783 research outputs found
Chemokine (C-C motif) ligand 2 mediates direct and indirect fibrotic responses in human and murine cultured fibrocytes
- Author
- A Andersson-Sjoland
- A Micera
- A Micera
- A Moeller
- Anuk M Das
- B Mehrad
- BB Moore
- BB Moore
- BC Willis
- D Pilling
- D Pilling
- EJ Kovacs
- H Shinoda
- Hai Sheng
- HW van Deventer
- I Puxeddu
- J Chesney
- J Chesney
- J Wesierska-Gadek
- Jason E Ekert
- Jill Giles-Komar
- KM Hong
- KM Vannella
- LA Murray
- LA Murray
- LA Murray
- LA Murray
- Lynne A Murray
- M Schmidt
- M Suga
- Michael A Rycyzyn
- MN Sarafi
- N Hashimoto
- R Abe
- R Bucala
- RJ Phillips
- RJ Phillips
- S Abe
- SH Phan
- SK Mathai
- TJ Gross
- VN Lama
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Fibrocytes are a population of circulating bone-marrow-derived cells that express surface markers for leukocytes and mesenchymal cells, and are capable of differentiating into myofibroblasts. They have been observed at sites of active fibrosis and increased circulating numbers correlate with mortality in idiopathic pulmonary fibrosis (IPF). Inhibition of chemokine (C-C motif) receptor 2 (CCR2) during experimental models of lung fibrosis reduces lung collagen deposition, as well as reducing lung fibrocyte accumulation. The aim of the present study was to determine whether human and mouse fibrocytes express functional CCR2.</p> <p>Results</p> <p>Following optimized and identical human and murine fibrocyte isolation, both cell sources were shown to be positive for CCR2 by flow cytometry and this expression colocalized with collagen I and CD45. Human blood fibrocytes stimulated with the CCR2 ligand chemokine (C-C motif) ligand 2 (CCL2), demonstrated increased proliferation (<it>P </it>< 0.005) and differentiation into myofibroblasts (<it>P </it>< 0.001), as well as a chemotactic response (<it>P </it>< 0.05). Murine fibrocytes also responded to CCR2 stimulation, with CCL12 being more potent than CCL2.</p> <p>Conclusions</p> <p>This study directly compares the functional responses of human and murine fibrocytes to CCR2 ligands, and following comparable isolation techniques. We have shown comparable biological effects, strengthening the translatability of the murine models to human disease with respect to targeting the CCR2 axis to ameliorate disease in IPF patients.</p
X-ray emission from the Sombrero galaxy: discrete sources
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
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- Acosta MV
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- Wulz CE
- Wurthwein F
- Wyslouch B
- Xiao H
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- Yilmaz Y
- Yohay R
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- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
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- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
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- Zheng Y
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- Zhu RY
- Zhukov V
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- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zoeller MH
- Zorbilmez C
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
We present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alda Junior WL
- Alexander J
- Aliev T
- Almeida N
- Alver B
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Aranyi A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arora S
- Asawatangtrakuldee C
- Asghar MI
- Askew A
- Assran Y
- Ata M
- Atac M
- Atramentov O
- Attikis A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
- Bacchetta N
- Bachtis M
- Baden A
- Baeni L
- Baesso P
- Baffioni S
- Bagliesi G
- Bai Y
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Ball AH
- Ball G
- Ban Y
- Banerjee S
- Banerjee S
- Bansal S
- Banzuzi K
- Barbagli G
- Barberis E
- Barbone L
- Bardak C
- Barfuss AF
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- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
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- Yoo J
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- Yumiceva F
- Yun JC
- Zabel J
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- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
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- Zoeller MH
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- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
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- Adiguzel A
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- Anastassov A
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- Yildirim E
- Yilmaz Y
- Yohay R
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- Yumiceva F
- Yun JC
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- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
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- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
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- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
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- Ziebarth EB
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- Zoeller MH
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
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- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alexander J
- Aliev T
- Alimena J
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- Alverson G
- Alves GA
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- Amsler C
- Anagnostou G
- Anastassov A
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- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
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- Arcidiacono R
- Arenton MW
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- Brochero Cifuentes JA
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- Bryer AG
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- Cabrillo IJ
- Caebergs T
- Cakir A
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- Camporesi T
- Cankocak K
- Capiluppi P
- Cappello G
- Cardaci M
- Carlin R
- Carlsmith D
- Carrillo Moreno S
- Carroll R
- Cartiglia N
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- Castaldi R
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- Chamizo Llatas M
- Chan M
- Chang P
- Chang S
- Chang YH
- Chang YH
- Chang YW
- Chanon N
- Chao Y
- Charaf O
- Charlot C
- Chasco M
- Chasserat J
- Chatrchyan S
- Chatterjee A
- Chauhan S
- Checchia P
- Chen GM
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- Chen KF
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- Chen M
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- Chen Z
- Cherepanov V
- Chertok M
- Chetluru V
- Cheung HWK
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- Choudhary BC
- Choudhury RK
- Choudhury S
- Christiansen T
- Chuang SH
- Chung J
- Chung K
- Chung YS
- Chwalek T
- Ciesielski R
- Cimmino A
- Cipriano PMR
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clarida W
- Clement E
- Clerbaux B
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- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
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- Yumiceva F
- Yun JC
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- Zabi A
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- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
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- Zatserklyaniy A
- Zeinali M
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- Zeuner WD
- Zeyrek M
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- Zhukov V
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- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
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- Acharya BS
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- Adomeit S
- Adragna P
- Adye T
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- Aguilar-Saavedra JA
- Aharrouche M
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- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
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- Akesson TPA
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- Alam MA
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- Aleksandrov IN
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- Bracinik J
- Braem A
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- Carvalho J
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- Casado MP
- Cascella M
- Caso C
- Castaneda-Miranda E
- Castanheira MTD
- Castillo LRF
- Castro NF
- Cataldi G
- Cataneo F
- Catinaccio A
- Catmore JR
- Cattai A
- Cattani G
- Caughron S
- Cauz D
- Cavalcanti TP
- Cavalleri P
- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Ceradini F
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cetin SA
- Cevenini F
- Chafaq A
- Chakraborty D
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- Chapman JD
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- Chareyre E
- Charlton DG
- Chavda V
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- Chelkov GA
- Chelstowska MA
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- Curull XE
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- Czirr H
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- Zeller M
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
- Zhang D
- Zhang H
- Zhang J
- Zhang Q
- Zhang X
- Zhang Z
- Zhao L
- Zhao T
- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
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- Abdallah J
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- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam N
- Adam W
- Adams JR
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- Adiguzel A
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- Aldaya Martin M
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- Yilmaz Y
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- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
A search for new physics is performed in events with two same-sign isolated
leptons, hadronic jets, and missing transverse energy in the final state. The
analysis is based on a data sample corresponding to an integrated luminosity of
4.98 inverse femtobarns produced in pp collisions at a center-of-mass energy of
7 TeV collected by the CMS experiment at the LHC. This constitutes a factor of
140 increase in integrated luminosity over previously published results. The
observed yields agree with the standard model predictions and thus no evidence
for new physics is found. The observations are used to set upper limits on
possible new physics contributions and to constrain supersymmetric models. To
facilitate the interpretation of the data in a broader range of new physics
scenarios, information on the event selection, detector response, and
efficiencies is provided.Comment: Published in Physical Review Letter
Compressed representation of a partially defined integer function over multiple arguments
- Author
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- Abbiendi G
- Abbrescia M
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- Abdullin S
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- Civinini C
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- Cline D
- CMS Collaboration
- Coarasa Perez JA
- Cockerill DJA
- Colafranceschi S
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- Costanza F
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- Cremaldi LM
- Cripps N
- Cuevas J
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- Cumalat JP
- Cussans D
- Custodio A
- Cutajar M
- Cutts D
- Cwiok M
- Czellar S
- D'Agnolo RT
- D'Alessandro R
- D'Alfonso M
- d'Enterria D
- D'Hondt J
- Da Costa EM
- Dabrowski A
- Daci N
- Dahmes B
- Dahms T
- Dalchenko M
- Dallavalle GM
- Damgov J
- Danielson T
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- Daskalakis G
- Dasu S
- Daubie E
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- David A
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- de Barbaro P
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- de Cassagnac RG
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
- …