InGaAs/InP SPAD with Monolithically Integrated Zinc-Diffused Resistor

Afterpulsing and optical crosstalk are significant performance limitations for applications employing near-infrared single-photon avalanche diodes (SPADs). In this paper, we describe an InGaAs/InP SPAD with monolithically integrated resistor that is fully compatible with the planar fabrication process and provides a significant reduction of the avalanche charge and, thus, of afterpulsing and optical crosstalk. In order to have a fast SPAD reset (<50 ns), we fabricated quenching resistors ranging from 10 to 200 k\Ω, smaller than what is available in the literature. The resistor, fabricated with the zinc diffusions already used for avoiding premature edge-breakdown, promptly reduces the avalanche current to a low value ∼ 100~ μ A in less than 1 ns, while an active circuit completes the quenching and enforces a well-defined hold-off. The proposed mixed-quenching approach guarantees an avalanche charge reduction of more than 20 times compared with similar plain SPADs, enough to reduce the hold-off time down to 1 μ s. Finally, a compact single-photon counting module based on this detector and featuring 70-ps photon-timing jitter is presented

InGaAs/InP single-photon detector with low noise, low timing jitter and high count rate

We present a new InGaAs/InP Single-Photon Avalanche Diode (SPAD) with high detection efficiency and low noise, which has been employed in a sinusoidal-gated setup to achieve very low afterpulsing probability and high count rate. The new InGaAs/InP SPAD has lower noise compared to previous generations thanks to the improvement of Zinc diffusion conditions and the optimization of the vertical structure. A detector with 25 μm active-area diameter, operated in gated-mode with ON time of tens of nanoseconds, has a dark count rate of few kilo-counts per second at 225 K and 5 V of excess bias, 30% photon detection efficiency at 1550 nm and a timing jitter of less than 90 ps (FWHM) at 7 V of excess bias. In order to reduce significantly the afterpulsing probability, these detectors were operated with a sinusoidal gate at 1.3 GHz. The extremely short gate ON time (less than 200 ps) reduces the charge flowing through the junction, thus reducing the number of trapped carriers and, eventually, lowering the afterpulsing probability. The resulting detection system achieves a maximum count rate higher than 650 Mcount/s with an afterpulsing probability of about 1.5%, a photon detection efficiency greater than 30% at 1550 nm and a temporal resolution of less than 90 ps (FWHM)

Propriétés du Boson de Higgs se désintégrant en 4 leptons au LHC dans l’expérience ATLAS : masse, limite sur la contribution à haute masse et sur la largeur

