14 research outputs found
Multiple sclerosis and SARS-CoV-2 infection
Universitatea de Medicină și Farmacie „Grigore T. Popa” Iași, România,
Clinica I Oftalmologie, Spitalul Clinic Județean de Urgență „Sf. Spiridon”, Iași, RomâniaSummary. We analyzed the case of a patient with multiple sclerosis associated with SARS-CoV-2 infection. The clinical appearance of the
ophthalmologist does not justify the decrease in AV, which is why it is recommended to perform an MRI in an emergency. The
patient accuses the decrease in visual acuity in the left eye. The appearance described is suggestive for multiple sclerosis. PCR
testing was positive. After 14 days PCR test was negative but the ophthalmological evolution was unfavorable. Intravenous
emergency treatment with Solumedrol was initiated for 5 days. The particularity of the case is due to the fulminant onset of
multiple sclerosis in the context of SARS-CoV-2 infection and the unfavorable evolution in terms of AV, despite early treatment.Introducere. Pacientă, în vârstă de 16 ani, se
prezintă în Clinica I Oftalmologie a Spitalului „Sf.
Spiridon”, Iași, acuzând scăderea acuității vizuale
la ochiul stâng cu debut acut. Pacienta nu prezintă
alte antecedente personale patologice. AVOD=1
fc, AVOS= pmm., PIOAO=12mmHg. La examinarea
polului anterior, nu se constată elemente patologice.
La examinarea polului posterior, discul optic este
normal colorat, are contur net, C/D=0,1, artere și vene
cu calibru normal, maculă fără leziuni. Aspectul clinic
oftalmologic nu justifică scăderea AV, motiv pentru
care se recomandă efectuarea unui RMN în urgență.
Se identifică leziuni în hipersemnal T2 și FLAIR cu
restricție de difuzie localizată periventricular pe
partea dreaptă, în contrast cu cornul posterior al
ventriculului lateral drept cu diametru de 17/15 mm
și două în centri senzoriali, una mai mare de 9,6mm
parietal drept în substanța albă, periventricular,
talamic drept, 9,6 mm în medulla oblongata de 13
mm. Aspectul descris este sugestiv pentru scleroză
multiplă. Testarea PCR pentru SARS-CoV-2 a avut
rezultat pozitiv, pacienta fiind asimptomatică. S-a
format o echipă multidisciplinară alcătuită din oftalmologi,
neurologi și medici infecționiști și s-a inițiat
tratamentul în urgență intravenos cu Solumedrol
timp de 5 zile, continuat cu Medrol per os.
Evoluție. După 14 zile, testul PCR pentru SARSCoV-
2 s-a negativat, însă evoluția oftalmologică a
fost nefavorabilă. Pacienta se prezintă după 3 luni,
în urgență, acuzând percepția unui scotom central
la OD. AVOD=0,6, iar AVOS a rămas pmm. La RMN
leziunile au aspect staționar. După tratamentul intravenos
cu Solumedrol 3 zile și per os cu Medrol,
scotomul central de la OD se reduce în dimensiuni
și AVOD se îmbunătățește la 0,8 fcnc.
Discuții: Rămâne în discuție deschisă dacă
infecția cu SARS-CoV-2 la persoane nevaccinate
poate precipita debutul fulminant al unor patologii
în stare latentă.
Concluzii. Particularitatea cazului se datorează
debutului fulminant al sclerozei multiple în contextul
infecției cu SARS-CoV-2 și evoluției nefavorabile
din punct de vedere al AV, în ciuda tratamentului
instaurat precoce
Research and Science Today No. 1(5)/2013
Research and Science Today Journal is a publication founded in 2011 and it is dedicated to the students of all levels (license, master and doctoral) of faculties in the country and abroad. We want to offer the participants the opportunity to present their scientific works in the following areas: Social Sciences, Economic Sciences, Legal Sciences, Humanities, Education Sciences, Engineering, Medicine and Sport.
This journal provides students the opportunity to create and/or to improve their abilities to write scientific papers. So each appearance (two appearances per year at which we can add supplements) contains a number of papers written by students, masters and doctoral from the faculties from the country or/and abroad. The journal promotes original studies contributing to the progress of knowledge and it is motivated by the need to address issues of theory and practice in the areas mentioned above
Research and Science Today No. 1(5)/2013
Research and Science Today Journal is a publication founded in 2011 and it is dedicated to the students of all levels (license, master and doctoral) of faculties in the country and abroad. We want to offer the participants the opportunity to present their scientific works in the following areas: Social Sciences, Economic Sciences, Legal Sciences, Humanities, Education Sciences, Engineering, Medicine and Sport.
This journal provides students the opportunity to create and/or to improve their abilities to write scientific papers. So each appearance (two appearances per year at which we can add supplements) contains a number of papers written by students, masters and doctoral from the faculties from the country or/and abroad. The journal promotes original studies contributing to the progress of knowledge and it is motivated by the need to address issues of theory and practice in the areas mentioned above
Research and Science Today No. 1(5)/2013
Research and Science Today Journal is a publication founded in 2011 and it is dedicated to the students of all levels (license, master and doctoral) of faculties in the country and abroad. We want to offer the participants the opportunity to present their scientific works in the following areas: Social Sciences, Economic Sciences, Legal Sciences, Humanities, Education Sciences, Engineering, Medicine and Sport.
This journal provides students the opportunity to create and/or to improve their abilities to write scientific papers. So each appearance (two appearances per year at which we can add supplements) contains a number of papers written by students, masters and doctoral from the faculties from the country or/and abroad. The journal promotes original studies contributing to the progress of knowledge and it is motivated by the need to address issues of theory and practice in the areas mentioned above
Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers
https://deepblue.lib.umich.edu/bitstream/2027.42/138963/1/12987_2017_Article_71.pd
Synthesis and Degradation of Schiff Bases Containing Heterocyclic Pharmacophore
This paper reports on the synthesis and characterization of two Schiff bases bearing 1,2,4-triazolic moieties, namely 4H-4-(2-hydroxy-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole and 4H-4-(4-nitro-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole using thin layer chromatography, melting interval, elemental analysis, spectroscopy and thermal stability studies
Preparation and Antibacterial Properties of Substituted 1,2,4-Triazoles
Background. Both 1,2,3- and 1,2,4-triazoles are nowadays incorporated in numerous antibacterial pharmaceutical formulations. Aim. Our study aimed to prepare three substituted 1,2,4-triazoles and to evaluate their antibacterial properties. Materials and Methods. One disubstituted and two trisubstituted 1,2,4-triazoles were prepared and characterised by physical and spectroscopic properties (melting point, FTIR, NMR, and GC-MS). The antibacterial properties were studied against three bacterial strains: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and Pseudomonas aeruginosa (ATCC 27853), by the agar disk diffusion method and the dilution method with MIC (minimal inhibitory concentration) determination. Results. The spectroscopic characterization of compounds and the working protocol for the synthesis of the triazolic derivatives are described. The compounds were obtained with 15–43% yields and with high purities, confirmed by the NMR analysis. The evaluation of biological activities showed that the compounds act as antibacterial agents against Staphylococcus aureus (ATCC 25923), while being inactive against Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). Conclusions. Our results indicate that compounds containing 1,2,4-triazolic moiety have great potential in developing a wide variety of new antibacterial formulations
Measurement of the relative width difference of the - system with the ATLAS detector
20 pages plus author list + cover page (38 pages total), 5 figures, 2 tables, submitted to Journal of High Energy Physics, All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/BPHY-2015-01/ - See paper for full list of authorsInternational audienceThis paper presents the measurement of the relative width difference of the - system using the data collected by the ATLAS experiment at the LHC in collisions at TeV and TeV and corresponding to an integrated luminosity of 25.2 fb. The value of is obtained by comparing the decay-time distributions of and decays. The result is \Delta \Gamma_d / \Gamma_d = (-0.1 \pm 1.1~\mbox{(stat.)} \pm 0.9~\mbox{(syst.)}) \times 10^{-2}. Currently, this is the most precise single measurement of . It agrees with the Standard Model prediction and the measurements by other experiments