Speech Rehabilitation After Total Laryngectomy: Long-term Results With Indwelling Voice Prosthesis Blom-singer®

To evaluate long-term use of indwelling Blom-Singer voice prosthesis (VP) for vocal rehabilitation of patients submitted to total laryngectomy (TL). We studied the influence of time of performance of tracheo-esophageal puncture (TEP), use of radiotherapy (XRT), patients' age and length of follow-up, on the rate of success of use of VP. Study Design: clinical prospective. Material and Method: Seventy-one patients were submitted to TL and rehabilitated with indwelling VP. Both otolaryngologist and speech pathologist evaluated all patients for the vocal functional issues during the follow-up. The relative data on time of placement of VP, time of use of PF, use of XRT, age, length of follow-up and interval of duration of each VP were recorded during the follow-up. Results: There was 87% of patients with primary TEP and 13% with secondary. The follow-up varied from 12 to 87 months, with average of 38 months for primary and 51 months for secondary TEP. There were 59% of patients submitted to XRT. The general rate of success was of 94%. In primary TEP it was of 97% and in the secondary, it was 78% (p=0.07) and after two years, the success rate was of 96% in primary TEP and 75% in secondary TEP (p=0.07). The use of XRT and patient age did not influence the success of use of VP among primary and secondary TEP, independently of length of follow-up. Conclusion: Tendency to greater success rate in voice rehabilitation after TL with primary TEP was observed. Postoperative XRT and age did not influence success rate.714504509Hamaker, R.C., Singer, M.J., Blom, E.D., Daniels, H.A., Primary voice restoration at laryngectomy (1985) Arch Otolaryngol, 111, pp. 182-186Maves, M.D., Lingeman, R.E., Primary vocal rehabilitation using the Blom-Singer and Pange voice prostheses (1982) Ann Otol Rhinol Laryngol, 91, pp. 458-460Singer, M.I., Blom, E.D., An endoscopic technique for restoration of voice after laryngectomy (1980) Ann Otol Rhinol Laryngol, 89, pp. 529-533Graville, D., Gross, N., Andersen, P., Everts, E., Cohen, J., The long-term indwelling tracheoesophageal prosthesis for a laryngeal voice rehabilitation (1999) Arch Otolaryngol Head Neck Surg, 125, pp. 288-292Blom, E.D., Hamaker, R.C., Tracheoesophageal voice restoration following total laryngectomy (1996) Cancer of the Head and Neck. Third Ed., pp. 839-852. , Myers EN, Suen JY. Philadelphia: W. B. Saunders CoBlom, E.D., Singer, M.I., Hamaker, R.C., A prospective study of tracheoesophageal speech (1986) Arch Otolaryngol Head Neck Surg, 112, pp. 440-447Hoffman, H.T., Fischer, H., Van Denmark, D., Peterson, K.L., McCulloch, T.M., Karnell, L.H., Funk, G.F., Botulinum toxin injection after total laryngectomy (1997) Head Neck, 19, pp. 92-97Lau, W.F., Wei, W.I., Ho, C.M., Lam, K.H., Immediate tracheoesophageal puncture for voice restoration in laryngopharyngeal resection (1988) Am J Surg, 156, pp. 269-272Lavertu, P., Guay, M.E., Meeker, S.S., Kmiecik, J.R., Secic, M., Wanamake, J.R., Eliachar, I., Wood, B.G., Secondary tracheoesophageal puncture: Factors predictive of voice quality and prosthesis use (1996) Head Neck, 18, pp. 