Occurrence and description of Dactylogyrus sphyrna Linstow, 1878 (Monogenea: Dactylogyride) on the gills of an Iranian endemic fish Leucisucs persidis Coad, 1981 as a new host

Leuciscus persidis as Iranian endemic fish in Kaftar lake and its headwaters (Mesopotamian subregion, Kor-Neiriz basin and Shadkam river) has been infected with a species of Dactylogyrus sphyrna. Comparison of collected parasites with Euro-Asian subregion showed that the similarity of them is more than their differences, although a little difference between them was observed. In this paper also introduce of Dactylogyrus sphyrna parasite to the new host is discussed

An investigation on fish parasites in Hanna Wetland, Semirom, Isfahan Province

As a part of a major ecological study of Hanna Wetland, Semirum Region, Isfahan Province, parasitic infestation of 3 native and one introduced fish species were investigated. A total of 120 fish specimens were collected by both cast net and a series of gillnets between fall and winter 2007, and spring and summer 2008. Some of the observed parasites are reported for the first time as new host records of: Trichodina perforata on gill and skin of Carassius auratus auratus and three species of leeches namely: Glossiphonia heteroclite, Thromyzon tessulatum and Hemiclepsis marginata on the skin and fin bases of Capoeta damascina. Moreover, 14 internal and external parasites including: one protozoan; Ichthyophthirius multifiliis and two myxosporeans; Myxobolus varicorhini, Myxobolus sp., three monogeneans; Dactylogyrus lenkoran, Dactylogyrus intermedius and Gyrodactylus sp., two immature digeneans; Diplostomum spathaceum, Tylodephys sp., two mature digeneans; Allocreadium isoporum and A. layman, one unknown cyst, one Acanthocephalan; Acanthocephalorhynchoides sp., one cestoda; Khawia armeniaca. The highest prevalence of Diplostomum spathaceum (100%) was observed in Aphanius isfahanensis and Alburnus sp. However, the lowest prevalence was related to A. layman in Capoeta damascina in winter (0%), and autumn and spring (11%). Leeches infections were only observed in Capoeta damascina and Alburnus sp. in winter and summer, respectively. The maximum average (±SD) infection intensity belonged to K. armeniaca in intestine of C. damascina in spring (12.50±3.40, range: 8-16). Among the parasites identified in the region, D. spathaceum showed the highest mean (±SD) abundance (41.67±11.79) in C. auratus auratus in spring. In general, a relatively high diversity of fish parasitic fauna exists in this water body which could jeopardize fish populations and the whole ecosystem if the ecological status of the Hanna Wetland is neglected

The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl

The cogrinding technique is one of most effective methods for improving the dissolution of poorly water-soluble drugs and it is superior to other approaches from an economical as well as an environmental standpoint, as the technique does not require any toxic organic solvents. Present work explores the role of d-glucosamine HCl (GL) as a potential excipient to improve dissolution of a low melting point drug, ibuprofen (Ibu), using physical mixtures and coground formulations. The dissolution of the poorly soluble drug has been improved by changing the ratio of Ibu:GL and also grinding time. The results also showed that although GL can enhance the solubility of Ibu, it also reduces pH around the Ibu particles which led to poor dissolution performance when the concentration of GL is high. The effect of GL on the solubility of Ibu could be misleading if the pH of the final solution was not measured. Grinding reduced the particle size of GL significantly but in case of Ibu it was less effective. Solid state analysis (XRPD, DSC, and FT-IR) showed that ibuprofen is stable under grinding conditions, but the presence of high concentration of GL in samples subjected to high grinding times caused changes in FT-IR spectrum of Ibu which could be due to intermolecular hydrogen bond or esterification between the carboxylic acid group in the ibuprofen and hydroxyl group in the GL

Fish parasites in Valasht Lake and Chalus River

Fish parasites from Valasht Lake and Chalus River were studied in spring 2005 and summer 2006. Fish specimens were caught by hand net and transported to local laboratory alive. We found three protozoa species, Trichodina trutta and Ichthyophthirius multifiliis on Oncorhynchus mykiss; and Chilodonella hexastica on the skin of 0. mykiss and Leuciscus cephalus. We also separated metazoan parasites from the fish in the two sampling sites that included Gyrodactylus derjavini infecting skin and gill of O. mykiss, G. spl infecting Alburnoides bipunctatus, G. sp2 from Barbus capito and G. sp3 from Capoeta capoeta gracilis and Tetraonchus menonteron that infested the gills of Esox lucius. Other parasites which we found were Myxobolus saidovi from the gills of C. c. gracilis, Bothriocephalus gowkongensis from intestine of Barbus capito, Raphidascaris acus from intestine of E. lucius and finally Argulus foliaceus from skin of Chalcalburnus chalcoides. This is a first time report of a new host, B. capito for Bothriocephalus gowkongensis and a new locality Chalus River for Myxobolus saidovi parasites. Furthermore, with the exception of Tetraonchus menonteron which have been reported before, the rest of the parasites of the fishes from Valasht Lake are reported for the first time

Comment on “Measurement and Correlation of Solubilities of ( Z

Article commenting on an article titled, "Measurement and correlation of solubilities of (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetic acid in different pure solvents and binary mixtures of water + (ethanol, methanol, or glycol)," published in March 2011

Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets

The aim was to enhance the dissolution of lornoxicam (LOR) and to produce mini-tablets with an optimised system to provide a rapid-release multi-particulate formulation. LOR systems were prepared through co-evaporation with either polyethylene glycol 6000 or Pluronic® F-68 (PLU) and adsorption onto Neusilin® US2 alone or co-adsorption in the presence of different amounts of polysorbate 80. All systems were characterised by FT-IR, differential scanning calorimetry, X-ray diffraction, flowability and dissolution techniques. Mini-tablets were prepared using the system with the optimum dissolution profile and flowability. Tensile strengths, content uniformity and dissolution profiles of the mini-tablets were evaluated. The effects of different excipients and storage conditions on mini-tablet properties were also studied. The optimised rapid-release LOR mini-tablets were further evaluated for their in vivo pharmacokinetic profile. The co-evaporate of LOR with PLU showed significantly faster dissolution and superior flowability and was evaluated together with three directly compressible excipients (Cellactose® 80, StarLac® (STA) and Emcompress®) for mini-tablet formulation. The formulation with STA provided the optimum results in terms of tensile strength content uniformity and rapid drug release following a 3-month stability study and was selected for further in vivo evaluation. The pharmacokinetic profile indicated the potential of the mini-tablets achieving rapid release and increased absorption of LO

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019 : a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Background Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10-14 and 50-54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings The global TFR decreased from 2.72 (95% uncertainty interval [UI] 2.66-2.79) in 2000 to 2.31 (2.17-2.46) in 2019. Global annual livebirths increased from 134.5 million (131.5-137.8) in 2000 to a peak of 139.6 million (133.0-146.9) in 2016. Global livebirths then declined to 135.3 million (127.2-144.1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2.1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27.1% (95% UI 26.4-27.8) of global livebirths. Global life expectancy at birth increased from 67.2 years (95% UI 66.8-67.6) in 2000 to 73.5 years (72.8-74.3) in 2019. The total number of deaths increased from 50.7 million (49.5-51.9) in 2000 to 56.5 million (53.7-59.2) in 2019. Under-5 deaths declined from 9.6 million (9.1-10.3) in 2000 to 5.0 million (4.3-6.0) in 2019. Global population increased by 25.7%, from 6.2 billion (6.0-6.3) in 2000 to 7.7 billion (7.5-8.0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58.6 years (56.1-60.8) in 2000 to 63.5 years (60.8-66.1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019. Interpretation Over the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. More recently, several countries have experienced a combination of low fertility and stagnating improvement in mortality rates, pushing more populations into the late stages of the demographic transition. Tracking demographic change and the emergence of new patterns will be essential for global health monitoring. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.Peer reviewe