59 research outputs found
Fully adaptive multiresolution schemes for strongly degenerate parabolic equations with discontinuous flux
- Author
- A Cohen
- A Coronel
- A Harten
- A Harten
- A Harten
- A Harten
- A Kurganov
- A Michel
- AC Dick
- AI Vol’pert
- AI Vol’pert
- B Cockburn
- B Engquist
- BL Bihari
- BL Bihari
- BS Kerner
- C Mascia
- CW Shu
- CW Shu
- D Helbing
- E Tadmor
- EF Toro
- G Chiavassa
- GQ Chen
- GQ Chen
- H Greenberg
- H Nessyahu
- J Carrillo
- K Eriksson
- Kai Schneider
- KH Karlsen
- KH Karlsen
- KH Karlsen
- KH Karlsen
- KH Karlsen
- KH Karlsen
- L Jameson
- M Garavello
- M Holmström
- M Ohlberger
- Mauricio A. Sepúlveda
- MG Crandall
- MJ Lighthill
- MS Espedal
- N Bellomo
- N Bellomo
- N Bellomo
- NN Kuznetsov
- O Roussel
- O Roussel
- P Nelson
- PI Richards
- R Bürger
- R Bürger
- R Bürger
- R Bürger
- R Bürger
- R Bürger
- R Bürger
- R Bürger
- R Bürger
- R Bürger
- R Verfürth
- Raimund Bürger
- Ricardo Ruiz
- S Berres
- S Berres
- S Evje
- S Mochon
- S Müller
- SN Kružkov
- W Dahmen
- Y Stiriba
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 02/07/2008
- Field of study
A fully adaptive finite volume multiresolution scheme for one-dimensional
strongly degenerate parabolic equations with discontinuous flux is presented.
The numerical scheme is based on a finite volume discretization using the
Engquist--Osher approximation for the flux and explicit time--stepping. An
adaptivemultiresolution scheme with cell averages is then used to speed up CPU
time and meet memory requirements. A particular feature of our scheme is the
storage of the multiresolution representation of the solution in a dynamic
graded tree, for the sake of data compression and to facilitate navigation.
Applications to traffic flow with driver reaction and a clarifier--thickener
model illustrate the efficiency of this method
MR fluoroscopy in vascular and cardiac interventions (review)
- Author
- A Arepally
- A Arepally
- A Berrington de Gonzalez
- A Bucker
- A Buecker
- A Buecker
- A Buecker
- A Buecker
- A Carrillo
- A D’Amico
- A Glowinski
- A Hirsch
- A Jacquier
- A Omeish
- A Roguin
- A Schaefer
- A Schmidt
- AD Moelker
- AH Mahnken
- AJ Dick
- AJ Dick
- AJ Dick
- AJ Martin
- AJ Martin
- AN Raval
- AN Raval
- AS Arbab
- B Assmus
- B Modan
- B Quesson
- BA Kersting-Sommerhoff
- C Flask
- C Manke
- C Manke
- C Paetzel
- C Paetzel
- C Rickers
- C Stamm
- CA Athanasoulis
- CJ Bakker
- CJ Bakker
- CJ Bakker
- CJ McGann
- CM Hillenbrand
- CM Kramer
- CM Strother
- D Bello
- D Brenner
- D Hou
- D Marelli
- D Zohlnhofer
- DA Leung
- DA Taylor
- DC Peters
- DC Peters
- DL Dicks
- DL Kraitchman
- DL Kraitchman
- DM Spielman
- DN Kenigsberg
- DP Frush
- DR Elgort
- DT Boll
- E Atalar
- E Bergvall
- E Samset
- E Spuentrup
- EA Sadowski
- ER McVeigh
- ER Schwarz
- F Fernandez-Aviles
- F Settecase
- FG Shellock
- FK Wacker
- FK Wacker
- G Adam
- G Bongartz
- G Narazaki
- H Saybasili
- HE Cline
- HE Cline
- HF Smits
- HF Smits
- HH Quick
- HJ Kang
- HM Klein
- J Bartunek
- J Dong
- J Heisterkamp
- JA Zwart de
- JD Pearlman
- JE Sousa
- JF Schenck
- JG Cleland
- JJ Krueger
- JL Duerk
- JM Hill
- Joey English
- JS Lewin
- K Hynynen
- K Kuroda
- KA Hutcheson
- KB Allen
- KC Patel
- KC Wollert
- KN Prasad
- KP Pruessmann
- KS Cahill
- L Axel
- L Hsu
- LC Amado
- LC Amado
- LW Bartels
- M Bock
- M Bock
- M Carlsson
- M Hofmann
- M Mansour
- M Ruel
- M Saeed
- M Saeed
- M Saeed
- M Saeed
- M Saeed
- M Saeed
- M Saeed
- M Simons
- M Wendt
- M Yousef
- Mark Wilson
- Maythem Saeed
- MD Budde
- ME Ladd
- MJ Post
- MK Konings
- N Himes
- NF Osman
- NS Kleiman
- O Kocaturk
- O Simonetti
- O Unal
- OM Weber
- OW Hamer
- P Menasche
- P Menasche
- P Steiner
- P Tossios
- PR Mueller
- PR Vulliet
- PV Karmarkar
- Q Zhang
- R Mekle
- R Mekle
- R Razavi
- R Salomir
- R Silva de
- R Weide van der
- RA Omary
- RA Omary
- RA Omary
- RB Schwartz
- RF Busse
- RJ Laham
- RM Maes
- RP Choudhury
- RS Ripa
- RW Grauss
- RW Gunther
- S Aime
- S Dimmeler
- S Janssens
- S Kos
- S Krueger
- S Nazarian
- S Nazarian
- S Schalla
- S Schalla
- S Sinha
- SE Lakhan
- SG Hushek
- SH Heywang-Kobrunner
- SL Chen
- SM Hashemi
- SM Park
- SN Ebert
- Steve W. Hetts
- SV Babu-Narayan
- T Arai
- T Dill
- T Freyman
- T Klemm
- T Kuehne
- T Kuehne
- T Kuehne
- T Kuehne
- T Kuehne
- T Kuehne
- T Niendorf
- T Saito
- T Sommer
- T Ziebart
- TJ Vogl
- TM Peters
- TP Roberts
- V Demas
- V Muthurangu
- V Rasche
- V Rasche
- V Schachinger
- V Schachinger
- V Schachinger
- VK Raman
- VY Reddy
- WE Kyriakos
- WR Nitz
- X Yang
- X Yang
- Y Liu
- Y Popowski
- YC Chung
- YM Dion
- Publication venue
- Springer Netherlands
- Publication date
- 01/01/2011
- Field of study
