Transit timing with fast cameras on large telescopes

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Earth, Atmospheric, and Planetary Sciences, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p. 171-178).Timing and system parameters were measured for seven transiting exoplanets: OGLETR- 56b (11 transits), OGLE-TR-132b (7), OGLE-TR-111b (6), OGLE-TR-113b (6), CoRoT-2b (3), OGLE-TR-10b (3), and XO-2b (2). Ground-based observations of 38 transits were made using three new frame-transfer instruments: POETS and MagICe2v on the 6.5m Magellan telescopes, and MORIS on the 3m IRTF. For each planet, all transit light curves including available literature data were jointly fit using a Monte Carlo Markov Chain method, providing accurate new values for the planetary radius and other parameters. Transit ephemerides have been updated and transit midtimes have been investigated for potential transit timing variations (TTVs) caused by other planets or moons. Our transit midtime analysis contradicts a claimed TTV for OGLE-TR-111b (Diaz et al., 2008), finding no evidence in data from 2005-2009. The radius, 1.019 + 0.026 Rj, is intermediate to previous values (Winn et al., 2007; Diaz et al., 2008). We confirm the radius of OGLE-TR-56b, which previously had only one light curve (Pont et al., 2007), as 1.332 ± 0.063 Rj, but find a longer duration by 15 minutes, while the orbital period, 1.2119094 ± 0.0000024, is unchanged. Times for OGLE-TR-10b are consistent with the ephemeris of Holman et al. (2007), though two literature transits show large deviations (586 ± 86 s; Pont et al., 2007) and (-612 ± 26 s; Bentley et al., 2009). Times for four planets (OGLE-TR-113b, OGLE-TR-132b, CoRoT-2b, and XO-2b), with midtime errors as small as 9 s, agree with published ephemerides and show no signs of TTVs. The orbital period of OGLE-TR-113b derived from new data from 2007-2009, however, is shorter by 0.24 ± 0.12 s compared to the period calculated for literature data from 2002 and 2005. If confirmed, this would be the first detection of a change in the orbital period of an exoplanet, which could be caused by orbital decay as the planet falls onto its star.by Elisabeth Rose Adams.Ph.D

Transit Timing Variation Analysis of Ogle-Tr-132b with Seven New Transits

December 15, 2010We report the results of the first transit timing variation analysis of the very hot Jupiter OGLE-TR-132b, using 10 transits collected over a seven-year period. Our analysis combines three previously published transit light curves with seven new transits, which were observed between 2008 February and 2009 May with the new MagIC-e2V instrument on the Magellan Telescopes in Chile. We provide a revised planetary radius of R[subscript p] = 1.23 ± 0.07R[subscript J] , which is slightly larger, but consistent within the errors, than that given by previously published results. Analysis of the planet-to-star radius ratio, orbital separation, inclination, and transit duration reveals no apparent variation in any of those parameters during the time span observed. We also find no sign of transit timing variations larger than –108 ± 49 s, with most residuals very close to zero. This allows us to place an upper limit of 5-10 M [subscript ⊕] for a coplanar, low-eccentricity perturber in either the 2:1 or 3:2 mean-motion resonance with OGLE-TR-132b. We similarly find that the data are entirely consistent with a constant orbital period and there is no evidence for orbital decay within the limits of precision of our data.United States. National Aeronautics and Space Administration (Origins Grant NNX07AN63G

Six High-Precision Transits of Ogle-Tr-113b

We present six new transits of the hot Jupiter OGLE-TR-113b observed with MagIC on the Magellan Telescopes between 2007 January and 2009 May. We update the system parameters and revise the planetary radius to R[subscript p] = 1.084 ± 0.029R[subscript J] , where the error is dominated by stellar radius uncertainties. The new transit midtimes reveal no transit timing variations from a constant ephemeris of greater than 13 ± 28 s over two years, placing an upper limit of 1–2M[subscript ⊕] on the mass of any perturber in a 1:2 or 2:1 mean-motion resonance with OGLETR- 113b. Combining the new transit epochs with five epochs published between 2002 and 2006, we find hints that the orbital period of the planet may not be constant, with the best fit indicating a decrease of [dot over P] = −60±15 ms yr−1. If real, this change in period could result from either a long-period (more than eight years) timing variation due to a massive external perturber or more intriguingly from the orbital decay of the planet. The detection of a changing period is still tentative and requires additional observations, but if confirmed it would enable direct tests of tidal stability and dynamical models of close-in planets.United States. National Aeronautics and Space Administration (Origins Grant NNX07AN63G

