533 research outputs found
Towards the Continuum Limit of the Overlap Quark Propagator in Landau Gauge
The properties of the momentum space quark propagator in Landau gauge are
examined for the overlap quark action in quenched lattice QCD. Numerical
calculations were done on two lattices with different lattice spacing and
similar physical volumes to explore the quark propagator in the continuum
limit. We have calculated the nonperturbative wavefunction renormalization
function and the nonperturbative mass function for a variety of
bare quark masses and perform a simple linear extrapolation to the chiral
limit. We find the behaviour of and in the chiral limit are in
good agreement between the two lattices.Comment: 3 pages, 2 figures, talk, Lattice2002(Chiral Fermion
Nonperturbative renormalisation of composite operators with overlap quarks
We compute non-perturbatively the renormalisation constants of composite
operators on a lattice with lattice spacing = 0.093 fm
for the overlap fermion action by using the regularisation independent (RI)
scheme. The quenched gauge configurations are generated by tadpole improved
plaquette plus rectangle action. We test the perturbative continuum relation
and and find that they agree well above = 1.6 GeV.
We also perform a Renormalisation Group analysis at the next-to-next-to-leading
order and convert the renormalisation constants to the scheme.Comment: Talk given at LHP2003, Cairns, Australi
Flavour constraints on scenarios with two or three heavy squark generations
We re-assess constraints from flavour-changing neutral currents in the kaon
system on supersymmetric scenarios with a light gluino, two heavy generations
of squarks and a lighter third generation. We compute for the first time limits
in scenarios with three heavy squark families, taking into account QCD
corrections at the next-to-leading order. We compare our limits with those in
the case of two heavy families. We use the mass insertion approximation and
consider contributions from gluino exchange to constrain the mixing between the
first and second squark generation. While it is not possible to perform a
general analysis, we assess the relevance of each kind of flavour- and
CP-violating parameters. We also provide ready to use magic numbers for the
computation of the Wilson coefficients at 2 GeV for these scenarios.Comment: 23 pages, 14 figures; v3: matches published version (contains
improvements in the presentation and clarifications
Safety Outcomes and Near-Adult Height Gain of Growth Hormone-Treated Children with SHOX Deficiency: Data from an Observational Study and a Clinical Trial
Background/Aims: To assess auxological and safety data for growth hormone (GH)-Treated children with SHOX deficiency. Methods: Data were examined for GH-Treated SHOX-deficient children (n = 521) from the observational Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS). For patients with near-Adult height information, GeNeSIS results (n = 90) were compared with a clinical trial (n = 28) of SHOX-deficient patients. Near-Adult height was expressed as standard deviation score (SDS) for chronological age, potentially increasing the observed effect of treatment. Results: Most SHOX-deficient patients in GeNeSIS had diagnoses of Leri-Weill syndrome (n = 292) or non-syndromic short stature (n = 228). For GeNeSIS patients with near-Adult height data, mean age at GH treatment start was 11.0 years, treatment duration 4.4 years, and height SDS gain 0.83 (95% confidence interval 0.49-1.17). Respective ages, GH treatment durations and height SDS gains for GeNeSIS patients prepubertal at baseline (n = 42) were 9.2 years, 6.0 years and 1.19 (0.76-1.62), and for the clinical trial cohort they were 9.2 years, 6.0 years and 1.25 (0.92-1.58). No new GH-related safety concerns were identified. Conclusion: Patients with SHOX deficiency who had started GH treatment before puberty in routine clinical practice had a similar height gain to that of patients in the clinical trial on which approval for the indication was based, with no new safety concerns
Topology, Entropy and Witten Index of Dilaton Black Holes
We have found that for extreme dilaton black holes an inner boundary must be
introduced in addition to the outer boundary to give an integer value to the
Euler number. The resulting manifolds have (if one identifies imaginary time)
topology and Euler number in contrast to
the non-extreme case with . The entropy of extreme dilaton black
holes is already known to be zero. We include a review of some recent ideas due
to Hawking on the Reissner-Nordstr\"om case. By regarding all extreme black
holes as having an inner boundary, we conclude that the entropy of {\sl all}
extreme black holes, including black holes, vanishes. We discuss the
relevance of this to the vanishing of quantum corrections and the idea that the
functional integral for extreme holes gives a Witten Index. We have studied
also the topology of ``moduli space'' of multi black holes. The quantum
mechanics on black hole moduli spaces is expected to be supersymmetric despite
the fact that they are not HyperK\"ahler since the corresponding geometry has