Vascular and cardiac disease remains a leading cause of morbidity and mortality in developed and emerging countries. Vascular and cardiac interventions require extensive fluoroscopic guidance to navigate endovascular catheters. X-ray fluoroscopy is considered the current modality for real time imaging. It provides excellent spatial and temporal resolution, but is limited by exposure of patients and staff to ionizing radiation, poor soft tissue characterization and lack of quantitative physiologic information. MR fluoroscopy has been introduced with substantial progress during the last decade. Clinical and experimental studies performed under MR fluoroscopy have indicated the suitability of this modality for: delivery of ASD closure, aortic valves, and endovascular stents (aortic, carotid, iliac, renal arteries, inferior vena cava). It aids in performing ablation, creation of hepatic shunts and local delivery of therapies. Development of more MR compatible equipment and devices will widen the applications of MR-guided procedures. At post-intervention, MR imaging aids in assessing the efficacy of therapies, success of interventions. It also provides information on vascular flow and cardiac morphology, function, perfusion and viability. MR fluoroscopy has the potential to form the basis for minimally invasive image–guided surgeries that offer improved patient management and cost effectiveness
CMS physics technical design report : Addendum on high density QCD with heavy ions
- Author
- 1 A. HEIKKINEN
- 1 A. T. LAASANEN
- 1 E. LOCCI
- 1 K. MAESHIMA
- 1 L. VAN LANCKER
- 1 R. DEMINA
- 1 V. VELEV
- 2 R. L. IOPE
- 28 P. LECOQ
- 3 A. DEBRAINE
- 45 W. CLARIDA
- 5 Y. PATOIS
- 6 C. MAAZOUZI
- 6 P. GRAEHLING
- 6 S. MOREAU
- 8 P. KOVESARKI
- 9 S. CHATTERJI
- A. A. SHAH
- A. ADOLF
- A. AERTS
- A. AFFOLDER
- A. ALBERT
- A. ALEKHIN
- A. ALI
- A. ALLEN
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- A. APRESYAN
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- R. N. C. GRAY
- R. N. J. HALSALL
- R. NARDÒ
- R. NOBREGA
- R. P. SMITH
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- S. CHURCHWELL
- S. CIHANGIR
- S. CITTOLIN
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- S. COOPER
- S. COSTA
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- S. D. ILIE
- S. D. KALMANI
- S. D. WORM
- S. DA MOTA SILVA
- S. DAMBACH
- S. DAS
- S. DASU
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- S. DE WEIRDT
- S. DHAWAN
- S. DI VINCENZO
- S. DOLINSKY
- S. DOS SANTOS
- S. DRIS
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- S. FROSALI
- S. GANJOUR
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- S. GIUSTI
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- S. GREDER
- S. GREENWOOD
- S. GUERRA
- S. GURAGAIN
- S. H. AHN
- S. H. CHUANG
- S. HAGOPIAN
- S. HANNAERT
- S. HEIER
- S. HERMANN
- S. HOLM
- S. HÄNSEL
- S. J. HONG
- S. J. LEE
- S. J. LEE
- S. J. MURRAY
- S. J. NASH
- S. J. QIAN
- S. J. WATTS
- S. K. KATARIA
- S. K. NAM
- S. K. PARK
- S. KAILAS
- S. KALININ
- S. KAPPLER
- S. KARAEVSKII
- S. KASSELMANN
- S. KHABAROV
- S. KHALATIAN
- S. KLIMENKO
- S. KORJENEVSKI
- S. KOSSIAKOV
- S. KULESHOV
- S. KUNORI
- S. KWAN
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- S. KYRIAZOPOULOU
- S. KÖNIG
- S. L. BALLY
- S. LACAPRARA
- S. LEHTI
- S. LIEUNARD
- S. LINARI
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- S. LOWETTE
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- S. LUSIN
- S. M. ABBAS
- S. MAGNI
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- S. MASELLI
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- S. MEYER
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- S. MOCCIA
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- S. MOVCHAN
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- S. MUELLER
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- S. MY
- S. NAHN
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- S. NEEMA
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- S. NUZZO
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- S. ONISHCHENKO
- S. OTWINOWSKI
- S. OVYN
- S. OZKORUCUKLU
- S. OZTURK
- S. P. H. QUINTON
- S. P. RATTI
- S. PAKTINAT MEHDIABADI
- S. PAOLETTI
- S. PATHAK
- S. PAVLON
- S. PERRIES
- S. PETRUSHANKO
- S. PIPEROV
- S. R. RO
- S. R. WAGNER
- S. RAGAZZI
- S. RAHATLOU
- S. REUCROFT
- S. REYNAUD
- S. REZNIKOV
- S. RUGOVAC
- S. RUTHERFORD
- S. SALA
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- S. SERGEEV
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- S. SHARMA
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- S. SHMATOV
- S. SHULHA
- S. SILVA
- S. SIMON
- S. SLABOSPITSKY
- S. SOKHA
- S. SOMALWAR
- S. SPANIER
- S. SQUIZZATO
- S. STEINER
- S. STOENCHEV
- S. STOYKOVA
- S. STOYNEV
- S. STROINEY
- S. SWAIN
- S. TAGHAVI
- S. TANWIR
- S. TARONI
- S. TATAURSCHIKOV
- S. TAVERNIER
- S. TISSOT
- S. TKACZYK
- S. TOLAINI
- S. TRALDI
- S. TROITSKY
- S. TROSHIN
- S. TUPPUTI
- S. TZAMARIAS
- S. UDRIOT
- S. V. GLEYZER
- S. V. RUSAKOV
- S. VANINI
- S. VANZETTO
- S. VASIL’EV
- S. VAURYNOVICH
- S. VAVILOV
- S. VENTURA
- S. VILLA
- S. VLACHOS
- S. VOLKOV
- S. W. LEE
- S. W. LI
- S. W. LIN
- S. WAKEFIELD
- S. WALDMEIER WICKI
- S. WANG
- S. WATKINS
- S. WESELER
- S. WHITEHEAD
- S. WIMPENNY
- S. WON
- S. WYNHOFF
- S. X. WU
- S. Y. JUN
- S. Y. JUNG
- S. Y. PARK
- S. ZAVODTHIKOV
- S. ZELEPOUKINE
- S. ZUB
- SIROLI GIAN PIERO
- SUDESHNA BANERJEE
- SUNANDA BANERJEE
- T. ADAMS
- T. ANGUELOV
- T. AZIZ
- T. BAPTY
- T. BARATA MONTEIRO
- T. BARVICH
- T. BAUER
- T. BERGAUER
- T. BOCCALI
- T. BOLTON
- T. BOSE
- T. CAMPORESI
- T. CHRISTIANSEN
- T. DE VISSER
- T. DORIGO
- T. DUPASQUIER
- T. FERGUSON
- T. GERALIS
- T. GOELTZENLICHTER
- T. GORSKI
- T. GRASSI
- T. HAUER
- T. HEBBEKER
- T. HENKES
- T. HERMANNS
- T. HESSELROTH
- T. J. KIM
- T. KACHELHOFFER
- T. KAMON
- T. KELLY
- T. KESKINPALA
- T. KEUTGEN
- T. KOLBERG
- T. KRAMER
- T. KRESS
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- T. LAMPÉN
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- T. LINDÉN
- T. LOMTADZE
- T. M. SHAW
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- T. MAHMOUD
- T. MARTIN
- T. MCCAULEY
- T. MEYER
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- T. MOERS
- T. MÄENPÄÄ
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- T. NYMAN
- T. NÖBAUER
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- T. P. VANHALA
- T. PIERZCHALA
- T. PUNZ
- T. RODRIGO
- T. ROHE
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- T. ROMMERSKIRCHEN
- T. SAKHELASHVILI
- T. SCHREINER
- T. SOBRIER
- T. SPEER
- T. STAPELBERG
- T. TABARELLI DE FATIS
- T. TODOROV
- T. TOMEI
- T. TOOLE
- T. TUUVA
- T. VIRDEE
- T. WEILER
- T. WILDISH
- T. Y. LING
- T. YETKIN
- T. ZIMMERMAN
- T.H. MÜLLER
- TRAVAGLINI RICCARDO
- U. AHMAD
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- U. BERZANO
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- U. DOSSELLI
- U. FELZMANN
- U. GASPARINI
- U. GASTALDI
- U. GOERLACH
- U. HOLM
- U. HORISBERGER
- U. JOSHI
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- U. NAUENBERG
- U. PEIN
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- V. BRIGLJEVIC
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- V. CHIOCHIA
- V. CHOROWICZ
- V. CIULLI
- V. CUPLOV
- V. D. CAFARO
- V. D. ELVIRA
- V. DELACHENAL
- V. DUK
- V. E. BARNES
- V. E. BAZTERRA
- V. E. POSTOEV
- V. ELSHA
- V. EPSHTEYN
- V. GAULTNEY
- V. GAVRILOV
- V. GENCHEV
- V. GIORDANO
- V. GOLOVTSOV
- V. GRISHIN
- V. HAGOPIAN
- V. HALYO
- V. HERMEL
- V. ILYIN
- V. INNOCENTE
- V. ISSAKOV
- V. J. SMITH
- V. KACHANOV
- V. KAFTANOV
- V. KALAGIN
- V. KARIMÄKI
- V. KARJAVIN
- V. KARPISHIN
- V. KASEY
- V. KHABAROV
- V. KHACHATRYAN
- V. KHOMENKOV
- V. KIM
- V. KLYUKHIN
- V. KOLOSOV
- V. KONOPLYANIKOV
- V. KORENKOV
- V. KOZHUHAROV
- V. KOZLOV
- V. KOZLOV
- V. KRUTELYOV
- V. KRYCHKINE
- V. KUDINOV
- V. KUZNETSOV
- V. LEBEDEV
- V. LEFÉBURE
- V. LEMAITRE
- V. LITVINE
- V. LUKANIN
- V. LUKYANOV
- V. LYSIAKOV
- V. LYUBYNSKIY
- V. M. GHETE
- V. MACK
- V. MAKARENKO
- V. MAROUSSOV
- V. MATVEEV
- V. MICCIO
- V. MIKHAYLIN
- V. MOLCHANOV
- V. MONACO
- V. MOSSOLOV
- V. OGURI
- V. O’DELL
- V. PALICHIK
- V. PATRAS
- V. PAVLUNIN
- V. PERELYGIN
- V. PETROV
- V. PETROV
- V. PETUKHOV
- V. PIKALOV
- V. PODRASKY
- V. POSTOLACHE
- V. PROSOLOVICH
- V. R. LAKKIREDDI
- V. RADICCI
- V. ROBERFROID
- V. ROINISHVILI
- V. RYJOV
- V. SAKHAROV
- V. SAMSONOV
- V. SAVRIN
- V. SEHGAL
- V. SEKHRI
- V. SENCHYSHYN
- V. SHARMA
- V. SHELIKHOV
- V. SKNAR
- V. SKOROBOGATOV
- V. SKVORTSOV
- V. SMETANNIKOV
- V. SMIRNOV
- V. SPASSOV
- V. STOLIN
- V. SULIMOV
- V. SUNDARARAJAN
- V. SYTNIK
- V. TALOV
- V. TANCINI
- V. TARAKANOV
- V. TIMCIUC
- V. V. MITSYN
- V. VALUEV
- V. VANIEV
- V. VERGUILOV
- V. YARBA
- V. ZAYTSEV
- V. ZHUKOV
- V. ZHUKOVA
- VERONESE GIULIO PAOLO
- W. ADAM
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- W. DULINSKI
- W. E. KAHL
- W. ERDMANN
- W. FUNK
- W. G. D. DHARMARATNA
- W. GANNON
- W. GEIST
- W. GLESSING
- W. GORN
- W. H. SMITH
- W. H. THÜMMEL
- W. HINTZ
- W. J. GILBERT
- W. J. HAYNES
- W. J. SPALDING
- W. J. WOMERSLEY
- W. JANK
- W. JOHNS
- W. KARPINSKI
- W. KASTLI
- W. KO
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- W. LIN
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- X. ASLANOGLOU
- X. LAGRUE
- X. QU
- X. ROUBY
- X. SU
- X. T. HUANG
- X. Y. SHEN
- X. YANG
- Y. B. HSIUNG
- Y. BAGATURIA
- Y. BAN
- Y. BONUSHKIN
- Y. C. GE
- Y. CHAO
- Y. E. KIM
- Y. ERSHOV
- Y. FISYAK
- Y. FU
- Y. GAVRIKOV
- Y. GEEREBAERT
- Y. GERSHTEIN
- Y. GOTRA
- Y. GUO
- Y. H. CHANG
- Y. HU
- Y. I. CHOI
- Y. IVANOV
- Y. J. KIM
- Y. J. LEI
- Y. K. JENG
- Y. KIRYUSHIN
- Y. KOZHEVNIKOV
- Y. KUBOTA
- Y. L. YE
- Y. LEMOIGNE
- Y. M. TZENG
- Y. MA
- Y. MARAVIN
- Y. MEL’NIK
- Y. MUSIENKO
- Y. N. KOBLIK
- Y. ONEL
- Y. PAKHOTIN
- Y. PISCHALNIKOV
- Y. RIAHI
- Y. ROH
