Slaughterhouse zoonoses: Are workers reservoirs of zoonotic disease?

Slaughterhouse workers are considered a high risk group for zoonotic disease due to increased contact with animals, animal products and excreta. Globally, slaughterhouse workers have been shown to have an increased seroprevalence to zoonotic pathogens, though no such studies exist in Kenya. Slaughterhouse workers may also act as reservoirs of these zoonotic organisms and asymptomatic carriage of pathogenic bacteria has been demonstrated. This study aimed to determine the carriage of enteropathogens in slaughterhouse workers in rural western Kenya and to determine if there was asymptomatic carriage of Staphylococcus aureus specifically Methicillin Resistant S. aureus (MRSA). This study was conducted in the Lake Victoria Crescent region of western Kenya. Five hundred slaughterhouse workers from this region were asked a comprehensive questionnaire regarding risk factors for zoonotic disease, faecal samples were collected for examination and culture and a nasal swab was cultured for S. aureus. This study reports on the seroprevalence of Salmonella spp, Shigella spp, pathogenic Escherichia coli and Campylobacter spp. in these individuals as well as reporting the nasal carriage of S. aureus and MRSA. This is the first community based study regarding S. aureus and MRSA in Kenya. The asymptomatic carriage of these organisms in slaughterhouse workers highlights a reservoir that may be important in the dissemination of these pathogens. The study further comments on the risk factors for infection with these pathogens and suggestions are made for simple hygiene interventions that can reduce disease in slaughterhouse workers and dissemination to the wider communit

Relativistic Hydrodynamic Evolutions with Black Hole Excision

We present a numerical code designed to study astrophysical phenomena involving dynamical spacetimes containing black holes in the presence of relativistic hydrodynamic matter. We present evolutions of the collapse of a fluid star from the onset of collapse to the settling of the resulting black hole to a final stationary state. In order to evolve stably after the black hole forms, we excise a region inside the hole before a singularity is encountered. This excision region is introduced after the appearance of an apparent horizon, but while a significant amount of matter remains outside the hole. We test our code by evolving accurately a vacuum Schwarzschild black hole, a relativistic Bondi accretion flow onto a black hole, Oppenheimer-Snyder dust collapse, and the collapse of nonrotating and rotating stars. These systems are tracked reliably for hundreds of M following excision, where M is the mass of the black hole. We perform these tests both in axisymmetry and in full 3+1 dimensions. We then apply our code to study the effect of the stellar spin parameter J/M^2 on the final outcome of gravitational collapse of rapidly rotating n = 1 polytropes. We find that a black hole forms only if J/M^2<1, in agreement with previous simulations. When J/M^2>1, the collapsing star forms a torus which fragments into nonaxisymmetric clumps, capable of generating appreciable ``splash'' gravitational radiation.Comment: 17 pages, 14 figures, submitted to PR

Historical abundance and distribution of the native flat oyster (Ostrea angasi) in estuaries of the Great Southern region of Western Australia help to prioritise potential sites for contemporary oyster reef restoration

Reefs of the flat oyster (Ostrea angasi) were once common along the southern coasts of Australia. Historical and current literature relating to O. angasi was used to identify bays and estuaries where this species once existed. In many estuaries of Western Australia, current populations are significantly lower than historical levels, including in Princess Royal Harbour and Oyster Harbour, near Albany. The main causes of the declines included overfishing, combined with the use of destructive fishing methods, such as dredging. Other factors, such as sedimentation, increased nutrient input and loss of seagrass, may have contributed to the loss of oyster reefs, and may have inhibited effective recovery. The possible impact of the protozoan pathogen Bonamia exitiosa is uncertain, although it is known to have severely affected flat oyster populations in other parts of the world. The fact that O. angasi reefs in Oyster Harbour did not recover after the fishery ceased suggests that restoration activities, aimed at restarting the ecosystem services that the oyster reefs once provided, should be undertaken. This paper suggests that the historical presence of O. angasi could be an effective starting point for prioritising potential restoration sites and details the prioritisation protocol that was used in recent restoration activities

Measurement of D*+/- meson production in jets from pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

This paper reports a measurement of D*+/- meson production in jets from proton-proton collisions at a center-of-mass energy of sqrt(s) = 7 TeV at the CERN Large Hadron Collider. The measurement is based on a data sample recorded with the ATLAS detector with an integrated luminosity of 0.30 pb^-1 for jets with transverse momentum between 25 and 70 GeV in the pseudorapidity range |eta| < 2.5. D*+/- mesons found in jets are fully reconstructed in the decay chain: D*+ -> D0pi+, D0 -> K-pi+, and its charge conjugate. The production rate is found to be N(D*+/-)/N(jet) = 0.025 +/- 0.001(stat.) +/- 0.004(syst.) for D*+/- mesons that carry a fraction z of the jet momentum in the range 0.3 < z < 1. Monte Carlo predictions fail to describe the data at small values of z, and this is most marked at low jet transverse momentum.Comment: 10 pages plus author list (22 pages total), 5 figures, 1 table, matches published version in Physical Review

Intrauterine devices and endometrial cancer risk : a pooled analysis of the Epidemiology of Endometrial Cancer Consortium

Intrauterine devices (IUDs), long-acting and reversible contraceptives, induce a number of immunological and biochemical changes in the uterine environment that could affect endometrial cancer (EC) risk. We addressed this relationship through a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We combined individual-level data from 4 cohort and 14 case-control studies, in total 8,801 EC cases and 15,357 controls. Using multivariable logistic regression, we estimated pooled odds ratios (pooled-ORs) and 95% confidence intervals (CIs) for EC risk associated with ever use, type of device, ages at first and last use, duration of use and time since last use, stratified by study and adjusted for confounders. Ever use of IUDs was inversely related to EC risk (pooled-OR = 0.81, 95% CI = 0.74-0.90). Compared with never use, reduced risk of EC was observed for inert IUDs (pooled-OR = 0.69, 95% CI = 0.58-0.82), older age at first use (≥35 years pooled-OR = 0.53, 95% CI = 0.43-0.67), older age at last use (≥45 years pooled-OR = 0.60, 95% CI = 0.50-0.72), longer duration of use (≥10 years pooled-OR = 0.61, 95% CI = 0.52-0.71) and recent use (within 1 year of study entry pooled-OR = 0.39, 95% CI = 0.30-0.49). Future studies are needed to assess the respective roles of detection biases and biologic effects related to foreign body responses in the endometrium, heavier bleeding (and increased clearance of carcinogenic cells) and localized hormonal changes

How well do we understand the reaction rate of C burning?

Carbon burning plays a crucial role in stellar evolution, where this reaction is an important route for the production of heavier elements. A particle-γ coincidence technique that minimizes the backgrounds to which this reaction is subject and provides reliable cross sections has been used at the Argonne National Laboratory to measure fusion cross-sections at deep sub-barrier energies in the 12C+12C system. The corresponding excitation function has been extracted down to a cross section of about 6 nb. This indicates the existence of a broad S-factor maximum for this system. Experimental results are presented and discussed

Sintering behaviour of Al-Cu-Mg-Si blends

The increasing demand for automotive industries to reduce the weight of the vehicles has led to a growing usage of Al alloy powder metallurgy (P/M) parts such as camshaft bearing caps, shock absorber pistons and brake calipers [1,2]. In order to control the sintered microstructure and mechanical properties of the aluminium alloy powder metallurgical (P/M) parts, it is essential to establish a fundamental understanding of the microstructural development during the sintering process. Current research at Birmingham University is focussed on the investigation of the sintering behaviour of Al-Cu-Mg-Si powder blends using a combination of Scanning Electron Microscopy, Energy Dispersive Microanaylsis (SEM) and Differential Scanning Calorimetry (DSC). This paper presents a detailed study of the effect of temperature and initial starting materials on the evolution of microstructure during the sintering of Al-Cu-Mg-Si blends for PM

Search for supersymmetry in final states with jets, missing transverse momentum and one isolated lepton in sqrt{s} = 7 TeV pp collisions using 1 fb-1 of ATLAS data

We present an update of a search for supersymmetry in final states containing jets, missing transverse momentum, and one isolated electron or muon, using 1.04 fb^-1 of proton-proton collision data at sqrt{s} = 7 TeV recorded by the ATLAS experiment at the LHC in the first half of 2011. The analysis is carried out in four distinct signal regions with either three or four jets and variations on the (missing) transverse momentum cuts, resulting in optimized limits for various supersymmetry models. No excess above the standard model background expectation is observed. Limits are set on the visible cross-section of new physics within the kinematic requirements of the search. The results are interpreted as limits on the parameters of the minimal supergravity framework, limits on cross-sections of simplified models with specific squark and gluino decay modes, and limits on parameters of a model with bilinear R-parity violation.Comment: 18 pages plus author list (30 pages total), 9 figures, 4 tables, final version to appear in Physical Review

A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007

We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - September 2007, which coincided with the fifth and first science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed for candidate gravitational-wave signals coincident in time and direction with the neutrino events. No significant coincident events were observed. We place limits on the density of joint high energy neutrino - gravitational wave emission events in the local universe, and compare them with densities of merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access area to figures, tables at https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000