The theme of the analyses presented in this Thesis is the measurement of the Higgs boson properties in the H→ZZ→4l decay channel with the ATLAS experiment at the LHC. A detailed overview on the electron calibration process is first presented. In this regard, the track-cluster combination algorithm is found to improve the energy resolution of low ET electrons by exploiting both track and cluster information into a maximum likelihood fit. The improvement in resolution is approximately 18-20% for J/Ψ dielectron decays, and of the order of 3% for Z→ee events. In addition, the E-p combination algorithm has also been applied to the H→ZZ→4l channel with electrons in the final state resulting in a non-negligible gain on the invariant mass distribution (4-5%). Secondly, the Higgs mass and its total width are evaluated in the H→ZZ→4l channel. The Higgs mass is measured in the 4l decay channel with particular interest on the beneficial effects brought by the improved electron calibration and the track-cluster combination. The mass on the full 2011 and 2012 datasets is worked out with a 2-dimensional fit on the invariant mass of the 4 lepton final state, m4l, and on a boosted decision tree (BDT)-based output conceived against the main ZZ irreducible background and constructed on variables that are sensitive to the Higgs boson spin-parity state. Regarding the Higgs width, results are based on a relatively recent approach aimed at indirectly constraining the Higgs boson width by exploiting the m4l high-mass region where the Higgs boson acts as a propagator. The Higgs production cross section in the on-shell m4l region, where the Higgs boson is a resonance, depends on the total Higgs width, whereas this is not the case for the high mass m4l (off-shell). Limits on the Higgs width can be therefore set when merging the off-shell results with the on-shell ones. A limit of ∼ 6.7 times ΓSMH is obtained in the four lepton channel. Secondly, by combining with the on-shell measurement and using all the decay channels in the analysis, i.e. ZZ→4l, ZZ→2l2ν and WW→lνlν, the results lead to an observed (expected) 95% C.L. upper limit on the Higgs boson total width of 22.7 (33.0) MeV (4.2 MeV is the Standard Model predicted Higgs width at mH=125 GeV).The last section of the thesis is devoted to the evaluation of the Higgs width at √s=14 TeV in the high luminosity scenario (High Luminosity LHC), 300 fb⁻¹ and 3000 fb⁻¹, by employing the same techniques exploited in the previous Run 1 analysis at √s=8 TeV.Le thème des analyses présentées dans ce document est la mesure des propriétés du boson de Higgs se désintégrant dans le mode H→ZZ→4l dans l'expérience ATLAS au CERN. Le document commence par un résumé détaillé concernant la procédure d'étalonnage des électrons: l'algorithme de combinaison trace-cluster améliore la résolution en énergie (surtout pour les électrons ayant une faible énergie transverse) en exploitant les informations du cluster et de la trace dans un ajustement par maximum de vraisemblance. L'amélioration en résolution est approximativement de 18-20% pour les désintégrations du J/Ψ en di-électrons, et 3% pour Z→ee. Par la suite, la combinaison E-p est appliquée au canal H→ZZ→4l avec électrons dans l'état final permettant d’obtenir un gain modéré sur la distribution de la masse invariante (4-5%). En deuxième lieu, la masse du boson de Higgs et sa largeur sont estimées, en particulier afin de comprendre les effets apportés par l'utilisation de l'algorithme de combinaison trace-cluster. La masse a été calculée en se servant d'un ajustement à deux dimensions appliqué sur la masse invariante m4l et un score de discrimination du signal contre le bruit de fond ZZ*. Cette discrimination est obtenue en exploitant les corrélations angulaires dont les distributions sont sensibles au spin et à la parité du boson de Higgs. L’étude sur la largeur du boson est ensuite détaillée : les résultats sont basés sur une approche qui vise à contraindre cette largeur en analysant la région de haute masse m4l où le boson de Higgs se comporte comme un propagateur. La section efficace au pic de la résonance (« on-shell ») dépend de la largeur totale du boson de Higgs, ce qui n’est pas le cas pour la production dans la région de haute masse (« off-shell »). Par conséquent, des limites indirectes sur la largeur peuvent être déterminées en combinant les régions « on-shell » et « off-shell ». Une limite à 6.7 fois la largeur Higgs ΓSMH est obtenue via le canal 4l. En combinant la mesure « on-shell » avec tous les canaux de désintégration étudiés (notamment ZZ→4l, ZZ→2l2ν and WW→lνlν), les résultats aboutissent à une limite observée (attendue) sur la largeur totale de 22.7 (33.0) MeV. La dernière partie de ce travail de thèse est consacrée à l'analyse sur la largeur du boson de Higgs en quatre leptons à haute (High-Luminosity LHC) luminosité intégrée (respectivement 300 fb⁻¹ et 3000 fb⁻¹) : il s’agit d’une étude extrapolant à √s =14 TeV les techniques utilisées pour l’analyse à 8 TeV (Run 1)

Predictores de respuesta favorable a la colocación de derivación ventriculoperitoneal en pacientes con hidrocefalia normotensiva idiopática

Introduction: The indication of a ventriculoperitoneal shunt (VPS) is discussed in patients with idiopathic normal pressure hydrocephalus (iNPH), due to the heterogeneity of the response to treatment and the risks involved in neurosurgery. Objective: To search for clinical factors and complementary studies in order to determine predictors of a favorable response to the VPS placement in patients with iNPH. Methodology: A retrospective study of patients with probable iNPH (according to international guidelines) treated with VPS assisted in a neurological clinic from January 2014 to January 2017 was conducted. A univariate statisticalanalysis of the variables considered as possible prognostic factors was performed. Results: 58 patients were included. Women presented 3.68 times more chances of improvement after the VPS (p=0.019). Good response to the gait test was associated with better response to the VPS (p=0.024). Conclusions: Female sex and good response to the gait test could be considered as predictors of a favorable response to the VPS placement in patients with iNPH. A prospective study is necessary to achieve a homogeneous diagnostic evaluation and a more extensive longitudinal follow-up to evaluate the clinical evolution in this group of patients.Introducción: La indicación de la derivación ventriculoperitoneal (DVP) se discute en pacientes con hidrocefalia normotensiva idiopática (HNTi), debido a la heterogeneidad de la respuesta al tratamiento y los riesgos que conlleva la neurocirugía. Objetivo: Búsqueda de factores clínicos y estudios complementarios, para determinar predictores de respuesta favorable a la colocación de DVP en pacientes con HNTi. Metodología: Estudio retrospectivo de pacientes con probable HNTi (según guías internacionales) tratados con DVP asistidos en una clnica neurológica desde enero de 2014 hasta enero de 2017. Se realizó un análisis estadístico univariado de las variables consideradas como posibles factores pronósticos. Resultados: seincluyeron 58 pacientes. Las mujeres presentaron 3,68 veces más posibilidades de mejora tras la DVP (p=0,019). La buena respuesta a la prueba de la marcha se asoció con una mejor respuesta a la DVP (p=0,024). Conclusiones: el sexo femenino y la buena respuesta a la prueba de la marcha podrían&nbsp; considerarse predictores de una respuesta favorable a la colocación de la DVP en pacientes con HNTi. Es necesario un estudio prospectivo para lograr una evaluación diagnóstica homogénea y un seguimiento longitudinal más extenso para evaluar la evolución clínica en este grupo de pacientes