393-398Stiernberg, C.M., Bailey, B.J., Calhoun, K.H., Perez, D.G., Primary traqueoesophageal fistula procedure for voice restoration: The University of Texas medical branch experience (1987) Laryngoscope, 97, pp. 820-824Yoshida, G.Y., Hamaker, R.C., Singer, M.I., Blom, E.D., Charles, G.A., Primary voice restoration at laryngectomy: 1989 Update (1989) Laryngoscope, 99, pp. 1093-1095McIvor, J., Evans, P.F., Perry, A., Cheesman, A.D., Radiological assessment of post laryngectomy speech (1990) Clin. Radiol., 41, pp. 312-316Guily, J.L.S., Angelard, B., El-bez, M., Julien, N., Debry, C., Fichaux, P., Gondret, R., Postlaryngectomy voice restoration: A prospective study in 83 patients (1992) Arch Otolaryngol Head Neck Surg, 118, pp. 252-255Kao, W.W., Mohr, R.M., Kimmel, C.A., Getch, C., Silverman, C., The outcome and techniques of primary and secondary tracheoesophageal puncture (1994) Arch Otolaryngol Head Neck Surg, 120, pp. 301-307Maniglia, A.J., Lundy, D.S., Casiano, R.C., Swim, S.C., Speech restoration and complications of primary versus secondary tracheoesophageal puncture following total laryngectomy (1989) Laryngoscope, 99, pp. 489-491Trudeau, M.D., Hirsch, S.M., Schuller, D.E., Vocal restorative surgery: Why wait? (1986) Laryngoscope, 96, pp. 975-977Aust, M.R., McCaffrey, T.V., Early speech results with the Provox prosthesis after laryngectomy (1997) Arch Otolaryngol Head Neck Surg, 123, pp. 966-968Akbas, Y.I., Dursun, G., Voice restoration with low pressure blom singer voice prosthesis after total laryngectomy (2003) Yonsei Med J, 44, pp. 615-618Fagan, J.J., Lentin, R., Oyarzabal, M.F., Isaacs, S., Sellars, S.L., Tracheoesophageal speech in a developing world community (2002) Arch Otolaryngol Head Neck Surg, 128, pp. 50-53Ferrer Ramírez, M.J., Guallart Doménech, F., Brotons Durbán, S., Carrasco Llatas, M., Estellés Ferriol, E., López Martínez, R., Surgical voice restoration after total laryngectomy: Long-term results (2001) Eur Arch Otorhinolaryngol, 258, pp. 463-466De Raucourt, D., Rame, J.P., Daliphard, F., Le Pennec, D., Béquignon, A., Luquet, A., Voice rehabilitation with a voice prosthesis. Study of 62 patients with 5 years follow-up (1998) Rev Laryngol Otol Rhinol, 119, pp. 297-300. , BordVan Den Hoogen, F.J., Van Den Berg, R.J., Oudes, M.J., Manni, J.J., A prospective study of speech and voice rehabilitation after total laryngectomy with the low-resistance Groningen, Nijdam and Provox voice prostheses (1998) Clin Otolaryngol, 23, pp. 425-431Labruna, A., Klatsky, I., Huo, J., Weiss, M.H., Tracheoesophageal puncture in irradiated patients (1995) Ann Otol Rhinol Laryngol, 104, pp. 279-281Trudeau, M.D., Schuller, D.E., Hall, D.A., The effects of radiation on tracheoesophageal puncture (1989) Arch Otolaryngol Head Neck Surg, 115, pp. 1116-1117Baugh, R.F., Jewis, J.S., Baker, S.B., Vocal rehabilitation of tracheoesophageal speech failures (1990) Head Neck, 12, pp. 69-73Baugh, R.F., Jewis, J.S., Baker, S.B., Preoperative assessment of tracheoesophageal speech (1987) Laryngoscope, 97, pp. 461-466Blom, E.D., Singer, M.I., Hamaker, R.C., An improved esophageal insufflation test (1985) Arch Otolaryngol, 111, pp. 211-212Crary, M.A., Glowalski, A.L., Using botulinum toxin A to improve speech and swallowing function following