11,673,760 research outputs found
Hard scattering and jets--from p-p collisions in the 1970's to Au+Au collisions at RHIC
Hard scattering in p-p collisions, discovered at the CERN ISR in 1972 by the
method of leading particles, proved that the partons of Deeply Inelastic
Scattering strongly interacted with each other. Further ISR measurements
utilizing inclusive single or pairs of hadrons established that high pT
particles are produced from states with two roughly back-to-back jets which are
the result of scattering of constituents of the nucleons as described by
Quantum Chromodynamics (QCD), which was developed during the course of these
measurements. These techniques, which are the only practical method to study
hard-scattering and jet phenomena in Au+Au central collisions, are reviewed,
with application to measurements at RHIC.Comment: 4 pages, 5 figures, Proceedings of Hard Probes 2004, International
Conference on Hard and Electromagnetic Probes of High Energy Nuclear
Collisions, Nov 4-10, 2004, to appear in EPJ
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University press publishing consortium for Africa : lessons from academic libraries
This paper presents the results of a case study of the policies and practices of six African university presses. Based on the findings, it posits the formation of a consortium of African university presses. It borrows heavily from consortium formation in the library world
DNA Renaturation at the Water-Phenol Interface
We study DNA adsorption and renaturation in a water-phenol two-phase system,
with or without shaking. In very dilute solutions, single-stranded DNA is
adsorbed at the interface in a salt-dependent manner. At high salt
concentrations the adsorption is irreversible. The adsorption of the
single-stranded DNA is specific to phenol and relies on stacking and hydrogen
bonding. We establish the interfacial nature of a DNA renaturation at a high
salt concentration. In the absence of shaking, this reaction involves an
efficient surface diffusion of the single-stranded DNA chains. In the presence
of a vigorous shaking, the bimolecular rate of the reaction exceeds the
Smoluchowski limit for a three-dimensional diffusion-controlled reaction. DNA
renaturation in these conditions is known as the Phenol Emulsion Reassociation
Technique or PERT. Our results establish the interfacial nature of PERT. A
comparison of this interfacial reaction with other approaches shows that PERT
is the most efficient technique and reveals similarities between PERT and the
renaturation performed by single-stranded nucleic acid binding proteins. Our
results lead to a better understanding of the partitioning of nucleic acids in
two-phase systems, and should help design improved extraction procedures for
damaged nucleic acids. We present arguments in favor of a role of phenol and
water-phenol interface in prebiotic chemistry. The most efficient renaturation
reactions (in the presence of condensing agents or with PERT) occur in
heterogeneous systems. This reveals the limitations of homogeneous approaches
to the biochemistry of nucleic acids. We propose a heterogeneous approach to
overcome the limitations of the homogeneous viewpoint
Josephson oscillation of a superfluid Fermi gas
Using the complete numerical solution of a time-dependent three-dimensional
mean-field model we study the Josephson oscillation of a superfluid Fermi gas
(SFG) at zero temperature formed in a combined axially-symmetric harmonic plus
one-dimensional periodic optical-lattice (OL) potentials after displacing the
harmonic trap along the axial OL axis. We study the dependence of Josephson
frequency on the strength of the OL potential. The Josephson frequency
decreases with increasing strength as found in the experiment of Cataliotti et
al. [Science 293 (2001) 843] for a Bose-Einstein condensate and of the
experiment of Pezze et al. [Phys. Rev. Lett. 93 (2004) 120401] for an ideal
Fermi gas. We demonstrate a breakdown of Josephson oscillation in the SFG for a
large displacement of the harmonic trap. These features of Josephson
oscillation of a SFG can be tested experimentally.Comment: 7 pages, 10 figure
Heavy Quark Potentials and Quarkonia Binding
I review recent progress in studying in-medium modification of inter-quark
forces at finite temperature in lattice QCD. Some applications to the problem
of quarkonium binding in potential models is also discussed.Comment: Invited plenary talk presented at Hard Probes 2004, International
Conference on Hard and Electromagnetic Probes of High Energy Nuclear
Collisions, Nov. 4-10, 2004, Ericeira, Portuga
Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2010 Patani.Background: Ubiquitin modification of proteins influences cellular processes relevant to carcinogenesis. CHIP (carboxyl-terminus of Hsc70-interacting protein) is a chaperone-dependent E3 ubiquitin ligase, regulating the stability of heat shock protein 90 (HSP90) interacting proteins. CHIP is implicated in the modulation of estrogen receptor (ESR1) and Her-2/neu (ERBB2) stability. LOX (lysyl-oxidase) serves intracellular roles and catalyses the cross-linking of extracellular matrix (ECM) collagens and elastin. LOX expression is altered in human malignancies and their peri-tumoral stroma. However, paradoxical roles are reported. In this study, the level of mRNA expression of CHIP and LOX were assessed in normal and malignant breast tissue and correlated with clinico-pathological parameters. Materials and Methods: Breast cancer (BC) tissues (n = 127) and normal tissues (n = 33) underwent RNA extraction and reverse transcription; transcript levels were determined using real-time quantitative PCR and normalized against CK-19. Transcript levels were analyzed against TNM stage, nodal involvement, tumor grade and clinical outcome over a ten-year follow-up period. Results: CHIP expression decreased with increasing Nottingham Prognostic Index (NPI): NPI-1 vs. NPI-3 (12.2 vs. 0.2, P = 0.0264), NPI-2 vs. NPI-3 (3 vs. 0.2, P = 0.0275). CHIP expression decreased with increasing TNM stage: TNM-1 vs. TNM-2 (12 vs. 0, P = 0.0639), TNM-1 vs. TNM-2-4 (12 vs. 0, P = 0.0434). Lower transcript levels were associated with increasing tumor grade: grade 1 vs. grade 3 (17.7 vs. 0.3, P = 0.0266), grade 2 vs. grade 3 (5 vs. 0.3, P = 0.0454). The overall survival (OS) for tumors classified as ‘low-level expression’, was poorer than those with ‘high-level expression’ (118.1 vs. 152.3 months, P = 0.039). LOX expression decreased with increasing NPI: NPI-1 vs. NPI-2 (3 vs. 0, P = 0.0301) and TNM stage: TNM-1 = 3854639, TNM-2 = 908900, TNM-3 = 329, TNM-4 = 1.232 (P = NS). Conclusion: CHIP expression is associated with favorable prognostic parameters, including tumor grade, TNM stage and NPI. CHIP expression predicts OS. LOX expression is associated with improved NPI. In addition to their prognostic utility, mechanistic insights into tumor suppressor function may offer potential therapeutic strategies
Strange particle production in proton-proton collisions at TeV with ALICE at the LHC
The production of mesons containing strange quarks (K, ) and both
singly and doubly strange baryons (, Anti-, and
+Anti-) are measured at central rapidity in pp collisions at
= 0.9 TeV with the ALICE experiment at the LHC. The results are
obtained from the analysis of about 250 k minimum bias events recorded in 2009.
Measurements of yields (dN/dy) and transverse momentum spectra at central
rapidities for inelastic pp collisions are presented. For mesons, we report
yields () of 0.184 0.002 stat. 0.006 syst. for K and
0.021 0.004 stat. 0.003 syst. for . For baryons, we find
= 0.048 0.001 stat. 0.004 syst. for , 0.047
0.002 stat. 0.005 syst. for Anti- and 0.0101 0.0020 stat.
0.0009 syst. for +Anti-. The results are also compared with
predictions for identified particle spectra from QCD-inspired models and
provide a baseline for comparisons with both future pp measurements at higher
energies and heavy-ion collisions.Comment: 33 pages, 21 captioned figures, 10 tables, authors from page 28,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/387
Two-pion Bose-Einstein correlations in central Pb-Pb collisions at = 2.76 TeV
The first measurement of two-pion Bose-Einstein correlations in central Pb-Pb
collisions at TeV at the Large Hadron Collider is
presented. We observe a growing trend with energy now not only for the
longitudinal and the outward but also for the sideward pion source radius. The
pion homogeneity volume and the decoupling time are significantly larger than
those measured at RHIC.Comment: 17 pages, 5 captioned figures, 1 table, authors from page 12,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/388
Ophthalmic disorders among students of School for the Deaf
Aim: This study aimed at determining the prevalence and pattern of ophthalmic disorders amongstudents of School for the Deaf, Akure, Ondo State, Nigeria.Methodology: This is a cross sectional descriptive study was conducted in October, 2011 aspart of activities marking the Annual Physicians’ week of Nigerian Medical Association (NMA),Ondo State. Ethical clearance was obtained from the Ethical Review Committee of FederalMedical Centre, Owo prior to commencement of this study. The permission of the SchoolAuthority was also obtained before the commencement of this study. The respondents wereselected by simple random sampling technique. All enrolled participants were interviewed withthe aid of the study instrument (questionnaire) by the authors and interpreters (school teachers).Results: The respondents comprised of 91(56.9%) Males and 69 Females (43.1%). Nearly all therespondents;158(98.8%) were deaf and dumb. Most respondents; 116(72.5%) had ocularexamination in the past. Few respondents; 118(73.75%) had ophthalmic disorder. The commonest ophthalmic disorder was refractive error which was found in 16 respondents(38.1%). Myopia was diagnosed in 9 respondents.CONCLUSION: Most of the respondents were deaf and dumb. Few respondents hadophthalmic disorder. The commonest ophthalmic disorder was refractive error. Myopia was themost predominant refractive error. There is need for periodic ocular screening and treatment atthe School for the Deaf.
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