61 research outputs found
Database management and analysis of fisheries in Illinois: Final report, 1 March 1999-28 February 2002
- Author
- Publication venue
- INHS Center for Aquatic Ecology
- Publication date
- 01/01/2002
- Field of study
Get PDFIssued May 2002; F-69-RReport issued on: May 200
Alignment of the CMS tracker with LHC and cosmic ray data
- Author
- Abbaneo D.
- Abbiendi G.
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- Field of study
Get PDF© CERN 2014 for the benefit of the CMS collaboration, published under the terms of the Creative Commons Attribution 3.0 License by IOP Publishing Ltd and Sissa Medialab srl. Any further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation and DOI.The central component of the CMS detector is the largest silicon tracker ever built. The precise alignment of this complex device is a formidable challenge, and only achievable with a significant extension of the technologies routinely used for tracking detectors in the past. This article describes the full-scale alignment procedure as it is used during LHC operations. Among the specific features of the method are the simultaneous determination of up to 200 000 alignment parameters with tracks, the measurement of individual sensor curvature parameters, the control of systematic misalignment effects, and the implementation of the whole procedure in a multi-processor environment for high execution speed. Overall, the achieved statistical accuracy on the module alignment is found to be significantly better than 10μm
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
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- Assaly Michele
- Assareh Amelia A
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- Belden Christine M
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- Bis Joshua C
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- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
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- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
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- Willeke Diana
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- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
Get PDFThe cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
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- Armstrong Jon
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- Arredondo Heather Hope
- Artiguenave François
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- Hammond Sian
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- Han Guiqing
- Han Shunsheng
- Han Xurong
- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
- Harper David
- Harper Georgina
- Harper Patrik
- Harradence Grant
- Harris Anthony
- Harrison Charlene-Lou
- Harrison Elliot
- Harrison Ruth
- Hart Elizabeth
- Hasegawa Tomoko
- Hashimoto Etsuko
- Hashimoto Wakako
- Hassan Daniel
- Hatcher Beath
- Hattori Masahira
- Haugen Eric
- Haussler David
- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
- Hawkins Trevor
- Hawley Kellie
- Haydu Lauren
- Hayes Kerry
- He Fengying
- He Jiaying
- He Lin
- Heaford Andrew
- Heath Paul
- Heathcott Rosemary
- Heilig Roland
- Heiner Cheryl
- Heinze Ivonne
- Heitmann Katja
- Helfenbein Keven
- Heller Andrew
- Hellsten Uffe
- Hembry Cathy
- Henderson Carl
- Henderson Nicholas
- Henderson Nina
- Hendrix David
- Hennig Steffen
- Henning Karla
- Hepa Victor
- Herd Tim
- Herman Charles
- Hernandez Judith
- Hernandez Omar
- Herseim Allyson
- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
- Holden Jane
- Holdgate Janet
- Hollaway Mara
- Hollins Barbara
- Holloway Ele
- Holmes Andrea
- Holmes Ian
- Holmes Sarah
- Holroyd Simon
- Holtz Ann
- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
- Honan Tracy
- Hood Leroy
- Hooper Alison
- Hopewell Lucy
- Hopkins Ben
- Horne Jennifer
- Hornett Gary
- Hornischer Klaus
- Hornsby Amber
- Hornsby Geoff
- Hornsby Tony
- Horsley Sharon
- Horton Roger
- Hosage-Norman Catherine
- Hosoda Kei
- Hosono Katsuhiro
- Hosseini Roya
- Hou Shunfang
- Hou Xiaodi
- Houde Nathan
- Howard Philip
- Howard Stephanie R.
- Howden Philip
- Howe Kevin
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- Howell Latoya Lynette
- Howells Sally Lucinda
- Hsu Fan
- Hu George
- Hu Jie
- Hu Songnian
- Huang Fang
- Huang Guyang
- Huang Katherine
- Huang Mei
- Huang Wayne
- Huang Wei
- Huang Wei
- Huang Wei
- Huang Zhengping
- Hubbard Timothy
- Huber James W.
- Huckle Elizabeth
- Hue Heather
- Hughes Jaime
- Hughes Jennifer
- Hughes Lee
- Hughes-Hull Hillary
- Hull Louisa
- Hulme Bill
- Hulyk Steven
- Hume Jennifer
- Hummeric Holger
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- Humphries David
- Humphries Matthew
- Hunt Adrienne
- Hunt Michael
- Hunt Paul
- Hunt Sarah
- Hunter Giselle
- Hunter Rov, II
- Hupman Matt
- Huynh Sandy
- Hyde David
- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
- Ingram Drew
- Inoue Shuuji
- Isak Amber
- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
- Isozaki Emi
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- Ito Fumiaki
- Ito Noriko
- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
- Iwatsu Mikiko
- Iyer Vivek
- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
- Jacintho Mark
- Jackson Laronda R.
- Jackson Terri
- Jacob Leni Susan
- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
- Jeffery Kim
- Jeffrey Colin
- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
- Jia Xingchang
- Jiang Lu
- Jiang Yanrui
- Jiang Ziyou
- Jimenez Alberto
- Jin Jian
- Jin Yetao
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- Johnson Bennie
- Johnson Cheryl
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- Jones Matthew
- Jones Michael
- Jones Micheil
- Jones Myrna D.
- Jones Steven
- Jong Pieter De
- Jordan Yun
- Joseph Shirin
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- Jubb Mark
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- Järke Doris
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- Kamal Michael
- Kamat Asha
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- Kang Hui
- Kang Kelie
- Kang Ning
- Kapur Hitesh
- Karolchik Donna
- Karunaratne Kanchi
- Kasprzyk Arek
- Katayama Takujiro
- Kato Takako
- Kauer Gerhard
- Kaul Rajinder
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- Kawagoe Chiharu
- Kawasaki Kazuhiko
- Kay Michael
- Kaye Danielle
- Kearney Lyndal
- Keefe Damian
- Keen Gifford
- Keenan Stephen
- Kegelmeyer Laura
- Kegg Lisa
- Kelley Simon
- Kells Cristyn
- Kelly Shayna P.
- Kelly Susan H.
- Kershaw Joanna
- Kettleborough Ross
- Keys David
- Khan Arsi
- Khan Umer F.
- Khan Ziad Mohid
- Khine Susu
- Khurama Divya
- Kidd Cathy
- Kierstan Peter
- Kieu Alix
- Kim Jennifer
- Kim Joomyeong
- Kim Kyung
- Kimball Heather
- Kimberley Andrew
- Kimura Moe
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- King Mary-Clare
- Kingsley Simon
- Kingswood Colin
- Kisamo Haika
- Kisner Peter
- Kitts Paul
- Kiyooka Miho
- Klages Sven
- Klingle Gillian
- Knights Andrew
- Kobayashi Mai
- Kodira Chinnappa
- Kohlberg Sara
- Kojima Kazuyasu
- Kolbe William
- Kong Yi
- Korf Ian
- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
- Kudoh Jun
- Kuehl Jennifer
- Kuharic Patrick
- Kuhn Carol
- Kulish Larissa
- Kuroki Yoko
- Kwan Chinnie
- Kyle Amy
- LaButti Kurt
- Lacombe Anne
- Lad Heena
- Lafrades Melanie
- Lagemann Dorothee
- Lai Jianghua
- Lai Teresa
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- Laing Michael
- Laird Gavin
- Lam Edward
- Lam Marissa
- Lama Dawa
- Lamar Betty
- Lambart Christine
- Lamble Ralph
- Lamerdin Jane E.
- Lander Eric S.
- Landers Tom
- Langford Cordelia
- Lansang Christine
- Lao Victoria
- Lapidus Alla
- Larke Ben
- Lato Bernadette
- Latreille Phil
- Lau Timun
- Lawlor Stephanie
- Layman Dan
- Leal Belita
- Leather Sampsa
- Lebow Heather
- Lee Byung-in
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- Lee Denise
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- Lee Kenneth
- Lee Lisa
- Lee Peter
- Legall Fitzherbert Henderson, III
- Leger Jean Pierre
- Lehman Karl
- Lehmann Rüdiger
- Lehoczky Jessica
- Lehrach Hans
- Lehvaslaiho Minna
- Lei Meng
- Lemke Johannes
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- Leonard Shawn
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- Leongamornlert Daniel
- Lesar Kendra
- Levan Jaclyn M.
- Leversha Margaret
- Levine Rosie
- Levy Andrew
- Levy Michaël
- Lewis Doreen
- Lewis Ernest K.
- Lewis Keith
- Lewis Lakeshia C.
- Lewis Lora R.
- Lewis Tammy
- Leyba Tina
- Li Changfeng
- Li Chenji
- Li Eryao
- Li Feifei
- Li Gang
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- Li Jiayang
- Li Jiayang
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- Li Jingfei
- Li Jingxiang
- Li Li
- Li Lili
- Li Lin
- Li Ming
- Li Nan
- Li Ran
- Li Shengbin
- Li Shuangding
- Li Shuangli
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- Li Songgang
- Li Tao
- Li Wei
- Li Zaiping
- Li Zhangwan
- Lieuallen Kim
- Lightning Julia
- Lim Meng K.
- Lindblad-Toh Kerstin
- Lindo Ken
- Lindquist K.
- Lindsay Sarah
- Lindstrom Kirsten
- LIne Matthew
- Ling Wei
- Linkowski Albert
- Linsdell Sally
- Little Peter
- Liu Boyong
- Liu Boyong
- Liu Cong
- Liu Dianwu
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- Liu Jing
- Liu Jing Mei
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- Liu Ning
- Liu Qian
- Liu Siqi
- Liu Stephanie
- Liu Wei
- Liu Wen
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- Liu Yilin
- Liu Ying
- Liu Yu
- Liu Yu
- Liu Zhanwei
- Liyanage Dhammika
- Llewellyn-Silva Crystal
- Lloyd Christine
- Lloyd David
- Lobb Rebecca
- Lock Victoria
- Lock William
- Lodziak Anne
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- London Darin
- London Pamela
- Longden Ian
- Longmire Johnathan L.
- Lopez Frederick
- Lopez John
- Lopez Jose
- Lopez Lora
- Loraine Howard
- Lord Rachel
- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
- Loveland Jane
- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
- Lu Tao
- Lu Xiuhua
- Lu Yongxiang
- Lu Yontao T.
- Lu Yue
- Lucas Robert
- Lucas Susan
- Lucier Alice
- Lucier Raymond L.
- Ludeman Thom
- Lui Annie
- Lundgren Lyndsey
- Luo Chunqing
- Luo Chunqing
- Lv Gang
- Lv Gang
- Lye Georgina
- Lynch Daniel
- Löhnert Tschong-Hun
- Ma Cheng
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- Ma Peter
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- Maas Jason
- Mabbitt Richard
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- Machrus Migdad
- Macht Madison
- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
- Maglott Donna
- Maheshwari Manjula
- Mahindartne Mathew
- Mahmoodi Venus
- Mahnke Ryan
- Mailey Brian
- Major John
- Malfatti Stephanie
- Malloy Kevin
- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
- Manohar Chitra
- Mapua Patricia
- Marabella Dick
- Mardis Elaine R.
- Mareth David
- Mariano Marisa
- Marinelli Lisa
- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
- Marroquin Christian
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- Marsh Victoria
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- Martin Joel
- Martin Kirt
- Martin Matthew
- Martin Sancha
- Martindale Ashley D.
- Martinez Diego
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- Martinez Michele
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- Maslen Gareth
- Mason Debbie
- Masood Hadi
- Massey Elizabeth
- Matsuda Fumihiko
- Matsumoto Shuko
- Matsushita Yoshitaka
- Matthews Charles D.
- Matthews Lucy
- Matthews Nick
- Matthews Paul
- Matthews Sterling D.
- Mauceli Evan
- Maunes Cynthia
- Maupin Rachel
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- Maynard Madalynne
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- McClay Joseph
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- McGuire Sarah
- McGurn Phil
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- McLaren Stuart
- McLay Kirsten
- McLean James
- McLellan Michael D.
- McLeod Michael P.
- McMurdo John
- McMurray Amanda
- McMurray Des
- McMurray Kimberly
- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
- McPherson John D.
- McVicker Graham
- McWilliams Natalie
- Mead Kelly
- Meador Michael G.
- Medina Catherine
- Mehta Nalini
- Meidi Patrick
- Meier Elke
- Meincke Linda J.
- Mejima Mio
- Meldrim James
- Melsopp Craig
- Mendez Sylvia
- Meneus Louis
- Meng Shanshan
- Menuge Noel
- Mercado Christian
- Mercado George
- Mercado Iracema C.
- Mercer Simon
- Merritt Christina E.
- Mesirov Jill P.
- Metzker Michael Lee
- Meyer Rekha
- Meyer Rick
- Miah Asab
- Michaelis Evelyn
- Micklem Gos
- Mieczkowski Carl
- Mier Maggie
- Miguel Trini
- Mihalev Atanas
- Mihalkanin Danielle
- Mihova Tanya
- Miles Simon
- Mileur Mason W.
- Miller Christie
- Miller Donald
- Miller Nancy
- Milne Sarah
- Miner George R.
- Miner Sheri
- Miner Tracie
- Minja Emmanuel
- Minoshima Shinsei
- Minx Patrick J.
- Misra Monica
- Mistry Dippica
- Mistry Shailesh
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- Monforte Joseph
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- Montgomery Mishelle
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- Moore Niki
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- Morgan Jenna
- Morgan Margaret B.
- Morita Hiroko
- Morris Sidney
- Mortimore Beverly
- Morton Jerry
- Motoyama Ayuko
- Mott Richard
- Moyzis Robert K.
- Mu Feng
- Mukherjee Shibani
- Mullenger Ian
- Mullikin Jim
- Mulrain Leon
- Munday Brian
- Munday Elaine
- Mundt Mark O.
- Mungall Andy
- Munidasa Mala
- Munk A. Christine
- Munk Christie A.
- Munson Glen
- Murakami Katsuhiko
- Murayama Yuji
- Murnane Clare
- Murphy Matthew B.
- Murphy Michael
- Murray Christine
- Murray Debra Dianne
- Murray Jennifer
- Murrell Kerry
- Muzny Donna Marie
- Myers Alison
- Myers Richard
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- Nagamine Kentaro
- Nagao Syunsuke
- Nagaraja R.
- Nair Latha
- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
- Nanavati Amit N.
- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
- Nash William
- Naylor Jerome
- Nazareth Lynne V.
- Neal Dearl D.
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- Nelson Catherine
- Nelson David O.
- Nelson Deborah A.
- Nelson Joanne
- Nelson Kathryn
- Nelson Ward
- Nesbitt Ryan
- Neunkirch Jennifer
- Newes Christian
- Newman April
- Ng Bee
- Ng Terrance
- Ngo Robin Ngoc
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- Nguyen Cindy
- Nguyen Hoa
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- Nguyen Lisa
- Nguyen Minh
- Nguyen Na
- Nguyen Natalie M.
- Nguyen Ngoc Bich
- Nguyen Thu
- Nhan Mike
- Ni Lin
- Niblett David
- Nicholson Jonathan
- Nickerson Elizabeth
- Nickerson Tim
- Nicol Robert
- Nijjar Sukhjit
- Ning Zemin
- Nisbet James
- Nishida Aki
- Niu Yuxin
- Niu Yuxin
- Nivens Amber
- Noguchi Hideki
- Nolan Matt
- Norbu Chou Dolma
- Norbu Nyima
- Nordsiek Gabriele
- Norris Sarah Louise
- Novik Karen
- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
- Obregon Melissa
- Oddone Paola
- Oddone Pierre
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- Oguh Maryann
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- Ohno Saho
- Ohta Nao
- Ohtsubo Masafumi
- Oinn Tom
- Okoawo Ose
- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
- Oliver Karen
- Olsen Anne S.
- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
- Oomori Nobuhiro
- Ooshima Kenshiro
- Oragunye Njideka
- Orantes Jerry
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- Osborn Anthony
- Osborne Joan
- Osman Sahal
- Ovcharenko Ivan
- Overton-Larty Emma
- Oviedo Rodolfo J.
- Ow David
- Ozawa Ritsuko
- Ozersky Philip
- Pace Araceli C.
- Pack Elizabeth
- Padki Anuradha
- Pahlavan Shane
- Palaniappan Krishnaveni
- Palazzolo Michael
- Palmeiri Anthony
- Palmer Sophie
- Pan Jiaofeng
- Pan Sisu
- Panasenko Vladimir
- Pandian Richard
- Parker Adrian
- Parker David Neil
- Parker Stephen
- Parkin Christopher
- Parkin Kim
- Parks Kenya L.
- Parry-Brown Ginny
- Parson-Quintana Beverly
- Pasternak Shiran
- Patel Bella Mayurkumar
- Patel Dina
- Patel Jalpa N.
- Patel Ritesh
- Patel Shripa
- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
- Paulson Edward
- Payton Brett A.
- Pearce Alexandra
- Pearman Charlene
- Pearson Danita
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- Peck Anna
- Peck Richard
- Pedan John
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- Pelletier Eric
- Peng Vivian
- Peng Vivian
- Peng Yi
- Peng Yi
- Peng Ze
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- Pennacchio Len A.
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- Percy Chantel
- Perez Agapito
- Perez Lesette M.
- Perito Andrew
- Perrault Isabelle
- Perrier Rene
- Perrier Rene
- Perrin William
- Pesavento Brad
- Peters Anna
- Peters Leonard G.
- Peterson Jane
- Peterson Karl
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- Pettett Roger
- Petz Uta
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- Phunkang Pema
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- Piqani Bruno
- Piscia C.
- Pitesky Maurice
- Pitluck Sam
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- Poliakov Alex
- Pollard Martin
- Polman Jos
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- Porter Keith
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- Potter Christopher
- Potter Simon
- Poundstone Pat
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- Prado Daisy
- Prange Christa
- Prathalingham Radhika
- Predki Paul
- Prigmore Elena
- Primus Eltrick L.
- Primus Jennifer
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- Qi Xiaohua
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- Qiang Boqin
- Qiang Boqin
- Qiao Zhenyong
- Qin Xiang
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- Quan Glenda
- Quarrie Hannah
- Quiles Miyo M.
- Quince Chris
- Quiroz Juana B.
- Qureshi Matloob
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- Rachupka Anthony
- Radionenko Maxim
- Rajagopal Mohan
- Ramasami Umadevi
- Rameau Rayale
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- Ratford Lewis
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- Ray Aditya
- Ray Vernada
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- Raymond Christina
- Read Daniel
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- Regala Warren
- Reichwald Kathrin
- Reid Mary
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- Reily Amy D.
- Reinhardt Astrid
- Reinhardt Richard
- Reiter Charlie
- Ren Shuangxi
- Ren Shuangxi
- Ren Yanru
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- Rice Alex
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- Rice Peter
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- Richard Suzzanne
- Richards Stephen
- Richardson Kristi
- Richardson Paul
- Richardson Paul
- Richardson Susan
- Ricke Darryl O.
- Ridler Kerry
- Riethman Harold
- Riethoven Lyn
- Rigby Rachel
- Riley B.E
- Rise Cecil
- Rivera Angel
- Rives Catharine M.
- Road JungShing
- Robert Catherine
- Roberts Simon
- Robinson Chris
- Robinson Dezere
- Robinson Donna I.
- Robinson Donna L.
- Robinson Melanie
- Rochford Rebecca
- Rock Susan M.
- Rodkey Travis L.
- Rodriguez Alex
- Rodriguez Joseph
- Rodriguez Juan
- Rogers Jane
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- Rogers Stephanine
- Rogosin Andrea
- Rogov Peter
- Rohlfing Theresa
- Rojas Alberto
- Rokhsar Daniel
- Rong Li
- Rong Li
- Rosenbloom Kate R.
- Roskin Krishna M.
- Ross Hugh
- Ross Mark
- Ross Stephanie
- Rowen Lee
- Rubenfield Marc
- Rubin Edward M.
- Ruef Barbara
- Ruiz Erica M.
- Ruiz San Juana
- Rule Angela
- Rule James
- Rule Jeffrey
- Russell Ben
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- Sabo Aniko
- Saenphimmachak Channakhone
- Safdar Kamal
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- Sanders Brent
- Sanders Christina
- Sanders Wendi
- Santibanez Jireh
- Santoyo-Lopez Javier
- Sanuki Naoko
- Sarmiento R.
- Sasaki Takashi
- Satpathy Suraj
- Saunders David
- Saunders Elizabeth H.
- Saurin William
- Savery Glenford G.
- Sawada Nori
- Sawhill William W.
- Saxman Eric
- Scarpelli Claude
- Scharfe Maren
- Schatzkamer Kyriena L.
- Scherer Steven Edward
- Schilhabel Markus
- Schlessinger David
- Schmeits James
- Schmidt Esther
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- Searle Margaret
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- Sehra Harminder
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- Seymour Burt
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- Shen Yan
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- Sheridan Andrew
- Sheridan Elizabeth
- Sherpa Ngawang
- Shi Guibin
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- Shimizu Nobuyoshi
- Shimizu Yoshiko
- Shin Maria
- Shindoh Nobuaki
- Shintani Ai
- Shiohama Aiko
- Shoji Minami
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- Yada Tetsushi
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- Yakub Syed
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- Yang Hao
- Yang Huanming
- Yang Huanming
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- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
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- Yang Yongkui
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- Yao Zhijian
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- Ye Chen
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- Yeh Mimi
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- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
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- Zhang Bo
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- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
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- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
Get PDFThe sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum
- Author
- Adeli Anahita
- Aisen Paul
- Albers Colleen S.
- Albert Marilyn
- Allard Joanne
- Ances Beau
- Anderson Karen
- Apostolova Liana
- Ashok Raj Balebail
- Assaly Michele
- Asthana Sanjay
- Bachman David
- Bartha Rob
- Bartzokis George
- Bates Vernice
- Beccera Mauricio
- Beckett Laurel
- Belden Christine M.
- Bell Karen L.
- Bergman Howard
- Bernick Charles
- Black Sandra
- Blank Karen
- Bonakdarpour Borna
- Borges-Neto Salvador
- Borrie Michael
- Brand Connie
- Brewer James
- Brockington John
- Brooks William M.
- Brosch Jared R.
- Brown Alice D.
- Budson Andrew E.
- Burke Anna
- Burns Jeffrey M.
- Caldwell Curtis
- Capote Horacio
- Carlsson Cynthia M.
- Carmichael Owen
- Carroll Maria
- Carson Richard E.
- Carter Raina
- Cellar Janet S.
- Celmins Dzintra
- Cerbone Brittany
- Chaing Gloria
- Chertkow Howard
- Chowdhury Munir
- Clark David
- Coleman Edward
- Conrad Gary
- Correia Stephen
- Creech Mary L.
- Dang Mimi
- de Leon Mony J.
- De Santi Susan
- DeCarli Charles
- deToledo-Morrell Leyla
- Dolen Sara
- Doody Rachelle S.
- Doraiswamy P. Murali
- Duara Ranjan
- D’Agostino Daniel
- Fargher Kristin
- Farlow Martin R.
- Fatica Parianne
- Feldman Howard
- Finger Elizabeth
- Flashman Laura A.
- Fleisher Adam
- Fletcher Evan
- Franklin Erin
- Galvin James E.
- Garg Pradeep
- Geldmacher David
- Glodzik Lidia
- Goldstein Bonnie S.
- Gordineer Leslie
- Graff-Radford Neill R.
- Green Robert C.
- Greig Maria T.
- Griffith Randall
- Grossman Hillel
- Hake Ann Marie
- Hardy Peter
- Heidebrink Judith L.
- Hernando Raymundo
- Herring Scott
- Honig Lawrence S.
- Hosein Chris
- Hunt Cynthia
- Hynes Mary L.
- Ismail M. Saleem
- Jack Clifford R.
- Jacobson Sandra A.
- Jagust William
- Jiang Teng
- Jicha Greg
- Johnson Heather
- Johnson Kathleen
- Johnson Keith A.
- Johnson Kris
- Johnson Nancy
- Johnson Sterling
- Kataki Maria
- Kaye Jeffrey
- Kendall Tracy
- Kertesz Andrew
- Kerwin Diana
- Kielb Stephanie
- Killiany Ronald
- Kittur Smita
- Knopman David
- Kowall Neil
- Lah James J.
- Lane Barton
- Lee T-Y
- Lerner Alan
- Levey Allan I.
- Lin Michael
- Lind Betty
- Lipowski Kristine
- Lord Joanne L.
- Lu Po H.
- Lynn Johnson Patricia
- MacAvoy Martha G.
- Maillard Pauline
- Makino Kelly M.
- Malloy Paul
- Marshall Gad
- Marson Daniel
- Martin Kim
- Mason Sara S.
- Mathews Dana
- Matthews Brandy R.
- Mc-Adams-Ortiz Catherine
- Mesulam Marek-Marsel
- Miao Dan
- Michel Christina A.
- Miller Bruce L.
- Mintun Mark A.
- Mintzer Jacobo
- Mitsis Effie
- Morris John
- Morris John C.
- Mudge Benita
- Mulnard Ruth A.
- Munic Donna
- Natelson Love Marissa
- Nguyen Dana
- Norbash Alexander
- Oates Elizabeth
- Obisesan Thomas O.
- Ogrocki Paula
- Olichney John
- Oliver Angela
- Onyike Chiadi
- Ott Brian R.
- Parfitt Francine
- Pasternack Stephen
- Pawluczyk Sonia
- Pearlson Godfrey D.
- Perry David
- Petersen Ronald
- Petrella Jeffrey R.
- Pogorelec Dana M.
- Pomara Nunzio
- Porsteinsson Anton P.
- Potkin Steven G.
- Preda Adrian
- Querfurth Henry
- Quiceno Mary
- Quinn Joseph
- Rachisky Irina
- Rainka Michelle
- Ravdin Lisa
- Reeder Stephanie
- Relkin Norman
- Reynolds Brigid
- Roberson Erik
- Roberts Peggy
- Robin Hsiung Ging-Yuek
- Rosen Allyson
- Rosen Howard J.
- Rountree Susan
- Rusinek Henry
- Sabbagh Marwan N.
- Sadowsky Carl
- Salloway Stephen
- Santulli Robert B.
- Sarrael Antero
- Saykin Andrew J.
- Scharre Douglas W
- Schneider Lon S.
- Schneider Stacy
- Scott Turner Raymond
- Seltzer Marc
- Shah Raj C.
- Shaw Leslie M.
- Silbert Lisa
- Silverman Daniel H.S.
- Sinha Partha
- Sink Kaycee M.
- Sirrel Sherye A.
- Smith Amanda
- Smith Charles D.
- Spann Bryan M.
- Sperling Reisa A.
- Spicer Kenneth
- Stefanovic Bojana
- Stern Yaakov
- Swerdlow Russell H.
- Tan Chen-Chen
- Tan Lan
- Tan Lin
- Tan Meng-Shan
- Tariot Pierre
- Tatsuoka Curtis
- Taylor Joy L.
- Teodoro Liberty
- Thai Gaby
- Tingus Kathleen
- Tinklenberg Jared
- Toga Arthur W.
- Tremont Geoffrey
- Trncic Nadira
- Trojanowki John Q.
- Trost Dick
- van Dyck Christopher H.
- Vanderswag Helen
- Varma Pradeep
- Varon Daniel
- Villanueva-Meyer Javier
- Villena Teresa
- Wang Hui-Fu
- Watkins Franklin
- Weiner Michael W.
- Weintraub Sandra
- Williamson Jeff D.
- Wolday Saba
- Womack Kyle
- Wong Terence Z.
- Woo Ellen
- Wu Chuang-Kuo
- Xu Wei
- Yesavage Jerome
- Yu Jin-Tai
- Yu Wan-Jiang
- Zhu Xi-Chen
- Zimmerman Earl A.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 02/05/2016
- Field of study
Get PDFPhosphatidylinositolbinding clathrin assembly protein (PICALM) gene is one novel genetic player associated with late-onset Alzheimer’s disease (LOAD), based on recent genome wide association studies (GWAS). However, how it affects AD occurrence is still unknown. Brain reserve hypothesis highlights the tolerant capacities of brain as a passive means to fight against neurodegenerations. Here, we took the baseline volume and/or thickness of LOAD-associated brain regions as proxies of brain reserve capacities and investigated whether PICALM genetic variations can influence the baseline reserve capacities and the longitudinal atrophy rate of these specific regions using data from Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. In mixed population, we found that brain region significantly affected by PICALM genetic variations was majorly restricted to posterior cingulate. In sub-population analysis, we found that one PICALM variation (C allele of rs642949) was associated with larger baseline thickness of posterior cingulate in health. We found seven variations in health and two variations (rs543293 and rs592297) in individuals with mild cognitive impairment were associated with slower atrophy rate of posterior cingulate. Our study provided preliminary evidences supporting that PICALM variations render protections by facilitating reserve capacities of posterior cingulate in non-demented elderly
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Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis
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- Adeli Anahita
- Aisen Paul
- Albers Colleen S.
- Albert Marilyn
- Albert Marylyn
- Allard Joanne
- Ances Beau
- Anderson Heather S.
- Anderson Karen
- Apostolova Liana
- Arfanakis Konstantinos
- Arnold Steven E.
- Assaly Michele
- Asthana Sanjay
- Bachman David
- Bartha Rob
- Bartzokis George
- Bates Vernice
- Beccera Mauricio
- Beckett Laurel
- Belden Christine M.
- Bell Karen L.
- Bergman Howard
- Bernick Charles
- Bernstein Matthew
- Black Sandra
- Blank Karen
- Borowski Bret
- Borrie Michael
- Brand Connie
- Brewer James
- Brockington John
- Brown Alice D.
- Buckholtz Neil
- Budson Andrew E.
- Burns Jeffrey M.
- Cairns Nigel J.
- Caldwell Curtis
- Capote Horacio
- Carlsson Cynthia M.
- Carmichael Owen
- Carroll Maria
- Carson Richard E.
- Carter Raina
- Cellar Janet S.
- Celmins Dzintra
- Cerbone Brittany
- Chaing Gloria
- Chen Kewei
- Chertkow Howard
- Chowdhury Munir
- Clark David
- Conrad Gary
- Correia Stephen
- Crawford Karen
- D'Agostino Daniel
- Dang Mimi
- Davies Peter
- Davis Melissa
- de Leon Mony J.
- De Santi Susan
- de Toledo-Morrell Leyla
- DeCarli Charles
- DeVous Michael
- Diaz-Arrastia Ramon
- Dolen Sara
- Donohue Michael
- Doody Rachelle S.
- Doraiswamy P. Murali
- Drost Dick
- Duara Ranjan
- Evans A. C.
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- Fargher Kristin
- Farlow Martin R.
- Feldman Howard
- Figurski Michal
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- Fleischman Debra
- Fleisher Adam
- Fletcher Evan
- Foroud Tatiana M.
- Foster Norm
- Fox Nick
- Frank Richard
- Frey Meghan
- Friedl Karl
- Fruehling J. Jay
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- Gessert Devon
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- Graff-Radford Neill R.
- Grafman Jordan
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- Hunt Cynthia
- Ismail M. Saleem
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- Jacobson Sandra A.
- Jagust William
- James Olga
- Jicha Greg
- Jiminez Gus
- Johnson Heather
- Johnson Kathleen
- Johnson Keith A.
- Johnson Kris
- Johnson Nancy
- Johnson Patricia Lynn
- Johnson Sterling
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- Mc-Adams-Ortiz Catherine
- Mesulam M Marcel
- Mesulam Marek-Marsel
- Michel Christina A.
- Miller Bruce L.
- Mintun Mark A.
- Mintzer Jacobo
- Mitsis Effie
- Montine Tom
- Morris John
- Morrison Rosemary
- Mudge Benita
- Mulnard Ruth A.
- Munic Donna
- Neu Scott
- Neylan Thomas
- Nguyen Dana
- Nho Kwangsik
- Norbash Alexander
- Oakley MaryAnn
- Oates Elizabeth
- Ogrocki Paula
- Olichney John
- Oliver Angela
- Onyike Chiadi
- Ott Brian R.
- Parfitt Francine
- Pasternak Stephen
- Paul Steven
- Pawluczyk Sonia
- Pearlson Godfrey D.
- Peskind Elaine R.
- Petersen Ronald
- Petrella Jeffrey R.
- Petrie Eric C.
- Pomara Nunzio
- Ponto Laura L. Boles
- Porsteinsson Anton P.
- Potkin Steven
- Potkin Steven G.
- Potter William
- Preda Adrian
- Querfurth Henry
- Quiceno Mary
- Quinn Joseph
- Rachinsky Irina
- Raichle Marc
- Rainka Michelle
- Raj Balebail Ashok
- Raudin Lisa
- Reeder Stephanie
- Reiman Eric M.
- Relkin Norman
- Reynolds Brigid
- Roberson Erik
- Roberts Peggy
- Rogers John
- Rosen Allyson
- Rosen Howard J.
- Rountree Susan
- Rusinek Henry
- Sabbagh Marwan N.
- Sadowsky Carl
- Salloway Stephen
- Santulli Robert B.
- Sarrael Antero
- Sather Tamie
- Saykin Andrew J.
- Scharre Douglas W.
- Schneider Lon S.
- Schneider Stacy
- Schuff Norbert
- Schultz Susan K.
- Schwartz Adam
- Schwartz Eben S.
- Senjem Matt
- Shah Raj C.
- Shaw Leslie M.
- Shen Li
- Shim Hyungsub
- Silverman Daniel H. S.
- Simpson Donna M.
- Sinha Partha
- Sink Kaycee M.
- Sirrel Sherye A.
- Smith Amanda
- Smith Charles D.
- Smith Karen Elizabeth
- Snyder Peter
- Sorensen Greg
- Sotero R. C.
- Spann Bryan M.
- Sperling Reisa A.
- Spicer Kenneth
- Stefanovic Bojana
- Stern Yaakov
- Swerdlow Russell H.
- Tariot Pierre
- Taylor Joy L.
- Taylor-Reinwald Lisa
- Teodoro Liberty
- Thai Gaby
- Thal Leon
- Thomas Ronald G.
- Thompson Paul
- Tingus Kathleen
- Tinklenberg Jared
- Toga Arthur W.
- Toussaint P. J.
- Tremont Geoffrey
- Trojanowki John Q.
- Turner Raymond Scott
- van Dyck Christopher H.
- Vanderswag Helen
- Varon Daniel
- Vemuri Prashanthi
- Villanueva-Meyer Javier
- Villena Teresa
- Walter Sarah
- Ward Chad
- Watkins Franklin
- Weiner Michael W.
- Weiner Myron
- Williamson Jeff D.
- Wolk David
- Womack Kyle
- Wong Terence Z.
- Woo Ellen
- Wu Chuang-Kuo
- Yesavage Jerome A.
- Zimmerman Earl A.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 09/08/2016
- Field of study
Get PDFMultifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD progression. We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD–abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development. Cognitive decline is noticeable from initial LOAD stages, suggesting early memory deficit associated with the primary disease factors. High abnormality levels are also observed for specific proteins associated with the vascular system's integrity. Although still subjected to the sensitivity of the algorithms and biomarkers employed, our results might contribute to the development of preventive therapeutic interventions
Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients
- Author
- Adam Fleisher
- Adam Fleisher
- Adam Schwartz
- Adrian Preda
- Adrian Preda
- Adrian Preda
- Alan Lerner
- Alexander Norbash
- Alice D. Brown
- Allan I. Levey
- Allyson Rosen
- Alzheimer's Disease Neuroimaging Initiative
- Amanda Smith
- Andrew E. Budson
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew Kertesz
- Andrew Kertesz
- Angela Oliver
- Ann Marie Hake
- Ann Marie Milliken
- Anna Burke
- Ansgar J. Furst
- Antero Sarrael
- Anton P. Porsteinsson
- Anton P. Porsteinsson
- Archana B. Balasubramanian
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Balebail Ashok Raj
- Barton Lane
- Beau Ances
- Becerra Mauricio
- Benita Mudge
- Betty Lind
- Bojana Stefanovic
- Bonnie Goldstein
- Bonnie S. Goldstein
- Borna Bonakdarpour
- Brandy R. Matthews
- Brendan Kelley
- Bret Borowski
- Bret Borowski
- Bret Borowski
- Brian R. Ott
- Brigid Reynolds
- Brigid Reynolds
- Bruce L. Miller
- Bryan M. Spann
- Carl Sadowsky
- Carl Sadowsky
- Chad Ward
- Chad Ward
- Charles Bernick
- Charles D. Smith
- Charles DeCArli
- Charles DeCarli
- Charles DeCarli
- Chet Mathis
- Chiadi Onyike
- Chris Hosein
- Christine M. Belden
- Christopher H. van Dyck
- Christopher M. Clark
- Chuang-Kuo Wu
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Colleen S. Albers
- Connie Brand
- Craig Nelson
- Craig Nelson
- Crawford Karen
- Curtis Caldwell
- Curtis Tatsuoka
- Cynthia M. Carlsson
- Dana Mathews
- Dana Nguyen
- Dana Nguyen
- Dana Nguyen
- Daniel Catalinotto
- Daniel D'Agostino
- Daniel H.S. Silverman
- Daniel Marson
- Daniel Varon
- Danielle Harvey
- Danielle Harvey
- Danielle Harvey
- Dariella Fernandez
- David A. Wolk
- David Bachman
- David Bickford
- David Bickford
- David Clark
- David Geldmacher
- David Holtzman
- David Jones
- David Knopman
- David Perry
- David Perry
- Davis Melissa
- Debra Fleischman
- Denise Reyes
- Devon Gessert
- Devon Gessert
- Diana Kerwin
- Dick Drost
- Dick Trost
- Dino Massoglia
- Donna M. Simpson
- Donna M. Simpson
- Donna Munic
- Douglas W. Scharre
- Dzintra Celmins
- Earl A. Zimmerman
- Edward Coleman
- Effie Mitsis
- Elaine R. Peskind
- Elise Ong
- Elizabeth Finger
- Elizabeth Finger
- Elizabeth Oates
- Elizabeth Shaffer
- Ellen Woo
- Emily Rogalski
- Eric C. Petrie
- Eric M. Reiman
- Eric M. Reiman
- Erik Roberson
- Erin Drake
- Erin Franklin
- Erin Franklin
- Erin Householder
- Evan Fletcher
- Finley Shannon
- Francine Parfitt
- Franklin Watkins
- Franz Hefti
- Friedl Karl
- Gad Marshall
- Gad Marshall
- Gaikwad Mrunalini
- Gail Li
- Gary Conrad
- Geoffrey Tremont
- George Bartzokis
- Gessert Devon
- Ging-Yuek Robin Hsiung
- Gloria Chiang
- Gloria Chiang
- Godfrey D. Pearlson
- Gordineer Leslie
- Greg Jicha
- Greg Sorensen
- Gus Jiminez
- Gus Jiminez
- Gustavo Jimenez
- Hayes Jacqueline
- Helen Vanderswag
- Helen Vanderswag
- Hillel Grossman
- Horacio Capote
- Howard Bergman
- Howard Chertkow
- Howard Feldman
- Howard Fillit
- Howard J. Rosen
- Howard Rosen
- Howard Rosen
- Hristina Koleva
- Hyungsub Shim
- Irina Rachinsky
- Irina Rachisky
- Iris Sim
- J. Jay Fruehling
- Jacobo Mintzer
- Jacobo Mintzer
- James Brewer
- James Brewer
- James J. Lah
- Janet S. Cellar
- Jared R. Brosch
- Jared Tinklenberg
- Jason H. Karlawish
- Javier Villanueva-Meyer
- Jeff D. Williamson
- Jeff Gunter
- Jeff Gunter
- Jeff Gunter
- Jeffrey Kaye
- Jeffrey M. Burns
- Jeffrey R. Petrella
- Jeffrey R. Petrella
- Jennifer Mason
- Jennifer Salazar
- Jerome A. Yesavage
- Jerome Yesavage
- Joanne Allard
- Joanne Allard
- Joanne L. Lord
- John Brockington
- John C. Morris
- John C. Morris
- John C. Morris
- John C. Morris
- John Hsiao
- John Morris
- John Olichney
- John Q. Trojanowki
- John Q. Trojanowki
- John Q. Trojanowki
- John Q. Trojanowki
- John Rogers
- Jordan Grafman
- Joseph Quinn
- Joy L. Taylor
- Joy L. Taylor
- Judith L. Heidebrink
- Kantarci Kejal
- Karen Anderson
- Karen Blank
- Karen Crawford
- Karen Crawford
- Karen Ekstam Smith
- Karen L. Bell
- Karen L. Bell
- Kathleen Johnson
- Kathleen Tingus
- Kaycee M. Sink
- Keith A. Johnson
- Keith A. Johnson
- Kejal Kantarci
- Kejal Kantarci
- Kelley Faber
- Kelley Faber
- Kelley M. Faber
- Kelly Behan
- Kelly Harless
- Kelly M. Makino
- Kelly N. Nudelman
- Kelly Scherer
- Kenneth Spicer
- Kewei Chen
- Kewei Chen
- Ki Won Nam
- Kim Martin
- Kim Poki-Walker
- Kimberly S. Martin
- Konstantinos Arfanakis
- Kris Johnson
- Kristin Fargher
- Kristine Lipowski
- Kwangsik Nho
- Kwangsik Nho
- Kwangsik Nho
- Kyle Womack
- Laura A. Flashman
- Laurel Beckett
- Laurel Beckett
- Lawrence S. Honig
- Lawrence S. Honig
- Lean Thal
- Leon Thal
- Leslie M. Shaw
- Leslie M. Shaw
- Leslie M. Shaw
- Leslie M. Shaw
- Lew Kuller
- Leyla deToledo-Morrell
- Li Shen
- Li Shen
- Liana Apostolova
- Liberty Teodoro
- Lindsey Hergesheimer
- Lingxia Ha
- Lingxia Ha
- Lisa Ravdin
- Lisa Ravdin
- Lisa Ravdin
- Lisa Silbert
- Lisa Taylor-Reinwald
- Lon S. Schneider
- Lon S. Schneider
- Lori A. Daiello
- M. Marcel Mesulam
- M. Saleem Ismail
- Magdalena Korecka
- Magdalena Korecka
- Marc Raichle
- Marc Seltzer
- Marek-Marsel Mesulam
- Maria Carrillo
- Maria Carroll
- Maria Kataki
- Maria T Greig
- Maria T. Greig-Custo
- Marilyn Albert
- Marilyn Albert
- Marissa Natelson Love
- Mark A. Mintun
- Martha G. MacAvoy
- Martin R. Farlow
- Martin Sadowski
- Marwan N. Sabbagh
- Marwan N. Sabbagh
- Mary L. Creech
- Mary L. Hynes
- Mary Quiceno
- MaryAnn Oakley
- MaryAnn Oakley
- Matt Senjem
- Matt Senjem
- Matt Senjem
- Matthew Bernstein
- Matthew Bernstein
- Matthew Bernstein
- Mauricio Becerra
- Meryl Butters
- Meryl Butters
- Michael Borrie
- Michael Donohue
- Michael Donohue
- Michael Donohue
- Michael Donohue
- Michael Lin
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael Weiner
- Michael Weiner
- Michael Weiner
- Michael Weiner
- Michael Weiner
- Michal Figurski
- Michal Figurski
- Michele Assaly
- Michelle Rainka
- Michelle Zmuda
- Michelle Zmuda
- Mike Donohue
- Mimi Dang
- Min Liu
- Min Liu
- Mohammed O. Sheikh
- Munir Chowdhury
- Nadira Trncic
- Nancy Johnson
- Neil Buckholtz
- Neil Kowall
- Neill R Graff-Radford
- Neu Scott
- Nick Fox
- Nigel J. Cairns
- Nigel J. Cairns
- Norbert Schuff
- Norm Foster
- Norm Foster
- Norman Relkin
- Norman Relkin
- Nunzio Pomara
- Olga Brawman-Mintzer
- Olga James
- Oscar L. Lopez
- Oscar L. Lopez
- Owen Carmichael
- P. Murali Doraiswamy
- P. Murali Doraiswamy
- Parianne Fatica
- Partha Sinha
- Patricia Lynn Johnson
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Malloy
- Paul Thompson
- Paula Ogrocki
- Pauline Maillard
- Peter Davies
- Peter Hardy
- Peter J. Snyder
- Peter Snyder
- Pierre Tariot
- Po H. Lu
- Pradeep Garg
- Pradeep Varma
- Prashanthi Vemuri
- Qian Zhao
- Qian Zhao
- Rachelle S. Doody
- Raina Carter
- Raj C. Shah
- Raj C. Shah
- Randall Griffith
- Ranjan Duara
- Ranjan Duara
- Raymond Scott Turner
- Raymond Scott Turner
- Raymundo Hernando
- Reisa A. Sperling
- Reisa A. Sperling
- Rema Raman
- Rema Raman
- Rema Raman
- Richard E. Carson
- Richard Frank
- Rob Bartha
- Robert A. Koeppe
- Robert A. Koeppe
- Robert A. Koeppe
- Robert A. Koeppe
- Robert B. Santulli
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Ronald G. Thomas
- Ronald G. Thomas
- Ronald Killiany
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Rosemary Morrison
- Russell H. Swerdlow
- Saba Wolday
- Saba Wolday
- Salvador Borges-Neto
- Samuel Stark
- Sandra A. Jacobson
- Sandra A. Jacobson
- Sandra Black
- Sandra Harding
- Sandra Weintraub
- Sanjay Asthana
- Sara Dolen
- Sara S. Mason
- Sarah Walter
- Sarah Walter
- Scott Herring
- Scott Mackin
- Scott Mackin
- Scott Mackin
- Scott Mackin
- Scott Neu
- Scott Neu
- Sherye A. Sirrel
- Sherye A. Sirrel
- Smita Kittur
- Sonia Pawluczyk
- Sonia Pawluczyk
- Stacy Schneider
- Stephanie Kielb
- Stephanie Reeder
- Stephen Correia
- Stephen Pasternack
- Stephen Pasternak
- Stephen Salloway
- Sterling C. Johnson
- Sterling Johnson
- Steven Chao
- Steven E. Arnold
- Steven G. Potkin
- Steven G. Potkin
- Steven G. Potkin
- Steven Paul
- Steven Paul
- Steven Potkin
- Steven Potkin
- Sungeun Kim
- Sungeun Kim
- Susan K. Schultz
- Susan Landau
- Susan Landau
- Susan Landau
- Susan Landau
- Susan Landau
- Susan Rountree
- T-Y Lee
- Tamie Sather
- Tamie Sather
- Tatiana M. Foroud
- Tatiana M. Foroud
- Tatiana M. Foroud
- Terence Z. Wong
- Teresa Villena
- Teresa Villena
- Thomas Neylan
- Thomas Neylan
- Thomas O. Obisesan
- Thomas O. Obisesan
- Tom Montine
- Tom Montine
- Ulysse Anaztasia
- Valory Pavlik
- Vernice Bates
- Vesna Sossi
- Victoria Shibley
- Virginia Lee
- Virginia Lee
- Walter Martinez
- Ward Chad
- Warren Barker
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William M. Brooks
- William Potter
- William Potter
- Yaakov Stern
- Yaakov Stern
- Yiu Ho Au
- Yuliana Cabrera
- Yun Zhou
- Yun Zhou
- Zaven Khachaturian
- Zaven Khachaturian
- Zaven Khachaturian
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/05/2019
- Field of study
Get PDFRecent developments of tau Positron Emission Tomography (PET) allows assessment of regional neurofibrillary tangles (NFTs) deposition in human brain. Among the tau PET molecular probes, 18F-AV1451 is characterized by high selectivity for pathologic tau aggregates over amyloid plaques, limited non-specific binding in white and gray matter, and confined off-target binding. The objectives of the study are (1) to quantitatively characterize regional brain tau deposition measured by 18F-AV1451 PET in cognitively normal older adults (CN), mild cognitive impairment (MCI), and AD participants; (2) to evaluate the correlations between cerebrospinal fluid (CSF) biomarkers or Mini-Mental State Examination (MMSE) and 18F-AV1451 PET standardized uptake value ratio (SUVR); and (3) to evaluate the partial volume effects on 18F-AV1451 brain uptake.Methods: The study included total 115 participants (CN = 49, MCI = 58, and AD = 8) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Preprocessed 18F-AV1451 PET images, structural MRIs, and demographic and clinical assessments were downloaded from the ADNI database. A reblurred Van Cittertiteration method was used for voxelwise partial volume correction (PVC) on PET images. Structural MRIs were used for PET spatial normalization and region of interest (ROI) definition in standard space. The parametric images of 18F-AV1451 SUVR relative to cerebellum were calculated. The ROI SUVR measurements from PVC and non-PVC SUVR images were compared. The correlation between ROI 18F-AV1451 SUVR and the measurements of MMSE, CSF total tau (t-tau), and phosphorylated tau (p-tau) were also assessed.Results:18F-AV1451 prominently specific binding was found in the amygdala, entorhinal cortex, parahippocampus, fusiform, posterior cingulate, temporal, parietal, and frontal brain regions. Most regional SUVRs showed significantly higher uptake of 18F-AV1451 in AD than MCI and CN participants. SUVRs of small regions like amygdala, entorhinal cortex and parahippocampus were statistically improved by PVC in all groups (p < 0.01). Although there was an increasing tendency of 18F-AV-1451 SUVRs in MCI group compared with CN group, no significant difference of 18F-AV1451 deposition was found between CN and MCI brains with or without PVC (p > 0.05). Declined MMSE score was observed with increasing 18F-AV1451 binding in amygdala, entorhinal cortex, parahippocampus, and fusiform. CSF p-tau was positively correlated with 18F-AV1451 deposition. PVC improved the results of 18F-AV-1451 tau deposition and correlation studies in small brain regions.Conclusion: The typical deposition of 18F-AV1451 tau PET imaging in AD brain was found in amygdala, entorhinal cortex, fusiform and parahippocampus, and these regions were strongly associated with cognitive impairment and CSF biomarkers. Although more deposition was observed in MCI group, the 18F-AV-1451 PET imaging could not differentiate the MCI patients from CN population. More tau deposition related to decreased MMSE score and increased level of CSF p-tau, especially in ROIs of amygdala, entorhinal cortex and parahippocampus. PVC did improve the results of tau deposition and correlation studies in small brain regions and suggest to be routinely used in 18F-AV1451 tau PET quantification
Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images
- Author
- Adam Fleisher
- Adam Fleisher
- Adam Schwartz
- Adrian Preda
- Adrian Preda
- Adrian Preda
- Alan Lerner
- Alexander Norbash
- Alice D. Brown
- Allan I. Levey
- Allyson Rosen
- Amanda Smith
- Andrew E. Budson
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew Kertesz
- Andrew Kertesz
- Angela Oliver
- Ann Marie Hake
- Ann Marie Milliken
- Anna Burke
- Ansgar J. Furst
- Antero Sarrael
- Anton P. Porsteinsson
- Anton P. Porsteinsson
- Archana B. Balasubramanian
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Balebail Ashok Raj
- Barton Lane
- Beau Ances
- Becerra Mauricio
- Benita Mudge
- Betty Lind
- Bojana Stefanovic
- Bonnie Goldstein
- Bonnie S. Goldstein
- Borna Bonakdarpour
- Brandy R. Matthews
- Brendan Kelley
- Bret Borowski
- Bret Borowski
- Brian R. Ott
- Brigid Reynolds
- Brigid Reynolds
- Bruce L. Miller
- Bryan M. Spann
- Carl Sadowsky
- Carl Sadowsky
- Chad Ward
- Charles Bernick
- Charles D. Smith
- Charles DeCArli
- Charles DeCarli
- Chet Mathis
- Chiadi Onyike
- Chris Hosein
- Christine M. Belden
- Christopher H. van Dyck
- Christopher M. Clark
- Chuang-Kuo Wu
- Chunren Lai
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Colleen S. Albers
- Congling Wu
- Connie Brand
- Crawford Karen
- Curtis Caldwell
- Curtis Tatsuoka
- Cynthia M. Carlsson
- Dana Mathews
- Dana Nguyen
- Dana Nguyen
- Dana Nguyen
- Daniel D'Agostino
- Daniel H.S. Silverman
- Daniel Marson
- Daniel Varon
- Danielle Harvey
- Danielle Harvey
- Danielle Harvey
- David A. Wolk
- David Bachman
- David Clark
- David Geldmacher
- David Holtzman
- David Jones
- David Knopman
- David Perry
- David Perry
- Davis Melissa
- Debra Fleischman
- Devon Gessert
- Diana Kerwin
- Dick Drost
- Dick Trost
- Dino Massoglia
- Donna M. Simpson
- Donna Munic
- Douglas W. Scharre
- Dzintra Celmins
- Earl A. Zimmerman
- Edward Coleman
- Effie Mitsis
- Elaine R. Peskind
- Elizabeth Finger
- Elizabeth Finger
- Elizabeth Oates
- Ellen Woo
- Emily Rogalski
- Eric C. Petrie
- Eric M. Reiman
- Eric M. Reiman
- Erik Roberson
- Erin Franklin
- Erin Franklin
- Erin Householder
- Evan Fletcher
- Finley Shannon
- Francine Parfitt
- Franklin Watkins
- Franz Hefti
- Friedl Karl
- Gad Marshall
- Gad Marshall
- Gaikwad Mrunalini
- Gail Li
- Gary Conrad
- Geoffrey Tremont
- George Bartzokis
- Gessert Devon
- Ging-Yuek Robin Hsiung
- Gloria Chiang
- Gloria Chiang
- Godfrey D. Pearlson
- Gordineer Leslie
- Greg Jicha
- Greg Sorensen
- Guiyin Cen
- Gus Jiminez
- Gus Jiminez
- Hayes Jacqueline
- Helen Vanderswag
- Helen Vanderswag
- Hillel Grossman
- Horacio Capote
- Howard Bergman
- Howard Chertkow
- Howard Feldman
- Howard Fillit
- Howard J. Rosen
- Howard Rosen
- Hristina Koleva
- Hyungsub Shim
- Irina Rachinsky
- Irina Rachisky
- Iris Sim
- J. Jay Fruehling
- Jacobo Mintzer
- Jacobo Mintzer
- James Brewer
- James Brewer
- James J. Lah
- Janet S. Cellar
- Jared R. Brosch
- Jared Tinklenberg
- Jason H. Karlawish
- Javier Villanueva-Meyer
- Jeff D. Williamson
- Jeff Gunter
- Jeff Gunter
- Jeffrey Kaye
- Jeffrey M. Burns
- Jeffrey R. Petrella
- Jeffrey R. Petrella
- Jennifer Mason
- Jerome A. Yesavage
- Jerome Yesavage
- Joanne Allard
- Joanne Allard
- Joanne L. Lord
- John Brockington
- John C. Morris
- John C. Morris
- John C. Morris
- John C. Morris
- John Hsiao
- John Morris
- John Olichney
- John Q. Trojanowki
- John Q. Trojanowki
- John Q. Trojanowki
- John Q. Trojanowki
- John Rogers
- Jordan Grafman
- Joseph Quinn
- Joy L. Taylor
- Joy L. Taylor
- Judith L. Heidebrink
- Kantarci Kejal
- Karen Anderson
- Karen Blank
- Karen Crawford
- Karen Ekstam Smith
- Karen L. Bell
- Karen L. Bell
- Kathleen Johnson
- Kathleen Tingus
- Kaycee M. Sink
- Keith A. Johnson
- Keith A. Johnson
- Kejal Kantarci
- Kelley Faber
- Kelley Faber
- Kelly Behan
- Kelly M. Makino
- Kenneth Spicer
- Kewei Chen
- Kewei Chen
- Ki Won Nam
- Kim Martin
- Kim Poki-Walker
- Kimberly S. Martin
- Konstantinos Arfanakis
- Kris Johnson
- Kristin Fargher
- Kristine Lipowski
- Kwangsik Nho
- Kwangsik Nho
- Kyle Womack
- Laura A. Flashman
- Laurel Beckett
- Laurel Beckett
- Lawrence S. Honig
- Lawrence S. Honig
- Lean Thal
- Leon Thal
- Leslie M. Shaw
- Leslie M. Shaw
- Leslie M. Shaw
- Leslie M. Shaw
- Lew Kuller
- Leyla deToledo-Morrell
- Li Shen
- Li Shen
- Liana Apostolova
- Liberty Teodoro
- Lisa Ravdin
- Lisa Ravdin
- Lisa Silbert
- Lisa Taylor-Reinwald
- Lon S. Schneider
- Lon S. Schneider
- Lori A. Daiello
- M. Marcel Mesulam
- M. Saleem Ismail
- Magdalena Korecka
- Magdalena Korecka
- Marc Raichle
- Marc Seltzer
- Marek-Marsel Mesulam
- Maria Carrillo
- Maria Carroll
- Maria Kataki
- Maria T Greig
- Maria T. Greig-Custo
- Marilyn Albert
- Marilyn Albert
- Marissa Natelson Love
- Mark A. Mintun
- Martha G. MacAvoy
- Martin R. Farlow
- Martin Sadowski
- Marwan N. Sabbagh
- Marwan N. Sabbagh
- Mary L. Creech
- Mary L. Hynes
- Mary Quiceno
- MaryAnn Oakley
- Matt Senjem
- Matt Senjem
- Matthew Bernstein
- Matthew Bernstein
- Mauricio Becerra
- Michael Borrie
- Michael Donohue
- Michael Donohue
- Michael Donohue
- Michael Donohue
- Michael Lin
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael Weiner
- Michael Weiner
- Michael Weiner
- Michal Figurski
- Michal Figurski
- Michele Assaly
- Michelle Rainka
- Mimi Dang
- Mohammed O. Sheikh
- Munir Chowdhury
- Nadira Trncic
- Nancy Johnson
- Neil Buckholtz
- Neil Kowall
- Neill R Graff-Radford
- Neu Scott
- Nick Fox
- Nigel J. Cairns
- Nigel J. Cairns
- Norbert Schuff
- Norm Foster
- Norm Foster
- Norman Relkin
- Norman Relkin
- Nunzio Pomara
- Olga Brawman-Mintzer
- Olga James
- Oscar L. Lopez
- Owen Carmichael
- P. Murali Doraiswamy
- P. Murali Doraiswamy
- Parianne Fatica
- Partha Sinha
- Patricia Lynn Johnson
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Malloy
- Paul Thompson
- Paula Ogrocki
- Pauline Maillard
- Peter Davies
- Peter Hardy
- Peter J. Snyder
- Peter Snyder
- Pierre Tariot
- Po H. Lu
- Pradeep Garg
- Pradeep Varma
- Prashanthi Vemuri
- Rachelle S. Doody
- Raina Carter
- Raj C. Shah
- Raj C. Shah
- Randall Griffith
- Ranjan Duara
- Ranjan Duara
- Raymond Scott Turner
- Raymond Scott Turner
- Raymundo Hernando
- Reisa A. Sperling
- Reisa A. Sperling
- Richard E. Carson
- Richard Frank
- Rob Bartha
- Robert A. Koeppe
- Robert A. Koeppe
- Robert B. Santulli
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Ronald G. Thomas
- Ronald G. Thomas
- Ronald Killiany
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Rosemary Morrison
- Russell H. Swerdlow
- Saba Wolday
- Saba Wolday
- Salvador Borges-Neto
- Sandra A. Jacobson
- Sandra A. Jacobson
- Sandra Black
- Sandra Harding
- Sandra Weintraub
- Sanjay Asthana
- Sara Dolen
- Sara S. Mason
- Sarah Walter
- Scott Herring
- Scott Neu
- Shengwen Guo
- Sherye A. Sirrel
- Sherye A. Sirrel
- Smita Kittur
- Sonia Pawluczyk
- Sonia Pawluczyk
- Stacy Schneider
- Stephanie Kielb
- Stephanie Reeder
- Stephen Correia
- Stephen Pasternack
- Stephen Pasternak
- Stephen Salloway
- Sterling C. Johnson
- Sterling Johnson
- Steven Chao
- Steven E. Arnold
- Steven G. Potkin
- Steven G. Potkin
- Steven G. Potkin
- Steven Paul
- Steven Paul
- Steven Potkin
- Steven Potkin
- Sungeun Kim
- Sungeun Kim
- Susan K. Schultz
- Susan Landau
- Susan Landau
- Susan Landau
- Susan Rountree
- T-Y Lee
- Tamie Sather
- Tamie Sather
- Tatiana M. Foroud
- Tatiana M. Foroud
- Terence Z. Wong
- Teresa Villena
- Teresa Villena
- The Alzheimer's Disease Neuroimaging Initiative
- Thomas Neylan
- Thomas Neylan
- Thomas O. Obisesan
- Thomas O. Obisesan
- Tom Montine
- Tom Montine
- Ulysse Anaztasia
- Valory Pavlik
- Vernice Bates
- Vesna Sossi
- Victoria Shibley
- Virginia Lee
- Virginia Lee
- Walter Martinez
- Ward Chad
- Warren Barker
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William M. Brooks
- William Potter
- William Potter
- Yaakov Stern
- Yaakov Stern
- Zaven Khachaturian
- Zaven Khachaturian
- Zaven Khachaturian
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/05/2017
- Field of study
Get PDFNeuroimaging measurements derived from magnetic resonance imaging provide important information required for detecting changes related to the progression of mild cognitive impairment (MCI). Cortical features and changes play a crucial role in revealing unique anatomical patterns of brain regions, and further differentiate MCI patients from normal states. Four cortical features, namely, gray matter volume, cortical thickness, surface area, and mean curvature, were explored for discriminative analysis among three groups including the stable MCI (sMCI), the converted MCI (cMCI), and the normal control (NC) groups. In this study, 158 subjects (72 NC, 46 sMCI, and 40 cMCI) were selected from the Alzheimer's Disease Neuroimaging Initiative. A sparse-constrained regression model based on the l2-1-norm was introduced to reduce the feature dimensionality and retrieve essential features for the discrimination of the three groups by using a support vector machine (SVM). An optimized strategy of feature addition based on the weight of each feature was adopted for the SVM classifier in order to achieve the best classification performance. The baseline cortical features combined with the longitudinal measurements for 2 years of follow-up data yielded prominent classification results. In particular, the cortical thickness produced a classification with 98.84% accuracy, 97.5% sensitivity, and 100% specificity for the sMCI–cMCI comparison; 92.37% accuracy, 84.78% sensitivity, and 97.22% specificity for the cMCI–NC comparison; and 93.75% accuracy, 92.5% sensitivity, and 94.44% specificity for the sMCI–NC comparison. The best performances obtained by the SVM classifier using the essential features were 5–40% more than those using all of the retained features. The feasibility of the cortical features for the recognition of anatomical patterns was certified; thus, the proposed method has the potential to improve the clinical diagnosis of sub-types of MCI and predict the risk of its conversion to Alzheimer's disease
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.
- Author
- Aban Marites
- Abayomi Fatola
- Abeyskera Kushala
- Aboagye Jeremy
- Adam Matthew
- Adams Kirsty
- Adamson James
- Adelaja Yemi A.
- Adlou Syed
- Ahmed Khatija
- Akhalwaya Saajida
- Akhalwaya Yasmeen
- Alcock Andrew
- Aley Parvinder K.
- Ali Aabidah
- Allen Elizabeth R.
- Allen Lauren
- Almeida Thamires C. D. S. C
- Alves Mariana P.S.
- Amorim Fabio
- Andritsou Foteini
- Angus Brian
- Anslow Rachel
- Appleby Matthew
- Arbe-Barnes Edward H.
- Ariaans Mark P.
- Arns Beatriz
- Arruda Laiana
- Awedetan Gbadebo
- Azi Lorena
- Azi Paula
- Babbage Gavin
- Bailey Catherine
- Baillie Vicky L.
- Baker Kenneth F.
- Baker Megan
- Baker Natalie
- Baker Philip
- Baldwin Lisa
- Baleanu Ioana
- Bandeira Danieli
- Bara Anna
- Barbosa Marcella A.S.
- Barker Debbie
- Barlow Gavin D.
- Barnabas Shaun L.
- Barnes Eleanor
- Barr Andrew S.
- Barrett Jessica
- Barrett Jordan R.
- Bates Louise
- Batten Alexander
- Beadon Kirsten
- Beales Emily
- Beckley Rebecca
- Belij-Rammerstorfer Sandra
- Bell Jonathan
- Bellamy Duncan
- Bellei Nancy
- Belton Sue
- Berg Adam
- Bermejo Laura
- Berrie Eleanor
- Berry Lisa
- Berzenyi Daniella
- Beveridge Amy
- Bewley Kevin R.
- Bexhell Helen
- Bhikha Sutika
- Bhorat Asad E.
- Bhorat Qasim E.
- Bhorat Zaheda E.
- Bibi Sagida
- Bijker Else
- Birch Geeta
- Birch Sarah
- Bird Adam
- Bird Olivia
- Bisnauthsing Karen
- Bittaye Mustapha
- Blackstone Katherine
- Blackwell Luke
- Bletchly Heather
- Blundell Caitlin L.
- Blundell Susannah R.
- Bodalia Pritesh
- Boettger Bruno C.
- Bolam Emma
- Boland Elena
- Bormans Daan
- Borthwick Nicola
- Bowring Francesca
- Boyd Amy
- Bradley Penny
- Brenner Tanja
- Briner Carmen
- Brown Claire
- Brown Phillip
- Brown-O'Sullivan Charlie
- Bruce Scott
- Brunt Emily
- Buchan Ruaridh
- Budd William
- Bulbulia Yusuf A.
- Bull Melanie
- Burbage Jamie
- Burhan Hassan
- Burn Aileen
- Buttigieg Karen R.
- Byard Nicholas
- Cabera Puig Ingrid
- Calderon Gloria
- Calvert Anna
- Camara Susana
- Cao Michelangelo
- Cappuccini Federica
- Cardoso João R.
- Carr Melanie
- Carroll Miles W.
- Carson-Stevens Andrew
- Carvalho José A.M.
- Carvalho Yasmin de M.
- Casey Helen R.
- Cashen Paul
- Castro Lucia Carratala
- Castro Thais
- Cathie Katrina
- Cavey Ana
- Cerbino-Neto José
- Chadwick Jim
- Chapman David
- Charlton Sue
- Chelysheva Irina
- Chester Oliver
- Chita Sunder
- Cho Jee-Sun
- Cicconi Paola
- Cifuentes Liliana
- Clark Elizabeth
- Clark Matthew
- Clarke Andrea
- Clemens Sue Ann Costa
- Clutterbuck Elizabeth A.
- Colin-Jones Rachel
- Collins Andrea M.
- Collins Sarah L.K.
- Conlon Christopher P.
- Connarty Sean
- Coombes Naomi
- Cooper Cushla
- Cooper Rachel
- Cornelissen Lynne
- Corrah Tumena
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- Crocker Wendy E.M.
- Crosbie Sarah
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- Cullen Lorraine
- Cunha Debora R.M.F.
- Cunningham Christina
- Cuthbertson Fiona C.
- Cutland Clare L.
- Da Guarda Suzete N. Farias
- da Silva Moraes Antonio Carlos
- da Silva Larissa P.
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- Danos Zsofia
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- Darton Thomas C.
- Datoo Mehreen S.
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- De Nobrega Maristela M.D.
- De Oliveira Kalid Lis Moreno
- Dearlove David
- Demissie Tesfaye
- Desai Amisha
- Dheda Keertan
- Di Marco Stefania
- Di Maso Claudio
- Dinelli Maria I.S.
- Dinesh Tanya
- Docksey Claire
- Dold Christina
- Dong Tao
- Donnellan Francesca R.
- Dos Santos Erika Pachecho
- Dos Santos Tannyth
- dos Santos Thainá G.
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- Douglas Naomi
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- Drake Jonathan
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- Driver Kimberley
- Drury Ruth
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- Dunachie Susanna J.
- Duncan Christopher J. A.
- Durham Benjamin S.
- Dutra Lidiana
- Easom Nicholas J.W.
- Edwards Mandy
- Edwards Nick J.
- El Muhanna Omar M.
- Elias Sean C.
- Elmore Mike
- Emary Katherine R. W.
- English Marcus
- Esmail Alisgair
- Essack Yakub Moosa
- Ewer Katie J.
- Fairlie Lee
- Farmer Eoghan
- Farooq Mutjaba
- Farrar Madi
- Farrugia Leonard
- Faulkner Beverley
- Faust Saul N.
- Fedosyuk Sofiya
- Felle Sally
- Feng Shuo
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- Ferreira Da Silva Carla
- Ferreira Daniela M.
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- Fisher Richard
- Flaxman Amy
- Fletcher James
- Fofie Hazel
- Fok Henry
- Folegatti Pedro M.
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- Fowler Jamie
- Fraiman Pedro H.A.
- Francis Emma
- Franco Marilia M.
- Frater John
- Freire Marilúcia S.M.
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- Furze Julie
- Fuskova Michelle
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- Garlant Harriet
- Gavrila Madita
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- Gibbons Karyna A.
- Gilbert Sarah C
- Gilbride Ciaran
- Gill Hardeep
- Glynn Sharon
- Godwin Kerry
- Gokani Karishma
- Goldoni Ursula Carvalho
- Goncalves Maria
- Gonzalez Isabela G.S.
- Goodman Anna L.
- Goodwin Jayne
- Goondiwala Amina
- Gordon-Quayle Katherine
- Gorini Giacomo
- Grab Janet
- Gracie Lara
- Green Catherine M.
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- Greenwood Nicola
- Greffrath Johann
- Groenewald Marisa M.
- Grossi Leonardo
- Gupta Gaurav
- Hackett Mark
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- Jenkin Daniel
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- Joe Carina C. D.
- Jones Bryony
- Jones Christopher
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- Jorge Marianna Rocha
- Jose Aylin
- Joshi Amar
- Júnior Eduardo A.M.S.
- Kadziola Joanne
- Kailath Reshma
- Kana Faeeza
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- Libri Vincenzo
- Lillie Patrick J.
- Linder Aline
- Lipworth Samuel
- Liu Shuchang
- Liu Xinxue
- Lloyd Adam
- Lloyd Stephanie
- Loew Lisa
- Lopez Ramon Raquel
- Lora Leandro
- Lowthorpe Vicki
- Luz Kleber
- MacDonald Jonathan C.
- MacGregor Gordon
- Madhavan Meera
- Madhi Shabir A.
- Mainwaring David O.
- Makambwa Edson
- Makinson Rebecca
- Malahleha Mookho
- Malamatsho Ross
- Mallett Garry
- Mallory Raburn
- Mansatta Kushal
- Maoko Takalani
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- Masenya Masebole
- Masilela Mduduzi
- Masters Shauna K.
- Mathew Moncy
- Matlebjane Hosea
- Matshidiso Kedidimetse
- Mazur Olga
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- McIntyre Zoe
- McLenaghan Daniela
- McRobert Nicky
- McSwiggan Steve
- Megson Clare
- Mehdipour Savviz
- Meijs Wilma
- Mendes Ana V .A.
- Mendonça Renata N.Á.
- Mentzer Alexander J.
- Milan Eveline P.
- Minassian Angela M.
- Mirtorabi Neginsadat
- Mitton Celia
- Mnyakeni Sibusiso
- Moghaddas Fiona
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- Moran Marni
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- Morris Helen C.
- Morris Sheila
- Morris Susan
- Morrison Hazel
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- Morshead Gertraud
- Morter Richard
- Mottal Lynelle
- Moultrie Andrew
- Moya Nathifa
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- Msomi Sibekezelo
- Mugodi Yvonne
- Mujadidi Yama F.
- Mukhopadhyay Ekta
- Muller Jilly
- Munro Alasdair
- Munro Claire
- Murphy Sarah
- Mweu Philomena
- Myasaki Celia Hatsuko
- Naik Gurudutt
- Naker Kush
- Nana Anusha
- Nastouli Eleni
- Nazir Abida
- Ndlovu Bongani
- Neffa Fabio
- Njenga Cecilia
- Noal Helena
- Novaes Gabrielle
- Noé Andrés
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- Nunes Géssika
- O'Brien Katie
- O'Connor Daniel
- O'Reilly Paula
- O'Reilly Peter J.
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- Oguti Blanche
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- Oldfield Neil J.
- Oliveira Catarina
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- Owen David R.J.
- Owen Lydia
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- Pacurar Mihaela
- Padayachee Sherman D.
- Paiva Brenda V.B.
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- Parkinson Sivapriyai
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- Patel Faeezah
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- Peralta Alvarez Marco Polo
- Perring James
- Perry Nicola
- Perumal Rubeshan
- Petkar Sahir
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- Phillips Daniel J.
- Phillips Jennifer
- Phohu Mary Kgomotso
- Pickup Lorinda
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- Ramasamy Maheshi N.
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- Ramos Alberto San Francisco
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- Shiham Farah
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- Szigeti Anna
- Tahiri-Alaoui Abdessamad
- Tanner Rachel
- Taoushanis Carol
- Tarr Alexander W.
- Tarrant Richard
- Taylor Iona Jennifer
- Taylor Justin
- Taylor Keja
- Taylor Ursula
- te Water Naude Rebecca
- Themistocleous Andreas
- Themistocleous Yrene
- Thomas Kelly
- Thomas Merin
- Thomas Tonia M.
- Thombrayil Asha
- Thompson Amber
- Thompson Ameeka
- Thompson Fawziyah
- Thompson Kevin
- Thomson Emma C.
- Thomson Julia
- Thornton-Jones Viv
- Tighe Patrick J.
- Tinoco Lygia Accioly
- Tiongson Gerlynn
- Tladinyane Bonolo
- Tomasicchio Michele
- Tomic Adriana
- Tonks Susan
- Toshner Mark
- Tran Nguyen
- Tree Julia
- Trillana Gerry
- Trinham Charlotte
- Trivett Rose
- Truby Adam
- Tsheko Betty Lebogang
- Turabi Aadil
- Turner Cheryl
- Turner David P. J.
- Turner Richard
- Török M Estée
- Ulaszewska Marta
- Underwood Benjamin R.
- van Eck Samual
- Varughese Rachel
- Vekemans Johan
- Verbart Dennis
- Verheul Marije
- Vichos Iason
- Vieira Taiane
- Villafana Tonya L.
- Voysey Merryn
- Waddington Claire S.
- Walker Laura
- Wallis Erica
- Wand Matthew
- Warbick Deborah
- Wardell Theresa
- Warimwe George
- Warren Sarah C.
- Watkins Bridget
- Watson Ekaterina
- Watson Marion E. E.
- Webb Stewart
- Webb-Bridges Alice
- Webster Angela
- Weckx Lily Y.
- Welch Jessica
- Wells Jeanette
- West Alison
- White Caroline
- White Rachel
- Williams Christopher J.
- Williams Paul
- Williams Rachel L.
- Winslow Rebecca
- Woodyer Mark
- Worth Andrew T.
- Wright Danny
- Wroblewska Marzena
- Yao Andy
- Zimmer Rafael
- Zizi Dalila
- Zuidewind Peter
- Publication venue
- 'Elsevier BV'
- Publication date
- 03/12/2020
- Field of study
Get PDFBACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
- Author
- Aban Marites
- Abayomi Fatola
- Abeyskera Kushala
- Aboagye Jeremy
- Adam Matthew
- Adams Kirsty
- Adamson James
- Adelaja Yemi A.
- Adlou Syed
- Ahmed Khatija
- Akhalwaya Saajida
- Akhalwaya Yasmeen
- Alcock Andrew
- Aley Parvinder K.
- Ali Aabidah
- Allen Elizabeth R.
- Allen Lauren
- Almeida Thamires C. D. S. C
- Alves Mariana P.S.
- Amorim Fabio
- Andritsou Foteini
- Angus Brian
- Anslow Rachel
- Appleby Matthew
- Arbe-Barnes Edward H.
- Ariaans Mark P.
- Arns Beatriz
- Arruda Laiana
- Awedetan Gbadebo
- Azi Lorena
- Azi Paula
- Babbage Gavin
- Bailey Catherine
- Baillie Vicky L.
- Baker Kenneth F.
- Baker Megan
- Baker Natalie
- Baker Philip
- Baldwin Lisa
- Baleanu Ioana
- Bandeira Danieli
- Bara Anna
- Barbosa Marcella A.S.
- Barker Debbie
- Barlow Gavin D.
- Barnabas Shaun L.
- Barnes Eleanor
- Barr Andrew S.
- Barrett Jessica
- Barrett Jordan R.
- Bates Louise
- Batten Alexander
- Beadon Kirsten
- Beales Emily
- Beckley Rebecca
- Belij-Rammerstorfer Sandra
- Bell Jonathan
- Bellamy Duncan
- Bellei Nancy
- Belton Sue
- Berg Adam
- Bermejo Laura
- Berrie Eleanor
- Berry Lisa
- Berzenyi Daniella
- Beveridge Amy
- Bewley Kevin R.
- Bexhell Helen
- Bhikha Sutika
- Bhorat Asad E.
- Bhorat Qasim E.
- Bhorat Zaheda E.
- Bibi Sagida
- Bijker Else
- Birch Geeta
- Birch Sarah
- Bird Adam
- Bird Olivia
- Bisnauthsing Karen
- Bittaye Mustapha
- Blackstone Katherine
- Blackwell Luke
- Bletchly Heather
- Blundell Caitlin L.
- Blundell Susannah R.
- Bodalia Pritesh
- Boettger Bruno C.
- Bolam Emma
- Boland Elena
- Bormans Daan
- Borthwick Nicola
- Bowring Francesca
- Boyd Amy
- Bradley Penny
- Brenner Tanja
- Briner Carmen
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- Brown Phillip
- Brown-O'Sullivan Charlie
- Bruce Scott
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- Buchan Ruaridh
- Budd William
- Bulbulia Yusuf A.
- Bull Melanie
- Burbage Jamie
- Burhan Hassan
- Burn Aileen
- Buttigieg Karen R.
- Byard Nicholas
- Cabera Puig Ingrid
- Calderon Gloria
- Calvert Anna
- Camara Susana
- Cao Michelangelo
- Cappuccini Federica
- Cardoso João R.
- Carr Melanie
- Carroll Miles W.
- Carson-Stevens Andrew
- Carvalho José A.M.
- Carvalho Yasmin de M.
- Casey Helen R.
- Cashen Paul
- Castro Lucia Carratala
- Castro Thais
- Cathie Katrina
- Cavey Ana
- Cerbino-Neto José
- Chadwick Jim
- Chapman David
- Charlton Sue
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- Chester Oliver
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- Cho Jee-Sun
- Cicconi Paola
- Cifuentes Liliana
- Clark Elizabeth
- Clark Matthew
- Clarke Andrea
- Clemens Sue Ann Costa
- Clutterbuck Elizabeth A.
- Colin-Jones Rachel
- Collins Andrea M.
- Collins Sarah L.K.
- Conlon Christopher P.
- Connarty Sean
- Coombes Naomi
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- Cooper Rachel
- Cornelissen Lynne
- Corrah Tumena
- Cosgrove Catherine
- Cox Tony
- Crocker Wendy E.M.
- Crosbie Sarah
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- Cullen Lorraine
- Cunha Debora R.M.F.
- Cunningham Christina
- Cuthbertson Fiona C.
- Cutland Clare L.
- Da Guarda Suzete N. Farias
- da Silva Moraes Antonio Carlos
- da Silva Larissa P.
- Damratoski Brad E.
- Danos Zsofia
- Dantas Maria T.D.C.
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- Datoo Mehreen S.
- Datta Chandrabali
- Davids Malika
- Davies Hannah
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- De Nobrega Maristela M.D.
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- Ferreira Daniela M.
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- Soares Airanuédida
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- Sprinz Eduardo
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- Starinskij Igor
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- Sturdy Ann
- Sutherland Rebecca K.
- Sutton Natalina
- Szigeti Anna
- Tahiri-Alaoui Abdessamad
- Tanner Rachel
- Taoushanis Carol
- Tarr Alexander W.
- Tarrant Richard
- Taylor Iona Jennifer
- Taylor Justin
- Taylor Keja
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- te Water Naude Rebecca
- Themistocleous Andreas
- Themistocleous Yrene
- Thomas Kelly
- Thomas Merin
- Thomas Tonia M.
- Thombrayil Asha
- Thompson Amber
- Thompson Ameeka
- Thompson Fawziyah
- Thompson Kevin
- Thomson Emma C.
- Thomson Julia
- Thornton-Jones Viv
- Tighe Patrick J.
- Tinoco Lygia Accioly
- Tiongson Gerlynn
- Tladinyane Bonolo
- Tomasicchio Michele
- Tomic Adriana
- Tonks Susan
- Toshner Mark
- Tran Nguyen
- Tree Julia
- Trillana Gerry
- Trinham Charlotte
- Trivett Rose
- Truby Adam
- Tsheko Betty Lebogang
- Turabi Aadil
- Turner Cheryl
- Turner David P. J.
- Turner Richard
- Török M Estée
- Ulaszewska Marta
- Underwood Benjamin R.
- van Eck Samual
- Varughese Rachel
- Vekemans Johan
- Verbart Dennis
- Verheul Marije
- Vichos Iason
- Vieira Taiane
- Villafana Tonya L.
- Voysey Merryn
- Waddington Claire S.
- Walker Laura
- Wallis Erica
- Wand Matthew
- Warbick Deborah
- Wardell Theresa
- Warimwe George
- Warren Sarah C.
- Watkins Bridget
- Watson Ekaterina
- Watson Marion E. E.
- Webb Stewart
- Webb-Bridges Alice
- Webster Angela
- Weckx Lily Y.
- Welch Jessica
- Wells Jeanette
- West Alison
- White Caroline
- White Rachel
- Williams Christopher J.
- Williams Paul
- Williams Rachel L.
- Winslow Rebecca
- Woodyer Mark
- Worth Andrew T.
- Wright Danny
- Wroblewska Marzena
- Yao Andy
- Zimmer Rafael
- Zizi Dalila
- Zuidewind Peter
- Publication venue
- 'Elsevier BV'
- Publication date
- 09/01/2021
- Field of study
Get PDFBackground
A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials.
Methods
This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674.
Findings
Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation.
Interpretation
ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials
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