total laryngectomy (1996) Arch Otolaryngol Head Neck Surg, 122, pp. 760-763Lewin, J.S., Baugh, R.F., Baker, S.B., An objective method for prediction of tracheoesophageal speech production (1987) J Speech Hear Disord, 52, pp. 212-217Blom, E.D., Pauloski, B.R., Hamaker, R.C., Functional outcome after surgery for prevention of pharyngospasms in tracheoesophageal speakers. Part I: Speech characteristics (1995) Laryngoscope, 105, pp. 1093-1103Callaway, E., Truelson, J.M., Wolf, G.T., Kincaid, L.T., Cannon, S., Predictive value of objective esophageal insufflation testing for acquisition of tracheoesophageal speech (1992) Laryngoscope, 102, pp. 704-708Mahieu, H.F., Annyas, A.A., Schutte, H.K., Van Der Jagt, E.J., Pharyngoesophageal myotomy for vocal rehabilitation of laryngectomees (1987) Laryngoscope, 97, pp. 451-457Singer, M.I., Blom, E.D., Selective myotomy for voice restoration after total laryngectomy (1981) Arch Otolaryngol, 107, pp. 670-673Singer, M.I., Blom, E.D., Hamaker, R.C., Pharyngeal plexus neurectomy for alaryngeal speech rehabilitation (1986) Laryngoscope, 96, pp. 50-53Sloane, P.M., Griffin, J.M., O'Dwyer, T.P., Esophageal insufflation and videofluoroscopy for evaluation of esophageal speech in laryngectomy patients: Clinical implications (1993) Radiology, 181, pp. 433-437Hamaker, R.C., Blom, E.D., Botulinum neurotoxin for pharyngeal constrictor muscle spasm in tracheoesophageal voice restoration (2003) Laryngoscope, 113, pp. 1479-1482Lewin, J.S., Bishop-Leone, J.K., Forman, A.D., Diaz, E.M., Further experience with Botox injection for tracheoesophageal speech failure (2001) Head Neck, 23, pp. 456-460Blitzer, A., Komisar, A., Baredes, S., Brin, M.F., Stewart, C., Voice failure after tracheoesophageal puncture: Management with botulinum toxin (1995) Otolaryngol Head Neck Surg, 113, pp. 668-670Terell, J.E., Lewin, J.S., Esclamado, R., Botulinum toxin injection for postlaryngectomy tracheoesophageal speech failure (1995) Otolaryngol Head Neck Surg, 113, pp. 788-791Zormeier, M.M., Meleca, R.J., Simpsom, M.L., Dworkin, J.P., Klein, R., Gross, M., Mathog, D., Botulinum toxin injection to improve tracheoesophageal speech after total laryngectomy (1999) Otolaryngol Head Neck Surg, 120, pp. 14-19Quer, M., Burgués-Vila, J., Garcia-Crespillo, P., Primary tracheoesophageal puncture vs esophageal speech (1992) Arch Otolaryngology Head Neck Surg, 118, pp. 188-190Izdebsky, K., Reed, C.G., Ross, J.C., Hilsinger, R.L., Problems with tracheoesophageal fistula voice restoration in totally laryngectomized patients (1994) Arch Otolaryngol Head Neck Surg, 120, pp. 840-845Merwin, G.E., Goldstein, L.P., Rothman, H.B., A comparison of speech using artificial larynx and tracheoesophageal puncture with valve in the same speaker (1985) Laryngoscope, 95, pp. 730-734Robbins, J., Acoustic differentiation of laryngeal, esophageal, and tracheoesophageal speech (1984) J Speech Hear Res, 27, pp. 577-585Robbins, J., Fisher, H.B., Blom, E.C., Singer, M.I., A comparative acoustic study of normal, esophageal and tracheoesophageal speech production (1984) J Speech Hear Res, 49, pp. 202-210Willians, S.E., Watson, J.B., Speaking proficiency variation according to method of alaryngeal voicing (1987) Laryngoscope, 97, pp. 737-73

Correlation Between Voice And Life Quality And Occupation

Dysphonia may impair the quality of communication and social relations of people, thereby direcdy affecting quality of life. It is common knowledge amongst professionals involved with the treatment of voice disorders the need for objective protocols to evaluate voice quality and measure its impact on the individual's quality of life. Aim: To associate life quality with the degree of dysphonia and professional voice use in a group of dysphonic patients. Materials and Methods: A prospective clinical study was undertaken with a group of dysphonic patients using an internationally validated voice-related quality-of-life protocol. A statistical analysis of the results was carried out, not distinguishing between those who use their voices professionally and those who don't. Results: dysphonia had an impact on the quality of life of all patients. There was no statistically significant difference between the groups - professional users and non-users of their voices; however, considering the groups separately, this correlation was significant only in the group of patients who do not use their voices professionally. Conclusion: Dysphonia affected the quality of life of all subjects regardless of their voice use.752275279Wilson, J.A., Deary, I.J., Millar, A., Mackenzie, K., The quality of life impact of dysphonia (2002) Clinical Otolaryngology and Allied Sciences, 27 (3), pp. 179-182. , DOI 10.1046/j.1365-2273.2002.00559.xThe world health organization quality of life assessment (WHOQOL): Position paper from the world health organization (1995) Soc Sci Med, 41 (10), pp. 1403-1409. , The WHOQOL Group 1995. OxfordBerlim, M.T., Fleck, M.P.A., Quality of life: A brand new concept for research and practice in psychiatry (2003) Revista Brasileira de Psiquiatria, 25 (4), pp. 249-252Jacobson, B.H., Johnson, A., Grywalsky, C., Silbergleit, A., Jacobson, G., Benninger, M.S., The voice handicap index: Development and validation (1996) Am J Speech Lang Pathol, 6 (3), pp. 66-70. , RockvilleBehlau, M., Madazio, G., Feijó, D., Pontes, P., Avaliação de voz (2001) Voz: O Livro Do Especialista, 1, pp. 121-124. , Behlau: Rio de Janeiro: RevinterHogikyan, N.D., Sethuraman, G., Validation of an instrument to measure voice-related quality of life (V- RQOL) (1999) Journal of Voice, 13 (4), pp. 557-569Dejonckere, P.H., Bradley, P., Clemente, P., Cornut, G., Crevier-Buchman, L., Friedrich, G., Van De Heyning, P., Woisard, V., A basic protocol for functional assessment of voice pathology, especially for investigating the efficacy of (phonosurgical) treatments and evaluating new assessment techniques: Guideline elaborated by the Committee on Phoniatrics of the European Laryngological Society (ELS) (2001) European Archives of Oto-Rhino-Laryngology, 258 (2), pp. 77-82. , DOI 10.1007/s004050000299Rasch, T., Gunther, S., Hoppe, U., Eysholdt, U., Rosanowski, F., Voice-related quality of life in organic and functional voice disorders (2005) Logopedics Phoniatrics Vocology, 30 (1), pp. 9-13. , DOI 10.1080/14015430510006640Krischke, S., Weigelt, S., Hoppe, U., Kollner, V., Klotz, M., Eyshouldt, U., Quality of life in dysphonic patients (2004) J Voice, 19 (1), pp. 132-137Kasama, S.T., Brasolotto, A.G., Vocal perception and quality of life (2007) Pro Fono, 19 (1), pp. 19-28. , original titleMurry, T., Medrado, R., Hogikyan, N.D., Aviv, J.E., The relationship between ratings of voice quality and quality of life measures (2004) Journal of Voice, 18 (2), pp. 183-192. , DOI 10.1016/j.jvoice.2003.11.003, PII S0892199703001607Behlau, M., Hogikyan, N.D., Gasparini, G., Quality of life and voice: Study of a Brazilian population using the voice-related quality of life measure (2007) Folia Phoniatrica et Logopaedica, 59 (6), pp. 286-296. , DOI 10.1159/00010833

The Role of Historical Narrative in Biblical Thought:the Tendencies Underlying Old Testament Historiography

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68403/2/10.1177_030908928100602102.pd

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Combination of searches for Higgs boson pairs in pp collisions at \sqrts = 13 TeV with the ATLAS detector

This letter presents a combination of searches for Higgs boson pair production using up to 36.1 fb(-1) of proton-proton collision data at a centre-of-mass energy root s = 13 TeV recorded with the ATLAS detector at the LHC. The combination is performed using six analyses searching for Higgs boson pairs decaying into the b (b) over barb (b) over bar, b (b) over barW(+)W(-), b (b) over bar tau(+)tau(-), W+W-W+W-, b (b) over bar gamma gamma and W+W-gamma gamma final states. Results are presented for non-resonant and resonant Higgs boson pair production modes. No statistically significant excess in data above the Standard Model predictions is found. The combined observed (expected) limit at 95% confidence level on the non-resonant Higgs boson pair production cross-section is 6.9 (10) times the predicted Standard Model cross-section. Limits are also set on the ratio (kappa(lambda)) of the Higgs boson self-coupling to its Standard Model value. This ratio is constrained at 95% confidence level in observation (expectation) to -5.0 &lt; kappa(lambda) &lt; 12.0 (-5.8 &lt; kappa(lambda) &lt; 12.0). In addition, limits are set on the production of narrow scalar resonances and spin-2 Kaluza-Klein Randall-Sundrum gravitons. Exclusion regions are also provided in the parameter space of the habemus Minimal Supersymmetric Standard Model and the Electroweak Singlet Model. For complete list of authors see http://dx.doi.org/10.1016/j.physletb.2019.135103</p

Searches for lepton-flavour-violating decays of the Higgs boson in s=13\sqrt{s}=13 TeV pp\mathit{pp} collisions with the ATLAS detector

This Letter presents direct searches for lepton flavour violation in Higgs boson decays, H → eτ and H → μτ , performed with the ATLAS detector at the LHC. The searches are based on a data sample of proton–proton collisions at a centre-of-mass energy √s = 13 TeV, corresponding to an integrated luminosity of 36.1 fb−1. No significant excess is observed above the expected background from Standard Model processes. The observed (median expected) 95% confidence-level upper limits on the leptonflavour-violating branching ratios are 0.47% (0.34+0.13−0.10%) and 0.28% (0.37+0.14−0.10%) for H → eτ and H → μτ , respectively.publishedVersio

Search for flavour-changing neutral currents in processes with one top quark and a photon using 81 fb⁻¹ of pp collisions at \sqrts = 13 TeV with the ATLAS experiment

A search for flavour-changing neutral current (FCNC) events via the coupling of a top quark, a photon, and an up or charm quark is presented using 81 fb−1 of proton–proton collision data taken at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. Events with a photon, an electron or muon, a b-tagged jet, and missing transverse momentum are selected. A neural network based on kinematic variables differentiates between events from signal and background processes. The data are consistent with the background-only hypothesis, and limits are set on the strength of the tqγ coupling in an effective field theory. These are also interpreted as 95% CL upper limits on the cross section for FCNC tγ production via a left-handed (right-handed) tuγ coupling of 36 fb (78 fb) and on the branching ratio for t→γu of 2.8×10−5 (6.1×10−5). In addition, they are interpreted as 95% CL upper limits on the cross section for FCNC tγ production via a left-handed (right-handed) tcγ coupling of 40 fb (33 fb) and on the branching ratio for t→γc of 22×10−5 (18×10−5). © 2019 The Author(s

Stellar clusters in 4MOST

Instrumentatio

Brain volumetric deficits in MAPT mutation carriers: a multisite study

Objective: MAPT mutations typically cause behavioral variant frontotemporal dementia with or without parkinsonism. Previous studies have shown that symptomatic MAPT mutation carriers have frontotemporal atrophy, yet studies have shown mixed results as to whether presymptomatic carriers have low gray matter volumes. To elucidate whether presymptomatic carriers have lower structural brain volumes within regions atrophied during the symptomatic phase, we studied a large cohort of MAPT mutation carriers using a voxelwise approach. Methods: We studied 22 symptomatic carriers (age 54.7 ± 9.1, 13 female) and 43 presymptomatic carriers (age 39.2 ± 10.4, 21 female). Symptomatic carriers’ clinical syndromes included: behavioral variant frontotemporal dementia (18), an amnestic dementia syndrome (2), Parkinson’s disease (1), and mild cognitive impairment (1). We performed voxel-based morphometry on T1 images and assessed brain volumetrics by clinical subgroup, age, and mutation subtype. Results: Symptomatic carriers showed gray matter atrophy in bilateral frontotemporal cortex, insula, and striatum, and white matter atrophy in bilateral corpus callosum and uncinate fasciculus. Approximately 20% of presymptomatic carriers had low gray matter volumes in bilateral hippocampus, amygdala, and lateral temporal cortex. Within these regions, low gray matter volume

Search for single vector-like B quark production and decay via B → bH(b¯b) in pp collisions at √s = 13 TeV with the ATLAS detector

A search is presented for single production of a vector-like B quark decaying into a Standard Model b-quark and a Standard Model Higgs boson, which decays into a b¯b pair. The search is carried out in 139 fb−1 of √s = 13 TeV proton-proton collision data collected by the ATLAS detector at the LHC between 2015 and 2018. No significant deviation from the Standard Model background prediction is observed, and mass-dependent exclusion limits at the 95% confidence level are set on the resonance production cross-section in several theoretical scenarios determined by the couplings cW, cZ and cH between the B quark and the Standard Model W, Z and Higgs bosons, respectively. For a vector-like B occurring as an isospin singlet, the search excludes values of cW greater than 0.45 for a B resonance mass (mB) between 1.0 and 1.2 TeV. For 1.2 TeV < mB < 2.0 TeV, cW values larger than 0.50–0.65 are excluded. If the B occurs as part of a (B, Y) doublet, the smallest excluded cZ coupling values range between 0.3 and 0.5 across the investigated resonance mass range 1.0 TeV < mB < 2.0 TeV