- Nguyen Ngoc Bich
- Nguyen Thu
- Nhan Mike
- Ni Lin
- Niblett David
- Nicholson Jonathan
- Nickerson Elizabeth
- Nickerson Tim
- Nicol Robert
- Nijjar Sukhjit
- Ning Zemin
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- Nishida Aki
- Niu Yuxin
- Niu Yuxin
- Nivens Amber
- Noguchi Hideki
- Nolan Matt
- Norbu Chou Dolma
- Norbu Nyima
- Nordsiek Gabriele
- Norris Sarah Louise
- Novik Karen
- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
- Obregon Melissa
- Oddone Paola
- Oddone Pierre
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- Ohno Saho
- Ohta Nao
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- Okoawo Ose
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- Omotosho Bamidele
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- Oomori Nobuhiro
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- Oragunye Njideka
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- Osada Misuzu
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- Osman Sahal
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- Palazzolo Michael
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- Panasenko Vladimir
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- Parson-Quintana Beverly
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- Perez Agapito
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- Perrault Isabelle
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- Pettett Roger
- Petz Uta
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- Phunkang Pema
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- Pieper Natasha
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- Piqani Bruno
- Piscia C.
- Pitesky Maurice
- Pitluck Sam
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- Poliakov Alex
- Pollard Martin
- Polman Jos
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- Potter Christopher
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- Prathalingham Radhika
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- Qasem Osama
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- Qiang Boqin
- Qiang Boqin
- Qiao Zhenyong
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- Quince Chris
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- Rajagopal Mohan
- Ramasami Umadevi
- Rameau Rayale
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- Ray Aditya
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- Richardson Paul
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- Satpathy Suraj
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- Schlessinger David
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- Shin Maria
- Shindoh Nobuaki
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- Shoji Minami
- Shotland Yoram
- Shought Timothy
- Shownkeen Ratna
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- Siddiqui Roman
- Siepel Adam C.
- Silk Richard
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- Sims Matthew
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- Sivadasan Shanthi
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- Smith James
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- Sneath Hannah
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- Sodergren Erica
- Soderlund Cari
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- Solovyev Victor
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- Sonaike Titilola
- Song Liping
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- Song Xing-Zhi
- Sonnhammer Erik
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- Sotheran Elizabeth
- Sougnez Carrie
- Spainhower Corey
- Sparks Anastasia L.
- Spencer Brian
- Spieth John
- Spooner William
- Spraggon Lee
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- Squares Janet
- Stabenau Arne
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- Stalker James
- Stalker John
- Stallings Raymond I.
- Stalvey Malinda
- Stamford Steve
- Stammers Melanie
- Standring Lisa
- Stange-Thomann Nicole
- Stavropoulos Sharon
- Steffen David
- Stege Justin T.
- Steingruber Helen
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- Stephens-Bolds Shaela
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- Steward Charles
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- Stultz Janet
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- Su Xiaohu
- Subramanian Sandhya
- Subramanian Sandhya
- Sudbrak Ralf
- Sugnet Charles W.
- Sulston John
- Summers Leslie J.
- Sun Hui
- Sun Jiajia
- Sun Jiandong
- Sun Jiu Qin
- Sun Min
- Sun Tao
- Sun Wei
- Sun Yongqiao
- Sun Yu
- Sun Yue
- Sutherland Grant R.
- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
- Svetz Jessica
- Svetz Leah Anne
- Swainson Chris
- Swann Mark
- Swarbreck David
- Swearengen-Shahid Sharhonda
- Sycamore Neil
- Ségurens Béatrice
- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
- Tagney Matthew
- Tahara Takashi
- Takahashi Keiko
- Takano Nobuhiro
- Takaoka Tori
- Takayanagi Atsushi
- Takenaka Tracy
- Talamas Jessica
- Tam Serena
- Tamerisa Kavitha S.
- Tamirisa Aparna
- Tan Olivia
- Tan Steven
- Tan Xinyu
- Tan Xinyu
- Tang Hongli
- Tang Xiangjun
- Tansey Jennifer
- Tao Ran
- Tapia Roxanne
- Taring Elizabeth
- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
- Taylor Christina C.
- Taylor Gillian
- Taylor Kate
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- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
- Tenzin Pema
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- Terry Astrid
- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
- Theodore Joumathe
- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
- Thomas Daryl J.
- Thomas Karen
- Thomas Nicole
- Thomas Paulette
- Thomas Ruth
- Thomas Shereen
- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
- Thoulutsang Yama
- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
- Tian Wei
- Tian Yan
- Tian Yong
- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
- Tran-Gyamfi Mary
- Trani Lee
- Trankiem Margie
- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
- Tromans Anthony
- Trong Stephan
- Trumbower Heather
- Tsai Ming
- Tsamla Tsamla
- Tsolas Jason
- Tsomo Nawang
- Tsujimoto Susan
- Tsukamoto Yumi
- Tsuruoka Hiromi
- Tsuzuki Rina
- Tu Yuefeng
- Tu Yuefeng
- Tubby Ben
- Tufarelli Cristina
- Turner Heidi
- Turney Kathryn
- Tynan Katherine
- Ueland Stephanie
- Ueng Samantha
- Ukegbu Ogechi Nkemdirim
- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
- Upson Darren
- Urban Jeremy B.
- Ureta-Vidal Abel
- Ureta-Vidal Abel
- Usmani Kamran
- Ustaszewska Anna
- Uyama Nozomi
- Valas Ruben E.
- Valdez Michelle
- Valle Duane
- Valles Yvonne
- Van Brunt Andrew
- Van Dilla Marvin
- Van Helmond Zoe
- Van Luchene Ryan
- Vardanian Zachary
- Vargas Michelle
- Vargo Charles E.
- Vartanian Steffan
- Vasquez Lydia I.
- Vassiliev Helen
- Vastrik Imre
- Vaudin Mark
- Veil Rose
- Veklerov Eugene
- Velasco Nelson
- Velasquez Lisa
- Venkataranan Vijay
- Vera Virginia A.
- Verduzco Daniel
- Vergez Lisa
- Vico Virginie
- Viknaraja Ramya
- Villasana Donna M.
- Vine Wendy
- Viswanathan Vijay
- Vo Andy
- Vo Nu
- Voak Paul
- Vollenhoven David
- Wada Hiromi
- Wagner Mark
- Wagner-McPherson Caryn
- Waldron Lenee
- Waligorski Jason E.
- Walker Davian L.
- Walker Keya
- Walker Sarah
- Wall Melanie
- Wall Randy E.
- Wallace John
- Wallis Justine
- Wallis Michelle
- Walsh Jennifer
- Walsham Natalie
- Wan Ma
- Wang Chunyan
- Wang Dong
- Wang Feng
- Wang Guangxin
- Wang Guihai
- Wang Guihai
- Wang Hongjuan
- Wang Hongwei
- Wang Huanjie
- Wang Huifeng
- Wang Huifeng
- Wang Jian
- Wang Jian
- Wang Jian
- Wang Jie
- Wang Jing
- Wang Jingqiang
- Wang Jingqiang
- Wang Jinhua
- Wang Joann
- Wang Juan
- Wang Jun
- Wang Jun
- Wang Jun
- Wang Li
- Wang Lijie
- Wang Lijuan
- Wang Lijun
- Wang Ling
- Wang Liqun
- Wang Mei
- Wang Qiaoyan
- Wang Shifen
- Wang Shu
- Wang Suzhen
- Wang Wenjun
- Wang Xiaoling
- Wang Xiaoning
- Wang Xuefei
- Wang Xuegang
- Wang Yan
- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
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- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
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- Wen Gaiping
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- Wheatley Carl
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- Wheeler Gideon
- Wheeler Jeremy
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- White P. Scott
- White Scott P.
- White Simon
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- Whitmore Scott
- Whittaker Adam
- Whittaker Charles
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- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
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- Wilkinson Jane
- Wilkinson Jane
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- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
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- Wilson Margaret
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- Wilson Richard K.
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- Wleczyk Regina
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- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies
- Author
- Absher Devin M.
- Allison Matthew A.
- Amin Najaf
- Arnold Alice
- Asselbergs Folkert W.
- Assimes Themistocles L.
- Aulchenko Yurii
- Bandinelli Stefania
- Barbalic Maja
- Bis Joshua C.
- Blankenberg Stefan
- Boban Mladen
- Boerwinkle Eric
- Borecki Ingrid B.
- Broer Linda
- Brown-Gentry Kristin
- Campbell Harry
- Coassin Stefan
- Cooke John P.
- Couper David J.
- Crawford Dana C.
- Criqui Michael H.
- Cupples L. Adrienne
- De Graaf Jacqueline
- Dehghan Abbas
- Den Heijer Martin
- Dieplinger Benjamin
- Ding Jingzhong
- Dörr Marcus
- Espinola-Klein Christine
- Feitosa Mary F.
- Felix Stephan B.
- Ferrucci Luigi
- Folsom Aaron R.
- Fraedrich Gustav
- Franceschini Nora
- Frikke-Schmidt Ruth
- Gibson Quince
- Goodloe Robert
- Gunjaca Grgo
- Haltmayer Meinhard
- Haun Margot
- Hayward Caroline
- Heiss Gerardo
- Herrington David
- Hofman Albert
- Holewijn Suzanne
- Huffman Jennifer E.
- Hwang Shih Jen
- Kardia Sharon L.R.
- Kavousi Maryam
- Kieback Arne
- Kiechl Stefan
- Kiemeney Lambertus A.
- Kolcic Ivana
- Kollerits Barbara
- Kritchevsky Stephen B.
- Kronenberg Florian
- Kullo Iftikhar J.
- Lackner Karl J.
- Lamina Claudia
- Li Xiaohui
- Lieb Wolfgang
- Liu Yongmei
- Lohman Kurt
- Meisinger Christa
- Melzer David
- Mitchell Braxton D.
- Mohler III Emile R.
- Montasser May E.
- Mudnic Ivana
- Mueller Thomas
- Murabito Joanne M.
- Murray Anna
- Münzel Thomas
- Nambi Vijay
- Navis Gerjan
- Newman Anne B.
- Nolte Ilja M.
- North Kari E.
- O'Connell Jeff
- O'Donnell Christopher J.
- Oberhollenzer Friedrich
- Olin Jeffrey W.
- Oostra Ben A.
- Palmas Walter
- Penninx Brenda W.
- Petersmann Astrid
- Polasek Ozren
- Psaty Bruce M.
- Rantner Barbara
- Rice Ken
- Rivadeneira Fernando
- Rotter Jerome I.
- Rudan Igor
- Rudock Megan E.
- Schillert Arne
- Seldenrijk Adrie
- Senft Andrea
- Shuldiner Alan R.
- Snieder Harold
- Stadler Marietta
- Summerer Monika
- Sun Yan V.
- Tanaka Toshiko
- Teumer Alexander
- Tybjaerg-Hansen Anne
- Uitterlinden Andre G.
- Van Der Harst Pim
- Van Duijn Cornelia M.
- Van Gilst Wiek H.
- Vermeulen Sita H.
- Vitart Veronique
- Völker Uwe
- Waite Lindsay L.
- Wassel Christina L.
- White Charles C.
- Wichmann H. Erich
- Wild Philipp S.
- Wild Sarah H.
- Willeit Johann
- Wilson James F.
- Witteman Jacqueline C.M.
- Wood Andrew R.
- Wright Alan F.
- Zeller Tanja
- Zemunik Tatijana
- Zgaga Lina
- Ziegler Andreas
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- Author
- An Ping
- Ardlie Kristin
- Ariyurek Yavuz
- Balkau Beverley
- Barter Philip
- Beilby John P.
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J.
- Bergmann Sven
- Bochud Murielle
- Boerwinkle Eric
- Bonnefond Amelie
- Bonnycastle Lori L.
- Borch-Johnsen Knut
- Borecki Ingrid B.
- Bornstein Stefan R.
- Bottcher Yvonne
- Bouatia-Naji Nabila
- Brunner Eric
- Bumpstead Suzannah J.
- Campbell Harry
- Cavalcanti-Proenca Christine
- Charpentier Guillaume
- Chen Yii-Der Ida
- Chines Peter
- Clarke Robert
- Coin Lachlan J.M.
- Cooper Cyrus
- Cooper Matthew N.
- Cornelis Marilyn
- Crawford Gabe
- Crisponi Laura
- Day Ian N.M.
- de Geus Eco J. C.
- Dedoussis George V.
- Dehghan Abbas
- Delplanque Jerome
- DIAGRAM Consortium
- Dina Christian
- Doney Alex
- Dupuis Josee
- Ebrahim Shah
- Egan Josephine M.
- Elliott Amanda
- Elliott Paul
- Erdos Michael R.
- Fedson Annette C.
- Fischer-Rosinsky Antje
- Forouhi Nita G.
- Fox Caroline S.
- Franklin Christopher S.
- Franks Paul W.
- Frants Rune
- Franzosi Maria Grazia
- Galan Pilar
- GIANT Consortium
- Gieger Christian
- Glazer Nicole L.
- Global BPgen Consrotium
- Gloyn Anna L.
- Goel Anuj
- Goodarzi Mark O.
- Graessler Jurgen
- Grallert Harald
- Grarup Niels
- Groves Christopher J.
- Grundy Scott
- Gwilliam Rhian
- Gyllensten Ulf
- Hadjadj Samy
- Hallmans Goran
- Hammond Naomi
- Hamsten Anders
- Han Xijing
- Hansen Torben
- Hartikainen Anna-Liisa
- Hassanali Neelam
- Hattersley Andrew T.
- Hayward Caroline
- Heath Simon C.
- Henneman Peter
- Hercberg Serge
- Herder Christian
- Hicks Andrew A.
- Hillman David R.
- Hingorani Aroon D.
- Hofman Albert
- Hottenga Jouke Jan
- Hu Frank B.
- Hui Jennie
- Hung Joe
- Illig Thomas
- Ingelsson Erik
- Isomaa Bo
- Jackson Anne U.
- Johnson Paul R.V.
- Johnson Toby
- Jorgensen Torben
- Jula Antti
- Kaakinen Marika
- Kanoni Stavroula
- Kao W.H. Linda
- Kaprio Jaakko
- Karpe Fredrik
- Kesaniemi Y. Antero
- Kivimaki Mika
- Knight Beatrice
- Koskinen Seppo
- Kovacs Peter
- Kumari Meena
- Kuusisto Johanna
- Kyvik Kirsten Ohm
- Laakso Markku
- Lajunen Taina
- Langenberg Claudia
- Lathrop G. Mark
- Lawlor Debbie A.
- Le Bacquer Olivier
- Lecoeur Cecile
- Li Man
- Li Yun
- Lind Lars
- Lindgren Cecilia M.
- Loos Ruth J.F.
- Luan Jian'an
- Lyssenko Valeriya
- Magi Reedik
- Magnusson Patrik K.E.
- Mahley Robert
- Mangino Massimo
- Manning Alisa K.
- Marmot Michael
- Martinez-Larrad Maria Teresa
- McAteer Jarred B.
- McCarroll Steven A.
- McCulloch Laura J.
- McPherson Ruth
- Meisinger Christa
- Melzer David
- Meneton Pierre
- Meyre David
- Mitchell Braxton D.
- Morken Mario A.
- Morris Andrew D.
- Morris Andrew P.
- Mukherjee Sutapa
- Naitza Silvia
- Narisu Narisu
- Nathan David M.
- Navarro Paul
- Neville Matthew J.
- O'Connell Jeffrey
- Oostra Ben A.
- Orru Marco
- Pakyz Ruth
- Palmer Colin N.A.
- Palmer Lyel J.
- Pankow James S.
- Paolisso Giuseppe
- Pattaro Cristian
- Pattou Francois
- Payne Felicity
- Pearson Daniel
- Peden John F.
- Pedersen Nancy L.
- Pedersen Oluf
- Perola Markus
- Perry John R.B.
- Pfeiffer Andreas F.H.
- Pichler Irene
- Polasek Ozren
- Posthuma Danielle
- Potter Simon C.
- Pouta Anneli
- Pramstaller Peter Paul
- Prokopenko Inga
- Province Michael A.
- Psaty Bruce M.
- Qi Lu
- Randall Joshua
- Rathmann Wolfgang
- Rayner Nigel W.
- Rice Kenneth
- Ripatti Samuli
- Rivadeneira Fernando
- Roccasecca Rosa Maria
- Rocheleau Ghislain
- Roden Michael
- Rolandsson Olov
- Rudan Igor
- Rybin Denis
- Salomaa Veikko
- Sampson Michael J.
- Sandbaek Annelli
- Sandhu Manjinder
- Sanna Serena
- Saxena Richa
- Sayer Avan Aihie
- Scheet Paul
- Schwarz Peter
- Scott Laura J.
- Seedorf Udo
- Serrano-Rios Manuel
- Sethupathy Praveen
- Sharp Stephen J.
- Shields Beverley
- Shrader Peter
- Shuldiner Alan R.
- Sigurdsson Gunnar
- Sijbrands Eric J.G.