torsion unlike the BPS monopole case. Finally, we describe the possibility of
extreme black hole fission for states with an energy gap. The energy released,
as a proportion of the initial rest mass, during the decay of an
electro-magnetic black hole is 300 times greater than that released by the
fission of an nucleus.Comment: 51 pages, 4 figures, LaTeX. Considerably extended version. New
sections include discussion of the Witten index, topology of the moduli
space, black hole sigma model, and black hole fission with huge energy
releas
Stellar structure and compact objects before 1940: Towards relativistic astrophysics
Since the mid-1920s, different strands of research used stars as "physics
laboratories" for investigating the nature of matter under extreme densities
and pressures, impossible to realize on Earth. To trace this process this paper
is following the evolution of the concept of a dense core in stars, which was
important both for an understanding of stellar evolution and as a testing
ground for the fast-evolving field of nuclear physics. In spite of the divide
between physicists and astrophysicists, some key actors working in the
cross-fertilized soil of overlapping but different scientific cultures
formulated models and tentative theories that gradually evolved into more
realistic and structured astrophysical objects. These investigations culminated
in the first contact with general relativity in 1939, when J. Robert
Oppenheimer and his students George Volkoff and Hartland Snyder systematically
applied the theory to the dense core of a collapsing neutron star. This
pioneering application of Einstein's theory to an astrophysical compact object
can be regarded as a milestone in the path eventually leading to the emergence
of relativistic astrophysics in the early 1960s.Comment: 83 pages, 4 figures, submitted to the European Physical Journal
Subclinical Thyroid Dysfunction and Fracture Risk: A Meta-analysis
IMPORTANCE
Associations between subclinical thyroid dysfunction and fractures are unclear and clinical trials are lacking.
OBJECTIVE
To assess the association of subclinical thyroid dysfunction with hip, nonspine, spine, or any fractures.
DATA SOURCES AND STUDY SELECTION
The databases of MEDLINE and EMBASE (inception to March 26, 2015) were searched without language restrictions for prospective cohort studies with thyroid function data and subsequent fractures.
DATA EXTRACTION
Individual participant data were obtained from 13 prospective cohorts in the United States, Europe, Australia, and Japan. Levels of thyroid function were defined as euthyroidism (thyroid-stimulating hormone [TSH], 0.45-4.49 mIU/L), subclinical hyperthyroidism (TSH <0.45 mIU/L), and subclinical hypothyroidism (TSH ≥4.50-19.99 mIU/L) with normal thyroxine concentrations.
MAIN OUTCOME AND MEASURES
The primary outcome was hip fracture. Any fractures, nonspine fractures, and clinical spine fractures were secondary outcomes.
RESULTS
Among 70,298 participants, 4092 (5.8%) had subclinical hypothyroidism and 2219 (3.2%) had subclinical hyperthyroidism. During 762,401 person-years of follow-up, hip fracture occurred in 2975 participants (4.6%; 12 studies), any fracture in 2528 participants (9.0%; 8 studies), nonspine fracture in 2018 participants (8.4%; 8 studies), and spine fracture in 296 participants (1.3%; 6 studies). In age- and sex-adjusted analyses, the hazard ratio (HR) for subclinical hyperthyroidism vs euthyroidism was 1.36 for hip fracture (95% CI, 1.13-1.64; 146 events in 2082 participants vs 2534 in 56,471); for any fracture, HR was 1.28 (95% CI, 1.06-1.53; 121 events in 888 participants vs 2203 in 25,901); for nonspine fracture, HR was 1.16 (95% CI, 0.95-1.41; 107 events in 946 participants vs 1745 in 21,722); and for spine fracture, HR was 1.51 (95% CI, 0.93-2.45; 17 events in 732 participants vs 255 in 20,328). Lower TSH was associated with higher fracture rates: for TSH of less than 0.10 mIU/L, HR was 1.61 for hip fracture (95% CI, 1.21-2.15; 47 events in 510 participants); for any fracture, HR was 1.98 (95% CI, 1.41-2.78; 44 events in 212 participants); for nonspine fracture, HR was 1.61 (95% CI, 0.96-2.71; 32 events in 185 participants); and for spine fracture, HR was 3.57 (95% CI, 1.88-6.78; 8 events in 162 participants). Risks were similar after adjustment for other fracture risk factors. Endogenous subclinical hyperthyroidism (excluding thyroid medication users) was associated with HRs of 1.52 (95% CI, 1.19-1.93) for hip fracture, 1.42 (95% CI, 1.16-1.74) for any fracture, and 1.74 (95% CI, 1.01-2.99) for spine fracture. No association was found between subclinical hypothyroidism and fracture risk.
CONCLUSIONS AND RELEVANCE
Subclinical hyperthyroidism was associated with an increased risk of hip and other fractures, particularly among those with TSH levels of less than 0.10 mIU/L and those with endogenous subclinical hyperthyroidism. Further study is needed to determine whether treating subclinical hyperthyroidism can prevent fractures
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
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