A Giant Planet Candidate Transiting a White Dwarf

Astronomers have discovered thousands of planets outside the solar system, most of which orbit stars that will eventually evolve into red giants and then into white dwarfs. During the red giant phase, any close-orbiting planets will be engulfed by the star, but more distant planets can survive this phase and remain in orbit around the white dwarf. Some white dwarfs show evidence for rocky material floating in their atmospheres, in warm debris disks, or orbiting very closely, which has been interpreted as the debris of rocky planets that were scattered inward and tidally disrupted. Recently, the discovery of a gaseous debris disk with a composition similar to ice giant planets demonstrated that massive planets might also find their way into tight orbits around white dwarfs, but it is unclear whether the planets can survive the journey. So far, the detection of intact planets in close orbits around white dwarfs has remained elusive. Here, we report the discovery of a giant planet candidate transiting the white dwarf WD 1856+534 (TIC 267574918) every 1.4 days. The planet candidate is roughly the same size as Jupiter and is no more than 14 times as massive (with 95% confidence). Other cases of white dwarfs with close brown dwarf or stellar companions are explained as the consequence of common-envelope evolution, wherein the original orbit is enveloped during the red-giant phase and shrinks due to friction. In this case, though, the low mass and relatively long orbital period of the planet candidate make common-envelope evolution less likely. Instead, the WD 1856+534 system seems to demonstrate that giant planets can be scattered into tight orbits without being tidally disrupted, and motivates searches for smaller transiting planets around white dwarfs.Comment: 50 pages, 12 figures, 2 tables. Published in Nature on Sept. 17, 2020. The final authenticated version is available online at: https://www.nature.com/articles/s41586-020-2713-

Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors

<p>Abstract</p> <p>Background</p> <p>Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. The 5-year survival rate of histologic grade III chondrosarcoma is less than 30%. An animal model of chondrosarcoma has been established - namely, the Swarm Rat Chondrosarcoma (SRC) - and shown to resemble the human disease. Previous studies with this model revealed that tumor microenvironment could significantly influence chondrosarcoma malignancy.</p> <p>Methods</p> <p>To examine the effect of the microenvironment, SRC tumors were initiated at different transplantation sites. Pyrosequencing assays were utilized to assess the DNA methylation of the tumors, and SAGE libraries were constructed and sequenced to determine the gene expression profiles of the tumors. Based on the gene expression analysis, subsequent functional assays were designed to determine the relevancy of the specific genes in the development and progression of the SRC.</p> <p>Results</p> <p>The site of transplantation had a significant impact on the epigenetic and gene expression profiles of SRC tumors. Our analyses revealed that SRC tumors were hypomethylated compared to control tissue, and that tumors at each transplantation site had a unique expression profile. Subsequent functional analysis of differentially expressed genes, albeit preliminary, provided some insight into the role that thymosin-β4, c-fos, and CTGF may play in chondrosarcoma development and progression.</p> <p>Conclusion</p> <p>This report describes the first global molecular characterization of the SRC model, and it demonstrates that the tumor microenvironment can induce epigenetic alterations and changes in gene expression in the SRC tumors. We documented changes in gene expression that accompany changes in tumor phenotype, and these gene expression changes provide insight into the pathways that may play a role in the development and progression of chondrosarcoma. Furthermore, specific functional analysis indicates that thymosin-β4 may have a role in chondrosarcoma metastasis.</p

BHPR research: qualitative1. Complex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis

Background: Foot surgery is common in patients with RA but research into surgical outcomes is limited and conceptually flawed as current outcome measures lack face validity: to date no one has asked patients what is important to them. This study aimed to determine which factors are important to patients when evaluating the success of foot surgery in RA Methods: Semi structured interviews of RA patients who had undergone foot surgery were conducted and transcribed verbatim. Thematic analysis of interviews was conducted to explore issues that were important to patients. Results: 11 RA patients (9 ♂, mean age 59, dis dur = 22yrs, mean of 3 yrs post op) with mixed experiences of foot surgery were interviewed. Patients interpreted outcome in respect to a multitude of factors, frequently positive change in one aspect contrasted with negative opinions about another. Overall, four major themes emerged. Function: Functional ability & participation in valued activities were very important to patients. Walking ability was a key concern but patients interpreted levels of activity in light of other aspects of their disease, reflecting on change in functional ability more than overall level. Positive feelings of improved mobility were often moderated by negative self perception ("I mean, I still walk like a waddling duck”). Appearance: Appearance was important to almost all patients but perhaps the most complex theme of all. Physical appearance, foot shape, and footwear were closely interlinked, yet patients saw these as distinct separate concepts. Patients need to legitimize these feelings was clear and they frequently entered into a defensive repertoire ("it's not cosmetic surgery; it's something that's more important than that, you know?”). Clinician opinion: Surgeons' post operative evaluation of the procedure was very influential. The impact of this appraisal continued to affect patients' lasting impression irrespective of how the outcome compared to their initial goals ("when he'd done it ... he said that hasn't worked as good as he'd wanted to ... but the pain has gone”). Pain: Whilst pain was important to almost all patients, it appeared to be less important than the other themes. Pain was predominately raised when it influenced other themes, such as function; many still felt the need to legitimize their foot pain in order for health professionals to take it seriously ("in the end I went to my GP because it had happened a few times and I went to an orthopaedic surgeon who was quite dismissive of it, it was like what are you complaining about”). Conclusions: Patients interpret the outcome of foot surgery using a multitude of interrelated factors, particularly functional ability, appearance and surgeons' appraisal of the procedure. While pain was often noted, this appeared less important than other factors in the overall outcome of the surgery. Future research into foot surgery should incorporate the complexity of how patients determine their outcome Disclosure statement: All authors have declared no conflicts of interes

Shared genetic risk between eating disorder- and substance-use-related phenotypes:Evidence from genome-wide association studies

First published: 16 February 202

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio