Circulating levels of vascular endothelial growth factor and post-stroke long-term functional outcome

OBJECTIVES: Vascular endothelial growth factor (VEGF) acts in angiogenesis and neuroprotection, although the beneficial effects on experimental ischemic stroke (IS) have not been replicated in clinical studies. We investigated serum VEGF (s-VEGF) in the acute stage (baseline) and 3 months post-stroke in relation to stroke severity and functional outcome. METHODS: The s-VEGF and serum high-sensitivity C-reactive protein (hs-CRP) concentrations were measured in patients enrolled in the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS) at the acute time-point (median 4 days, N=492, 36% female; mean age, 57 years) and at 3 months post-stroke (N=469). Baseline stroke severity was classified according to the National Institutes of Health Stroke Scale (NIHSS) and functional outcomes (3 months and 2 years) were evaluated using the modified Rankin Scale (mRS), dichotomized into good (mRS 0-2) and poor (mRS 3-6) outcomes. Multivariable logistic regression analyses were adjusted for covariates. RESULTS: The baseline s-VEGF did not correlate with stroke severity but correlated moderately with hs-CRP (r=0.17, p<0.001). The baseline s-VEGF was 39.8% higher in total anterior cerebral infarctions than in lacunar cerebral infarctions. In binary logistic regression analysis, associations with 3-month functional outcome were non-significant. However, an association between the 3-month s-VEGF and poor 2-year outcome withstood adjustments for age, sex, cardiovascular covariates, and stroke severity (per ten-fold increase in s-VEGF, odds ratio [OR], 2.56, 95% confidence interval [CI] 1.12-5.82) or hs-CRP (OR 2.53, CI 1.15-5.55). CONCLUSIONS: High 3-month s-VEGF is independently associated with poor 2-year functional outcome but not with 3-month outcome

Developing SOEPsurvey and SOEPservice: The (Near) Future of the German Socio-Economic Panel Study (SOEP)

Das Sozio-oekonomische Panel (SOEP) ist als multidisziplinäres Haushaltspanel, das Informationen zu allen Personen, die in einem Panel-Haushalt leben, erhebt und damit alle Altersjahrgänge abdeckt, nach 25 Jahren Laufzeit auch zu einer Kohorten- Studie geworden. Der zunehmende Erfolg der Forschungsinfrastruktur-Einrichtung SOEP speist sich in erster Linie daraus, dass die Analysekraft von Längsschnittstudien mit jedem weiteren Erhebungsjahr zunimmt. Hinzu kommen im Falle des SOEP seit Beginn an eine lange Reihe von Innovationen bei der Erhebung, Datenaufbereitung und Nutzer-Service. Deswegen gilt es zu überlegen, wie die wissenschaftliche Power des SOEP weiter gestärkt werden kann. Nicht zuletzt auch, da es für neue, spezialisierte Panel-Studien (wie das Nationale Bildungspanel oder das DFG-geförderte Familienpanel PAIRFAM) eine Referenz und ggf. Verankerung der Hochrechnung darstellt. Zudem kann das SOEP künftig eine größere Rolle als ,,Kontroll-Stichprobe" für Interventions-Studien spielen; etwa im Bereich der Kindheitsentwicklung. Auf diese neuen Rollen muss es vorbereitet sein. Die im SOEP in den letzten Jahren realisierten Erhebungsinnovationen wie z. B. die Inkorporation psychologischer Konzepte, physische Gesundheitsmessungen (Greifkraft), die Messung kognitiver Fähigkeiten und die Erprobung von Verhaltens- Experimenten werden in anderen Panel-Studien aufgegriffen und auf eine größere Stichprobenbasis gestellt. Im UK wird mit ,,Understanding Society" ein Haushaltspanel mit 40.000 Haushalten begonnen; in den Niederlanden wird mit MESS ein Haushaltspanel von über 5.000 Haushalten für innovative Messmethoden zur Verfügung gestellt. Die Erhebungsinhalte des SOEP werden von den Forschungs- und Politikberatungs-Communities unverändert stark nachgefragt. In UK hat ein für ,,Understanding Society" breit angelegter Konsultationsprozess keine grundsätzlich neuen Befragungsinhalte zu Tage gefördert, die das SOEP nicht bereits enthält oder die für das SOEP ohnehin im Gespräch sind. Wichtiger als die ,,Entdeckung" völlig neuer Erhebungsinhalte ist das thematische wie zeitliche ,,Zuschneiden" der Details von Befragungsinhalten auf (zugespitzte) neue (theoretische) Fragestellungen und dabei gleichzeitig bewährte sowie viel genutzte zentrale Befragungsinhalte und deren Befragungsrhythmen beizubehalten. Das ,,Maßschneidern" von Erhebungsinhalten wird in den nächsten Jahren die eigentliche Herausforderung für Infrastruktur- Erhebungen wie die PSID, ,,Understanding Society" und das SOEP sein. Bei den Erhebungsinhalten sollten die ,,Ränder" des Lebenslaufs eine größere Rolle spielen, da diese von Haushalts-Panels besonders gut erfasst werden können. Diese Verbesserungen der Erhebungen beziehen sich einerseits auf die fötale Phase von in das SOEP hineingeborenen Kindern und die (frühe) Kindheit, andererseits auf die letzte Lebensphase und das Sterben. In der Mitte des Lebenslaufs werden verbesserte Fragen zum Einkommen, Sparen und Vermögen sowie auch psychologische Konstrukte eine zentrale Rolle spielen, außerdem gezielte Fragen (event triggered questionnaires) in Verbindung mit zentralen Lebensereignissen wie z. B. Eheschließung, Scheidung, Eintritt in und Austritt aus Arbeitslosigkeit. Es wird die Etablierung einer SOEP-"Innovations-Stichprobe" vorbereitet, um theoriegeleitete Forschungsfragen gezielter unterstützen zu können. Dazu wird es auch notwendig sein, neue Messkonzepte zu erproben (z. B. die Erhebung von Biomarkern, qualitative Erhebungen, aber auch Experimente und gezielte Interventionsstudien). Um die Power von Längsschnittdaten von Anfang an für die Innovations-Stichprobe ausnutzen zu können, ist geplant, zwei kleinere Teilstichproben des SOEP, die seit 1998 bzw. 2006 laufen (Subsamples E und H), in die Innovationsstichprobe zu überführen. Um die statistische Power langlaufender Längsschnittdaten entscheidend zu verbessern, schätzen wir eine Mindestfallzahl von etwa 500 Personen pro Geburtsund Alterskohorte für ausreichend ein. Um dieses Ziel zu erreichen, muss die Fallzahl des SOEP-Standard-Samples erhöht werden. Als ,,Nebeneffekt" werden dadurch wesentlich bessere Analysen für relativ kleine Gruppen in der Bevölkerung möglich; etwa für allein Erziehende oder bestimme Immigrantengruppen. Außerdem verbessern sich als weiterer ,,Nebeneffekt" auch regionale Analysemöglichkeiten, z. B. für die meisten Bundesländer und in großen Bundesländern bis hin zu Regierungsbezirken (oder ähnlich abgegrenzten regionalen Einheiten). In letzter Zeit wird immer deutlicher, welche große Bedeutung das SOEP als ,,Referenz-Datensatz" für spezialisierte und vom SOEP völlig unabhängige Erhebungen hat (neben Beobachtungsstudien, wie etwa Zwillings-Studien, auch Labor- und Interventions-Studien). Zur Unterstützung dieser Funktion ist eine neue Art von Service, der in Deutschland bislang nicht vorgehalten wird, notwendig (Beratung von Spezial-Erhebungen; ggf. Datenaufbereitung von längsschnittlichen Spezial-Erhebungen), der auch in ein Datenservicezentrum eingebracht werden könnte. After 25 years as a multidisciplinary household panel containing information on all individuals residing in panel households and thus covering all age cohorts, the German Socio-Economic Panel (SOEP) has become a true cohort study as well. The increasing success of the SOEP research infrastructure comes above all from the increasing analytical power that longitudinal studies attain with each successive survey year. In the case of SOEP, a long series of innovations in surveying, data preparation, and user service have also played a major role. For this reason, it is important to consider how the scientific capacity of SOEP can be further enhanced-- not least of all since the SOEP can form a key point of reference (or "anchor") for new, specialized panel studies (such as the National Educational Panel and the family panel PAIRFAM, funded by the German Research Foundation). Furthermore SOEP can become a kind of "control sample" for intervention studies, for example, in the field of child development. The SOEP survey and its governance structures must be prepared for these new tasks. The numerous innovations introduced into SOEP in recent years--questions dealing with psychological concepts, physical health measures (grip strength), measures of cognitive capabilities, and behavioral experiments--have been incorporated into other panel studies as well, and thus provided with a larger sample base. In the UK, the "Understanding Society" household panel study was launched with 40,000 households; in the Netherlands, the MESS household panel study of over 5,000 households offered a new basis for testing innovative measurement methods. The results of the SOEP survey are in continuing high demand in the research and policy advisory community. From our point of view, the large-scale consultation process conducted to define the content of the UK survey "Understanding Society" failed to identify any fundamentally new survey content that the SOEP either did not already contain or that was not already being discussed for the SOEP. More important than "discovering" entirely new survey areas is "tailoring" the details of existing survey content to address new, more specific (theoretical) questions, and thus maintaining proven and widely used elements of survey content. The "tailoring" of survey content will be the real challenge facing infrastructure surveys like PSID, "Understanding Society," and the SOEP in the coming years. In the future, the "margins" of the life course should play a stronger role in survey content, since household panels are able to provide outstanding data of these life phases. The SOEP, and other household panel surveys, can be improved, on the one hand, by including the fetal phase of life and early childhood for children born into the panel, and on the other, by including late life and death. In the middle of the life course, improved questions on income, savings, and wealth as well as psychological constructs will play a central role, as will specific questions (in "eventtriggered" questionnaires) on central life occurrences such as marriage, divorce, and entry into and exit from unemployment. Current plans for SOEP foresee the addition of an "Innovation Sample" that will make it possible to better address theory-based research questions required for testing new measurement concepts (e.g., the surveying of biomarkers, qualitative surveys, but also experiments and targeted intervention studies). In order to exploit the power of longitudinal data from the outset, we plan to incorporate two smaller SOEP subsamples that have been running since 1998 and 2006 (Subsamples E and H, respectively) into the Innovation Sample. In order to decisively improve the statistical power of long-term longitudinal data, we believe that a minimum case number of about 500 persons per birth and age cohort is required. In order to reach this goal, the case number in the SOEP standard samples needs to be increased. A positive side-effect of this enlargement would be a significantly improved potential for analyses of relatively small groups within the population: for example, lone parents or specific immigrant groups. Another positive side-effect would be an improved potential for regional analyses: for example, for the majority of federal states. In recent times, the importance of SOEP as a "reference dataset" for specialized surveys which are independent from SOEP (observational studies such as twin studies, and laboratory and intervention studies) has become strikingly evident. To enhance this important function, new types of service are needed (advice on special surveys, possibly also data preparation for special surveys), which could become part of a Data Service Center.Household Panels, German Socio-Economic Panel Study, SOEP

Circulating granulocyte colony-stimulating factor and functional outcome after ischemic stroke: an observational study

Objectives: While granulocyte colony-stimulating factor (G-CSF) has shown beneficial effects in experimental ischemic stroke (IS), these effects have not been reproduced clinically. Small-to-medium-sized observational studies have reported varying associations for G-CSF with stroke severity and post-stroke functional outcome, prompting their investigation in a larger study. Methods: Endogenous serum G-CSF (S-GCSF) was measured in the acute phase and after 3 months in patients with IS (N = 435; 36% females; mean age, 57 years) from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). Stroke severity was scored according to the National Institutes of Health Stroke Scale (NIHSS), and the modified Rankin Scale (mRS) assessed functional outcomes at 3-month and 2-year post-stroke. Correlation and logistic regression analyses with confounder adjustments assessed the relationships. Results: The acute S-GCSF level was 23% higher than at 3-month post-stroke (p < 0.001). Acute G-CSF correlated weakly with stroke severity quintiles (r = 0.12, p = 0.013) and with high-sensitivity C-reactive protein (r = 0.29, p < 0.001). The association between S-GCSF (as quintiles, q) and poor functional outcome at 3 months (mRS 3–6; S-GCSF-q5 vs. S-GCSF-q1, age- and sex-adjusted odds ratio: 4.27, 95% confidence interval: 1.82–9.99; p = 0.001) withstood adjustment for cardiovascular risk factors and stroke subtype, but not additional correction for stroke severity. Post-stroke changes in S-GSCF and absolute 3-month S-GCSF were not associated with 3-month or 2-year functional outcomes. Discussion: Early post-stroke S-GCSF is increased in severe IS and associated with 3-month poor functional outcomes. The change in S-GCSF and the 3-month S-GCSF appear to be less-important, and S-GCSF likely reflects inflammation in large infarctions

Patterns of medical management of overactive bladder (OAB) and benign prostatic hyperplasia (BPH) in the United States

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142147/1/nau23276.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142147/2/nau23276_am.pd

Cooperative coupling of ultracold atoms and surface plasmons

Cooperative coupling between optical emitters and light fields is one of the outstanding goals in quantum technology. It is both fundamentally interesting for the extraordinary radiation properties of the participating emitters and has many potential applications in photonics. While this goal has been achieved using high-finesse optical cavities, cavity-free approaches that are broadband and easy to build have attracted much attention recently. Here we demonstrate cooperative coupling of ultracold atoms with surface plasmons propagating on a plane gold surface. While the atoms are moving towards the surface they are excited by an external laser pulse. Excited surface plasmons are detected via leakage radiation into the substrate of the gold layer. A maximum Purcell factor of $\eta_\mathrm{P}=4.9$ is reached at an optimum distance of $z=250~\mathrm{nm}$ from the surface. The coupling leads to the observation of a Fano-like resonance in the spectrum.Comment: 9 pages, 4 figure

Accréditation et ACP

Issu des actes du Carrefour Pathologie 2010, symposium de l'Association française d'assurance qualité en anatomie pathologique (AFAQAP), 22-26 novembre 2010, Maison de la Chimie, Paris.International audienc

Measurements of fiducial and differential cross sections for Higgs boson production in the diphoton decay channel at s√=8 TeV with ATLAS

Measurements of fiducial and differential cross sections are presented for Higgs boson production in proton-proton collisions at a centre-of-mass energy of s√=8 TeV. The analysis is performed in the H → γγ decay channel using 20.3 fb−1 of data recorded by the ATLAS experiment at the CERN Large Hadron Collider. The signal is extracted using a fit to the diphoton invariant mass spectrum assuming that the width of the resonance is much smaller than the experimental resolution. The signal yields are corrected for the effects of detector inefficiency and resolution. The pp → H → γγ fiducial cross section is measured to be 43.2 ±9.4(stat.) − 2.9 + 3.2 (syst.) ±1.2(lumi)fb for a Higgs boson of mass 125.4GeV decaying to two isolated photons that have transverse momentum greater than 35% and 25% of the diphoton invariant mass and each with absolute pseudorapidity less than 2.37. Four additional fiducial cross sections and two cross-section limits are presented in phase space regions that test the theoretical modelling of different Higgs boson production mechanisms, or are sensitive to physics beyond the Standard Model. Differential cross sections are also presented, as a function of variables related to the diphoton kinematics and the jet activity produced in the Higgs boson events. The observed spectra are statistically limited but broadly in line with the theoretical expectations

Search for squarks and gluinos in events with isolated leptons, jets and missing transverse momentum at s√=8 TeV with the ATLAS detector

The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. The search is based on proton-proton collision data at a centre-of-mass energy s√=8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb−1. No significant excess above the Standard Model expectation is observed. Limits are set on supersymmetric particle masses for various supersymmetric models. Depending on the model, the search excludes gluino masses up to 1.32 TeV and squark masses up to 840 GeV. Limits are also set on the parameters of a minimal universal extra dimension model, excluding a compactification radius of 1/R c = 950 GeV for a cut-off scale times radius (ΛR c) of approximately 30

Evidence for the Higgs-boson Yukawa coupling to tau leptons with the ATLAS detector

Results of a search for H → τ τ decays are presented, based on the full set of proton-proton collision data recorded by the ATLAS experiment at the LHC during 2011 and 2012. The data correspond to integrated luminosities of 4.5 fb−1 and 20.3 fb−1 at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV respectively. All combinations of leptonic (τ → `νν¯ with ` = e, µ) and hadronic (τ → hadrons ν) tau decays are considered. An excess of events over the expected background from other Standard Model processes is found with an observed (expected) significance of 4.5 (3.4) standard deviations. This excess provides evidence for the direct coupling of the recently discovered Higgs boson to fermions. The measured signal strength, normalised to the Standard Model expectation, of µ = 1.43 +0.43 −0.37 is consistent with the predicted Yukawa coupling strength in the Standard Model