Bridging the Distance: The Agencement of Complex Affordances on Social Media Platforms

This research focuses on the actualization of technological affordances in complex technological environments, such as social media, where in addition to human and material agents, algorithmic agents also proliferate. Unlike material agents, algorithmic agents can act in the absence of proximal instigation by human agents, and can influence the actions of other agents distanced in space and time. By borrowing from actor-network theory, this paper foregrounds the role of algorithmic agents in the actualization of complex affordances by advertisers on a social media platform. It is illustrated that a complex affordance is actualized through an agencement, that is, a collective enactment of heterogeneous agencies. Through such an enactment, human agents are able to act at a distance too. This research highlights that in addition to material features of the user-interface, the underlying algorithms of a complex technology also partake in the actualization of affordances

Understanding the Role of Online Support to Tourist Spots in India

The online travel agencies or popularly known as OTAs have become one of the most reliable options for the travellers to make their arrangements. The number of players both across the world and in India have seen a rise and the same has quite successfully helped in planning trips for many tourists. The study here is curious to understand the role of these OTAs in the process of resuming the tourist destination especially in India. The situation in India with respect to the use of OTAs is quite different as the country is an emerging one and there are issues of digital divide still persistent in the economy The study here collected 238 primary responses from tourist across the country to identify their perception about the online travel agencies and recognise the factors that cause an impact in the adoption process. The study has used a number of advanced statistical methods such as principal component analyses and multiple linear regression to establish the factors as well as the relationship with the adoption process. The regression model being formulated is able to estimate of variance of 14% on the intention of using online modes to put the two responses in India by highlighting the two main factors causing an impact on it. The perceived ease of use and the information transparency are the main reasons why a tourist based in India prefers to book their destination requirements using online travel agencies

Brief Announcement: Crash-Tolerant Consensus in Directed Graph Revisited

We revisit the problem of distributed consensus in directed graphs tolerating crash failures; we improve the round and communication complexity of the existing protocols. Moreover, we prove that our protocol requires the optimal number of communication rounds, required by any protocol belonging to a specific class of crash-tolerant consensus protocols in directed graphs

Fast and Universally-Composable Oblivious Transfer and Commitment Scheme with Adaptive Security

Adaptive security embodies one of the strongest notions of security that allows an adversary to corrupt parties at any point during protocol execution and gain access to its internal state. Since it models real-life situations such as ``hacking , efficient adaptively-secure multiparty computation (MPC) protocols are desirable. Such protocols demand primitives such as oblivious transfer (OT) and commitment schemes that are adaptively-secure as building blocks. Efficient realizations of these primitives have been found to be challenging, especially in the no erasure model. We make progress in this direction and provide efficient constructions that are Universally-Composable in the random oracle model. Oblivious Transfer: We present the first round optimal framework for building adaptively-secure OT in the programmable random oracle (PRO) model, relying upon the framework of Peikert et al. (Crypto 2008). When instantiated with Decisional Diffie Hellman assumption, it incurs a minimal communication overhead of one k bit string and computational overhead of 5 random oracle queries over its static counterpart, where k is the security parameter. This computation overhead translates to 0.02% and 1% in the LAN and WAN setting. Additionally, we obtain a construction of adaptively-secure 1-out-of-N OT by extending the result of Naor et al. (Journal of Cryptology 2005) that transforms logN copies of 1-out-of-2 OTs to one 1-out-of-N OT in the PRO model. We complete the picture of efficient OT constructions by presenting the first adaptively secure OT Extension, extending the protocol of Asharov et al. (Eurocrypt 2015) for the adaptive setting using PRO. Our OT extension enables us to obtain adaptive OTs at an amortized cost of 3 symmetric key operations and communication of 3k bit strings. It incurs a runtime overhead of 2% and 11.95%, in the LAN and WAN setting and almost no communication overhead over the static OT extension protocol. In concrete terms, the cost is 2microsecs and 115 microsecs for each OT in LAN and WAN. Commitment Scheme: We present an adaptively secure commitment scheme in the Global Random Oracle model solely relying on observable random oracle (ORO). Our commitment scheme has a one-time offline setup phase, where a common reference string (crs) is generated between the parties using an ORO. In the online phase, the parties use the crs and ORO to generate commitments in a non-interactive fashion. Our construction incurs communication of 4k bit strings and computation of 4 exponentiations and 4 random oracle queries for committing to an arbitrary length message. Empirically, it takes around 0.18ms and 0.2 ms for committing to 128 bits and 2048 bits respectively. It finds applications in secure two-party computation (2PC) protocols that adopt offline-online paradigm, where the crs can be generated in the offline phase and the scheme can be used in the online phase

Crash-tolerant Consensus in Directed Graph Revisited

Fault-tolerant distributed consensus is a fundamental problem in secure distributed computing. In this work, we consider the problem of distributed consensus in directed graphs tolerating crash failures. Tseng and Vaidya (PODC\u2715) presented necessary and sufficient condition for the existence of consensus protocols in directed graphs. We improve the round and communication complexity of their protocol. Moreover, we prove that our protocol requires the optimal number of communication rounds, required by any protocol belonging to a restricted class of crash-tolerant consensus protocols in directed graphs

How participatory is parental consent in low literacy rural settings in low income countries? Lessons learned from a community based study of infants in South India

<p>Abstract</p> <p>Background</p> <p>A requisite for ethical human subjects research is that participation should be informed and voluntary. Participation during the informed consent process by way of asking questions is an indicator of the extent to which consent is informed.</p> <p>Aims</p> <p>The aims of this study were to assess the extent to which parents providing consent for children's participation in an observational tuberculosis (TB) research study in India actively participated during the informed consent discussion, and to identify correlates of that participation.</p> <p>Methods</p> <p>In an observational cohort study of tuberculosis in infants in South India, field supervisors who were responsible for obtaining informed consent noted down questions asked during the informed consent discussions for 4,382 infants who were enrolled in the study. These questions were post-coded by topic. Bivariate and multivariate analysis was conducted to examine factors associated with asking at least one question during the informed consent process.</p> <p>Results</p> <p>In total, 590 out of 4,382 (13.4%) parents/guardians asked any question during the informed consent process. We found that the likelihood of parents asking questions during the informed consent process was significantly associated with education level of either parent both parents being present, and location.</p> <p>Conclusions</p> <p>The findings have implications for planning the informed consent process in a largely rural setting with low levels of literacy. Greater effort needs to be directed towards developing simple participatory communication materials for the informed consent process. Furthermore, including both parents in a discussion about a child's participation in a research study may increase the extent to which consent is truly informed. Finally, continuing efforts need to be made to improve the communication skills of research workers with regard to explaining research processes and putting potential research participants at ease.</p

Sustained proliferation in cancer: mechanisms and novel therapeutic targets

Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of many signal transduction pathways also stimulates cell growth. Early steps in tumor development are associated with a fibrogenic response and the development of a hypoxic environment which favors the survival and proliferation of cancer stem cells. Part of the survival strategy of cancer stem cells may manifested by alterations in cell metabolism. Once tumors appear, growth and metastasis may be supported by overproduction of appropriate hormones (in hormonally dependent cancers), by promoting angiogenesis, by undergoing epithelial to mesenchymal transition, by triggering autophagy, and by taking cues from surrounding stromal cells. A number of natural compounds (e.g., curcumin, resveratrol, indole-3-carbinol, brassinin, sulforaphane, epigallocatechin-3-gallate, genistein, ellagitannins, lycopene and quercetin) have been found to inhibit one or more pathways that contribute to proliferation (e.g., hypoxia inducible factor 1, nuclear factor kappa B, phosphoinositide 3 kinase/Akt, insulin-like growth factor receptor 1, Wnt, cell cycle associated proteins, as well as androgen and estrogen receptor signaling). These data, in combination with bioinformatics analyses, will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression

Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial

Importance: Easy-to-administer anti-SARS-CoV-2 treatments may be used to prevent progression from asymptomatic infection to symptomatic disease and to reduce viral carriage. Objective: To evaluate the effect of combination subcutaneous casirivimab and imdevimab on progression from early asymptomatic SARS-CoV-2 infection to symptomatic COVID-19. Design, Setting, and Participants: Randomized, double-blind, placebo-controlled, phase 3 trial of close household contacts of a SARS-CoV-2-infected index case at 112 sites in the US, Romania, and Moldova enrolled July 13, 2020-January 28, 2021; follow-up ended March 11, 2021. Asymptomatic individuals (aged ≥12 years) were eligible if identified within 96 hours of index case positive test collection. Results from 314 individuals positive on SARS-CoV-2 reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) testing are reported. Interventions: Individuals were randomized 1:1 to receive 1 dose of subcutaneous casirivimab and imdevimab, 1200 mg (600 mg of each; n = 158), or placebo (n = 156). Main Outcomes and Measures: The primary end point was the proportion of seronegative participants who developed symptomatic COVID-19 during the 28-day efficacy assessment period. The key secondary efficacy end points were the number of weeks of symptomatic SARS-CoV-2 infection and the number of weeks of high viral load (&gt;4 log10copies/mL). Results: Among 314 randomized participants (mean age, 41.0 years; 51.6% women), 310 (99.7%) completed the efficacy assessment period; 204 were asymptomatic and seronegative at baseline and included in the primary efficacy analysis. Subcutaneous casirivimab and imdevimab, 1200 mg, significantly prevented progression to symptomatic disease (29/100 [29.0%] vs 44/104 [42.3%] with placebo; odds ratio, 0.54 [95% CI, 0.30-0.97]; P =.04; absolute risk difference, -13.3% [95% CI, -26.3% to -0.3%]). Casirivimab and imdevimab reduced the number of symptomatic weeks per 1000 participants (895.7 weeks vs 1637.4 weeks with placebo; P =.03), an approximately 5.6-day reduction in symptom duration per symptomatic participant. Treatment with casirivimab and imdevimab also reduced the number of high viral load weeks per 1000 participants (489.8 weeks vs 811.9 weeks with placebo; P =.001). The proportion of participants receiving casirivimab and imdevimab who had 1 or more treatment-emergent adverse event was 33.5% vs 48.1% for placebo, including events related (25.8% vs 39.7%) or not related (11.0% vs 16.0%) to COVID-19. Conclusions and Relevance: Among asymptomatic SARS-CoV-2 RT-qPCR-positive individuals living with an infected household contact, treatment with subcutaneous casirivimab and imdevimab antibody combination vs placebo significantly reduced the incidence of symptomatic COVID-19 over 28 days. Trial Registration: ClinicalTrials.gov Identifier: NCT04452318

Municipal waste management systems for domestic use

© 2017 The Authors. Every year, the average citizen of a developed country produces about half a tonne of waste, thus waste management is an essential industry. Old waste management systems based on the collection of mixed/ sorted waste and transporting it a long way to disposal sites has a significant negative impact on the environment and humans. This paper will review the available waste management systems for house- holds. Biological methods (such as composting or anaerobic digestion) and physicochemical methods (such as burning or pyrolysis) of waste utilization will be considered from the householder’s point of view. The most important features of each system will be discussed and compared. Municipal waste management systems for domestic use could eliminate or significantly reduce the stage of waste collection and transportation. Additionally, they should not require special infrastructure and at the same time should allow garbage to be changed into safe products or energy sources with no harmful emissions. The aim of the work is to identify the best available waste disposal systems for domestic use.This reported work was conducted as part of the“Design Optimisation of the HERU Waste Treatment System”project that wasfunded by Manik Ventures Limited Project ID: 10300