Amnesia global transitoria: características clínicas y factores pronósticos sugestivos de recurrencia

Objective: The risk of recurrence of new amnesia events in patients having previously experienced transient global amnesia (TGA) ranges between 2.9-23.8%. Our objective was to search for recurrence predictors in TGA patients. Methods: Retrospective analysis to identify recurrence predictors in a cohort of 203 TGA patients from a single center in Buenos Aires, Argentina, diagnosed between January 2011 and March 2017 Clinical features and complementary studies (laboratory results, jugular vein Doppler ultrasound and brain MRI) were analyzed. Comparison between patients with recurrent versus single episode TGA was performed, applying a multivariate logistic regression model. Results: Mean age at presentation was 65 years (20-84); 52% were female. Median time elapsed between symptom onset and ER visit was two hours, with the average episode duration lasting four hours. Mean follow-up was 22 months. Sixty-six percent of patients referred to an identifiable trigger. Jugular reflux was present in 66% of patients; and 22% showed images with hippocampus restriction on diffusion-weighted MRI. Eight percent of patients had TGA recurrence. Patients with recurrent TGA had a more frequent history of migraine than patients without recurrence (37.5% vs. 14%; p = 0.03). None of the other clinical characteristics and complementary studies were predictors of increased risk of recurrence. Conclusions: Patients with migraine may have a higher risk of recurrent TGA. None of the other clinical characteristics evaluated allowed us to predict an increased risk of recurrence. Although the complementary studies allowed us to guide the diagnosis, they did not appear to have a significant impact on the prediction of recurrence risk.Fil: Alessandro, Lucas. Fleni. Departamento de Neurología; Argentina.Fil: Calandri, Ismael Luis. Fleni. Departamento de Neurología; Argentina.Fil: Fernández Suarez, Marcos. Fleni. Departamento de Neurología; Argentina.Fil: Heredia, María Liliana. Fleni. Centro de Rehabilitación Adultos CR. Rehabilitación Cognitiva y Lenguaje; Argentina.Fil: Chaves, Hernán. Fleni. Departamento de Diagnóstico por Imágenes; Argentina.Fil: Allegri, Ricardo Francisco. Fleni. Departamento de Neurología. Servicio de Neurología Cognitiva, Neuropsicología y Neuropsiquiatría; Argentina.Fil: Farez, Mauricio Franco. Fleni. Centro para la Investigación de Enfermedades Neuroinmunológicas; Argentina

Measurement of four-jet differential cross sections in s = 8 s=8 \sqrt{s}=8 TeV proton-proton collisions using the ATLAS detector

Differential cross sections for the production of at least four jets have been measured in proton-proton collisions at s√=8 TeV at the Large Hadron Collider using the ATLAS detector. Events are selected if the four anti-ktR = 0.4 jets with the largest transverse momentum (pT) within the rapidity range |y| &lt; 2.8 are well separated (ΔR4jmin &gt; 0.65), all have pT &gt; 64 GeV, and include at least one jet with pT &gt; 100 GeV. The dataset corresponds to an integrated luminosity of 20.3 fb−1. The cross sections, corrected for detector effects, are compared to leading-order and next-to-leading-order calculations as a function of the jet momenta, invariant masses, minimum and maximum opening angles and other kinematic variables

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements