452 research outputs found
Approximation of Fire-Return Intervals with Point Samples in the Southern Range of the Coast Redwood Forest, California, USA
- Author
- A Robichaud
- AC Caprio
- AC Caprio
- AK Brown
- AL Carroll
- BH Brockett
- BL Gordon
- BS Ramage
- CA Farris
- California Department of Water Resources
- CG Lorimer
- CR Clar
- CS Fowler
- DF Jacobs
- E Fritz
- EK Heyerdahl
- EK Heyerdahl
- FW Davis
- Gregory A. Jones
- HD Grissino-Mayer
- HH Biswell
- JA Johnstone
- JD Stuart
- JE Keeley
- JE Keeley
- JH Speer
- JM Greenlee
- JM Greenlee
- JO Sawyer
- JR McBride
- JW Wagtendonk van
- K Adams
- K Orvis
- KG Lightfoot
- KM Waring
- MA Finney
- MA Finney
- MA Stokes
- OC Stewart
- PE Kelly
- PM Brown
- PM Brown
- PM Brown
- PM Brown
- R Lazzeri-Aerts
- RE Martin
- RQ Cuthrell
- RT Milliken
- S Underwood
- SD Veirs
- SF Arno
- SL Stephens
- SL Stephens
- SP Norman
- SP Norman
- Swanton Pacific Ranch
- TE Dawson
- Will Russell
- WL Baker
- WS Cooper
- Publication venue
- 'Association for Fire Ecology'
- Publication date
- Field of study
Production of phi mesons at mid-rapidity in sqrt(s_NN) = 200 GeV Au+Au collisions at RHIC
- Author
- Adler SS
- Afanasiev S.
- Aidala C.
- Ajitanand NN
- Akiba Y.
- Alexander J.
- Amirikas R.
- Aphecetche L.
- Aronson SH
- Averbeck R.
- Awes TC
- Azmoun R.
- Babintsev V.
- Baldisseri A.
- Barish KN
- Barnes PD
- Bassalleck B.
- Bathe S.
- Batsouli S.
- Baublis V.
- Bazilevsky A.
- Belikov S.
- Berdnikov Y.
- Bhagavatula S.
- Boissevain JG
- Borel H.
- Borenstein S.
- Brooks ML
- Brown DS
- Bruner N.
- Bucher D.
- Buesching H.
- Bumazhnov V.
- Bunce G.
- Burward-Hoy JM
- Butsyk S.
- Camard X.
- Chai JS
- Chand P.
- Chang WC
- Chernichenko S.
- Chi CY
- Chiba J.
- Chiu M.
- Choi IJ
- Choi J.
- Choudhury R. K.
- Chujo T.
- Cianciolo V.
- Cobigo Y.
- Cole BA
- Constantin P.
- d'Enterria DG
- David G.
- de Cassagnac RG
- Delagrange H.
- Denisov A.
- Deshpande A.
- Desmond EJ
- Devismes A.
- Dietzsch O.
- Drapier O.
- Drees A.
- du Rietz R.
- Durum A.
- Dutta D.
- Efremenko YV
- El Chenawi K.
- En'yo H.
- Enokizono A.
- Esumi S.
- Ewell L.
- Fields DE
- Fleuret F.
- Fokin SL
- Fox BD
- Fraenkel Z.
- Frantz JE
- Franz A.
- Frawley AD
- Fung SY
- Garpman S.
- Ghosh TK
- Glenn A.
- Gogiberidze G.
- Gonin M.
- Gosset J.
- Goto Y.
- Grau N.
- Greene SV
- Guryn W.
- Gustafsson HA
- Hachiya T.
- Haggerty JS
- Hamagaki H.
- Hansen AG
- Hartouni EP
- Harvey M.
- Hayano R.
- Hayashi N.
- He X.
- Heffner M.
- Hemmick TK
- Heuser JM
- Hibino M.
- Hill JC
- Holzmann W.
- Homma K.
- Hong B.
- Hoover A.
- Ichihara T.
- Ikonnikov VV
- Imai K.
- Isenhower D.
- Ishihara M.
- Issah M.
- Isupov A.
- Jacak BV
- Jang WY
- Jeong Y.
- Jia J.
- Jinnouchi O.
- Johnson BM
- Johnson SC
- Joo KS
- Jouan D.
- Kametani S.
- Kamihara N.
- Kang JH
- Kapoor SS
- Katou K.
- Kelly S.
- Khachaturov B.
- Khanzadeev A.
- Kikuchi J.
- Kim DH
- Kim DJ
- Kim DW
- Kim E.
- Kim GB
- Kim HJ
- Kistenev E.
- Kiyomichi A.
- Kiyoyama K.
- Klein-Boesing C.
- Kobayashi H.
- Kochenda L.
- Kochetkov V.
- Koehler D.
- Kohama T.
- Kopytine M.
- Kotchetkov D.
- Kozlov A.
- Kroon PJ
- Kuberg CH
- Kurita K.
- Kuroki Y.
- Kweon MJ
- Kwon Y.
- Kyle GS
- Lacey R.
- Ladygin V.
- Lajoie JG
- Lebedev A.
- Leckey S.
- Lee DM
- Lee S.
- Leitch MJ
- Li XH
- Lim H.
- Litvinenko A.
- Liu MX
- Liu Y.
- Maguire CF
- Makdisi YI
- Malakhov A.
- Manko VI
- Mao Y.
- Martinez G.
- Marx MD
- Masui H.
- Matathias F.
- Matsumoto T.
- McGaughey PL
- Melnikov E.
- Messer F.
- Miake Y.
- Milan J.
- Miller TE
- Milov A.
- Mioduszewski Saskia
- Mischke RE
- Mishra GC
- Mitchell JT
- Mohanty AK
- Morrison DP
- Moss JM
- Muhlbacher F.
- Mukhopadhyay D.
- Muniruzzaman M.
- Murata J.
- Nagamiya S.
- Nagle JL
- Nakamura T.
- Nandi BK
- Nara M.
- Newby J.
- Nilsson P.
- Nyanin AS
- Nystrand J.
- O'Brien E.
- Ogilvie CA
- Ohnishi H.
- Ojha ID
- Okada K.
- Ono M.
- Onuchin V.
- Oskarsson A.
- Otterlund I.
- Oyama K.
- Ozawa K.
- Pal D.
- Palounek APT
- Pantuev VS
- Papavassiliou V.
- Park J.
- Parmar A.
- Pate SF
- Peitzmann T.
- Peng JC
- Perdekamp MG
- Peresedov V.
- PHENIX Collaboration.
- Pinkenburg C.
- Pisani RP
- Plasil F.
- Purschke ML
- Purwar AK
- Rak J.
- Ravinovich I.
- Read KF
- Reuter M.
- Reygers K.
- Riabov V.
- Riabov Y.
- Roche G.
- Romana A.
- Rosati M.
- Rosnet P.
- Ryu SS
- Sadler ME
- Saito N.
- Sakaguchi T.
- Sakai M.
- Sakai S.
- Samsonov V.
- Sanfratello L.
- Santo R.
- Sato HD
- Sato S.
- Sawada S.
- Schutz Y.
- Semenov V.
- Seto R.
- Shaw MR
- Shea TK
- Shibata TA
- Shigaki K.
- Shiina T.
- Silva CL
- Silvermyr D.
- Sim KS
- Singh CP
- Singh V.
- Sivertz M.
- Soldatov A.
- Soltz RA
- Sondheim WE
- Sorensen SP
- Sourikova IV
- Staley F.
- Stankus PW
- Stenlund E.
- Stepanov M.
- Ster A.
- Stoll SP
- Sugitate T.
- Sullivan J. P.
- Takagui EM
- Taketani A.
- Tamai M.
- Tanaka KH
- Tanaka Y.
- Tanida K.
- Tannenbaum MJ
- Tarjan P.
- Tepe JD
- Thomas TL
- Tojo J.
- Torii H.
- Towell RS
- Tserruya I.
- Tsuruoka H.
- Tuli SK
- Tydesjo H.
- Tyurin N.
- van Hecke HW
- Velkovska J.
- Velkovsky M.
- Veszpremi V.
- Villatte L.
- Vinogradov AA
- Volkov MA
- Vznuzdaev E.
- Wang XR
- Watanabe Y.
- White SN
- Wohn FK
- Woody CL
- Xie W.
- Yang Y.
- Yanovich A.
- Yokkaichi S.
- Young GR
- Yushmanov IE
- Zajc WA
- Zhang C.
- Zhou S.
- Zhou SJ
- Zolin L.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 08/10/2004
- Field of study
We present the first results of meson production in the K^+K^- decay channel
from Au+Au collisions at sqrt(s_NN) = 200 GeV as measured at mid-rapidity by
the PHENIX detector at RHIC. Precision resonance centroid and width values are
extracted as a function of collision centrality. No significant variation from
the PDG accepted values is observed. The transverse mass spectra are fitted
with a linear exponential function for which the derived inverse slope
parameter is seen to be constant as a function of centrality. These data are
also fitted by a hydrodynamic model with the result that the freeze-out
temperature and the expansion velocity values are consistent with the values
previously derived from fitting single hadron inclusive data. As a function of
transverse momentum the collisions scaled peripheral.to.central yield ratio RCP
for the is comparable to that of pions rather than that of protons. This result
lends support to theoretical models which distinguish between baryons and
mesons instead of particle mass for explaining the anomalous proton yield.Comment: 326 authors, 24 pages text, 23 figures, 6 tables, RevTeX 4. To be
submitted to Physical Review C as a regular article. Plain text data tables
for the points plotted in figures for this and previous PHENIX publications
are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm
Combined effects of precipitation and nitrogen deposition on native and invasive winter annual production in California deserts
- Author
- AA Schoenherr
- AA Sher
- AE Kelly
- AM Prasad
- CJ Scifres
- CM D’Antonio
- DE Brown
- DT Patten
- DU Hooper
- EB Allen
- Edith B. Allen
- EM Romney
- FW Went
- G Brown
- G De’Ath
- GF Rogers
- HD Grissino-Mayer
- HT Mun
- I Noy-Meir
- JA Ludwig
- JC Beatley
- JD Miller
- JL Bell
- JL Bell
- JM Lenihan
- JM Levine
- JR Gutierrez
- JR Gutierrez
- JS Dukes
- JT Lundholm
- K Zouhar
- L Breiman
- L Yahdjian
- LE Rao
- Leela E. Rao
- LF Salo
- LF Salo
- M Juhren
- MA Bowers
- ME Fenn
- ME Fenn
- ML Brooks
- ML Brooks
- ML Brooks
- ML Brooks
- ML Brooks
- ML Brooks
- ML Brooks
- MP Vayssieres
- PG Rowlands
- R Hereford
- R Hunter
- RA Minnich
- RA Minnich
- S Harris
- SA Drury
- TA Monaco
- TJ Sullivan
- TW Swetnam
- WG Whitford
- Y Gutterman
- YA Wood
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2009
- Field of study
Primary production in deserts is limited by soil moisture and N availability, and thus is likely to be influenced by both anthropogenic N deposition and precipitation regimes altered as a consequence of climate change. Invasive annual grasses are particularly responsive to increases in N and water availabilities, which may result in competition with native forb communities. Additionally, conditions favoring increased invasive grass production in arid and semi-arid regions can increase fire risk, negatively impacting woody vegetation that is not adapted to fire. We conducted a seeded garden experiment and a 5-year field fertilization experiment to investigate how winter annual production is altered by increasing N supply under a range of water availabilities. The greatest production of invasive grasses and native forbs in the garden experiment occurred under the highest soil N (inorganic N after fertilization = 2.99 g m−2) and highest watering regime, indicating these species are limited by both water and N. A classification and regression tree (CART) analysis on the multi-year field fertilization study showed that winter annual biomass was primarily limited by November–December precipitation. Biomass exceeded the threshold capable of carrying fire when inorganic soil N availability was at least 3.2 g m−2 in piñon-juniper woodland. Due to water limitation in creosote bush scrub, biomass exceeded the fire threshold only under very wet conditions regardless of soil N status. The CART analyses also revealed that percent cover of invasive grasses and native forbs is primarily dependent on the timing and amount of precipitation and secondarily dependent on soil N and site-specific characteristics. In total, our results indicate that areas of high N deposition will be susceptible to grass invasion, particularly in wet years, potentially reducing native species cover and increasing the risk of fire
Recommended from our members
A Search for Dark Higgs Bosons
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- Acosta JG
- Adam N
- Adametz A.
- Adye T.
- Ahmed H.
- Akar S.
- Akchurin N
- Alagoz E
- Alam M. S.
- Albert J.
- Alver B
- Alverson G
- Anastassov A
- Anderson M
- Andreassen R.
- Angelini C.
- Antonelli L
- Anulli F.
- Appelt E
- Arenton MW
- Arnaud N.
- Asaadi J
- Asgeirsson D. J.
- Aston D.
- Atmacan H.
- Atramentov O
- Ayad R.
- Bachtis M
- Baden A
- Bailey D.
- Balazs M
- Baldini-Ferroli R.
- Band H. R.
- Banerjee Sw
- Barberis E
- Bard D. J.
- Barfuss AF
- Baringer P
- Barker A
- Barlow R. J.
- Barnes VE
- Barnett BA
- Bartoldus R.
- Batignani G.
- Bauer G
- Baumgartel D
- Baur U
- Bean A
- Behera P. K.
- Behn E.
- Bellinger JN
- Bellis M.
- Ben-Haim E.
- Bendavid J
- Benelli G
- Benitez J. F.
- Bernard D.
- Bernlochner F. U.
- Berry D
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- Betchart B
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- Blinov V. E.
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- Blumenfeld B
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- Bomben M.
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- Brau J.
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- Cali IA
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- Volobouev I
- Voss C.
- Wagner A. P.
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- Wood JS
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- Wray B. C.
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- Wulsin H. W.
- Xie S
- Yan M
- Yang M
- Yang ZC
- Yazgan E
- Yeche Ch
- Yi K
- Yilmaz Y
- Yohay R
- Yoo HD
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- Zablocki J
- Zallo A.
- Zanetti M
- Zatserklyaniy A
- Zhang J
- Zheng Y
- Zhukova V
- Ziegler J
- Ziegler V.
- Zielinski M
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
Recent astrophysical and terrestrial experiments have motivated the proposal
of a dark sector with GeV-scale gauge boson force carriers and new Higgs
bosons. We present a search for a dark Higgs boson using 516 fb-1 of data
collected with the BABAR detector. We do not observe a significant signal and
we set 90% confidence level upper limits on the product of the Standard
Model-dark sector mixing angle and the dark sector coupling constant.Comment: 7 pages, 5 postscript figures, published version with improved plots
for b/w printin
Update in Women’s Health for the General Internist
- Author
- AM Stuebe
- AM Stuebe
- American Academy of Pediatrics
- AO Arowojolu
- B Uebelhart
- CJ Crandall
- CJ Crandall
- CK Osborne
- CM Kelly
- D Wardlaw
- DA Berry
- DM Black
- DT Gray
- E Partridge
- E Raymond
- EB Schwarz
- EB Schwarz
- Eleanor Bimla Schwarz
- EP Gunderson
- H Jick
- HA Bischoff-Ferrari
- HD Nelson
- JA Cauley
- JE Rossouw
- JP Brown
- JR Nagell van Jr
- JS Mandelblatt
- Judith M.E. Walsh
- KJ Bell
- LB Finer
- LL Humphrey
- LM Grummer-Strawn
- LS Velentzis
- M Etminan
- M Messina
- M Schurks
- Megan McNamara
- NF Boyd
- O Lidegaard
- P Fine
- Redonda G. Miller
- SC He
- SF Hodgson
- SJ Skates
- U. S. Preventive Services Task Force
- U. S. Preventive Services Task Force
- U. S. Preventive Services Task Force
- XO Shu
- Y Jin
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
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- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
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- Acerbi E
- Acharya BS
- Adams DL
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- Adelman J
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- Adomeit S
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- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
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- Ahmad A
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- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
X-ray emission from the Sombrero galaxy: discrete sources
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
We present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
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- Acharya BS
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- Adragna P
- Adye T
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- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
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- Zhemchugov A
- Zheng S
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- Zieminska D
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- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
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- Aliev T
- Allfrey P
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- Altsybeev I
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- Zachariadou A
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Maternal hyperleptinemia is associated with male offspring’s altered vascular function and structure in mice
- Author
- A Aceti
- A Ericsson
- A Mehlem
- A Perez-Perez
- A Perez-Perez
- A Singhal
- AL Schenewerk
- AM Samuelsson
- AM Samuelsson
- AR Day
- ARS Day
- AU Momin
- AV Mousiolis
- B Erdos
- C Aoqui
- C Remacle
- C Stocker
- C Torrens
- Christopher A. Foote
- CJ Stocker
- Constantino C. Reyes-Aldasoro
- CS Mantzoros
- CY Ooi
- D Islami
- DA Lawlor
- DW Wilde
- FE Ramos-Alves
- FI Ramirez-Perez
- FM Souza-Smith
- Francisco I. Ramirez-Perez
- G Bifulco
- H Yamashita
- H Yamashita
- HD Intengan
- HD Intengan
- HJ Jang
- Ho-Hsiang Wu
- HY Park
- I Floris
- I Khan
- IY Khan
- J Gui
- J Udagawa
- JA Castorena-Gonzalez
- JA Kim
- JF Caro
- JM Ategbo
- JS Harrod
- K Holemans
- K Linnemann
- KA McLachlan
- KA Pennington
- Kathleen A. Pennington
- KE Pollock
- Kelly E. Pollock
- L Garcia-Vargas
- L Maple-Brown
- LA Martinez-Lemus
- LA Martinez-Lemus
- LA Martinez-Lemus
- Laura C. Schulz
- LC Schulz
- LC Schulz
- Luis A. Martinez-Lemus
- M Gil-Ortega
- M Groenink
- M Kawamura
- MC Staiculescu
- MJ Durand
- MJ Mulvany
- MJ Mulvany
- MP Magarinos
- N Jansson
- O Yilmaz
- Omonseigho O. Talton
- OO Talton
- P Cameo
- R Nadif
- R Wolk
- RC Kaufmann
- RM Weisbrod
- SB Bender
- SL Kirk
- SM Wells
- SO Rocha
- Tieming Ji
- TL Kleinschmidt
- UD Dincer
- X Cheng
- Yunchao Su
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2016
- Field of study
Children of mothers with gestational diabetes have greater risk of developing hypertension but little is known about the mechanisms by which this occurs. The objective of this study was to test the hypothesis that high maternal concentrations of leptin during pregnancy, which are present in mothers with gestational diabetes and/or obesity, alter blood pressure, vascular structure and vascular function in offspring. Wildtype (WT) offspring of hyperleptinemic, normoglycemic, Lepr db/+ dams were compared to genotype matched offspring of WT-control dams. Vascular function was assessed in male offspring at 6, and at 31 weeks of age after half the offspring had been fed a high fat, high sucrose diet (HFD) for 6 weeks. Blood pressure was increased by HFD but not affected by maternal hyperleptinemia. On a standard diet, offspring of hyperleptinemic dams had outwardly remodeled mesenteric arteries and an enhanced vasodilatory response to insulin. In offspring of WT but not Leprdb/+ dams, HFD induced vessel hypertrophy and enhanced vasodilatory responses to acetylcholine, while HFD reduced insulin responsiveness in offspring of hyperleptinemic dams. Offspring of hyperleptinemic dams had stiffer arteries regardless of diet. Therefore, while maternal hyperleptinemia was largely beneficial to offspring vascular health under astandard diet, it had detrimental effects in offspring fed HFD. These results suggest that circulating maternal leptin concentrations may interact with other factors in the pre- and post-natal environments to contribute to altered vascular function in offspring of diabetic pregnancie
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