- Y. S. CHUNG
- Y. S. SHAH
- Y. SHCHEGLOV
- Y. SHI
- Y. SIROIS
- Y. VELIKZHANIN
- Y. W. BAEK
- Y. WU
- Y. XIA
- Y. YANG
- Y. ZHANG
- Y. ZHENG
- Y.U. ANDREEV
- Z. AFTAB
- Z. ANTUNOVIC
- Z. C. YANG
- Z. CHEN
- Z. GAO
- Z. H. SUN
- Z. H. XUE
- Z. HOCHMAN
- Z. L. TROCSANYI
- Z. L. XUE
- Z. PRILUTSKAYA
- Z. SZABO
- Z. SZILLASI
- Z. TOTEVA
- Z. TSAMALAIDZE
- Z. WAN
- Z. WLODARCZYK
- Z. XIE
- Z. Y. CHEN
- Z. ZHANG
- Z. ZINONOS
- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING (IOP)
- Publication date
- 01/01/1989
- Field of study
Peer reviewe
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
- Author
- Abdallah J
- Abdul Ghani R
- Abdul Kadir K
- Abdullah R
- Abejuela Z
- Abouglila K
- Abraham O
- Abrahamsen I
- Abraira Munoz Ld
- Abramowitz M
- Abusnana S
- Accini Mendoza Jl
- Acosta I
- Agafyina A
- Agarwal R
- Agarwal Rajiv
- Aggarwal N
- Agra J
- Ahmed F
- Ahuad Guerrero Ra
- Aiello J
- Ainsworth P
- Aizenberg D
- Akiyama H
- Akright L
- Akyea-Djamson A
- Al-Karadsheh A
- Alamartine E
- Alappan R
- Albisu Jp
- Ali N
- Ali Z
- Alicic R
- Allison Dc
- Alvarez Garcia P
- Alvarisqueta A
- Alves da Costa Fa
- Amerena J
- Amigo A
- Amodeo C
- Andreeva V
- Andreotti Turatti La
- Angelescu Lm
- Angelova A
- Anghel V
- Antic S
- Aoki H
- Aquitania G
- Arauz-Pacheco C
- Arcos E
- Arfeen S
- Arif A
- Aronson R
- Arutchelvam V
- Arvind M
- Asano A
- Asmarats Mercadal L
- Atray N
- August P
- Avendano J
- Avram Ri
- Awad A
- Babikova J
- Badat A
- Bajaj H
- Baker J
- Bakris G
- Bakris George
- Barbarash O
- Barna O
- Barnard M
- Barnhill P
- Barranco E
- Barrera C
- Barrios C
- Bartaskova D
- Bartolacci I
- Barton P
- Barysheva O
- Beacom M
- Behara V
- Bellary S
- Belo D
- Belobradkova J
- Bentley-Lewis R
- Benusova O
- Berenguer R
- Berli Ma
- Bermudez L
- Bernardo M
- Bhushan Rs
- Bijata-Bronisz R
- Bilyk Sd
- Bin Shudim Ss
- Biscoveanu M
- Bompoint Severine
- Bonadonna R
- Bordonava A
- Borot S
- Botsyurko V
- Bowman-Stroud C
- Brandon D
- Breedt J
- Bregman R
- Brenner Barry M
- Brenner Bm
- Brusco O
- Buganova I
- Bull Scott
- Burst V
- Busch R
- Busegeanu Mm
- Calella P
- Camelo Sanches Fc
- Canaan Y
- Canani Lh
- Cannon Christopher P
- Cannon Cp
- Cantero Mc
- Capuano George
- Caringal C
- Cariou B
- Cartasegna Lr
- Castellino P
- Cercos E
- Cereto Castro F
- Ceriello A
- Chacra Ar
- Chae Dw
- Chang Ct
- Chang T
- Chapin L
- Charytan David M
- Charytan Dm
- Che Yusof Md
- Cheifetz A
- Chen E
- Chen N
- Chen Q
- Cherney D 3rd
- Chertow G
- Cheung Nw
- Chilito A
- Chiovato L
- Chizhov D
- Cho Ym
- Chouinard G
- Christensen T
- Christiano C
- Christofides E
- Chu Pei-Ling
- Chuang Lm
- Chuateco C
- Cif A
- Cigarran Guldris S
- Coffee L
- Cohen K
- Cohen R
- Cohen S
- Cohen-Stein D
- Coloma Gc
- Colombo H
- Comia Rs
- Commendatore V
- Conway J
- Cook C
- Correa Rotter Jr
- Cosma D
- Cournoyer S
- Coyne D
- Crisan C
- Cruz Jb
- Csecsei G
- Csiky B
- Cuadrado J
- Culak J
- Cuneo Ca
- Cunha Borges Jl
- Cunha V\ueancio Sa
- Cusumano Am
- D'Avila D
- da Silva Franco Rj
- Daboul N
- Danos P
- Daroza G
- Darwish R
- Daswani A
- David C
- Davies E
- Davies M
- Davies S
- Dawson A
- De Brouwer K
- de Carvalho Contieri Fl
- De Cosmo S
- De Nicola L
- De Serres S
- de Souza Portes E
- de Souza P
- de Zeeuw D
- de Zeeuw Dick
- Deak L
- Deboni Lm
- Deck K
- Deepak D
- Delos Santos L
- Demian Ld
- Derosa G
- Desouza C
- Destree M
- Dev D
- Dhillon M
- Di Carlo A
- Di Cianni G
- Diaz Escalante T
- Diaz Ruiz Jea
- Dimitrov S
- Distiller L
- Distiller L
- Djordjevic M
- Dobronravov V
- Dohnalova L
- Dominquez Lopez M
- Douthat Wg
- Dran Rd
- Drasnar T
- Dreval A
- Droste C
- Dua S
- Dub\ue9 F
- Dudar I
- Dudas M
- Dussol B
- Dzupina A
- Dzuponova J
- Eder F
- Edwards Robert
- Edwin Fm
- Egido de Los Rios J
- El Kossi M
- El-Shahawy M
- Elosegui Am
- English P
- Enriquez Sosa Fe
- Ervin J
- Esquenazi A
- Evans J
- Faghih M
- Farias E
- Faulmann G
- Fauvel Jp
- Ferariu Ie
- Ferkl R
- Fern\ue1ndez Montenegro Ma
- Fernandez Fresnedo G
- Fernandez Mf
- Feuerstein J
- Filho Ff
- Finkelstein H
- Fishbane S
- Flores Lozano F
- Flota Cervera Lf
- Fragale G
- Frasc\ue0 G
- Fraser D
- Fraser I
- Frenk Baron P
- Fretes Jo
- Frias J
- Fuiano G
- Fulcher G
- Fulop P
- Fushtey I
- G\uf3rriz Jl
- Gaglia J
- Galan Serrano A
- Galindo-Ramos E
- Galphin C
- Gambaro G
- Gan Cl
- Gan S
- Garcia Ballesteros C
- Garcia Ortiz Lh
- Garcia I
- Garcia Nh
- Garibotto G
- Gastaldi A
- Gaupsiene E
- Gelersztein E
- Geloneze Neto B
- Genadieva V
- Genova-Hristova G
- George S
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- Zinman B
- Zinman Bernard
- Zlova T
- Zsom M
- Zub L
- Zykova T
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
New insights into the genetic etiology of Alzheimer's disease and related dementias
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- Aaltonen L.
- Aaltonen V.
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- Aavikko M.
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- Abdelnour Carla
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- Alarcón-Martín Emilio
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
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- Thompson Paul
- Thompson Paul M
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- Toga Arthur W
- Tolosa Eduardo
- Tooney Paul A
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- Tremont Geoffrey
- Trncic Nadira
- Trojanowki John Q
- Trollor Julian
- Trollor Julian N
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- Turner Raymond Scott
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- Uhlmann Anne
- Uitterlinden André G
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- Umek Robert
- Uribe Liz
- Vaishnavi Sanjeev
- Vallerga Costanza Ludovica
- van 't Ent Dennis
- van der Brug Marcel
- van der Lee Sven J
- van der Meer Dennis
- Van der Wee Nic J A
- van Donkelaar Marjolein M J
- van Duijn Cornelia M
- van Dyck Christopher H
- van Eijk Liza
- van Erp Theo G M
- van Haren Neeltje E M
- van Noort Betteke
- van Rooij Daan
- van Tol Marie-José
- Vanderswag Helen
- Varma Pradeep
- Veillette Suzanne
- Veldink Jan H
- Veltman Dick J
- Vemuri Prashanthi
- Venkov Heli
- Verhoef Ellen
- Vernooij Meike W
- Villena Teresa
- Villringer Arno
- Voyvodic James T
- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- Cássio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
- Dan Scharfstein
- Dana Cosma
- Daniel Coyne
- Daniel Hiser
- Daniel Kolansky
- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
- David Gorson
- David Johnson
- David M Charytan
- David Packham
- David Scott
- David Wheeler
- De Zeeuw D.
- Debbie Cohen-Stein
- Debbie Mascaro
- Deepak Koppolu
- Dennis Levinson
- Derek Lewis
- Detian Li
- Devasmita Dev
- Devesh Patel
- Dewan Deepak
- Dick de Zeeuw
- Diego Aizenberg
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- Dinesh Khullar
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- Shizuo Kajiyama
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- Sin Gon Kim
- Singhan Krishnan
- Sini George
- Slobodan Antic
- Sohan Dua
- Sonia Hermida
- Soo Kun Lim
- Sophie Borot
- Souhila Ounadjela
- Sreedhar Mandayam
- Srikanth Bellary
- Stanislav Zemek
- Stanislaw Mazur
- Stefan Dimitrov
- Stephan Maxeiner
- Stephen Grubb
- Stephen Smith
- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
- Swee Win Lam
- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- Sérgio Alberto Cunha Vêncio
- Sérgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
- Timothy Hall
- Tom Christensen
- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Advancing impact prediction and hypothesis testing in invasion ecology using a comparative functional response approach
- Author
- A Ricciardi
- A Ricciardi
- A Ricciardi
- A Ricciardi
- A Ricciardi
- A Sih
- AK Sakai
- AL Monserrat
- Alison M. Dunn
- AM Kestrup
- AM Lohrer
- AM Lohrer
- Anthony Ricciardi
- B Leung
- B Renai
- BD Griffen
- BD Griffen
- BEMW Stoffels
- BM Johnson
- C Jones
- CE deRivera
- CM Taylor
- CS Holling
- CS Holling
- D Carrillo
- D Simberloff
- D Sol
- DA Soluk
- David M. Richardson
- DB Eggleston
- DB Jones
- DG Chapple
- DJ Brousseau
- DL Strayer
- DL Strayer
- DL Taylor
- DM Ward
- DOL Dubs
- DR Barnhisel
- DW Kelly
- E Leeuwen Van
- ER Buhle
- FS Chapin
- GM Branch
- GR Walther
- H Moustahfid
- HE Roy
- Hugh J. MacIsaac
- IM Parker
- J Cucherousset
- JA Catford
- Jaimie T. A. Dick
- JD DeGraaf
- JD Olden
- JD Olden
- JD Parker
- JE Byers
- JL Funk
- JM Jeschke
- JM Jeschke
- JM Jeschke
- JM Jeschke
- Jonathan M. Jeschke
- JS Rehage
- JS Weis
- JTA Dick
- JTA Dick
- JW Laundré
- K Palacio-Lopez
- KD Farnsworth
- Keith D. Farnsworth
- KL Pangle
- KR Hayes
- L Bollache
- LA Twardochleb
- LM Pintor
- LM Pintor
- M Brooks
- M Clavero
- M Clinchy
- M Kleunen Van
- M Mistri
- M Remanjek
- MA Barbeau
- MA Rossong
- MC Andersen
- MC Tyrrell
- ME Alexander
- ME Solomon
- Melanie J. Hatcher
- MH Bayoumy
- Mhairi E. Alexander
- MJ Bishop
- ML Koski
- MP Hassell
- MP Marchetti
- MP Marchetti
- MS Thomsen
- MW Griswold
- MW Sabelis
- NJ Fielding
- Olaf L. F. Weyl
- P Pyšek
- P Salo
- P Veiga
- PE Bourdeau
- PJ Lester
- PM Vitousek
- R Drische Van
- Rachel A. Paterson
- RB Kushner
- RC Hooff
- RJ O’Neil
- RN Lipcius
- RN Mack
- RR Rindone
- S Farrokhi
- S Kumschick
- S Kumschick
- S Kumschick
- SA Juliano
- SA Kulhanek
- Sabrina Kumschick
- SE Richman
- SM Greenberg
- Tamara B. Robinson
- TF Wright
- TM Blackburn
- V Medoc
- W Nentwig
- WA Ruscoe
- WE Morrison
- WE Snyder
- WF Zuharah
- WW Murdoch
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abdullkutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adamo A
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Agnetti V
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alexopoulos D
- Alings M
- Alonso Martin JJ
- Alonso Orcajo N
- Alsweiler C
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Anchante Hernandez HA
- Andersen D
- Andersen K
- Andersen R
- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
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- Sheller J
- Sherwood MW
- Shetty S
- Shi X
- Shimizu M
- Shinde R
- Shinke T
- Shogenov Z
- Shou X
- Shoukfeh M
- Shustov S
- Shvarts Y
- Sijbrands EJG
- Sikic J
- Silva PGMDB
- Silva RP
- Silva SIB
- Silveira JA
- Silver K
- Simaitis A
- Sime I
- Simic D
- Simon T
- Simonis G
- Simoons ML
- Singal D
- Singh N
- Singsaas EG
- Sinha D
- Sinnaeve P
- Sionis D
- Sirisena T
- Siu DCW
- Skonieczny G
- Skorski M
- Skoumas I
- Slapikas R
- Smik R
- Smith L
- Soggia AP
- Soonfuang W
- Soopold U
- Soots M
- Sopena S
- Soran H
- Soroka E
- Sotnikova T
- Sotty M
- Sousa L
- Souza WKSB
- Soward A
- Sparby JA
- Speirs S
- Spinar J
- Sporn D
- Spriggs D
- Sritara P
- Stambuk K
- Staneta P
- Stanislavchuk M
- Stankovic A
- Starcevic B
- Starmer G
- Stasek J
- Stasiewski A
- Steg PG
- Steg PG
- Steiner S
- Stellbrink C
- Stewart R
- Stojic S
- Stone J
- Storey R
- Strader J
- Strain J
- Stratmann M
- Strbova J
- Strelnieks A
- Striekwold H
- Stringfellow K
- Strozzi M
- Stryuk R
- Su G
- Su X
- Suarez Otero R
- Subkovas E
- Sudnik W
- Sugino H
- Suh D
- Sujjavanich D
- Sukonthasarn A
- Suligoj NC
- Sulit DJ
- Sumner A
- Sun Y
- Sun Y
- Sundelin T
- Sundram PS
- Suryapranata H
- Sussex B
- Svab P
- Sy RAG
- Sy RG
- Sy RG
- Sydow K
- Szarek M
- Szarek M
- Szpajer M
- Szwed H
- Taguchi S
- Tahk S-J
- Takahashi T
- Takata T
- Takeda Y
- Tamby J-F
- Tamby J-F
- Tan E
- Tashchuk V
- Tasic N
- Taskinen M-R
- Taurio J
- Ternouth I
- Terzic I
- Tesloianu DN
- Tespili M
- Teufel E
- Thakkar M
- Thao H
- Thew S
- Tirador L
- Tissera N
- Todorov GV
- Toma M
- Tomala T
- Tomulic V
- Tonnessen G
- Torstensson I
- Toursarkissian N
- Tov N
- Treasure C
- Tretyakova TV
- Trevelyan J
- Triana MAU
- Tricoci P
- Tricoci P
- Troquay RP
- Trotter C
- Tsai W-C
- Tse H-F
- Tseluyko V
- Tumbev HS
- Tunon Fernandez J
- Tunon J
- Turgeman Y
- Turi T
- Turk S
- Tyrenko VV
- Tzekova ML
- Ueda Y
- Uehara H
- Ueng K-C
- Ungi I
- Ural E
- Ushakov O
- Utsu N
- Vahula V
- Vakaluyk I
- Valdivielso P
- Valdovinos PCM
- Valdovinos PCM
- Valgimigli M
- Valiris J
- Vallejo GS
- Vallejos JA
- Van Der Wal RMA
- Van Der Zwaan CC
- Van Diepen SFP
- Van Huysduynen-Monraats PSH
- Van Zyl LJ
- Vardas P
- Vardi G
- Vargas Gonzales RJ
- Varleta P
- Vatutin M
- Vedere A
- Vejar M
- Velcheva ES
- Verdel GJE
- Vered Z
- Verrier M
- Vervoort G
- Vico ML
- Vida M
- Videbaek L
- Vidotti MH
- Vidovich M
- Viergever EP
- Viigimaa M
- Vijay N
- Vijayaraghavan R
- Vikman S
- Viktorova I
- Vincendet M
- Violini R
- Vishnevsky AY
- Vizel S
- Vo A
- Voeller H
- Voevoda MI
- Vogel R
- Vohra R
- Vora K
- Voyce S
- Vrolix MCM
- Vulic D
- Vuurmans T
- Wada A
- Waider W
- Waisman GD
- Waites JH
- Wali A
- Walichiewicz PM
- Waltenberger J
- Waltman J
- Wang J
- Wang J
- Wang J
- Wattanakit K
- Wei M
- Weidinger F
- Weil J
- Weintraub H
- Weissbrodt M
- Welka S
- Welker J
- Wells T
- Werner N
- Westbrook M
- Westerhausen D
- Whitaker J
- White HD
- White L
- White M
- Wiersma JJ
- Wilkins G
- Wilkinson P
- Willems FF
- Wilson MD
- Winkelmann B
- Wiseman A
- Witt N
- Wlodarczak A
- Wojewod P
- Wollaert B
- Wong Y-K
- Wongpraparut N
- Wozniak J
- Wright S
- Wu C
- Xavier D
- Xenakis M
- Xu B
- Xu D
- Xu X
- Xu Y
- Yagensky A
- Yakushin S
- Yan AT-K
- Yan BPY
- Yanez M
- Yang E
- Yang X
- Yang X
- Yao Z
- Yazdani S
- Yerra SK
- Yin W-H
- Yong H
- Yoon JH
- Younis L
- Yu Y
- Yuan Z
- Yusoff K
- Yusoff K
- Zahger D
- Zaidman CJ
- Zainea M
- Zaman A
- Zapata G
- Zdravko B
- Zea Nunez CA
- Zeiher AM
- Zeiher AM
- Zhang R
- Zhang W
- Zhang X
- Zhang Z
- Zhao X
- Zheleznyy V
- Zheng Y
- Zheng Z
- Zhou Y
- Zhu C
- Zhu H
- Zhu J
- Zirlik A
- Zizka J
- Zobouyan I
- Zong W
- Zrazhevsky K
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 04/01/2019
- Field of study
Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402
Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images
- Author
- Adam Fleisher
- Adam Fleisher
- Adam Schwartz
- Adrian Preda
- Adrian Preda
- Adrian Preda
- Alan Lerner
- Alexander Norbash
- Alice D. Brown
- Allan I. Levey
- Allyson Rosen
- Amanda Smith
- Andrew E. Budson
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew J. Saykin
- Andrew Kertesz
- Andrew Kertesz
- Angela Oliver
- Ann Marie Hake
- Ann Marie Milliken
- Anna Burke
- Ansgar J. Furst
- Antero Sarrael
- Anton P. Porsteinsson
- Anton P. Porsteinsson
- Archana B. Balasubramanian
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Arthur W. Toga
- Balebail Ashok Raj
- Barton Lane
- Beau Ances
- Becerra Mauricio
- Benita Mudge
- Betty Lind
- Bojana Stefanovic
- Bonnie Goldstein
- Bonnie S. Goldstein
- Borna Bonakdarpour
- Brandy R. Matthews
- Brendan Kelley
- Bret Borowski
- Bret Borowski
- Brian R. Ott
- Brigid Reynolds
- Brigid Reynolds
- Bruce L. Miller
- Bryan M. Spann
- Carl Sadowsky
- Carl Sadowsky
- Chad Ward
- Charles Bernick
- Charles D. Smith
- Charles DeCArli
- Charles DeCarli
- Chet Mathis
- Chiadi Onyike
- Chris Hosein
- Christine M. Belden
- Christopher H. van Dyck
- Christopher M. Clark
- Chuang-Kuo Wu
- Chunren Lai
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Clifford R. Jack
- Colleen S. Albers
- Congling Wu
- Connie Brand
- Crawford Karen
- Curtis Caldwell
- Curtis Tatsuoka
- Cynthia M. Carlsson
- Dana Mathews
- Dana Nguyen
- Dana Nguyen
- Dana Nguyen
- Daniel D'Agostino
- Daniel H.S. Silverman
- Daniel Marson
- Daniel Varon
- Danielle Harvey
- Danielle Harvey
- Danielle Harvey
- David A. Wolk
- David Bachman
- David Clark
- David Geldmacher
- David Holtzman
- David Jones
- David Knopman
- David Perry
- David Perry
- Davis Melissa
- Debra Fleischman
- Devon Gessert
- Diana Kerwin
- Dick Drost
- Dick Trost
- Dino Massoglia
- Donna M. Simpson
- Donna Munic
- Douglas W. Scharre
- Dzintra Celmins
- Earl A. Zimmerman
- Edward Coleman
- Effie Mitsis
- Elaine R. Peskind
- Elizabeth Finger
- Elizabeth Finger
- Elizabeth Oates
- Ellen Woo
- Emily Rogalski
- Eric C. Petrie
- Eric M. Reiman
- Eric M. Reiman
- Erik Roberson
- Erin Franklin
- Erin Franklin
- Erin Householder
- Evan Fletcher
- Finley Shannon
- Francine Parfitt
- Franklin Watkins
- Franz Hefti
- Friedl Karl
- Gad Marshall
- Gad Marshall
- Gaikwad Mrunalini
- Gail Li
- Gary Conrad
- Geoffrey Tremont
- George Bartzokis
- Gessert Devon
- Ging-Yuek Robin Hsiung
- Gloria Chiang
- Gloria Chiang
- Godfrey D. Pearlson
- Gordineer Leslie
- Greg Jicha
- Greg Sorensen
- Guiyin Cen
- Gus Jiminez
- Gus Jiminez
- Hayes Jacqueline
- Helen Vanderswag
- Helen Vanderswag
- Hillel Grossman
- Horacio Capote
- Howard Bergman
- Howard Chertkow
- Howard Feldman
- Howard Fillit
- Howard J. Rosen
- Howard Rosen
- Hristina Koleva
- Hyungsub Shim
- Irina Rachinsky
- Irina Rachisky
- Iris Sim
- J. Jay Fruehling
- Jacobo Mintzer
- Jacobo Mintzer
- James Brewer
- James Brewer
- James J. Lah
- Janet S. Cellar
- Jared R. Brosch
- Jared Tinklenberg
- Jason H. Karlawish
- Javier Villanueva-Meyer
- Jeff D. Williamson
- Jeff Gunter
- Jeff Gunter
- Jeffrey Kaye
- Jeffrey M. Burns
- Jeffrey R. Petrella
- Jeffrey R. Petrella
- Jennifer Mason
- Jerome A. Yesavage
- Jerome Yesavage
- Joanne Allard
- Joanne Allard
- Joanne L. Lord
- John Brockington
- John C. Morris
- John C. Morris
- John C. Morris
- John C. Morris
- John Hsiao
- John Morris
- John Olichney
- John Q. Trojanowki
- John Q. Trojanowki
- John Q. Trojanowki
- John Q. Trojanowki
- John Rogers
- Jordan Grafman
- Joseph Quinn
- Joy L. Taylor
- Joy L. Taylor
- Judith L. Heidebrink
- Kantarci Kejal
- Karen Anderson
- Karen Blank
- Karen Crawford
- Karen Ekstam Smith
- Karen L. Bell
- Karen L. Bell
- Kathleen Johnson
- Kathleen Tingus
- Kaycee M. Sink
- Keith A. Johnson
- Keith A. Johnson
- Kejal Kantarci
- Kelley Faber
- Kelley Faber
- Kelly Behan
- Kelly M. Makino
- Kenneth Spicer
- Kewei Chen
- Kewei Chen
- Ki Won Nam
- Kim Martin
- Kim Poki-Walker
- Kimberly S. Martin
- Konstantinos Arfanakis
- Kris Johnson
- Kristin Fargher
- Kristine Lipowski
- Kwangsik Nho
- Kwangsik Nho
- Kyle Womack
- Laura A. Flashman
- Laurel Beckett
- Laurel Beckett
- Lawrence S. Honig
- Lawrence S. Honig
- Lean Thal
- Leon Thal
- Leslie M. Shaw
- Leslie M. Shaw
- Leslie M. Shaw
- Leslie M. Shaw
- Lew Kuller
- Leyla deToledo-Morrell
- Li Shen
- Li Shen
- Liana Apostolova
- Liberty Teodoro
- Lisa Ravdin
- Lisa Ravdin
- Lisa Silbert
- Lisa Taylor-Reinwald
- Lon S. Schneider
- Lon S. Schneider
- Lori A. Daiello
- M. Marcel Mesulam
- M. Saleem Ismail
- Magdalena Korecka
- Magdalena Korecka
- Marc Raichle
- Marc Seltzer
- Marek-Marsel Mesulam
- Maria Carrillo
- Maria Carroll
- Maria Kataki
- Maria T Greig
- Maria T. Greig-Custo
- Marilyn Albert
- Marilyn Albert
- Marissa Natelson Love
- Mark A. Mintun
- Martha G. MacAvoy
- Martin R. Farlow
- Martin Sadowski
- Marwan N. Sabbagh
- Marwan N. Sabbagh
- Mary L. Creech
- Mary L. Hynes
- Mary Quiceno
- MaryAnn Oakley
- Matt Senjem
- Matt Senjem
- Matthew Bernstein
- Matthew Bernstein
- Mauricio Becerra
- Michael Borrie
- Michael Donohue
- Michael Donohue
- Michael Donohue
- Michael Donohue
- Michael Lin
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael W. Weiner
- Michael Weiner
- Michael Weiner
- Michael Weiner
- Michal Figurski
- Michal Figurski
- Michele Assaly
- Michelle Rainka
- Mimi Dang
- Mohammed O. Sheikh
- Munir Chowdhury
- Nadira Trncic
- Nancy Johnson
- Neil Buckholtz
- Neil Kowall
- Neill R Graff-Radford
- Neu Scott
- Nick Fox
- Nigel J. Cairns
- Nigel J. Cairns
- Norbert Schuff
- Norm Foster
- Norm Foster
- Norman Relkin
- Norman Relkin
- Nunzio Pomara
- Olga Brawman-Mintzer
- Olga James
- Oscar L. Lopez
- Owen Carmichael
- P. Murali Doraiswamy
- P. Murali Doraiswamy
- Parianne Fatica
- Partha Sinha
- Patricia Lynn Johnson
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Aisen
- Paul Malloy
- Paul Thompson
- Paula Ogrocki
- Pauline Maillard
- Peter Davies
- Peter Hardy
- Peter J. Snyder
- Peter Snyder
- Pierre Tariot
- Po H. Lu
- Pradeep Garg
- Pradeep Varma
- Prashanthi Vemuri
- Rachelle S. Doody
- Raina Carter
- Raj C. Shah
- Raj C. Shah
- Randall Griffith
- Ranjan Duara
- Ranjan Duara
- Raymond Scott Turner
- Raymond Scott Turner
- Raymundo Hernando
- Reisa A. Sperling
- Reisa A. Sperling
- Richard E. Carson
- Richard Frank
- Rob Bartha
- Robert A. Koeppe
- Robert A. Koeppe
- Robert B. Santulli
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Robert C. Green
- Ronald G. Thomas
- Ronald G. Thomas
- Ronald Killiany
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Ronald Petersen
- Rosemary Morrison
- Russell H. Swerdlow
- Saba Wolday
- Saba Wolday
- Salvador Borges-Neto
- Sandra A. Jacobson
- Sandra A. Jacobson
- Sandra Black
- Sandra Harding
- Sandra Weintraub
- Sanjay Asthana
- Sara Dolen
- Sara S. Mason
- Sarah Walter
- Scott Herring
- Scott Neu
- Shengwen Guo
- Sherye A. Sirrel
- Sherye A. Sirrel
- Smita Kittur
- Sonia Pawluczyk
- Sonia Pawluczyk
- Stacy Schneider
- Stephanie Kielb
- Stephanie Reeder
- Stephen Correia
- Stephen Pasternack
- Stephen Pasternak
- Stephen Salloway
- Sterling C. Johnson
- Sterling Johnson
- Steven Chao
- Steven E. Arnold
- Steven G. Potkin
- Steven G. Potkin
- Steven G. Potkin
- Steven Paul
- Steven Paul
- Steven Potkin
- Steven Potkin
- Sungeun Kim
- Sungeun Kim
- Susan K. Schultz
- Susan Landau
- Susan Landau
- Susan Landau
- Susan Rountree
- T-Y Lee
- Tamie Sather
- Tamie Sather
- Tatiana M. Foroud
- Tatiana M. Foroud
- Terence Z. Wong
- Teresa Villena
- Teresa Villena
- The Alzheimer's Disease Neuroimaging Initiative
- Thomas Neylan
- Thomas Neylan
- Thomas O. Obisesan
- Thomas O. Obisesan
- Tom Montine
- Tom Montine
- Ulysse Anaztasia
- Valory Pavlik
- Vernice Bates
- Vesna Sossi
- Victoria Shibley
- Virginia Lee
- Virginia Lee
- Walter Martinez
- Ward Chad
- Warren Barker
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William Jagust
- William M. Brooks
- William Potter
- William Potter
- Yaakov Stern
- Yaakov Stern
- Zaven Khachaturian
- Zaven Khachaturian
- Zaven Khachaturian
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/05/2017
- Field of study
Neuroimaging measurements derived from magnetic resonance imaging provide important information required for detecting changes related to the progression of mild cognitive impairment (MCI). Cortical features and changes play a crucial role in revealing unique anatomical patterns of brain regions, and further differentiate MCI patients from normal states. Four cortical features, namely, gray matter volume, cortical thickness, surface area, and mean curvature, were explored for discriminative analysis among three groups including the stable MCI (sMCI), the converted MCI (cMCI), and the normal control (NC) groups. In this study, 158 subjects (72 NC, 46 sMCI, and 40 cMCI) were selected from the Alzheimer's Disease Neuroimaging Initiative. A sparse-constrained regression model based on the l2-1-norm was introduced to reduce the feature dimensionality and retrieve essential features for the discrimination of the three groups by using a support vector machine (SVM). An optimized strategy of feature addition based on the weight of each feature was adopted for the SVM classifier in order to achieve the best classification performance. The baseline cortical features combined with the longitudinal measurements for 2 years of follow-up data yielded prominent classification results. In particular, the cortical thickness produced a classification with 98.84% accuracy, 97.5% sensitivity, and 100% specificity for the sMCI–cMCI comparison; 92.37% accuracy, 84.78% sensitivity, and 97.22% specificity for the cMCI–NC comparison; and 93.75% accuracy, 92.5% sensitivity, and 94.44% specificity for the sMCI–NC comparison. The best performances obtained by the SVM classifier using the essential features were 5–40% more than those using all of the retained features. The feasibility of the cortical features for the recognition of anatomical patterns was certified; thus, the proposed method has the potential to improve the clinical diagnosis of sub-types of MCI and predict the risk of its conversion to Alzheimer's disease
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