- Silander Kaisa
- Silveira Angela
- Simpson Laila
- Singleton Andrew
- Smith George Davey
- Smith Nicholas L.
- Song Kijoung
- Soranzo Nicole
- Sovio Ulla
- Sparso Thomas
- Spranger Joachim
- Steinthorsdottir Valgerdur
- Stringham Heather M.
- Stumvoll Michael
- Swift Amy
- Syddall Holly
- Syvanen Ann-Christine
- Tanaka Toshiko
- Thorand Barbara
- Thorleifsson Gudmar
- Tichet Jean
- Timpson Nicholas J.
- Tonjes Anke
- Tuomi Tiinamaija
- Uitterlinden Andre G.
- van Dijk Ko Willems
- Varma Dhiraj
- Visvikis-Siest Sophie
- Vitart Veronique
- Vogelzangs Nicole
- Voight Benjamin F.
- von Hoek Mandy
- Waeber Gerard
- Wagner Peter J.
- Walley Andrew
- Walters G. Bragi
- Ward Kim L.
- Watkins Hugh
- Weedon Michael N.
- Wheeler Eleanor
- Wichmann H. Erich
- Wild Sarah H.
- Willemson Gonneke
- Williams Gordon H.
- Wilson James F.
- Witteman Jacqueline C.M.
- Wright Alan F.
- Yarnell John W.G.
- Zabena Carina
- Zeggini Eleftheria
- Zelenika Diana
- Zethelius Bjorn
- Zhai Guangju
- Zhao Jing Hua
- Zillikens M. Carola
- Publication venue
- Publication date
- 01/01/2010
- Field of study
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes
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Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
- Author
- Adjei Andrew A.
- Adolfson Jan
- Al Olama Ali Amin
- Albanes Demetrius
- Alexander Kimberly
- Aly Markus
- Arndt Volker
- Auvinen Anssi
- Barros-Silva Joao
- Batra Jyotsna
- Benlloch Sara
- Berg Christine
- Berndt Sonja I.
- Biritwum Richard B.
- Blot William J.
- Brenner Hermann
- Broms Michael
- Brown Paul
- Campa Daniele
- Cannon-Albright Lisa
- Carpten John
- Casey Graham
- Cavalli-Bjoerkman Carin
- Chokkalingam Anand P.
- Christova Svetlana
- Chu Lisa
- Clements Judith A.
- Collins Angus
- Conti David V.
- Cook Margaret
- Cook Michael B.
- Cox Angela
- Crawford E. David
- Cybulski Cezary
- Dadaev Tokhir
- Davis Michael
- Dieffenbach Aida K.
- Dikov Tihomir
- Diver W. Ryan
- Donovan Jenny L.
- Easton Douglas
- Eckert Allison
- Eeles Rosalind A.
- Fisher Cyril
- Fitzgerald Liesel M.
- Freedman Matthew L.
- Gapstur Susan M.
- Gaziano J. Michael
- George Anne
- Giles Graham G.
- Giovannucci Edward
- Goodman Phyllis J.
- Govindasami Koveela
- Gronberg Henrik
- Gusev Alexander
- Gustafsson Sven
- Guy Michelle
- Haiman Christopher A.
- Haley James
- Hamdy Freddie C.
- Hazel Steve
- Heathcote Peter
- Henderson Brian E.
- Hennis Anslem J. M.
- Henrique Rui
- Herkommer Kathleen
- Hoover Robert
- Hopper John L.
- Hsing Ann W.
- Hunter David J.
- Ingles Sue A.
- Isaacs William B.
- Iversen Peter
- Johansson Jan-Erik
- Johansson Mattias
- John Esther M.
- Kachakova Darina
- Kaggwa Sam
- Kaneva Radka
- Karlsson Ami
- Kedda Mary-Anne
- Kerr Kris
- Key Tim J.
- Khaw Kay-Tee
- Kibel Adam S.
- Kichaev Gleb
- Kierzek Andrzej
- Kittles Rick A.
- Klarskov Peter
- Klein Eric A.
- Kluzniak Wojciech
- Kote-Jarai ZSofia
- Kraft Peter
- Kujala Paula
- Lane Athene
- Le Marchand Loic
- Leongamornlert Daniel
- Leske M. Cristina
- Li Fugen
- Lin Hui-Yi
- Lindström Sara
- Livni Naomi
- Long Henry W.
- Lophatananon Artitaya
- Lubiski Jan
- Luedeke Manuel
- Maeaettaenen Liisa
- Maia Sofia
- Maier Christiane
- Malone Greg
- Marsden Gemma
- McDonnell Shannon K.
- Michael Agnieszka
- Mitev Vanio
- Mitkova Atanaska
- Morgan Angela
- Muir Kenneth
- Murphy Adam B.
- Murtola Teemu
- Navarro Carmen
- Neal David E.
- Nemesure Barbara
- Neslund-Dudas Christine
- Nielsen Sune F.
- Niwa Shelley
- Nordestgaard Børge G.
- Omara Tracy
- Overvad Kim
- Pandha Hardev
- Park Hyun
- Park Jong Y.
- Pasaniuc Bogdan
- Pashayan Nora
- Paulo Paula
- Pedersen John
- Pettaway Curtis A.
- Pharoah Paul
- Pinto Pedro
- Pomerantz Mark
- Popov Elenko
- Pow-Sang Julio
- Price Alkes L.
- Radlein Selina
- Raychaudhuri Soumya
- Riboli Elio
- Rinckleb Antje
- Rincon Maria
- Riska Shaun
- Roder Andreas
- Rybicki Benjamin A.
- Santos Joana
- Saunders Edward J.
- Saunders Pamela
- Sawyer Emma J.
- Schaid Daniel J.
- Schleutker Johanna
- Schumacher Frederick R.
- Sellers Thomas A.
- Shi Huwenbo
- Siddiq Afshan
- Signorello Lisa B.
- Slavov Chavdar
- Southey Melissa C.
- Spurdle Amanda
- Srinivasan Srilakshmi
- Stanford Janet L.
- Stattin Paer
- Stegmaier Christa
- Stevens Victoria L.
- Stram Daniel O.
- Strom Sara S.
- Taari Kimmo
- Tammela Teuvo L. J.
- Tay Evelyn
- Teerlink Craig
- Teixeira Manuel R.
- Tettey Yao
- Thibodeau Stephen N.
- Tillmans Lori
- Travis Ruth C.
- Trichopoulos Dimitrios
- Truelove Ann
- Trynka Gosia
- Turner Megan
- Tymrakiewicz Malgorzata
- Vineis Paolo
- Vlahova Aleksandrina
- Vogel Walther
- Wahlfors Tiina
- Wallinder Hans
- Wang Liang
- Weischer Maren
- Wiklund Fredrik
- Wilkinson Rosemary
- Witte John S.
- Wokolorczyk Dominika
- Wood Glenn
- Wu Huihai
- Wu Suh-Yuh
- Yeadon Trina
- Yeager Meredith
- Yeboah Edward D.
- Zachariah Babu
- Zheng Wei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 02/05/2016
- Field of study
Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa
A genome-wide association search for type 2 diabetes genes in African Americans.
- Author
- Abecasis Goncalo R
- Adeyemo Adebowale
- Altshuler David
- Amin Najaf
- An Ping
- An S Sandy
- Ardlie Kristin
- Ariyurek Yavuz
- Aulchenko Yurii S
- Balkau Beverley
- Barroso Inês
- Barter Philip
- Beilby John P
- Ben-Shlomo Yoav
- Benediktsson Rafn
- Bennett Amanda J
- Bergman Richard N
- Bergmann Sven
- Blagieva Roza
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Bonnefond Amélie
- Bonnycastle Lori L
- Boomsma Dorret I
- Borch-Johnsen Knut
- Borecki Ingrid B
- Bornstein Stefan R
- Bostrom Meredith A
- Boström Kristina Bengtsson
- Bouatia-Naji Nabila
- Bowden Donald W
- Bravenboer Bert
- Brunner Eric
- Buchanan Thomas A
- Bumpstead Suzannah
- Bumpstead Suzannah J
- Burtt Noël P
- Böttcher Yvonne
- Campbell Harry
- Cao Antonio
- Cauchi Stephane
- Cavalcanti-Proença Christine
- Charpentier Guillaume
- Chen Yii-Der Ida
- Chines Peter
- Chines Peter S
- Clarke Robert
- Coin Lachlan JM
- Collins Francis S
- Cooke Jessica N
- Cooper Cyrus
- Cooper Matthew N
- Cornelis Marilyn
- Couper David J
- Crawford Gabe
- Crisponi Laura
- Daly Mark J
- Day Ian NM
- de Geus Eco JC
- Dedoussis George V
- Dehghan Abbas
- Deloukas Panos
- Delplanque Jerome
- DIAGRAM Consortium
- Dina Christian
- Divers Jasmin
- Doney Alex
- Doney Alex SF
- Dupuis Josée
- Ebrahim Shah
- Egan Josephine M
- Elliott Amanda
- Elliott Amanda L
- Elliott Katherine S
- Elliott Paul
- Erdos Michael R
- Fedson Annette C
- Ferrara Assiamira
- Ferreira Teresa
- Ferrucci Luigi
- Fischer-Rosinsky Antje
- Florez Jose C
- Forouhi Nita G
- Fox Caroline S
- Franklin Christopher S
- Franks Paul W
- Frants Rune
- Franzosi Maria Grazia
- Frayling Timothy M
- Freedman Barry I
- Froguel Philippe
- Galan Pilar
- Ganser Martha
- Gieger Christian
- Glazer Nicole L
- Gloyn Anna L
- Goel Anuj
- Goodarzi Mark O
- Graessler Jürgen
- Grallert Harald
- Grarup Niels
- Green Todd
- Griffin Simon
- Groop Leif
- Groves Christopher J
- Grundy Scott
- Guiducci Candace
- Gwilliam Rhian
- Gyllensten Ulf
- Hadjadj Samy
- Hallmans Göran
- Hammond Naomi
- Hamsten Anders
- Han Xijing
- Hansen Torben
- Hartikainen Anna-Liisa
- Hassanali Neelam
- Hattersley Andrew T
- Hayward Caroline
- Heath Simon C
- Henneman Peter
- Hercberg Serge
- Herder Christian
- Hester Jessica M
- Hicks Andrew A
- Hicks Pamela J
- Hide Winston A
- Hillman David R
- Hingorani Aroon D
- Hitman Graham A
- Hofman Albert
- Hofmann Oliver M
- Hottenga Jouke Jan
- Hu Frank B
- Hui Jennie
- Hung Joe
- Hunter David J
- Huth Cornelia
- Hveem Kristian
- Illig Thomas
- Ingelsson Erik
- Isomaa Bo
- Jackson Anne U
- Jarvelin Marjo-Riitta
- Johnson Paul RV
- Johnson Toby
- Jula Antti
- Jørgensen Torben
- Kaakinen Marika
- Kanoni Stavroula
- Kao Wen HL
- Kao WH Linda
- Kaprio Jaakko
- Karpe Fredrik
- Kesaniemi Y Antero
- Kivimaki Mika
- Klopp Norman
- Knight Beatrice
- Kong Augustine
- Koskinen Seppo
- Kovacs Peter
- Kraft Peter
- Kumari Meena
- Kuusisto Johanna
- Kyvik Kirsten Ohm
- Laakso Markku
- Lajunen Taina
- Langefeld Carl D
- Langenberg Claudia
- Lathrop G Mark
- Lauritzen Torsten
- Lawlor Debbie A
- Le Bacquer Olivier
- Lecoeur Cécile
- Lewis Joshua P
- Li Man
- Li Yun
- Lieverse Aloysius
- Lind Lars
- Lindgren Cecilia M
- Loos Ruth JF
- Lu Lingyi
- Luan Jian'an
- Lyssenko Valeriya
- MAGIC Investigators
- Magnusson Patrik KE
- Mahley Robert
- Mangino Massimo
- Manning Alisa K
- Marmot Michael
- Marre Michel
- Martínez-Larrad María Teresa
- McAteer Jarred B
- McCarroll Steve A
- McCarroll Steven A
- McCarthy Mark I
- McCulloch Laura J
- McDonough Caitrin W
- McPherson Ruth
- Meigs James B
- Meisinger Christa
- Meitinger Thomas
- Melzer David
- Meneton Pierre
- Meyre David
- Midthjell Kristian
- Mitchell Braxton D
- Mohlke Karen L
- Mooser Vincent
- Morken Mario A
- Morris Andrew D
- Morris Andrew P
- Mukherjee Sutapa
- Mägi Reedik
- Naitza Silvia
- Narisu Narisu
- Nathan David M
- Navarro Pau
- Neville Matthew J
- Ng Maggie CY
- Nilsson Peter
- O'Connell Jeffrey
- Oostra Ben A
- Orrù Marco
- Owen Katharine R
- Pakyz Ruth
- Palmer Colin NA
- Palmer Lyle J
- Palmer Nicholette D
- Pankow James S
- Paolisso Giuseppe
- Pattaro Cristian
- Pattou François
- Payne Felicity
- Pearson Daniel
- Peden John F
- Pedersen Nancy L
- Pedersen Oluf
- Peltonen Leena
- Penninx Brenda WJH
- Perola Markus
- Perry John RB
- Petersen Ann-Kristin
- Pfeiffer Andreas FH
- Pichler Irene
- Platou Carl
- Polasek Ozren
- Posthuma Danielle
- Potter Simon C
- Pouta Anneli
- Pramstaller Peter P
- Pramstaller Peter Paul
- Proença Christine
- Prokopenko Inga
- Province Michael A
- Psaty Bruce M
- Qi Lu
- Randall Joshua
- Rathmann Wolfgang
- Raychaudhuri Soumya
- Rayner N William
- Rayner Nigel W
- Rice Kenneth
- Ripatti Samuli
- Rivadeneira Fernando
- Robertson Neil R
- Roccasecca Rosa Maria
- Rocheleau Ghislain
- Roden Michael
- Roh Bong H
- Rolandsson Olov
- Rotimi Charles N
- Rotter Jerome I
- Rudan Igor
- Rudock Megan E
- Ruokonen Aimo
- Rybin Denis
- Sale Michele M
- Salomaa Veikko
- Sampson Michael J
- Sandbaek Annelli
- Sandhu Manjinder
- Sanna Serena
- Saxena Richa
- Sayer Avan Aihie
- Scheet Paul
- Schlessinger David
- Schwarz Peter
- Scott Laura J
- Scuteri Angelo
- Seedorf Udo
- Segrè Ayellet V
- Serrano-Ríos Manuel
- Sethupathy Praveen
- Sharp Stephen J
- Shields Beverley
- Shields Beverley M
- Shrader Peter
- Shriner Daniel
- Shuldiner Alan R
- Sigurdsson Gunnar
- Sijbrands Eric
- Sijbrands Eric JG
- Silander Kaisa
- Silveira Angela
- Simpson Laila
- Singleton Andrew
- Siscovick David S
- Sladek Rob
- Sladek Robert
- Smith George Davey
- Smith Nicholas L
- Song Kijoung
- Soranzo Nicole
- Sovio Ulla
- Sparsø Thomas
- Spector Timothy D
- Spranger Joachim
- Stefansson Kari
- Stein Lincoln D
- Steinthorsdottir Valgerdur
- Strassburger Klaus
- Stringham Heather M
- Stumvoll Michael
- Sun Qi
- Swift Amy
- Swift Amy J
- Syddall Holly
- Syvänen Ann-Christine
- Talbert Matthew E
- Tanaka Toshiko
- Thorand Barbara
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tichet Jean
- Timpson Nicholas J
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tönjes Anke
- Uda Manuela
- Uitterlinden Andre
- Uitterlinden André G
- Valle Timo T
- van Dam Rob M
- van Dijk Ko Willems
- van Duijn Cornelia M
- van Haeften Timon W
- van Herpt Thijs
- van Hoek Mandy
- van Vliet-Ostaptchouk Jana V
- Varma Dhiraj
- Visvikis-Siest Sophie
- Vitart Veronique
- Vogelzangs Nicole
- Voight Benjamin F
- Vollenweider Peter
- Waeber Gérard
- Wagner Peter J
- Walker Mark
- Walley Andrew
- Walters G Bragi
- Ward Kim L
- Wareham Nicholas J
- Watanabe Richard M
- Waterworth Dawn M
- Watkins Hugh
- Weedon Michael N
- Welch Ryan P
- Wheeler Eleanor
- Wichmann H-Erich
- Wijmenga Cisca
- Wild Sarah H
- Willemsen Gonneke
- Willer Cristen J
- Williams Gordon H
- Wilson James F
- Wing Maria R
- Witteman Jacqueline
- Witteman Jaqueline CM
- Wright Alan F
- Wu Guanming
- Yarnell John WG
- Zabena Carina
- Zeggini Eleftheria
- Zelenika Diana
- Zethelius Björn
- Zhai Guangju
- Zhao Jing Hua
- Ziegler Julie T
- Zillikens M Carola
- Publication venue
- PLoS One
- Publication date
- 22/11/2011
- Field of study
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations