18 research outputs found
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
- Author
- AbellĂĄn Javier
- Acosta-isaac René
- Aguado Jose MarĂa
- Aguilar Carlos
- Aguilera-albesa Sergio
- Ahmadi Sabbagh Abdolah
- Alba Jorge
- Albu Sergiu
- AlcalĂĄ-gallardo Karla A. M.
- Alcoba-florez Julia
- Alcolea Batres Sergio
- Algarin-lara Holmes Rafael
- Almadana Virginia
- Almeida Julia
- Almoguera Berta
- Alonso MarĂa R.
- Andreu-bernabeu Ălvaro
- Antonijoan Maria Rosa
- Arana-arri Eunate
- Aranda Carlos
- Arango Celso
- Araque Carolina
- Araujo Izabel M. T.
- Araujo Nathalia K.
- Arcanjo Ana C.
- Arnaiz Ana
- Arnalich FernĂĄndez Francisco
- Arranz MarĂa J.
- Arribas López José Ramón
- Artiga Maria-jesĂșs
- Avello-malaver Yubelly
- Ayuso Carmen
- Balagué-dobón Laura
- Baldion Ana MarĂa
- Ballina MartĂn BelĂ©n
- Baptista-rosas RaĂșl C.
- Barranco-dĂaz Andrea
- Barreda-sĂĄnchez MarĂa
- Barrera-penagos Viviana
- Belhassen-garcia Moncef
- Bernal Enrique
- Bernal-bello David
- Bezerra Joao F.
- Bezerra Marcos A. C.
- Blanca-lĂłpez Natalia
- Blancas Rafael
- Boix-palop LucĂa
- Borobia Alberto
- Bravo Elsa
- Brion MarĂa
- Brochado-kith Ăscar
- Brugada RamĂłn
- Bustos Matilde
- Cabello Alfonso
- Calbo Esther
- CalderĂłn Enrique J.
- Camacho Shirley
- Campos Marcela C.
- Carbonell Cristina
- Cardona-huerta Servando
- Carioca Antonio Augusto F.
- Carpio Segura Carlos
- Carracedo Ăngel
- Carratto ThĂĄssia M. T.
- Carrillo-avila José Antonio
- Carvalho Maria C. C.
- Casasnovas Carlos
- Castaño Carlos F.
- Castaño Luis
- Castelao Jose E.
- Castellano Candalija Aranzazu
- Castillo MarĂa A.
- Cañadas Yolanda
- Ceballos Francisco C.
- Chaux Jessica G.
- Chaves-santiago Walter G.
- Chiquillo-gĂłmez Sylena
- Cid-lĂłpez Marco A.
- Cienfuegos-jimĂ©nez Ăscar
- Conde-vicente Rosa
- Cordero-lorenzana M. Lourdes
- Corella Dolores
- Corrales Almudena
- Corton Marta
- Cortés-sånchez Jose L.
- Costa Tatiana X.
- Cruz Marina S.
- Cruz Raquel
- Cuesta Luisa
- Cunha Gabriela C. R.
- CĂĄceres Alejandro
- CĂĄceres-agra Juan J.
- Dalmau David
- Dantas-komatsu Raquel C. S.
- Darnaude M. Teresa
- De Andrés Raimundo
- De AraĂșjo JĂ©ssica N. G.
- De Juan Carmen
- De La Cruz Troca Juan J.
- De La Horra Carmen
- De La Hoz Ana B.
- De Martino-rodrĂguez Alba
- De Sousa Alves Neri Julianna Lys
- Del Campo-pérez Victor
- Delgado-cuesta Juan
- Diaz De Bustamante Aranzazu
- Dietl Beatriz
- Diz-de Almeida Silvia
- Do Monte Alves Manoella
- DomĂnguez-garrido Elena
- Dos Santos Katiusse A.
- Duarte Alice L.
- DĂaz-caneja Covadonga M.
- DĂaz-pĂ©rez Anderson
- Echave-sustaeta Jose
- Eiros RocĂo
- Enciso-olivera CĂ©sar O.
- Escudero Gabriela
- Esko Tonu
- España Pedro Pablo
- Estigarribia Sanabria Gladys
- Fariñas MarĂa Carmen
- Fernandes Marianne R.
- Fernandez-nestosa MarĂa J.
- FernĂĄndez MartĂnez Yolanda
- FernĂĄndez RamĂłn
- FernĂĄndez Ruth
- FernĂĄndez-caballero Lidia
- FernĂĄndez-capitĂĄn Carmen
- FernĂĄndez-cruz Ana
- FernĂĄndez-ferrero Silvia
- FernĂĄndez-robelo UxĂa
- FernĂĄndez-rodrĂguez Amanda
- FernĂĄndez-sampedro Marta
- FernĂĄndez-villa Tania
- Flores Carlos
- Flores-pérez Patricia
- Friaza Vicente
- Fuenmayor-hernĂĄndez LĂĄcides
- Fuertes-nĂșñez Marta
- FumadĂł Victoria
- Gadea Ignacio
- Gagliardi Lidia
- Gago-domĂnguez Manuela
- Gallego Natalia
- Galoppo Cristina
- Garcia-garcĂa Josefina
- GarcĂa TorrejĂłn MarĂa Carmen
- GarcĂa InĂ©s
- GarcĂa Leticia
- GarcĂa Mercedes
- GarcĂa-cerrada Carlos
- GarcĂa-de-vicuña Aitor
- GarcĂa-garcĂa Irene
- GarcĂa-ibarbia Carmen
- GarcĂa-montero AndrĂ©s C.
- GarcĂa-soidĂĄn Ana
- GarcĂa-vĂĄzquez Elisa
- Garza-frias Emiliano
- Gentile Angela
- Gil-fournier Belén
- Gonzalez-sagrado Manuel
- Gonzalo-benito Hugo
- GonzĂĄlez Bernaldo De QuirĂłs FernĂĄn
- GonzĂĄlez Ălvarez Beatriz
- GonzĂĄlez Juan R.
- GonzĂĄlez Juan R.
- GonzĂĄlez-montelongo Rafaela
- GonzĂĄlez-neira Anna
- Gonzålez-peñas Javier
- Gorgojo-galindo Oscar
- Guaragna Florencia
- Guegel Genilson P.
- GuillĂ©n-guĂo Beatriz
- Guillén-navarro Encarna
- Guisado-vasco Pablo
- Gutiérrez-bautista Juan F.
- Gutiérrez-castañeda Luz D.
- GĂłmez Carrera Luis
- GĂłmez GarcĂa MarĂa
- GĂłmez SacristĂĄn Ăngela
- GĂłmez-arrue Javier
- GĂłmez-duque Mario
- GĂłrgolas Miguel
- Heili-frades Sara
- HernĂĄndez Estefania
- HernĂĄndez-moro Cristina
- HernĂĄndez-ortega Luis D.
- Hernåndez-pérez Guillermo
- HernĂĄndez-vaquero Rebeca
- Herranz M. Teresa
- Herrera MarĂa
- Herrero MarĂa JosĂ©
- Herrero-gonzĂĄlez Antonio
- Herråez Belén
- Horcajada Juan P.
- Imaz-ayo Natale
- Intxausti-urrutibeaskoa Maider
- Jacomo Rafael H.
- Jara Rubén
- Jiménez Pilar
- JimĂ©nez Ăngel
- Jiménez-alfaro Ignacio
- JimĂ©nez-sousa MarĂa A.
- Jordan Iolanda
- Laguna-goya RocĂo
- Laorden Daniel
- Lapunzina Pablo
- Lasa-lĂĄzaro MarĂa
- Lattig MarĂa Claudia
- Lauriente Ailen
- Liger Borja Anabel
- Llanos LucĂa
- Lopez-garcia Esther
- Lopez-rodriguez Rosario
- Lorente Leonardo
- Lorenzo-salazar José M.
- Lozano José E.
- Lozano-espinosa MarĂa
- Luchessi Andre D.
- LĂłpez De Heredia Miguel
- LĂłpez De Heredia Miguel
- LĂłpez-bernĂșs Amparo
- LĂłpez-granados Eduardo
- LĂłpez-ruz Miguel A.
- Mahillo Ignacio
- Mancebo Esther
- Mar Carmen
- Marcelo Calvo Cristina
- Marcos Miguel
- Marcos-delgado Alba
- Mariscal-aguilar Pablo
- Martin-fernandez Marta
- Martin-pedraza Laura
- Martinez Amalia
- Martinez-paz Pedro
- MartĂn MarĂa Dolores
- MartĂn MarĂa M.
- MartĂn Vicente
- MartĂn-lĂłpez Caridad
- MartĂn-oterino JosĂ©-Ăngel
- MartĂn-vicente MarĂa
- MartĂnez Juan JosĂ©
- MartĂnez Ricardo
- MartĂnez Silvia
- MartĂnez-aquino Eleno
- MartĂnez-gonzĂĄlez Ăscar
- MartĂnez-lĂłpez Iciar
- MartĂnez-nieto Ăscar
- MartĂnez-pĂ©rez Ăngel
- MartĂnez-ramas Andrea
- MartĂnez-resĂ©ndez Michel F.
- MartĂnez-robles Violeta
- Marzal Laura
- MarĂn-candĂłn Alicia
- Maya BelĂ©n RodrĂguez
- Mazzeu Juliana F.
- Medeiros Jeane F. P.
- Medeiros Kelliane A.
- Medrano Francisco J.
- Meijome Xose M.
- Mejuto-montero Natalia
- Mendes Ingrid
- Mendoza Charris Humberto
- Merayo MacĂas Eleuterio
- Mercadillo FĂĄtima
- Mercado-sesma Arieh R.
- Molina Antonio J. J.
- Molina-roldĂĄn Elena
- Montoya Juan José
- Moraes Vitor M. S.
- Moreira-escriche Patricia
- Morelos-arnedo Xenia
- Moreno Cuerda VĂctor
- Moreno FernĂĄndez Alberto
- Moreno RocĂo
- Moreno-docĂłn Antonio
- Moreno-escalante Junior
- Morilla Rubén
- Muñoz GarcĂa Patricia
- MĂ©ndez-echevarrĂa Ana
- MĂnguez Pablo
- Neira Pablo
- Nevado JuliĂĄn
- Nieto-gañån Israel
- Nunes Joana F. R.
- Nuñez-torres RocĂo
- Obrador-hevia AntĂČnia
- Ocejo-vinyals J. Gonzalo
- Olivar Virginia
- Oliveira Silviene F.
- Olivera MarĂa Rubio
- Ondo Lorena
- Orfao Alberto
- Ortega Luis
- Ortega-paino Eva
- Ortiz-flores Fernando
- Ortiz-lĂłpez RocĂo
- Oteo José A.
- Pacheco Manuel
- Pacheco-miranda Fredy Javier
- Padilla-conejo Irene
- Panadero-fajardo Sonia
- Parellada Mara
- Pariente-rodrĂguez Roberto
- Paz-artal Estela
- Peces-barba GermĂĄn
- Pedromingo Kus Miguel S.
- Perales Celia
- Perucho Teresa
- Pichardo Lisbeth A.
- Pinho Susana M. T.
- Pinsach-abuin Mel·lina
- PinzĂłn Luz Adriana
- Pita Guillermo
- Pla-juncĂ Francesc
- Planas-serra Laura
- Pompa-mera Ericka N.
- Porras-hurtado Gloria L.
- Pujol Aurora
- PĂ©rez Alexandra
- PĂ©rez CĂ©sar
- PĂ©rez MarĂa JazmĂn
- PĂ©rez Patricia
- PĂ©rez-de-nanclares Gustavo
- PĂ©rez-garcĂa Felipe
- PĂ©rez-jurado Luis A.
- PĂ©rez-matute Patricia
- PĂ©rez-tomĂĄs M. Elena
- Quevedo-chĂĄvez MarĂa Eugenia
- Quijada Maria Angeles
- Quintela Inés
- Quintela Inés
- Ramiro-leĂłn Soraya
- Rascado Sedes Pedro
- Recalde Delia
- Recio-fernĂĄndez Emma
- Resino Salvador
- Riancho José A.
- Ribeiro Adriana P.
- Rivadeneira-chamorro Carlos S.
- Roa-agudelo Diana
- Robelo Pardo Montserrat
- Rodriguez Marilyn Johanna
- Rodriguez-nicolas Antonio
- Rodriguez-palmero AgustĂ
- Rodriguez-urrego Paula A.
- RodrĂguez-artalejo Fernando
- RodrĂguez-ferrer Marena
- RodrĂguez-gallego Carlos
- RodrĂguez-garcĂa JosĂ© A.
- RodrĂguez-hernĂĄndez MarĂa A.
- RodrĂguez-novoa German Ezequiel
- RodrĂguez-ruiz Emilio
- Rojas-martinez Augusto
- Rojo Federico
- Romero-coronado Andrea
- RondĂłn-garcĂa Filomeno
- Rosa Lidia S.
- Rosales-castillo Antonio
- Rubio Cladelis
- Ruiz Montserrat
- Ruiz-cabello Francisco
- Ruiz-casares Eva
- Ruiz-cubillan Juan J.
- Ruiz-hornillos Javier
- Ryan Pablo
- Salamanca Hector D.
- Salazar-garcĂa Lorena
- Salgueiro-origlia Giorgina Gabriela
- Sancho-sainz Cristina
- Sande Esther
- Sangil Anna
- Santos Arnoldo
- Santos Ney P. C.
- SchlĂŒter Agatha
- Scourge Cohort Group
- Segovia Sonia
- Serra-llovich Alex
- Sevil-puras Fernando
- Sevilla-porras Marta
- Sicolo Miguel A.
- Silbiger Vivian N.
- Silva Fabiola T. C.
- Silva Gabriela V.
- Silva Nayara S.
- SilvĂĄn-fuentes Cristina
- Solé-violån Jordi
- Soria José Manuel
- SorlĂ Jose V.
- Sousa Renata R.
- Souto Juan Carlos
- Souza Karla S. C.
- Souza Vanessa S.
- Sprockel John J.
- Suårez-rama José Javier
- SuĂĄrez-zamora David A.
- SĂĄnchez LĂłpez Antonio J.
- SĂĄnchez Pedro-luis
- SĂĄnchez-carpintero Abad MarĂa
- SĂĄnchez-pablo Clara
- SĂĄnchez-pernaute Olga
- SĂĄnchez-prados MarĂa ConcepciĂłn
- SĂĄnchez-real Javier
- SĂĄnchez-redondo Jorge
- Taboada-fraga Xiana
- Tamayo Eduardo
- Tamayo-velasco Alvaro
- Taracido-fernĂĄndez Juan Carlos
- Tavares Nathali A. C.
- TellerĂa Carlos
- Tenorio-castaño Jair Antonio
- Teper Alejandro
- Torres-gutiérrez Ronald P.
- Torres-macho Juan
- Torres-tobar Lilian
- Troya JesĂșs
- Urioste Miguel
- Valencia-ramos Juan
- Valido AgustĂn
- Vargas-gallo Juan Pablo
- Varón Belén
- Vasconcelos Romero H. T.
- Vega Tomas
- Velasco-quirce Santiago
- Vidån-estévez Julia
- Vieitez-santiago Miriam
- Vilches Carlos
- Villalobos Lavinia
- Villar Felipe
- Villar-garcia Judit
- Villaverde Cristina
- Villoslada-blanco Pablo
- Virseda-berdices Ana
- VĂ©lez-santamarĂa Valentina
- VĂctor Virginia
- Yåñez Zuleima
- Zapatero-gaviria Antonio
- Zarate Ruth
- Zazo Sandra
- Ălvarez Nuria
- Ălvarez-benĂtez Yady
- Ălvarez-navia Felipe
- Ălvarez-sala Walther Rodolfo
- Ăñigo-campos Antonio
- Ăñiguez MarĂa
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 08/05/2024
- Field of study
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.
- Author
- Abdulla Amina
- Abelake Eugenia
- Adeel AOA
- Aebi Christoph
- Agapow Paul
- Agbeko Rachel
- Agyeman Philipp
- Alvarez Alvarez Cristina
- Alvez Gonzalez Fernando
- Anderson Suzanne
- Antonio Martin
- Arpe Volker
- Ausserer Bernd
- Baer Walter
- Barham Heather
- Barral-Arca Ruth
- Bartlett Maeve
- Beatriz Reyes Susana
- Beckmann Regina
- Bellos Evangelos
- Bensch Juergen
- Berger Christoph
- Berger Thomas
- Bernhard-Stirnemann Sara
- Binder Alexander
- Bindl Lutz
- Bittrich Hans J
- Boeddha NP
- Bojang Kalifa
- Bokhandi S
- Borghini Lisa
- Brangenberg Ralf
- Breuer HA
- Breukels MA
- Brinkman DMC
- Brio Sanagustin Sonia
- Broede Hans
- Bruckner Robert
- Carreras Eduardo
- Carrol Enitan D
- Carter Stephanie
- Cebey-Lopez Miriam
- Coin Lachlan J
- Cole Fatoumatta
- Concha Torre Andres
- Consortium EUCLIDS
- Cratev Lindsey
- Cremer Manfred
- Davies P
- Davila Sonia
- de Groot Ronald
- de Korte CCMM
- de Vries E
- de Waal WJ
- Deeg KH
- Deep Akash
- Dekkers R
- Diab Gedeon
- Dilch Alfred
- Dings-Lammertink A
- Doedens RA
- Donker AE
- Dousma M
- Driessen GJA
- Eitelberger Franz
- Eleftherohorinou Hariklia
- Emonts Marieke
- Evert W
- Faber TE
- Faust S
- Fedlmaier Michael
- Fernandez Silveira Laura
- Fernandez Reyes
- Fink Colin
- Foerster Kai Martin
- Fortune PM
- Frederick Hannah
- Fucik Peter
- Fusch Christoph
- Gabaldo Barrios Xavier
- Gabriel Markwart
- Galassini Rachel
- Garcia Vicente Luisa
- Garcia Natalia
- Geishofer Gotho
- Gerrits GPJM
- Gerver JAM
- Giannoni Eric
- Gimenez Sanchez Francisco
- Goepel Wolfgang
- Goerke W
- Gomez Rial Jose
- Gomez-Carballa Alberto
- Gormley Stuart
- Grela Beiroa Andrea
- Gribbin Andrew
- Groeblacher-Roth Helene
- Groneck Peter
- Grube Regina
- Gruber Alois
- Guillen Sara
- Hamilton Shea
- Hammer Jurg
- Hardy Katie
- Hasters Paul
- Hauser Erwin
- Hautz Juergen
- Hazelzet Jan
- Heidema J
- Heininger Ulrich
- Hennenberger Axel
- Herberg Jethro
- Herrmann Johanna
- Herting Egbert
- Hibberd Martin L
- Hofmann Thomas
- Hoggart Clive
- Homan-van der Veen J
- Hourmat Bernardo
- Hudnott Phil
- Huemer Christian
- Hueseman D
- Inwald David
- Jacobs MAM
- Jansen NJG
- Jennings Rebecca
- Johnston Joanne
- Jose Curras-Tuala Maria
- Jose Lozano Maria
- Justicia Grande Antonio
- Kaforou Myrsini
- Kahlert Christian
- Kalhoff Hermann
- Kasper Johannes-Martin
- Kawczynski P
- Kebbeh Ngane
- Kenwright Rhian
- Klinge Jens
- Klobassa Daniela
- Klucovska K
- Knaufer-Schiefer Suzanne
- Kneyber MCJ
- Koch Hartmut
- Koch Reinhard
- Koenig Michael
- Koopman-Keemink Y
- Kronberger Martina
- Kuijpers Taco W
- Kumlien Bjoern
- Kunze Wolfgang
- Kurnik Peter
- Laessig Wolfgang
- Langenhorst VJ
- Leborans Iglesias Pilar
- Lenz Kurt
- Leon Leon Maria Cruz
- Leusink J
- Levin Michael
- Lischka Andreas
- Loranth Kathrin
- Loza BF
- Luigs Petra
- Maak Bernhard
- Mahler Klaus
- Markart Markus
- Martin Mueller
- Martinez Padilla Ma del Carmen
- Martinez Santos Alba Elena
- Martinon Sanchez Jose Maria
- Martinon-Torres Federico
- Martinon-Torres Nazareth
- Mashbat Meg
- McCorkell Jenni
- McCready Sharon
- Meier Primrose
- Meissl Manfred
- Menikou Stefanie
- Merth IT
- Miedema CJ
- Miething Robert
- Mitter Horst
- Moreno David
- Moser Reinhard
- Mosquera Perez Belen
- Mueller Herbert
- Mustafa Sobia
- Nadel Simon
- Navarra Helen
- Navarro Mingorance Alvaro
- Navarro Marisa
- Neeleman C
- Neth Olaf
- Nicolai T Homas
- Niederer-Loher Anita
- Noordzij JG
- Nossal Robert
- Nsirim Eniola
- O'Neill Lauren
- Obando Pacheco Pablo
- Obihara CC
- Onate Vergara Eider
- Pajkrt D
- Paky Franz
- Palacios Alba
- Pardo-Seco Jacobo
- Patel Rekha
- Patel S
- Pathan N
- Paulus Stephane
- Penzien Johann M
- Pernice Walter
- Peters Jochen
- Peters Mark
- Pfau Eberhard
- Pfurtscheller Klaus
- Philipsen HLA
- Pinnock Ellie
- Pischedda Sara
- Png Eileen
- Pollard Andrew J
- Poortman GH
- Porto Silva Maria del Sol
- Posfay-Barbe Klara M
- Potgieter ST
- Potjewijd J
- Power Sue
- Prieto Tato Luis Manuel
- Quietzach J
- Rahman Rahmeen
- Ramaiah R
- Redondo-Collazo Lorenzo
- Reiter Hans-Ludwig
- Reiter Karl
- Relly Christa
- Ridout Jenna
- Rivero Calle Irene
- Rodriguez-Tenreiro Carmen
- Roedl Siegfried
- Rojo Pablo
- Rosias PPR
- Royad C
- Ruiz Contreras J
- Runge Klaus
- Saidykhan Momodou
- Salas Antonio
- Salzer Hans R
- Sanchez Forte Miguel
- Sancho-Shimizu Vanessa
- Sanders EAM
- Sarr Isatou
- Schaller Gerhard
- Scheibenpflug Christian
- Schermann Peter
- Schimmel Ulf
- Schlapbach Luregn J
- Schmidt Andreas
- Schuermann Roland
- Schulz Dietrich
- Schwarick Juergen
- Schwarz Rudolf
- Schweitzer-Krantz Susanne
- Secka Fatou
- Seidenberg Juergen
- Seidler Ekkehard
- Seitz Christiane
- Seren Fernandez Sonia
- Sey Gibbi
- Sillaber Ursula
- Simic-Schleicher G
- Simma Burkhard
- Sitzmann Friedrich C
- Sontheimer D
- Sperl Wolfgang
- Sprong T
- Standing Fran
- Stocker Martin
- Strasser Friedrich
- Streif Werner
- Ta Van Hop
- ten Tussher GW
- Thakker Clare
- Thio BJ
- Thomas Gilleh
- Thurston Sarah
- Tillmann Roland
- Toepke Baerbel
- Tramper-Stranders GA
- Tuffrey Catherine
- van de Beek D
- van der Ende A
- van der Flier M
- Van der Flier Michiel
- van der Meer H
- van Deuren M
- van Furth AM Tutu
- van Kuppevelt AJM
- van Overbeek-van Gils ALT
- van Wermeskerken AM
- Varnholt Verena
- Vega Ana
- Verwijs WA
- Vivanco Ana
- von der Wense Axel
- Walcher Wolfgang
- Weigand Nicola
- Weikmann Eckart
- Weiss Ute
- White Deborah
- White Sonia
- Willis Louise
- Wocko Lucia
- Wolfs TFW
- Wright Victoria J
- Young Zoe
- Zenz Werner
- Zobel Gerfried
- Zoehrer Bettina
- Zwiauer Karl
- Publication venue
- Sci Rep
- Publication date
- 01/01/2019
- Field of study
Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
- Author
- Liza
- - AP-HP) Bertrand Dousset (H\uf4pital Cochin
- - APHP) Anne Thomin (H\uf4pital Trousseau
- - ASST Rhodense) Carlo Corbellin (Ospedale Di Rho
- - NYU Winthrop Hospital) Amir H Sohail (NYU Langone Health
- - Xarxa Assistencial Universit\ue0ria de Manresa) Pablo Collera Ormazabal (Fundaci\uf3 Althaia
- / Columbia University Medical Center) Miriam Callahan (NewYork-Presbyterian
- 3 University Hospital) Bridget Egan (Tallaght
- 4 Lapolla Pierfrancesco
- 5 Spain: Eduardo E Rubio Susana Henriques (Hospital Garcia de Orta).
- 6 G\uf3mez Marcos
- \u2013 IRCCS Francesca Gaino (Humanitas Clinical and Research Center
- \u2013 Italy) 20089 Rozzano (MI)
- \uc1ngel Hern\ue1ndez Bartolom\ue9 Miguel
- A Aaraj Mahmoud
- A Ayeni Funbi
- A Bass Gary
- A Benson Ruth
- A Bozkurt Mehmet
- A Breen Kerry
- A Breen Kerry
- A Breen Kerry
- A Callcut Rachael
- A Chung Eric
- A Coughlin Patrick
- A de Gheldere Charles
- A De Marchi Joshua
- A Elliott Jessie
- A Fahey Brian
- A Griffiths Ewen
- A Griffiths Ewen
- A Griffiths Ewen
- A Guariglia Claudio
- A Hirji Sameer
- A Khalefa Mohamed
- A Marra (Fondazione Policlinico Universitario Agostino Gemelli) Angelo
- A Nguyen (Frankfurt University Hospital Truong
- A Olson (Duke University Medical Center) Steven
- A Raptis Dimitri
- A Rollett Rebecca
- A Saeed Samerah
- A Salama Hiba
- A Salamah Abdulrauf
- A Schnitzbauer Andreas
- A Schnitzbauer Andreas
- A Singh Aminder
- A Stevens Kent
- A Stylianides Nicholas
- A Thaha Mohamed
- A Vega (12 de Octubre University Hospital) Viviana
- A Vivas Alfredo
- A Zappa Marco
- Abate Emmanuele
- Abdalaziz (Gloucestershire Royal Hospital) Hossam
- Abdelkarim Mostafa
- Abdou Hossam
- Aboelkassem-Ibrahim Ahmad
- Abuown Ala
- Acebes-Garcia Fernando
- Acharya Metesh
- Adamina Michel
- Addae-Boateng Emmanuel
- Adolfo Pisanu (Cagliari University Hospital) Mauro Podda
- Aftab Raiyyan
- AG Moir John
- Agarwal Arnav
- AH Ibrahim Mohamed
- Aitken (Queen Elizabeth University Hospital) Emma
- Al-Azzawi Marwa
- Al-Embideen Somya
- Al-Sukaini Ahmad
- Alakaloko Felix
- Alam (Heartlands Hospital) Ruhina
- Alameer Ehab
- Alderson Derek
- Ali Mohamed Ali (Queen Elizabeth Hospital King's Lynn) Inthekab
- Aliyeva (Acibadem Mehmet Ali Aydinlar University Zumrud
- Aljanadi Firas
- Almasri Murad
- Alonso Poza (Hospital Universitario del Sureste) Alfredo
- Alonso-Ortu\uf1o Paula
- Alser Osaid
- Alser Osaid
- Alser Osaid
- Altintoprak (Sakarya University Faculty of Medicine) Fatih
- Amalina Che Bakri Nur
- Amjad Rabbia
- Anania Gabriele
- and Westminster Hospital NHS FT and Imperial College London) Chelsea
- Andabaka Tatjana
- Andrea Pisani Ceretti (ASST Santi Paolo e Carlo) Nicol\uf2 M Mariani
- Angelou Dimitrios
- Anita Volpe (New York Presbyterian Queens) Stephen Merola
- Annamalai Seethalakshmi
- Annessi Valerio
- Anthoney James
- Anuradha R Bhama (Rush University Medical Center) Alfonso Torquati
- Anwar Sibtain
- Aragon-Chamizo Juan
- Ardito Antonella
- Arigoni Michele
- Armao Teodora
- Arminio (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia) Armando
- Armstrong Lara
- Asaad Peter
- Ashcroft James
- Ashmore Christopher
- Asqalan Ahmad
- Asti (IRCCS Policlinico San Donato Emanuele
- Aubry Emmanuelle
- Aytac Erman
- Ayuso-Herrera Esther
- Azerbaijan:Elgun Samadov Joana FF Simoes (Chair). 2 Collaborators: (denotes Local Principal Investigator) Algeria: Faraj S Almaadany (\uc9tablissement Hospitalier Sp\ue9cialis\ue9 en Canc\ue9rologie - Centre Pierre-et- Marie-Curie).
- B Avellana Rocio
- B Catton Andrew
- B Fonsi Giovanni
- B Hing Caroline
- B O'Meara Lindsay
- B Schaffer Kathryn
- B Yousuf (Tobruk Medical Center) Farhat
- B\ue0mbina (Fabrizio Spaziani Hospital Fabrizio
- Bailon-Cuadrado (Hospital Universitario R\uedo Hortega) Martin
- Baldi Caterina
- Baldini Edoardo
- Baldo (Ospedale Santa Corona Stefano
- Ballabio Michele
- Baloyiannis Ioannis
- Baltazar Gerard
- Bandiera Alessandro
- Barlow Emma
- Barmasse (Ospedale Regionale Umberto Parini) Roberto
- Barmpagianni Christina
- Baronio (Policlinico San Pietro) Gianluca
- Barra Fabio
- Bartholomew's Hospital) St
- Bartsch Anne-Marie
- Basgaran Amedra
- Basha Amr
- Bashkirova (North Middlesex University Hospital) Varvara
- Bastazza Marco
- BB Sullivan (The Royal London Hospital) Tom
- Beak Philip
- Belcher Elizabeth
- Belgium: Gabrielle H van Ramshorst Sevda Jafarova (Leyla Medical Center).
- Beltr\ue1n de Heredia Juan
- Belvedere Angela
- Ben\uedtez-Linero Inmaculada
- Benjamin Franklin) Campus
- Bergeat Damien
- Bernasconi Matteo
- Bhalla Ashish
- Bhangu Aneel
- Bianco Federica
- Bisagni Pietro
- BJ Borgstein Alexander
- Blake (Southport and Formby District General Hospital) Iain
- Blanco-Colino Ruth
- Blazquez-Martin (Hospital Principe De Asturias) Alma
- Boal Matthew
- Bologna) Ausl
- Bonavina Giulia
- Bonavina Luigi
- Bond-Smith Giles
- Booth (Freeman Hospital) Karen
- Borges Filipe
- Borghi Felice
- Borja De Lacy (Hospital Clinic Barcelona) F
- Bourke Grainne
- Boyle Emily
- Brachini Gioia
- Brain Jessie
- Brar Amanpreet
- Breckles Lisa
- Brendan L Skelly (Altnagelvin Area Hospital) Catherine Rossborough
- Brianza) Carate
- Brixton Genevieve
- Bruzzaniti Placido
- Bueser Teofila
- Burnside Nathan
- C Bosanquet David
- C Brown (Manchester University NHS Foundation Trust Benjamin
- C De Souza Anthony
- C Glasbey James
- C Glasbey James
- C Hopkins James
- C Lauscher Johannes
- C McIntyre Robert
- C Mckay Siobhan
- C Neary Paul
- C Nugent III William
- C Rodriguez-Sanjuan (Marqu\ue9s de Valdecilla University Hospital) Juan
- C Roslani April
- C Tucker Sarah
- C Velmahos (Massachusetts General Hospital) George
- C Winter Stuart
- Caballero Albert
- Cairo University) Mahmoud MA Elfiky (Kasr Alainy Faculty of Medicine
- Calcerrada-Alises Enrique
- Camacho Fern\ue1ndez-Pacheco (Complejo Hospitalario Universitario Insular-Materno Infantil) Borja
- Camarero Enrique
- Campagnaro Tommaso
- Campanelli Michela
- Candiani Massimo
- Cannoletta (Royal Brompton Hospital) Marina
- Cantalejo-Diaz (Hospital Universitario Miguel Servet) Miguel
- Cao Han
- Capizzi Vita
- Carcano (Ospedale di Circolo Giulio
- Carissimi Francesca
- Carlini Massimo
- Carlos Bernal-Sprekelsen Juan
- Carlos Catal\ue1 Bauset (Consorcio Hospital General Universitario) Juan
- Carlucci Michele
- Carmela Giuffrida Maria
- Carmichael Heather
- Carrasco Milagros
- Carrillo Mariana
- Carvello Michele
- Casati Massimiliano
- Castoro Carlo
- Castro Ruiz Carolina
- Catalan Vanesa
- Catriona R Luney (Nuffield Orthopaedic Centre) Benjamin JF Dean
- Cavaleiro Salom\ue9
- Cellerino Paola
- Center Amsterdam) Cancer
- Centinaio (Ospedale Maggiore di Lodi) Giovanna
- Cernei Cristina
- Cervellera Maurizio
- Chakrabortee Sohini
- Chamberlain Stephanie
- Chan Jeffrey
- Chang Grace
- Chaudhry Daoud
- Chebaro Alexandre
- Chen (Jamaica Hospital) David
- Chetty Govind
- Chia (Royal Derby Hospital) Zoe
- Chiappini Ambra
- Chiarugi (Azienda Ospedaliero Universitaria Pisana) Massimo
- Chidambaram Swathikan
- Chiozza Matteo
- Cholewa Hanna
- Chong (Evelina London Children's Hospital) Clara
- Choolani-Bhojwani Ekta
- Christian Cotsoglou (ASST Vimercate) Stefano Granieri
- Chui Karen
- Chung Choyin
- Cirillo Bruno
- Citterio Davide
- Clermidi Pauline
- Coccolini Federico
- Colletti Gaia
- Compagnoni Bruno
- Concepci\uf3n-Mart\uedn Vanesa
- Confalonieri Marco
- Connolly Hannah
- Conso Christel
- Conti Luigi
- Cooper Zara
- Corral Javier
- Costa Marta
- Costanzi Andrea
- Cox Daniel
- Cozza Valerio
- CR Wormald Justin
- Croatia: Jakov Mihanovic Nicolas Duchateau (Heilig Hart Ziekenhuis Lier).
- CS Clough Ethan
- Cuming Tamzin
- Cuneo)
- Curtis Miles
- Cuschieri Joseph
- D Baron Ryan
- D Bosch Karen
- D Brown Oliver
- D Bueno-Ca\uf1ones Alejandro
- D Cato Liam
- D Drake Thomas
- D Jenkinson Michael
- D Jenkinson Michael
- D Liyanage Aloka S
- D Pinkney Thomas
- D Rajgor Amarkumar
- D Stewart Grant
- D Tebala Giovanni
- D'Agruma Michele
- D'Andrea Giancarlo
- D\uedaz P\ue9rez David
- D\uedaz-Garc\ueda (Hospital Universitario Nuestra Se\uf1ora de Candelaria) Alberto
- Da Roit Anna
- da Saliceto\u201d Patrizio Capelli (Ospedale \u201cG.
- Dare Oliver
- Darko Ebenezer
- Data Monitoring and Ethics Committee: Deborah S Keller H. Hunt Batjer (University of Texas Southwestern).
- Day Andrew
- De Andr\ue9s-Asenjo Beatriz
- de Medicina Facultad
- De Miguel-Ardevines Maria-Carmen
- De Nardi Paola
- De Simone Veronica
- De Toma Giorgio
- Deepti Sinha (University College London Hospital) Nicholas Kalavrezos
- Dehal (Kaiser Permanente Panorama City Medical Center) Ahmed
- Dehart Dustin
- Del Giudice Roberto
- Delgado-Oliver Eduardo
- Denmark: Henry G Smith Bernarda Bakmaz (Zadar General Hospital).
- Denning Max
- Desai Anant
- Desender (Ghent University Hospital) Liesbeth
- Dester (ASST Valcamonica Ospedale di Esine) Sara
- Di Candido Francesca
- Di Chiara Francesco
- Di Franco Gregorio
- Di Giuseppe (Ente Ospedaliero Cantonale del Canton Ticino) Matteo
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Diaz-Pe\uf1a Patricia
- Dieguez Fernandez Beatriz
- Dissemination Committee: Michel Adamina Aneel Bhangu.
- Dolores Del Toro M
- Domodossola
- Doussot Alexandre
- Duff Sarah
- Dunning Joel
- Dunstan Matt
- Duque-Mallen Victoria
- Dziakova Jana
- E Canova Michaela
- e Carle Hospital Chiara Peluso (Santa Croce
- e Carlo ASST Santi Paolo
- E Dawson Brett
- E Dickson Kathryn
- E Hudson Victoria
- E Jenny (Johns Hopkins Hospital) Hillary
- E Lewis Sophia
- E Nita George
- e Oftalmico) Giulio Iacob (Ospedale Fatebenefratelli
- E P\ue9rez-S\ue1nchez Luis
- E Rice Henry
- E Ssentongo Anna
- e Universit\ue1rio de Coimbra) Ana C Almeida (Centro Hospitalar
- E Xyda Souzana
- Edward Fitzgerald J
- EF Abbott Tom
- EF Abbott Tom
- Egan Richard
- Egypt: Mohamed El Kassas University of Copenhagen).
- El Youzouri Hanan
- El-Ali (Queen's Hospital Abess
- Elaine YL Leung (The Pan Birmingham Gynaecological Cancer Centre) Sudha Sundar
- Elfeki Hossam
- Elhadi Muhammed
- Eljareh (Aljalaa Hospital) Mohammed
- Elkadi Hannah
- Elkady Ramy
- Elkhafeefi Fatimah
- Elmore Ugo
- Elmoslemany (The Walton Centre NHS Foundation Trust) Tarek
- EM Bouhuwaish Ahmad
- EM Brathwaite Collin
- Emmerson (North Manchester General Hospital) Oliver
- Enemosah Ibrahim
- English Camilla
- English William
- Ereidge Simon
- Escartin Jorge
- Estaire-Gomez Mercedes
- EuroSurg
- Evans (Queen Elizabeth the Queen Mother Hospital Margate) Jessica
- Exley Rebecca
- F Bath Michael
- F Cunha Miguel
- F Cunha Miguel
- F Davis Niall
- F Ridgway Paul
- Fabbri Nicol\uf3
- Falco Giuseppe
- Familiari Pietro
- Fancellu (Cliniche San Pietro Alessandro
- Fanjul G\uf3mez Mar\ueda
- Farik Shebani
- Farr\ue9 Font Roser
- Farrell Tony
- Fehervari Matyas
- Fell Adam
- Fern\ue1ndez- Mart\uednez Mar\ueda
- Fern\ue1ndez-Gomez Cruzado (Hospital Urduliz) Laura
- Fern\ue1ndez-Mar\uedn Reyes
- Fernandez-Camu\uf1as Angel
- Ferrara)
- Ferrara Francesco
- Ferrari Guglielmo
- Ferrero Simone
- FF Simoes Joana
- FF Simoes Joana
- Findlay Laura
- Fiore Marco
- Fiore Marco
- Fiori Enrico
- FJ Dunne Declan
- Flatman Michael
- Flindall Ian
- Fontana (Vittorio Emanuele Tommaso
- Ford (The Robert Jones and Agnes Hunt Orthopaedic Hospital) David
- Ford Samuel
- Forlani Stefano
- Fr\ue9d\ue9ric Bretagnol (H\uf4pital Louis-Mourier - GHU AP-HP. Nord - Universit\ue9 de Paris) David Moszkowicz
- France: Zaher Lakkis Mohamed Sherief (MISR Cancer Center/MISR International Hospital).
- Francisco de Vitoria Universidad
- Francone Elisa
- Frattaruolo Colomba
- Frio (Institute of Neurological Sciences of Bologna Federico
- Frosinone)
- G Aoun Salah
- G Barranquero Alberto
- G Blazer III Dan
- G Collins Chris
- G Edwards John
- G Edwards John
- G Morton Dion
- G Povey Meical
- G Velopulos Catherine
- G Wade Ryckie
- Gabriel Kinnaman (IU Health Methodist Hospital) Ashley D Meagher
- Gagliano Annalisa
- Gagliardi Filippo
- Gahunia Sukhpreet
- Gala Tanzeela
- Galfrascoli Elisa
- Galimberti Luca
- Galindo Jara (Hospital Universitario de Torrej\uf3n Pablo
- Gallagher Phoebe
- Galleano Raffaele
- Gallo Gaetano
- Gallo Gaetano
- Gallo Gaetano
- Galv\ue1n-P\ue9rez Armando
- Gamal Amira Ibrahim Sallam
- Gammeri Emanuele
- Ganau Mario
- Garc\ue9s-Garc\ueda Ra\ufal
- Garcia Fernandez Andres
- Garcia-Conde Delgado Maria
- Garulli (Ospedale Infermi di Rimini) Gianluca
- Gascon-Ferrer Isabel
- Gattolin (Regina Montis Regalis Hospital Andrea
- Gaujoux Sebastien
- Gentilli Sergio
- Georgiades Fanourios
- Germany: Carsten Kamphues Didier Ollat (Institut Mutualiste Montsouris).
- Gerogiannis (Kingston Hospital NHS Foundation Trust) Ioannis
- Ghanbari (Homerton University Hospital) Amir
- Ghosh Dhruv
- Giacometti Marco
- Giblin Anna-Victoria
- Gilbert (Surrey and Sussex Healthcare NHS Trust) Catherine
- Gim\ue9nez Clara
- Giorgakis Emmanouil
- Gipponi Manuel
- Glen Paul
- GlobalPaedSurg GlobalSurg
- Goatly Giles
- Gobatti (San Carlo Borromeo Hospital Davide
- Godbole Chintamani
- Gohil Kajal
- Gomez-Rosado Juan-Carlos
- Gonullu Emre
- Gonzalez-De Miguel Melania
- Gonzalez-Gonzalez Enrique
- Gordini Luca
- Gracia Isabel
- Gracia-Roche Carlos
- Greece: Konstantinos Bouchagier Markus W L\uf6ffler (University Hospital Tu\u308bingen).
- Green Susanna
- Grivon Manuela
- Grove (Department of Colorectal Surgery Thomas
- Guaglio Marcello
- Guaitoli (Perrino) Eleonora
- Guglielmi Alfredo
- Guha Soumya
- Gustavino (Unit of Obstetrics and Gynecology IRCCS Ospedale Policlinico San Martino Genoa) Claudio
- Guti\ue9rrez Samaniego Mar\ueda
- H Babu Bheemanakone
- H Chowdhury Abeed
- H Davidson Giana
- H Davidson Giana
- H Davidson Giana
- H Elfallal Ahmed
- H Emile Sameh
- H Kirmani Bilal
- H Liu Helen
- H Murphy Suzanne
- H van Ramshorst Gabrielle
- H\uf6lzle Frank
- Habeeb Amir
- Hagger Robert
- Hakmi Hazim
- Halkias Constantine
- Halkias Constantine
- Hampton (Rotherham District General Hospital) Matthew
- Handa Siddhartha
- Haq Iram
- Harky (Liverpool Heart and Chest Hospital) Amer
- Harries (Morriston Hospital Rhiannon
- Harrison Joseph
- Hasan Raashad
- Hawari Mohammad
- Hawkin Paul
- Hebblethwaite Bethany
- Helier University Hospitals NHS Trust) St
- Heritage Emily
- Hernandez Garcia Miguel
- Hernandez-Juara Pilar
- Herrero-Lopez Maria
- Hervieux Erik
- Heyd Bruno
- Higgs Simon
- Hitchman (Hull University Teaching Hospitals NHS Trust) Louise
- Ho Beatrice
- Hogan Aisling
- Hospital of Varese University
- Hospital Universitario del Henares) Miguel Angel Garcia-Ure\uf1a (Universidad Francisco de Vitoria
- Hospital) Atakent
- Hospital) Wythenshawe
- Hossain Tanvir
- Houston Roy
- Hurt Libor
- HV Byrne Matthew
- i Pujol) Alba Zarate (Hospital Germans Trias
- I Roxo (Brigham and Women's Hospital) Vanessa
- I van Berge Henegouwen (Amsterdam UMC Mark
- I Alessandro Di Bartolomeo (Policlinico Umberto
- Iannone Immacolata
- Ibrahim Sherif
- Iovino Domenico
- Ireland: Arnold DK Hill Paraskevi Tourountzi (Kavala General Hospital).
- Isik Arda
- Israel: Oded Zmora Thomas M Aherne (Galway University Hospital).
- Italy: Maurizio Zizzo Nadav Kugler (Shamir Medical Center).
- J Abbott Sarah
- J Baker Olivia
- J Baldwin Alexander
- J Beamish Andrew
- J Carlos William
- J Caruana Edward
- J Caruana Edward
- J Davies Emma
- J Diaz Jose
- J Doe Matthew
- J Eardley Nicola
- J Fern\ue1ndez Antonio
- J G\uf3mez D\uedaz Carlos
- J Hainsworth Alison
- J Hall Bria
- J Holme Thomas
- J Hutchinson Peter
- J Hutchinson Peter
- J Kalkwarf Kyle
- J Lin Daniel
- J Lowery Aoife
- J McCluney Simon
- J Mehigan Brian
- J Mills Sarah
- J Pachl (Birmingham Children's Hospital) Max
- J Rogers Luke
- J Ryan \uc9anna
- J Scurrah Rachel
- J Shackcloth Michael
- J Smart Neil
- J Steinkamp Pieter
- J Tejero-Pintor Francisco
- J Thomas Amy
- J Torres Antonio
- J Warren Oliver
- J Warren Oliver
- J Williams Katherine
- James RW Hall (Stepping Hill Hospital) Claire Hall
- James's Hospital) Conor P Barry (St.
- Jamil Tahir
- Jayaraju (University Hospital of Wales) Ullas
- Jenner Edward
- JG Chase Thomas
- Jha Shane Lester (James Cook University Hospital) Madan
- Jimenez-Higuera Elisa
- Jimeno Jaime
- JM Dunne Naomi
- JM Ferguson Henry
- Jo\ue3o Lima Maria
- Johnstone Jack
- Jones Mark
- Jordan: Mahmoud Al-Masri Gela).
- JS Wall Joshua
- Judkins Nicholas
- JW Wilkin Richard
- K Abou Chaar Mohamad
- K Ambler Graeme
- K Bankhead-Kendall Brittany
- K Bankhead-Kendall Brittany
- K Bankhead-Kendall Brittany
- K Brown Allison
- K Fusai Giuseppe
- K Gill Charn
- K Kamarajah Sivesh
- K Patel Panna
- K Ubhi Harmony
- K Weerasinghe Chamindri
- K\uf6nigsrainer Alfred
- Kalidindi Venugopala
- Kamal Mona
- Kang Chong
- Kara Yasin
- Karam Edward
- Karim Ahmed
- Kashora Florence
- KC Jonker (University Medical Center Groningen (University of Groningen) Pascal
- Kearney (Beaumont Hospital) David
- Khajuria Apoorva
- Khan Azam
- Khan Umul
- Khatri Chetan
- Kinross James
- Kler Aaron
- Klimopoulos (Evangelismos General Hospital) Serafeim
- Kocata\u15f (Kanuni Sultan Suleyman Training and Research Hospital) Ali
- Kolias Angelos
- Kolias Angelos
- Kontovounisios Christos
- Kourdouli (Leicester Royal Infirmary) Amar
- Krishnan Emily
- Kristinsson Sverrir
- Kruijff Schelto
- KS Viswanath Yirupaiahgari
- Kudsk-Iversen S\uf8ren
- Kufeji Dorothy
- Kulkarni Rugved
- Kurihara Hayato
- L Biffl Walter
- L Coleman Natasha
- L Collins Michelle
- L Engel (Temple University Hospital) Jamie
- L Fowler Amy
- L Garcia Galocha Jose
- L Hughes Jane
- L J\uf6nsson (Bispebjerg Hospital Maria
- L Labib Peter
- L Marsh (Scripps Memorial Hospital) Christopher
- L McKevitt Kevin
- L Osorio Alexander
- L Romera Jose
- L Serevina Olivia
- L Venn Mary
- L Venn Mary
- L Venn Mary
- L Wright Franklin
- L Young Alastair
- L\ue1zaro Andr\ue9
- La Torre Filippo
- Laface (Ospedale Vittorio Emanuele III Letizia
- Lami Mariam
- Landaluce-Olavarria Aitor
- Laura Hansen 9
- Lawani Ismail
- Lawday (Southmead Hospital) Samuel
- Lawday Samuel
- Le Roy Bertrand
- Lecco) Asst
- Lecolle Katia
- Lederhuber Hans
- Lederhuber Hans
- Leeds)
- Leicester)
- Leventoglu Sezai
- Li Elizabeth
- Li Elizabeth
- Li Zoe
- Libya: Ghadah Z Alkadeeki Hani Al-Najjar (King Hussein Cancer Center).
- Liew Ignatius
- Ligure (SV) Pietra
- Lima Buarque Igor
- Lisi Giorgio
- Lizzi Vincenzo
- Lo Terence
- Lombardia) Regione
- Lomiento Daniele
- Longhi Marco
- Lopez Antonanzas (Hospital Clinico San Carlos Leyre
- Losada Ruiz Manuel
- Lostis Emilie
- Lostoridis Eftychios
- Loubani Mahmoud
- Lowy- Benoliel Alejandro
- Lucianetti (Papa Giovanni XXIII Hospital) Alessandro
- Luigi MP Marino Cosentino (PO San Filippo Neri - ASL ROMA 1) Andrea Sagnotta
- luis Blas Laina Juan
- Luke Evans (Norfolk and Norwich University Hospital) Mina MG Youssef
- Luke Louis
- Lunevicius Raimundas
- Luraghi Marco
- Lye George
- M Alrahawy (Menofiya University Hospital) Mahmoud
- M Andreani Stefano
- M Ashoush Fouad
- M Bajomo Oreoluwa
- M Blundell Chris
- M Cicerchia Pierfranco
- M Connolly Tara
- M Diez-Alonso Manuel
- M Dur\ue1n-Mu\uf1oz-Cruzado (Hospital Universitario Virgen del Rocio) Virginia
- M Emslie Katy
- M Harrison Ewen
- M Holbrook Charlotte
- M Isolani Simone
- M Keatley James
- M Leite-Moreira Andr\ue9
- M Mithany Reda H
- M Mohan Helen
- M Mohan Helen
- M Monteiro Joana
- M Morgom (Tripoli Central Hospital) Marwa
- M Muguerza Jose
- M Nunes Quentin
- M Nygaard Rachel
- M Omar Aneel Bhangu Omar
- M Philp Matthew
- M Pollok Joerg
- M Rooney Siobhan
- M Sampietro Gianluca
- M Sewards Joseph
- M Tang Alethea
- M Trout Isobel
- M Walters (Harborview Medical Center Andrew
- MA Kaafarani Haytham
- MA Kaafarani Haytham
- MA Kaafarani Haytham
- Maarten van Heinsbergen (VieCuri Medisch Centrum) Joop Konsten
- Mabrouk Islam
- Macchi Alberto
- MacDonald Luisa
- Machairas (Royal Free Hospital) Nikolaos
- Madonini Marco
- Madrid)
- Madrid)
- Magalh\ue3es Maia Mariana
- Magne Augestad Knut
- Magowan Drew
- Maha H Haqqani (Boston Medical Center) Frederick T Drake
- Maisonneuve Emeline
- Majkowska Agata
- Majkowski (Northern General Hospital Lawrence
- Mak (Queen Elizabeth Hospital Birmingham) Jason
- Malabarba Stefano
- Malerba Michele
- Maninder Kalkat 7
- Mannan Syed
- Manson Joanna
- Mansuri Ahmer
- Mantoglu (Sakarya University Research and Educational Hospital) Baris
- Manu Nichola
- Manzoni 56 Via
- Maqsood Afnan
- Marano Alessandra
- Marchbank Adrian
- Marcos-Santos Pablo
- Marinos Kouris (Buckinghamshire Healthcare NHS Trust) Spyros
- Marqueta De Salas Maria
- Marrano Enrico
- Mart\uedn-Rom\ue1n Lorena
- Mart\uednez P\ue9rez Carolina
- Mart\uednez-dePaz Fernando
- Martel Lozano Saida
- Martin (St Mary's Hospital) Guy
- Martin Emmeline
- Martin Janet
- Martin-Albo Lorena
- Martine Uittenbogaart (M\ue1xima Medical Center) Wouter KG Leclercq
- Martinelli Fabio
- Martinez-German Antonio
- Martinez-Pinedo Carlos
- Martins Ricardo
- Marwan Hisham
- Marzi Federica
- MAS Baig Mirza
- Mateos-Sierra (Hospital General Universitario Gregorio Mara\uf1\uf3n) Olga
- Mater Studiorum University of Bologna) Alma
- Mathieu (CHU Besan\ue7on) Pierre
- Matute-Najarro Maria-Soledad
- Maw Andrew
- Mazingi Dennis
- Mazzaferro (Fondazione IRCCS Istituto Nazionale dei Tumori Vincenzo
- McCanny (Antrim Area Hospital) Andrew
- McKenzie Katherine
- McLarty (Northumbria NHS Hospital Trust) Nicola
- McPherson Iain
- Medina Esther
- Mediratta Saniya
- Medone Marzia
- Mehra (Guy's and St Thomas\u2019 NHS Foundation Trust) Gautam
- Mele Simone
- Melero-Cort\ue9s Lidia
- Melody Baeza (Morales Meseguer University Hospital) Jos\ue9 Aguilar
- Mendon\ue7a Ata\uedde Gomes Gustavo
- Mendoza-Moreno Fernando
- Meneghini Simona
- Merate
- Mercante Giuseppe
- Merdrignac (Rennes University Hospital) Aude
- Metallidis Symeon
- Michel (Pinderfields Hospital) Martin
- Migliore Marco
- Milan)
- Milan)
- Milan)
- Miller Douglas
- Minaya- Bravo Ana
- Minaya-Bravo Ana
- Minaya-Bravo Ana
- Minaya-Bravo Ana
- Mingoli Andrea
- Minto Gary
- Mirabella Antonello
- Misra Nikhil
- Mitrasinovic Stefan
- Miu Victor
- Moawad (Royal Victoria Hospital) Nader
- Mochet Sylvie
- Modabber Ali
- Mohammad Adam
- Mohan Midhun
- Moliner-S\ue1nchez Carmen
- Mondov\uec)
- Mongelli Francesco
- Monteleone (Ospedale San Leopoldo Mandic Michela
- Montuori Mauro
- Moore Rachel
- Mora-Guzm\ue1n (Hospital Santa B\ue1rbara) Ismael
- Morales Dieter
- Morales Xavier
- Morelli Luca
- Morelli Lucia
- Morgan Richard
- Morris Chris
- Mortini Pietro
- Mosca Angelo
- Moszkowicz David
- Moszkowicz David
- Motter Dema
- Moug Susan
- Mukherjee Samrat
- Munoz Rivas Ana
- Murcia)
- N Bence Matthew
- N Hopkinson David
- N Mashbari Hassan
- N Mashbari Hassan
- N Mashbari Hassan
- N Naumann David
- N Rao Jagan
- N Townshend David
- N\ufa\uf1ez Jordi
- Najdy Manhal
- Nakas (Glenfield Hospital Apostolos
- Namazov Ilgar
- Naredla Pradyumna
- Nasef Emmhamed
- Nassa Heeam
- Nath Rahul
- Navarro-S\ue1nchez Antonio
- Nazarian (Bupa Cromwell Hospital) Scarlet
- Neal Bhutiani (University of Louisville Hospital and Norton Hospital) Robert CG Martin
- Negri Giampiero
- Nehra Deepika
- Neil-Dwyer Jason
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Neri Jacopo
- Netherlands: Suzanne S Gisbertz Mustafa R Bulugma (Zawia Teaching Hospital). Mexico: Fernando Cordera (ABC Medical Center).
- Newton (Manchester Royal Infirmary) Katy
- Nikaj (Azienda Ospedaliero Universitaria Maggiore della Carit\ue0 Herald
- Niquen Milagros
- Nobile (Azienda Ospedaliera Universitaria Integrata di Verona) Sara
- Nogueiro Jorge
- Nogues Pevidal (Royo Villanova) Ana
- Novara)
- Ntirenganya Faustin
- Nugent Michael
- O Ademuyiwa Adesoji
- O Kavanagh Dara
- O Larkin John
- Oca\uf1a Juan
- of Amsterdam University
- of Ferrara) University
- of Insubria University
- of Milan) University
- of Surgeons in Training (ASiT) Association
- of Surgery) Department
- of Washington) University
- Okafor Barbara U.
- Okechukwu Valentine
- Oliva-Mompean (Hospital Universitario Virgen Macarena) Fernando
- Oliveira Ana
- OM Abdalla Mutwakil
- Omar M Omar
- OO Ayorinde John
- Osagie-Clouard (Epsom &
- Osman (Walsall Manor Hospital) Khabab
- Ottolina Jessica
- Ourieff (Mount Sinai Hospital) Jared
- Outani Oumaima
- Oyewole Bankole
- P Arnaud Alexis
- P Arnaud Alexis
- P Arnaud Alexis
- P Baker Markus
- P Belgaumkar Ajay
- P Boddy Alexander
- P Duffy (Nottingham City Hospital) John
- P Evans Jonathan
- P Hazelton Joshua
- P Jones Andrew
- P Jones Robert
- P Joyce Doireann
- P Kisiel Aaron
- P Pezzuto Anna
- P Singh Rabindra
- P\ue9rez-Gonz\ue1lez Marta
- P\ue9rez-Saborido Baltasar
- Pacheco-Sanchez David
- Padilla-Valverde (Hospital General Universitario De Ciudad Real) David
- Pai (Hammersmith Hospital) Madhava
- Paiella Salvatore
- Paisley (Brighton and Sussex NHS Trust Samuel
- Palermo)
- Palini Gianmarco
- Palmeri Matteo
- Parente Alessandro
- Parlanti Daniele
- Parmar Chetan
- Pascual Angela
- Pata Francesco
- Pata Francesco
- Patel Mahul
- Pathak Abhijit
- Patil Sangram
- Pattyn Piet
- Peckham- Cooper Adam
- Pedram Panahi (University Hospitals Plymouth NHS Trust) Mariam Rela
- Pedrazzani Corrado
- Pellino Gianluca
- Pereira Andr\ue9
- Pereira-Neves Ant\uf3nio
- Perez-Diaz Md
- Perivoliotis (General University Hospital of Larissa) Konstantinos
- Perkins Clare
- Perotto (CHU Saint Etienne) Ornella
- Perra Teresa
- Petrone Patrizio
- Phenix George
- Piacenza)
- Picazo Sara
- Picon-Rodriguez Rafael
- Piloni Martina
- Pingarr\uf3n-Mart\uedn Lorena
- Pinotti Enrico
- Pizzini Paolo
- PM de Vries Jean-Paul
- Pockney Peter
- Podolsky Dina
- Poggioli Gilberto
- Pompili Cecilia
- Pontari Michael
- Porcu Alberto
- Portugal: Hugo Santos-Sousa Pakistan: Mariyah Anwer (Jinnah postgraduate medical center).
- Potter (Royal Bournemouth Hospital) Ryan
- Price Claire
- Prita Daliya 8
- Pruvot (Lille University Hospital) Fran\ue7ois-Ren\ue9
- PTSurg ItSURG
- Pujol-Muncunill Roger
- Puppo Andrea
- Q Mehdi (University of Texas Medical Branch) Mohammad
- Quante Markus
- Quintana-Villamandos Bego\uf1a
- Qureshi Ali
- R Burke Joshua
- R Davidson Brian
- R Dixon Jan
- R Fretwell Kenneth
- R Gujjuri Rohan
- R Gujjuri Rohan
- R Kowal Mikolaj
- R O\u2019Neill John
- R Sarma Diwakar
- R Spalding Duncan
- R Springford Laurie
- Rachel Baumber (Royal National Orthopaedic Hospital) James T Parry
- Radenkovic Dejan
- Rahman Saad (Medway Maritime Hospital) Abdel
- Rakvin Ivan
- Ramallo-Sol\ueds Irene
- Ramcharan Sean
- Ramos Diego
- Ramos-Bonilla Antonio
- Ramos-De la Medina Antonio
- Ramzi Joussi
- Rathinam Sridhar
- Rausa Emanuele
- Ravaioli Matteo
- Ravindran Sharanya
- Raymond (Royal Lancaster Infirmary) Thomas
- Razik Aisha
- Redfern (Furness General Hospital) Jennifer
- Reguera-Rosal Julio
- Rey-Biel Juan
- Rey-Valcarcel Cristina
- RG Sheel Andrea
- Ribolla Marta
- Richards Tomos
- Richmond (University of Maryland Medical Center) Michael
- Righini (Ospedale del Delta Erminio
- Rio-Gomez Javier
- Riuniti Villa Sofia-Cervello Ospedali
- Riyat Harjoat
- Rizvi Sana
- Roberts Keith
- Roberts Matthew
- Robertson (University Hospitals Coventry and Warwickshire) Stuart
- Robertson (University of Arkansas for Medical Sciences) Ronald
- Robin-Valle Alvaro
- Rochon Melissa
- Rojo Mikel
- Rolli Luigi
- Romano Silvio
- Rome)
- Romford)
- Ross Elizabeth
- Ross Howard
- Rottoli Matteo
- Royal Hospital) Princess
- Ruiz (Hospital General Universitario Reina Sof\ueda Miguel
- Ruiz- Grande Fernando
- Ruiz-Martin (Rey Juan Carlos University Hospital) Irene
- Ruiz-Soriano (Hospital Cl\uednico Universitario de Valladolid) Mar\ueda
- Ruzzenente Andrea
- Ryska Ondrej
- S Abdelaal (Alexandria Main University Hospital) Ahmed
- S Al Maadany Faraj
- S Faria Carlos
- S Hammond John
- S Hossain Fahad
- S Jeyaretna Deva
- S Jones Conor
- S Khan (Queen Alexandra Hospital) Jim
- S Moura Francisco
- S Ng-Kamstra Joshua
- S Sica Giuseppe
- S Tamimy Muhammad
- S Wadley Martin
- S\ue1nchez- Arteaga Alejandro
- SA Taher Ahmed
- Saez Carlos
- Sahnan Kapil
- Sahni Arun
- Salim Ali
- Salvia Roberto
- Sammarco Giuseppe
- Sampaio-Alves Mafalda
- San Miguel-Mendez Carlos
- Sanchez del Pueblo Cristina
- Sanchez-Fuentes Maria-Nieves
- Sanchez-Pelaez Daniel
- Sanchez-Perez Coral
- Sanchez-Rubio Maria
- Sancho-Muriel Jorge
- Sanchon Fructuoso Lorena
- Sanders Julie
- Santero-Ramirez Maria-Pilar
- Santora Thomas
- Santoro Antonio
- Santos Irene
- Sapienza Paolo
- Sartarelli (Sant\u2019Orsola Hospital Lodovico
- Sarveswaran Janahan
- Sasia Diego
- Sassari) A. O. U.
- Saudemont Alain
- Saudi-Moro Sef
- Saxena Dolly
- Saxena Shobhit
- Sayasneh Ahmad
- Scalabre Aurelien
- Schache Andrew
- Schiavina Riccardo
- Schineis (Charit\ue9 University Medicine Christian
- Schreckenbach Teresa
- Scorza Antonella
- Scott Lucy
- Seegert (ProMedica Toledo Hospital) Sara
- Seguin-Givelet Agathe
- Senent-Boza Ana
- Serrano Gonz\ue1lez Javier
- Sette Laghi Asst
- Seymour Keith
- Shabana Amanda
- Shah (The Whittington Hospital) Sujay
- Shah Jigar
- Shah Karishma
- Shah Preena
- Shakir Taner
- Shalaby (Mansoura University Hospital) Mostafa
- Shankar (Oxford University Hospitals NHS Foundation Trust Sushma
- Shaw Richard
- Sheffield)
- Shehata Sameh
- Shelley Hwang E.
- Shen Ban Vin
- Shenfine Amy
- Sheridan Kelda
- Sherief Ahmed
- Sherif Mohamed
- Shinkwin Michael
- Shu Sebastian
- Siaw-Acheampong Kwabena
- Sileri (San Raffaele Scientific Institute Pierpaolo
- Singh Abhinav
- Singh Shailendra
- Sinha Sanjay
- Siragusa (Policlinico Tor Vergata Hospital Leandro
- Sivaprakasam Rajesh
- Sivayoganathan Sriharan
- SJ Ledesma Frances
- Smillie Robert
- Smith (Countess of Chester Hospital) Claire
- Smith Andrew
- Smith Christopher
- Sochorova (Royal Liverpool University Hospital) Dana
- Society of Coloproctology (ESCP) European
- Society of Colorectal Surgery (SICCR) Italian
- Soggiu Fiammetta
- Sohrabi (St Bartholomew's Hospital) Catrin
- Sohrabi (Whipps Cross University Hospital) Catrin
- Sohrabi Catrin
- Solari (Royal Gwent Hospital) Francesca
- Solli Piergiorgio
- Soreide Kjetil
- Soto Montesinos Cristina
- SpainSurg
- Spinelli Antonino
- Spinelli Antonino
- Spoletini (Sant'Eugenio Hospital) Domenico
- Spriano Giuseppe
- Sravanam Sanskrithi
- Ssentongo (Pennsylvania State University) Paddy
- Stanger Sophie
- Stavroulias Dionisios
- Steel (Sunderland Royal Hospital) Ben
- Stella Marco
- Stewart Robbie
- Stringer Sally
- Sudan: Osman M Ali Elima P Cagigal- Ortega (Hospital Universitario Severo Ochoa).
- Sulen Nina
- Sundar Sudha
- Sundhu (Aintree University Hospital) Matthew
- Surgical Research Collaborative (ISRC) Irish
- Suri (University of California Davis Health Avni
- Swansea)
- Switzerland: Dimitri Christoforidis Ali A Ali karar (Al-rajhi).
- Syed Arooj
- Szatmary Peter
- T Colonna Emily
- T Enjuto Diego
- T Montella (Azienda Unit\ue0 Sanitaria Locale-IRCCS di Reggio Emilia) Maria
- TA Neely David
- Tabiri Stephen
- Tadross Daniel
- Taglietti Lucio
- Tansey (Princess Alexandra Hospital) Rosamond
- Tartaglia Dario
- Tawheed (Endemic Medicine Department Ahmed
- Tayeh Salim
- Testa Valentina
- Tewari Nilanjana
- Thoenissen Philipp
- Thomas (Worcestershire Acute Hospitals NHS Trust) Kane
- Thrush Jessica
- Tierney Sean
- Tiwari Abhinav
- Tobias Teles (Hospital de Cascais - Dr. Jos\ue9 de Almeida) Pedro A Serralheiro
- Toledo Enrique
- Tonini Valeria
- Torkington Jared
- Torzilli Guido
- Totty Joshua
- Tousidonis Manuel
- Townend Philip
- Townsend Catherine
- Trompeter (St George's Hospital) Alex
- Trotta Francesco
- Truant St\ue9phanie
- Trujillo-D\uedaz Jeancarlos
- Tsoulfas George
- Tsoulfas Georgios
- Turco Celia
- Turkey: Volkan Ozben Georgios Peros (Kantonsspital Winterthur).
- Turrado- Rodriguez Victor
- Turri Giulia
- Tustin (Cumberland Infirmary) Harry
- Tyler Jayne
- Tzedakis Stylianos
- Tzovaras George
- Ullah Ramzan
- Unit\ue0 Sanitaria Locale di Ferrara Azienda
- United Kingdom: Richard J Davies Alp Yildiz (Yildirim Beyazit University Yenimahalle Training and Research Hospital).
- United States: John RT Monson (AdventHealth Orlando) Lavinia Onos (York Teaching Hospitals NHS Trust).
- University Hospitals NHS Trust) Nottingham
- University of Rome) Sapienza
- University) Goethe
- University) Helwan
- Urban (University of Colorado Hospital) Shane
- Urbani (Azienda Ospedaliero Universitaria San'Anna Alessia
- Usai Antonella
- V Bhavaraju Avi
- V Comini Lara
- V Feo Carlo
- V Marino Marco
- V Shaw Abigail
- V\ue1zquez- Fern\ue1ndez Andrea
- Vaccarella (Azienda Ospedaliera Gianpaolo
- Valdes- Hernandez Javier
- Valsecchi Luca
- Vashisht Rajiv
- VCO) Asl
- Venkatesan (Glan Clwyd Hospital) Gowtham
- Vera-Mansilla Cristina
- Vergari (Ospedali Riuniti di Ancona) Roberto
- Vescio (University 'Magna Graecia' of Catanzaro) Giuseppina
- Vidya Raghavan
- Vieira (Centro Hospital Universit\ue1rio S\ue3oJo\ue3o) Paula
- Vijay Vardhini
- Vimalachandran Dale
- Vimalachandran Dale
- Violante Tommaso
- Vovola Fernanda
- Vulliamy Paul
- W Endorf (Hennepin Healthcare) Frederick
- W Etchill Eric
- W L\uf6ffler Markus
- W L\uf6ffler Markus
- Wall Rosemary
- Wallwork Kate
- Ward Alex
- Warwick (University Hospital Southampton) David
- Waseem Saima
- Weaver Helen
- Wells Fiona
- Wen Jiaxin
- West Raha
- Whitehall Emma
- Wild Laura
- Wilkins Alex
- Williams Gethin
- Williams Matthew
- Winnand (University Hospital Aachen) Philipp
- Wong (Addenbrooke's Hospital) Ken
- Worku (Queen\u2019s Medical Centre Dawit
- Wright Naomi
- WS Ho (Leeds Teaching Hospitals NHS Trust Michael
- WT Ngu Albert
- y Cajal) Cristina Cerro (Hospital Universitario Ram\uf3n
- Y Oo (Department of Cardiothoracic Surgery Aung
- y Polit\ue9cnico La Fe) Blas Flor (Hospital Universitario
- Y van der Plas Willemijn
- Yalamanchili Seema
- Yershov (South Warwickshire NHS Foundation Trust) Danylo
- Young Richard
- Yousra Ahmed (Portsmouth Hospital NHS Trust) Simon Toh
- Yurttas Can
- Zadegan Frederic
- Zafar (Northwick Park Hospital) Noman
- Zakaria Rasheed
- Zambon Martina
- Zanini Nicola
- ZE Durst Alexander
- Zerbib Philippe
- Zonta (Ospedale San Biagio Sandro
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28â2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65â3·22], p\textless0·0001), American Society of Anesthesiologists grades 3â5 versus grades 1â2 (2·35 [1·57â3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01â2·39], p=0·046), emergency versus elective surgery (1·67 [1·06â2·63], p=0·026), and major versus minor surgery (1·52 [1·01â2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
Plasma lipid profiles discriminate bacterial from viral infection in febrile children
- Author
- Abdulla Amina
- Abelake Eugenia
- Adeel AOA
- Aebi Christoph
- Aebi Christoph
- Agapow Paul
- Agbeko Rachel
- Agyeman Philipp
- Agyeman Philipp
- Alvarez Alvarez Cristina
- Alvez Gonzalez Fernando
- Anderson Suzanne
- Antonio Martin
- Baer Walter
- Barham Heather
- Barral-Arca Ruth
- Bartlett Maeve
- Baumgart Hinrich
- Baumgartner Markus
- Beatriz Reyes Susana
- Behrends Uta
- Bellos Evangelos
- Berger Christoph
- Berger Christoph
- Bernhard-Stirnemann Sara
- Biebl Ariane
- Binder Alexander
- Birnbacher Robert
- Blanke Jan-Gerd
- Boeddha NP
- Boelke Carsten
- Bojang Kalifa
- Bokhand S
- Breukels MA
- Breuling Kai
- Brinkman DMC
- Brio Sanagustin Sonia
- Brunner Juergen
- Buller Maria
- Camuzeaux Stephane
- Carreras Eduardo
- Carrol Enitan D
- Carter Stephanie
- Cebey-Lopez Miriam
- Coin Lachlan MJ
- Cole Fatoumata
- Concha Torre Andres
- Consortium EUCLIDS
- Crate Lindsey
- Dahlem Peter
- Davies P
- de Groot Ronald
- de Korte CCMM
- de Vries E
- de Waal WJ
- Deep Akash
- Dekkers R
- Dietrich Beate
- Dings-Lammertink A
- Doedens RA
- Donker AE
- Dousma M
- Driessen GJA
- Eber Ernst
- Eleftherohorinou Hariklia
- Elias Johannes
- Emhofer Josef
- Emonts M
- Emonts Marieke
- Epalza Ibarrondo Cristina
- Etschmaier Rosa
- Faber TE
- Farr Sebastian
- Faust S
- Fernandez Cooke Elizabeth
- Fernandez Silveira Laura
- Fernandez Reyes
- Fink Colin
- Fortune PM
- Frederick Hannah
- Gabaldo Barrios Xavier
- Galassini Rachel
- Garcia Vicente Luisa
- Garcia Natalia
- Gerrits GPJM
- Gerver JAM
- Giannoni Eric
- Gimenez Sanchez Francisco
- Girtler Ylenia
- Gomez Rial Jose
- Gomez-Carballa Alberto
- Gormley Stuart
- Grela Beiroa Andrea
- Gribbin Andrew
- Grigorow Irina
- Guillen Sara
- Hamilton Shea
- Hardy Katie
- Hasters Paul
- Hazelzet JA
- Heidema J
- Heimann Konrad
- Heininger Ulrich
- Herberg Jethro A
- Hoggart Clive
- Homan-van der Veen J
- Hourmat Bernardo
- Hudnott Phil
- Ihm Ulrike
- Inwald David
- Jackson Heather
- Jacobs MAM
- Jansen NJG
- Jaros Zdenek
- Jennings Rebecca
- Johnston Joanne
- Jose Curras-Tuala Maria
- Jose Lozano Maria
- Justicia Grande Antonio
- Kaforou Myrsini
- Kahlert Christian
- Kalhoff Hermann
- Kaulfersch Wilhelm
- Kawczynski P
- Kebbeh Ngange
- Kemen Christoph
- Kenwright Rhian
- Klobassa Daniela S
- Klocker Nina
- Klucovska K
- Kneyber MCJ
- Koester Bernhard
- Kohlmaier Benno
- Komini Eleni
- Koopman-Keemink Y
- Kramer Lydia
- Kuijpers Taco T
- Langenhorst VJ
- Leborans Iglesias Pilar
- Leon Leon Maria Cruz
- Leusink J
- Levin Michael
- Lewis Matthew R
- Loza BF
- Maconochie Ian
- Martinez Padilla Ma del Carmen
- Martinez Santos Alba Elena
- Martinon Sanchez Jose Maria
- Martinon-Torres Federico
- Martinon-Torres Federico
- MartinonTorres Nazareth
- Mashbat Meg
- McClure Myra
- McCorkell Jenni
- McCready Sharon
- Menikou Stefanie
- Merth IT
- Miedema CJ
- Momodou Saidy Khan
- Moreno David
- Morillo Gutierrez Beatriz
- Mosquera Perez Belen
- Mustafa Sobia
- Nadel Simon
- Navarra Helen
- Navarro Mingorance Alvaro
- Navarro Marisa
- Neeleman C
- Neth Olaf
- Neubert Antje
- Niederer-Loher Anita
- Nijman Ruud
- Noordzij JG
- Nsirim Eniola
- O'Neill Lauren
- Obando Pacheco Pablo
- Obihara CC
- Onate Vergara Eider
- Ortner Daniel
- Pajkrt D
- Palacios Alba
- Pardo-Seco Jacobo
- Patel Rekha
- Patel S
- Pathan N
- Paulus Stephane C
- Pescollderungg Lydia
- Peters Mark
- Pfurtscheller Klaus
- Philipsen HLA
- Pinnock Elli
- Pischedda Sara
- Pollard Andrew J
- Poortman GH
- Porto Silva Maria del Sol
- Posfay-Barbe Klara M
- Potgieter ST
- Potjewijd J
- Power Sue
- Prieto Tato Luis Manuel
- Rahman Rahmeen
- Ramaiah R
- Redondo-Collazo Lorenzo
- Reiter Karl
- Relly Christa
- Ridout Jenna
- Ristic Goran
- RiveroCalle Irene
- Rodriguez-Tenreiro Carmen
- Roedl Siegfried
- Rojo Pablo
- Rosias PPR
- Royad C
- Ruiz Contreras J
- Sagmeister Manfred
- Salas Ellacuriagal Antonio
- Salas Antonio
- Sanchez Forte Miguel
- Sancho-Shimizu Vanessa
- Sanders EAM
- Sands Caroline
- Sarr Isatou
- Schlapbach Luregn J
- Schweintzger Nina A
- Secka Fatou
- Sellner Andrea
- Seren Fernandez Sonia
- Sey Gibbi
- Sonnleitner Astrid
- Sperl Matthias
- Sprong T
- Standing Fran
- Stelzl Wolfgang
- Stocker Martin
- ten Tussher GW
- Thakker Clare
- Thio BJ
- Thomas Gilleh
- Thurston Sarah
- Till Holger
- Tramper-Stranders GA
- Trobisch Andreas
- Tuffrey Catherine
- van de Beek D
- van der Ende A
- Van der Flier Michiel
- van der Meer H
- van Deuren M
- van Furth AM Tutu
- van Kuppevelt AJM
- van Overbeek-van Gils ALT
- van Wermeskerken AM
- Vega Ana
- Verwijs WA
- Vierzig Anne
- Vilanova Trillo Lucia
- Vivanco Ana
- Vogel Ulrich
- Wang Xinzhu
- Weingarten Christina
- Welke Stefanie
- White Deborah
- White Sonia
- Willis Louise
- Wimmer Andreas
- Wintergerst Uwe
- Wolfs TFW
- Wright Victoria
- Wueller Daniel
- Young Zoe
- Zaunschirm Andrew
- Zenz Werner
- Ziuraite Ieva
- Zukovskaja Veslava
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics
Multiancestry analysis of the HLA locus in Alzheimerâs and Parkinsonâs diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
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- Aguilera N.
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- Al-Chalabi Ammar
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- Kölsch Heike
- KĂŒĂ§ĂŒkali Fahri
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- Lindström Jaana
- Lis Palacio Dana
- Lisso Julieta
- Liu Chunfeng
- Liu Jianjun
- Livingston Gill
- Livingston Gill
- LleĂł Alberto
- LleĂło A.
- Lord Jenny
- Love Seth
- Love Seth
- Lovestone Simon
- Lovestone Simon
- Luckcuck Lauren
- Luckcuck Lauren
- Luis Royo Jose
- Luo Guo
- Lupton Michelle
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- LuĂs Royo Jose
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- Lynch Aoibhinn
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- LĂłpez-GarcĂa Sara
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- MacĂas Juan
- Magda Tsolaki
- Maier Wolfgang
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- Mangone Carlos
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- Marco Spallazzi
- Maria GarcĂa-Alberca Jose
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- Marquié M.
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- MartĂn Montes A.
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- Matoska Vaclav
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- Mayhaus Manuel
- Mayo Kevin
- McGuinness Bernadette
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- McQuillin Andrew
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- Mead Simon
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- Meah Wee-Yang
- Mecocci Patrizia
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- Medel Nancy
- Medina M.
- Medina Miguel
- Meggy Alun
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- Mehrabian Shima
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- Mendoza Silvia
- Menéndez-Gonzålez M.
- Menéndez-Gonzålez Manuel
- Mignot Emmanuel
- Mir P.
- Mir Pablo
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- Miyashita Akinori
- Moebus Susanne
- Moebus Susanne
- Moebus Susanne
- Mok Shi Qi
- Mok Vincent
- Mol Merel
- Molina-Porcel Laura
- Montrreal L.
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- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno Fermin
- Moreno M.
- Moreno Mariona
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- Moreno-Grau Sonia
- Morgan Kevin
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- Morizono Takashi
- Morris John
- Muchnik Carolina
- Mummery Catherine
- Möthen Markus M
- Nacmias Benedetta
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- Naito Tatsuhiko
- Nash William
- Natunen Teemu
- Ng Ebonne Y.
- Ngandu Tiia
- Nicolas Aude
- Nicolas Gael
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- Niida Shumpei
- Nordestgaard BĂžrge G.
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- Novack Gisela
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- O'Donovan Michael
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- Okada Yukinori
- Olaso Robert
- Olivar Natividad
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- Pancho A.
- Pancho Ana
- Paola Zoia Chiara
- Paolo Caffarra
- Papenberg Goran
- Papenberg Goran
- Papma Janne
- Park Hyeonseul
- Parnetti Lucilla
- Parnetti Lucilla
- Parveen Kayenat
- Parveen Kayenat
- Pasquier Florence
- Pasquier Florence
- Pasquier Florence
- Passmore Peter
- Passmore Peter
- Pastor P.
- Pastor Pau
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- Patel Yogen
- Pei Zhong
- Peixoto Leal Thiago
- PelejĂ E.
- PelejĂ Esther
- Peltonen Markku
- Peng Rong
- Pericard Pierre
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- Thonberg HĂ„kan
- Toda Tatsushi
- Todd Stephen
- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
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- Tsolaki Magda
- Tsolaki Magda
- Tuomilehto Jaakko
- Turton James
- TybjĂŠrg-Hansen Anne
- Tzourio Christophe
- TĂĄarraga L.
- TĂĄrraga LluĂs
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
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- Uphill James
- Vacca Alessandro
- Valero S.
- Valero S.
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- Van Broeckhoven Christine
- van der Flier Wiesje
- van der Flier Wiesje M.
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- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- Van Duin Cornelia
- van Rooij Jeroen
- van Swieten John
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- Verhey Frans
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- Vidal Jean-SĂ©bastien
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- Vigo-Ortega R.
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- Vogelgsang Jonathan
- Vyhnalek Martin
- Vyhnalek Martin
- Waern Margda
- Wagner Michael
- Wallon David
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- Warren Jason D.
- Weber Heike
- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
- Williams Julie
- Williams Julie
- Williams Julie
- Wiltfang Jens
- Wiltfang Jens
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Ălvarez I.
- Ălvarez V.
- Ălvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinsonâs disease (PD) and Alzheimerâs disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased AÎČ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study
- Author
- 't Hart Ellen P.
- ?a?inkovĂĄ Pavla
- Aaserud Olaf
- Abbruzzese Giovanni
- Acharya T.
- Akhtar Shahbana
- Albanese Alberto
- Alegre Javier
- Alegre Javier
- Allain Philippe
- Alusi Sundus
- Amico Enrico
- Andrade Carlos
- Andrews S. C.
- Andrews Thomasin
- Andrews Thomasin
- Anheim Mathieu
- Antczak Jakub
- Armstrong Matthew
- Armstrong Richard
- Arques Penelope Navas
- Arran N.
- Arran Natalie
- Artiga MarĂa JosĂ© Saiz
- Axelson E.
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachoud-LĂ©vi Anne-Catherine
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Bardinet E.
- Barker Roger A.
- Barrero Francisco
- Barth Katrin
- Barth Katrin
- Barthélémy Rekha
- Bas Jordi
- Bascuñana Mónica
- Bechtel N.
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Bentivoglio Anna Rita
- Bentivoglio Rita
- Berglund Peter
- Berna C.
- Berrissoul Hassan
- Bertini Elisabetta
- Betz Sabrina
- Biunno Ida
- BjĂžrgo Kathrine
- BjĂžrnevoll Inga
- Blaszcyk Magdalena
- Blin Stéphanie
- Bocwinska Dorota
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen S.
- Bohlen Stefan
- Bojakowska-Jaremek Kamila
- Bolwijn J. J. W.
- Bonelli Raphael
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Boogaerts Andrea
- Borowsky B.
- Bos Reineke
- Bos Reineke
- Bosca Maria E.
- Bosredon Cecile
- Bost Marie
- Boukbiza Ouhaid Lagha
- Bourne Colin
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brockie Peter
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buck Andrea
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burrows Liz
- Busquets NĂșria
- Busse Monica
- Butcher Cynthia
- BĂŒrk Katrin
- C Jan Frich
- Caldentey Juan Garcia
- Callaghan J.
- Callaghan Jenny
- Callaghan Jenny
- Callaghan Jenny
- Calmeyn Godelinde
- Calopa Matilde
- Campbell C.
- Campbell C.
- Campbell M.
- Campos Anabel
- Capellari Sabina
- Capetian Philipp
- Carette Maryline Cabaret Anne-Sophie
- Carrillo FĂĄtima
- Carruesco Gemma Tome
- Cash D. M.
- Castaldo Anna
- Catena Judit LĂłpez
- Chu Carol
- Chu Carol
- Chu Carol
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Clapton Jackie
- Clayton Carole
- Clenaghan Catherine
- Coelho Miguel
- Coleman A.
- Come Adrien
- Connemann Julia
- Constantinescu Radu
- Cormio Claudia
- Cortegana Hermoso Eva Pacheco
- Cortelli Pietro
- Coulthard Elizabeth
- Courtin Françoise
- Craufurd D.
- Craufurd David
- Crawford H.
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- CĂĄceres MarĂa Teresa
- D'Alessio Barbara
- da Silva Wildson Vieira
- Damas Fatima
- Davies Rhys
- De Bruycker Christelle
- De Michele Giuseppe
- de Souza Jenny
- de Tommaso Marina
- de Weert A. Marit
- de YĂ©benes Justo GarcĂa
- de YĂ©benes Justo GarcĂa
- Debruxelles Sabrina
- Dec Malgorzata
- Decolongon J.
- Defebvre Eric Decorte Luc
- Dekker M.
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Delvaux Isabelle
- Descals AsunciĂłn MartĂnez
- Destee Alain
- Di Bella Daniela
- Di Donato Stefano
- Di Maio Luigi
- Di Pietro Anna
- di Poggio Monica Bandettini
- Di Renzo Martina
- Diercks Gabriele
- Dipple Heather
- Dixon Kathryn
- Doherty Karen
- Dose Matthias
- Dougherty Andrew
- Dressler Dirk
- Duché Charlotte
- Dujardin Kathy
- Dumas E. M.
- Dumas Eve M.
- Dunnett Stephen
- Dunnett Stephen
- Dupuit Michel
- Durr Alexandra
- Duru CĂ©cile
- Dziadkiewicz Artur
- Ecker Daniel
- Ecker Daniel
- Edwards Maureen
- Ellrichmann Gisa
- Esposito Chiara
- Eusebio Alexandre
- Evans Carole
- Fairtlough Helen
- Fannemel Madeleine
- Fasquel VĂ©ronique
- Favellato Mariagrazia
- Fenollar MarĂa
- Ferrandes Giovanna
- Ferreira Joaquim
- Ferreira Joaquim J.
- Ferrer Pilar Quiléz
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Fletcher Amy
- Fluchere Frédérique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Fox N. C.
- Foy Kevin
- Frajman E.
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frontali Marina
- Frost C.
- Fullam Ruth
- Fullam Ruth
- Fullam Ruth
- Gago Miguel
- Galassi Roberto
- Gallantrae Deena
- Gallentrae Deena
- Ganos Christos
- Garcia Patrocinio Moreno
- GarcĂa RocĂo GarcĂa-Ramos
- Garde Monica Bascuñana
- Garrett Carolina
- Gaston Itziar
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Gerrans Emily
- Gethin Louise
- Ghelli Elena
- Gibbard C.
- Gill Paul
- Gilling Mette
- Ginestroni Andrea
- Godefroy Olivier
- Gogol Anna
- Gohier Bénédicte
- Goizet Cyril
- Golding Charlotte
- Golding Charlotte
- Gonzenbach Roman
- GonzĂĄlez GonzĂĄlez Sonia
- Goodman Anna
- Gorospe AranzazĂș
- Gorzkowska Agnieszka
- Gorzolla Heike
- Grant Janet
- Griguoli Annamaria
- Gross Diana
- Guedes Leonor Correia
- Guedes Leonor Correia
- Guerra Maria RosĂĄlia
- Guerrero Rosa
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guisasola Luis Menéndez
- Gustafsson Lena
- Guzman Natalie Valle
- Guérid Marie-Anne
- GĂžrvell Per F.
- Haider Salman
- Hallam Caroline
- Hamer Stephanie
- Hamer Stephanie
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia
- Handley Olivia
- Handley Olivia J.
- Harding Alison
- Hare Marianne
- Harrison David
- Hauer Maria
- Hayward Beverley
- Hecht Karen
- Heiberg Arvid
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Held Christine
- Hensman Moss Davina J.
- Hensman Davina
- Hepperger Caroline
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen DurĂĄn
- Herrmann Lennard
- Hicks S.
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Hjermind Lena E.
- Ho Carrie
- Hobbs N.
- Hobson Emma
- Hoffmann Rainer
- Holas Christiane
- Holl Anna
- Holmans Peter
- Hotter Anna
- Howard Liz
- Hughes Max
- Hughes Teresa
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Hyppönen Hannele
- Hölzner Eva
- HĂžsterey-Ugander Ulrika
- Ialongo Tamara
- Idiago JesĂșs Miguel Ruiz
- Illmann Torsten
- Jachinska Katarzyna
- Jack Roisin
- Jacobsen Oda
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Jasinska-Myga Barbara
- Johns Nicola
- Johnson H.
- Johnson Liz
- Jones Lesley
- Jones Lesley
- Jones Mary
- Jones R.
- Jones Una
- Julié Celine
- Jung Hans H.
- Jurgens C.
- Justo D.
- Kaelin Alain
- Kaminski Barbara
- Kapfhammer Hans-Peter
- Kavalier Fred
- Kazoka Mbombe
- Keenan S.
- Kennard C.
- Kershaw Ann
- Kesse Andrea
- Khalil Hanan
- KlempĂr JirĂ
- Klimberg Aneta
- Klodowska-Duda Gabriela
- Klöppel Stefan
- Koivisto Susana Pro
- Koivisto Susana Pro
- Koivisto Susana Pro
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kotz Peter
- Kraus Alison
- Kraus Alison
- Kraus Alison
- Kraus P.
- Krawczyk Malgorzata
- Kremer B.
- Kremer Berry
- Krysa Wioletta
- Krystkowiak Pierre
- Kwiecinski Hubert
- Labuschagne I.
- LafoucriĂšre Danielle
- Lahiri N.
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer B.
- Landwehrmeyer Bernhard
- Landwehrmeyer G. Bernhard
- Lang Christina
- Langbehn Douglas
- Lange Herwig
- Lange Herwig
- Larsen Ida Unmack
- Lashwood Alison
- Lau Puay Ngoh
- LaurĂ Matilde
- Laver Fiona
- Leavitt Blair R.
- Lee S.
- Leenders K. L.
- Lehericy S.
- Lemaire Marie-HĂ©lĂšne
- Levey Jamie
- Lewerenz Jan
- Lewerenz Jan
- Lewis Monica
- Lewis Monica
- LeythÀuser Gabriele
- Lezius Franziska
- Liessens Dirk
- Lilek Sabine
- Linnsand Petra
- Lo Kitty
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera MĂłnica Rodriguez
- Lorentzen Eirin
- Loutfi Ghada
- Lucena Carolina Mendez
- Löhle Matthias
- Maass Antonia
- Magnet Markus
- Maiwald Robert
- MajerovĂĄ Veronika
- Malone I.
- Man A. Hoff
- Mandich Paola
- Manouvrier Sylvie
- Mantaux BĂ©atrice
- Manzanares Salvadora
- Marchese Roberta
- Marcinkowski Jerzy
- Marelli C.
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Markova Ivana
- Markova Ivana
- Marquard Ralf
- Martikainen Kirsti
- Martinez-Horta SaĂŒl
- Martinez-Jaurrieta Maria Dolores
- MartĂn Esther SuarĂ©z San
- MartĂnez-Descals AsunciĂłn
- Mason Sarah
- Massarelli Marco
- Massaro Francesca
- Matheson Kirsty
- Mazzante Irene
- McGill Marie
- McKenzie Sue
- Mead Simon
- Mechi Claudia
- Mendes Tiago
- Mestre Tiago
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Mihaylova Violeta
- Milchman C.
- Milkereit Eva
- Minet CĂ©cile
- Minster Sara
- Minster Sara
- Mir Pablo
- Monaco W.
- Monza Daniela
- Monza Daniela
- Morales Blas
- Moreau Laura Vivancos
- Moreno Jose Manuel Garcia
- Moreno José Luis López-Sendón
- Mundler Laura
- Murch Ann
- Murphy Helen
- Musgrave Hannah
- Möller Jens Carsten
- MĂŒhlau Mark
- MĂŒller Christoph
- MĂŒller Nicole
- MĂŒnchau Alexander
- MĂŒtze Lisanne
- Nanetti Lorenzo
- Neleborn-LingefjÀrd Liselotte
- Nemeth Andrea H.
- Nepper Solveig
- Nielsen JĂžrgen
- Nielsen JĂžrgen E.
- Niess Anke
- Nigaud K.
- Novak Marianne
- Nowak Malgorzata
- O'Donovan Kirsty
- O'Keefe Deidre
- O'Regan A.
- Oehmen Martin
- Olivier Audrey
- Olofsson Carina
- Opala Gregorz
- Ordidge R.
- Ortega Paloma
- Orth Michael
- Orth Michael
- Orth Michael
- Otti Daniela
- Oughton Emma
- Owen G.
- Owen Michael
- Padieu HĂ©lĂšne
- Paganini Marco
- Painold Annamaria
- Pardiñas Antonio F.
- Paridi Dominga
- Parkinson Andrew
- Partington-Jones Lucy
- Pastor Barbara Vives
- Pate Louise
- Patel A.
- Patel Aakta
- Paterski Laurent
- Paterson Nicole
- Pearson Pauline
- Peinemann Alexander
- Peluso Silvio
- Peppa Nadia
- Peppa Nadia
- Pepple T.
- Perea MarĂa Fuensanta Noguera
- Peter Mireille
- Petersen Jens
- Petrollini Martina
- Peña José Chacón
- Piacentini Silvia
- Piano Carla
- Pica Emmanul
- Piedad John
- Plomhouse Lucie
- Poda Roberto
- Poewe Werner
- Polo Cecilia Gil
- Porteous Mary
- Pourchot C.
- Pradella Silvia
- Prehn Christian
- Price Kathleen
- Priller Josef
- Probst Daniela
- Prundean Adriana
- PrĂŒĂ Harald
- PÀivÀrinta Markku
- Quarrell Oliver
- Queller S.
- Raab Tina
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Raman Ashok
- Raman Ashok
- Ramirez Inés Legarda
- Ramos-Arroyo Maria A.
- Ramos-Arroyo Maria A.
- Raymond Lucy
- Read J.
- Redondo Luis
- Reetz Kathrin
- REGISTRY investigators
- Reilmann R.
- Reilmann Ralf
- Reinante Gema
- Reisinger Karin
- Ret C. Jauff
- RetterstĂžl Lars
- Rialland Amandine
- Riballo Antonio Villa
- Ribas Guillermo GarcĂa
- RibaĂŻ Pascale
- Ribbat Michael
- Richter Przemyslaw
- Rickards Hugh
- Rissling Ida
- Rivadeneyra Perez Jessica
- Rizzo Giovanni
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- RodrĂguez MarĂa JosĂ© Torres
- Rogers Dawn
- Rohm Stefanie
- Rola Rafal
- Romano Silvia
- Romero Irene
- Romoli Anna Maria
- Roos Raymund
- Roos Raymund A. C.
- Roos Raymund A. C.
- Rosas H. D.
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzinska Monika
- Rumpf Silke
- Russo Cinzia Valeria
- RuĂz Pedro J. GarcĂa
- Ryglewicz Danuta
- RĂžren Niini
- SablonniĂšre Bernard
- Saft Carsten
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sando Sigrid Botne
- Santhouse Alastair
- Santos R. Dar
- Sass Christian
- Say M.
- Scaglione Cesa
- Scahill R.
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schrader Christoph
- Schwenk Daniela
- Schöggl Helmut
- SchĂŒpbach Michael
- Sciruicchio Vittorio
- SebastiĂĄn A. Rojo
- SebastiĂĄn Ana Rojo
- Sempolowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Silva Mark
- Simonin Clémence
- Simpson Sheila A.
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Smith Paul
- Snowden Julie
- Soleti Francesco
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Somers Nele
- Sorbi Sandro
- Sorrentino Pierpaolo
- Spadaro Maria
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike Jakob
- Squitieri Ferdinando
- Stattin Eva-Lena
- Stebler Yanik
- Stepniak Iwona
- Stokke Bodil
- Stompel Daniel
- Stopford C.
- Stopford Cheryl
- Storch Alexander
- Stout J.
- Stubbe Lars
- Sturrock A.
- StĂĄrkovĂĄ Irena
- StÀdtler Michael
- Suarez MarĂa JosĂ© Lama
- Sulek Anna
- Summers Fiona
- Swain Rachel
- Szczudlik Andrzej
- Szczygiel Elzbieta
- Szinwelski Michal
- SĂĄnchez Vicenta
- SĂŒĂmuth Sigurd
- t'Hart E. P.
- Tabrizi Sarah
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
- Tan Louis
- Taylor Cat
- Taylor Rachel
- Thibault-Tanchou Stéphanie
- Thomas Gareth
- Thompson Catherine
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Tobin A.
- Tomasello Chiara
- Torres MarĂa Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Townhill Jenny
- TRACK-HD investigators
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tuuha Katri
- Uhrova Tereza
- Ullah Jasmin
- Ure Alexandra
- ValabrĂšgue R.
- Valadas Anabela
- Valentine Ruth
- van den Bogaard S. J. A.
- van den Bogaard Simon J. A.
- van der Grond J.
- van Hout Monique S. E.
- van Oostrom J. C. H.
- van Paemel Dominique
- van Reijen Dimphna
- van Vugt Jeroen P. P.
- van Walsem Marleen R.
- van Walsem Marleen R.
- Vandenberghe Wim
- Vandenberghe Wim
- Vargas-GonzĂĄlez Laura
- Vaughan Vivien
- Ventura Marta FatĂĄs
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verhoeven Marloes E.
- Verny Christophe
- Verstappen C. C. P.
- Verstraelen Nichola
- Viladrich Celia Mareca
- Vilaplana Garcia Carmen PeirĂł
- Villanueva Clara
- Vinther-Jensen Tua
- Vuillaume Isabelle
- Wahlström Jan
- Wahlström Jan
- Wang C.
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Zaugg Sabine
- Weber Natalia
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wentzel Magnus
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Whalstedt Carina
- Whitehead D.
- Whitlock K.
- Wiedemann Alexandra
- Wikström Birgitta
- Wild E.
- Wild Edward
- Wild Sue
- Wild Sue
- Winkelmann Juliane
- Witjes-Ane M.-N.
- Witjes-Ané Marie-Noelle
- Witkowski Grzegorz
- Witkowski Grzegorz
- Wolz Annett
- Wolz Martin
- Wright Abigail
- Wright Abigail
- Wright Jan
- WĂłjcik Magdalena
- Yardumian Pam
- Yardumian Pam
- Yates Shona
- Zaremba Jacek
- Zaremba Jacek
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zieora-Jakutowicz Karolina
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zittel Simone
- Zucker Birgit
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008â11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003â13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 Ă 10â10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 Ă 10â8 DHFR p=8·37 Ă 10â7 MTRNR2L2 p=2·15 Ă 10â9) and to a lesser extent in REGISTRY (MSH3 p=9·36 Ă 10â4 DHFR p=8·45 Ă 10â4 MTRNR2L2 p=1·20 Ă 10â3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 Ă 10â8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16â0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06â0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation
Genomic investigations of unexplained acute hepatitis in children
- Author
- Abdulla Amina
- Aebi Christoph
- Agbeko Rachel
- Aggelos Pefanis
- Agranoff Dan
- Agwuh Ken
- Agyeman Philipp
- Alba-Alejandre Irene
- Ali Ladan
- Alkema Wynand
- Allen Karen
- Alrabiah Dimah K.
- Amatya Puja
- Anderson Glenn
- Anderson Suzanne
- Andrade Catarina
- Andreani Julien
- Anpananthar Amutha
- Ansari Imran
- Antinao Diaz Juan F.
- Arif Tasnim
- Armstrong Diane
- Armstrong Jane A.
- Armstrong Lawrence
- Asgarian Zeinab
- Atkinson Laura
- Avcin Tadej
- Avramoska Tanja
- Baas Bryan
- Bahovec Natalija
- Baillie Kenneth
- Balode Anda
- Bamford Alasdair
- Barendregt A. M.
- Barral-Arca Ruth
- Barzdina Arta
- Barzdina Elza
- Basmaci Romain
- Bath David
- Bauchinger Sebastian
- Baumard Lucas
- Baumgart Hinrich
- Baxter Frances
- Bayzid Nadua
- Beer Sally
- Bell Ashley
- Bell Claire
- Bell Kathryn
- Bellini Arianna
- Bello Xabier
- Bellos Evangelos
- Benesch Martin
- Benesch Martin
- Bennet Joshua
- Berger Christoph
- Bernhard-Stirnemann Sara
- Beudeker Coco R.
- Beveridge Laura
- Bibi Sagida
- Bidlingmaier Christoph
- Biesbroek Giske
- Bijukchhe Sanjeev Man
- Billing Kyle
- Binder Alexander
- Binder Vera
- Birt Mark
- Bogovic Petra
- Bohmova Kristyna
- Bojang Kalifa
- Bont Louis J.
- Borensztajn Dorine M.
- Bories Pauline
- Branch Nicole
- Brengel-Pesce Karen
- Breuer Judith
- Broderick Claire
- Brotherton Helen
- Brown Julianne R.
- Brown Rachel
- Buddle Sarah
- Burling Sara
- Buschbeck Judith
- Cabello Laura
- Calle Irene Rivero
- Calvo-Bado Leo
- Campos Luis
- Candlish Janie
- Capozzi Lisa
- Carnota Sandra
- Caro Ivan
- Carrol Enitan D.
- Carson Gail
- Carter Michael
- Carter Michael J.
- Castellano Sergi
- Castro Maria Barreiro
- Cebey-LĂłpez Miriam
- Ceesay Samba
- Celma Cristina
- Ceolotto Astrid
- Chan Adora
- Chand Meera
- Channon-Wells Samuel
- Charalambos Gogos
- Chikowore Primrose
- ChiurchiĂč Sara
- Chukkambotla Srikanth
- Chériaux Laura
- Clark Richard
- Clohisey Sara
- Cocklin Elizabeth
- Cohen Jonathan
- Cohen Laure
- Collings Kalvin
- Collins Emma
- Connon Maggie
- Cooray Samantha
- Cotillon Marie
- Counsell John R.
- Coutts Audrey
- Cresswell Fiona
- Crulley Stephen
- Cunnington Aubrey
- Curras-Tuala MarĂa JosĂ©
- Czap Agata
- D'alessandro Umberto
- D?Souza Giselle
- Dall Anna
- Danekova Nevena
- Danhauser Katharina
- Darboe Saffiatou
- Darnell Sarah
- Daubney Esther
- Davis Francesca
- Davoust Juraté
- Dawson Joy
- de Groc Thibault
- de Groot Ronald
- de Haan L.
- de Jonge Marien I.
- de Silva Thushan
- de Tugny Alice
- de Vries Gabriella
- De Surjo
- De Tisham
- Deep Akash
- Deheragoda Maesha
- Deksne D?rta
- Devine Kirsty
- Dewez Juan Emmanuel
- Dewez Manuel
- Diaba Cynthia
- Dickinson Holly
- Dik W.
- Donelly Lorna
- Donohue Chloe
- Dorward David
- Drysdale Simon B.
- Dudley Julia
- Dunning Jake
- DuRand Ingrid
- Eber Ernst
- Eisen Sarah
- Eleftheriou Irini
- Ellis Donna
- Elorrieta Leire Estramiana
- Emonts Marieke
- Ensom Ruth
- Epalza Cristina
- Estrada-Rivadeneyra Diego
- Evans Benjamin
- Fabian Daniel
- Farmer Sarah
- Farto Cristina Balo
- Faust Saul
- Fawkes Angie
- Ferguson Susie
- Fernåndez Sonia Serén
- Feuchtinger Tobias
- Fidler Katy
- Fink Colin
- Finlayson Lauren
- Fish Matthew
- Fitchett Elizabeth
- Fletcher Tom
- Floyd Sharon
- Fullerton Duncan
- Galassini Rachel
- Gallagher Eileen
- Gallistl Siegfried
- Gannon Louise
- GarcĂa Mirian Ben
- Gardiner Emma
- Garg Sanjeev
- Geissler J.
- Georgiou Pantelis
- Gerrits G. P. J. M.
- Giannoni Eric
- GijĂłn Manuel
- Gilchrist Tammy
- Gissen Paul
- Giuseppe Martina Di
- Gloerich Jolein
- Goetschalckx Ines
- Gonzalez Suam
- GonzĂĄlez Fernando Ălvez
- Gores Gunther
- Gormley Stuart
- Graham Clive
- Grammatikopoulos Tassos
- Gravele Dagne
- Griese Matthias
- Grope Ilze
- Gruppen Mariken
- Guerra-Assunção José Afonso
- Gunson Rory
- Gurung Meeru
- Gutiérrez Lourdes
- GĂłmez-Carballa Alberto
- Haas Nikolaus
- Habgood-Coote Dominic
- Hadzic Nedim
- Hafezi Katarzyna
- Hagedoorn Nienke N.
- Haidl Harald
- Hamilton Shea
- Hamzah Lisa
- Hanlon Killian S.
- Hanson Anita
- Hardwick Hayley
- Harper Rosemary
- Hartshorn Stuart
- Hatcher James
- Hauer Almuthe
- Heidema J.
- Heightman Melissa
- Heininger Ulrich
- Henderson Paul
- Henriet Stefanie
- Herberg Jethro
- HernĂĄndez Irene
- Hibberd Martin
- Hickey Naomy
- Ho Antonia Y. W.
- Hodgson Luke
- Hoffmann Florian
- Hoggart Clive
- Holden Jennifer
- Holden Matt
- Hope Susan
- Hopton Sarah
- Hoschler Katja
- Houlihan Catherine
- Hourmat Sara
- Howman Ruth
- Hude Christa
- Huijnen Martijn
- Hutchinson J. Ciaran
- Hösele Susanne
- Iglesias Marisol Vilas
- Iglesias Pilar LeborĂĄns
- Ijaz Samreen
- Ioanna Stergiou
- Irving Clare
- Isaacs John
- Jackson Heather
- Jacques Thomas S.
- Jansen Machiel H.
- Jarman Heather
- Jennings Aislinn
- Jennings Paul
- Jennings Rebecca
- Johnston Joanne
- Jones Amaryl
- Jongerius Ilse
- Jorgensen Rikke
- Juranek Sabrina
- Kaforou Mysini
- Kahlert Christian
- Kandasamy Rama
- Kapper Andreas
- Kappler Matthias
- Karolina Akinosoglou
- Kaufer Benedikt B.
- Kavanagh James
- Keil Julia
- Keldorfer Markus
- Kelgeri Chayarani
- Kelly Dominic F.
- Kelly Sarah
- Kenny Julia
- Khalid Nosheen
- Khanijau Aakash
- Khoo Say
- Kim Eunjung
- King Sharon
- Kishore Shyla
- Kitanovski Lidija
- Kloosterhuis Lieke
- KohlfĂŒrst Daniela S.
- Kohlmaier Benno
- Kolberg Laura
- Kolnik Mojca
- Koshy George
- Krenn Larissa
- Kuijpers Taco
- Kuijpers Taco
- Lachaume Noémie
- Laivacuma Sniedze
- Laivacuma Sniedze
- Law Andrew
- Le SĂ©bastien
- Lee Jack C. D.
- Leigh Simon
- Leiner Tamas
- Leitch Karen
- Leitner Manuel
- Lenihan Rebecca
- Lennon Alexander
- Lett Lauren
- Leurent Baptiste
- Levin Michael
- Lewis-Burke Nadia
- Liebeschuetz Susan
- Lim Emma
- Limb James
- Lin Naomi
- Linforth Michelle
- Little Jeff
- Liu Ching-Chuan
- Logan Sheena
- Lubinda Tim
- Luca Maia De
- Lurz Eberhard
- Löffler Sabine
- MacFarlane Susan
- MacGillivray Louise
- MachĂn FĂĄtima
- Mackerness Christine
- Maclean Alan
- Maconochie Ian
- Macpherson Hannah
- Madelane Monta
- Maier Esther
- Malcolm Ivone Lancoma
- Mallet François
- Mandal Sema
- Manzanares Ăngela
- Manzano Jesus-Rodriguez
- Maritsi Despoina
- Marjaneh Mahdi Moradi
- Markos Maragos
- Marmarinos Antonios
- Marmarinos Antonis
- Martin Bernal Luz Marina
- Martin Alex
- Martin Darran
- Martin Joanne
- Martin Mike
- MartinĂłn-Torres Federico
- MartinĂłn-Torres Nazareth
- Matovu Elijah
- Matthews Peter
- McAlinden Paul
- McArdle Andrew
- McCafferty Sarah
- McDonald Sam
- McDonald Sarah E.
- McDonnell Anne
- McGenily Laura
- McGill Fiona
- McKay Sarah
- Meiere Anija
- Meierford Anne
- Menikou Stephanie
- Merson Laura
- Michalis Voulgarelis
- Miedema C. J.
- Millar Margaret
- Miller Caroline
- Miller Danielle
- Milligan Barry
- Mills Sarah
- Miners Alec
- Mistry Ravi
- Mita Andrew
- Moll Henriëtte A.
- Mommert Marine
- Mommert-Tripon Marine
- Mondo Diana
- Montgomery Kylie-Ann
- Moore Catherine
- Moots Robert
- Moradi Marjaneh Mahdi
- Morfopoulou Sofia
- Morrice John
- Morrice Kirstie
- Morris Craig
- Moser Nicolas
- Muench Georg
- Murdoch David R.
- Murphy Lee
- Mustafa Sobia
- MĂĄrquez Sonia
- Nagelkerke Sietse
- Nahtigal Mirijam
- Nasher Magda
- Natalucci Giancarlo
- Neeleman C.
- Neill Claire
- Neshat Samira
- Newal Karen
- Newall Karen
- Ng Joanne
- Nichols Samuel
- Niederer-Loher Anita
- Niedrist Tobias
- Nijman Ruud
- Nijman Ruud
- Nokalna Ieva
- Nordberg Gudrun
- Norris Lucy
- Noursadeghi Mahdad
- Nyirenda Maggie
- O'Connor Daniel
- O?Reilly Peter
- O?Riordan Sean
- Obihara C. C.
- Obosi Lauren
- Odam Miranda
- Oliver Zoe
- Ong Kim-Thanh
- Oosthoek Wilma
- Oosthuyzen Wilna
- Openshaw Peter J. M.
- Ora Miguel Sadiki
- Osterman Veronika
- Owen Dan
- Pachot Alexandre
- Pajkrt D.
- Pajkrt Dasja
- Palmarini Massimo
- Panagiota Lourida
- Papst Lea
- Pardo-Seco Jacobo
- Patel Harsita
- Pathan Nazima
- Paulus Stéphane
- Paulus Stéphane
- Paulus Stéphane C.
- Pavare Jana
- Paz Ivonne Pena
- Pennisi Ivana
- Persand Salina
- Peters Mark
- Pfleger Andreas
- Pfurtscheller Klaus
- Philipsen Ria
- Pickering Ailsa
- Pierce Benjamin
- Pilch Heidemarie
- Pischedda Sara
- Player Jasmine
- Pokhrel Bhishma
- Pokorn Marko
- Pokorn Marko
- Pollara Gabriele
- Pollard Andrew J.
- Pollock Louisa
- Posfay-Barbe Klara M.
- Powell Natassia
- Powell Oliver
- Price Ashley
- Price David
- Price Nicholas
- Prunk Petra
- Pucuka Zanda
- Pérez Belén Mosquera
- Pölz Lena
- Rajic Glorija
- Rampling Tommy
- Ramsay Maxine
- Rashid Aqeela
- Redondo-Collazo Lorenzo
- Reich Jana
- Reid Ruth
- Reiter Karl
- Relly Christa
- Reschreiter Henrik
- Reynolds Tim
- Rhodes Mathew
- Rial Jose GĂłmez
- Richmond Vivien
- Riddell Anna
- Riedel Thomas
- Robbins Ceri
- RodrĂguez Lidia Piñeiro
- RodrĂguez-Tenreiro Carmen
- Roff Amy
- Rojo Pablo
- Romaine Sam
- Romani Lorenza
- Roome Tara
- Rosenheim Joshua
- Rowlands Emily
- Roy Sunando
- Rubick Lucy
- Rudzate Aleksandra
- Rughnani Prita
- Russell Clark D.
- Rusu Alexandra
- Rödl Siegfried
- Sagmeister Manfred G.
- Saidykhan Momodou
- Salas Antonio
- Santilli Giorgia
- Sarr Anna RocaIsatou
- Schlapbach Luregn
- Schlapbach Luregn J.
- SchlĂŒchter Stefanie
- Schmied Patricia
- Schoen Carola
- Scholefield Barnaby J.
- Schonenberg D.
- Schonenberg Dieneke
- Schranz Rachel
- Schroepf Sebastian
- Schweintzger Nina A.
- Schöbi Nina
- Seal Matthew
- Secka Fatou
- Segal Terry
- Selecka Katrina
- Semple Malcolm Gracie
- Shackley Fiona
- Shah Priyen
- Shaji Mariya
- Shankar-Hari
- Shaw Victoria
- Shen Ching-Fen
- Shenton Geoff
- Shepherd Samantha J.
- Shrestha Shrijana
- Siam Ala?a
- Sidorova Aleksandra
- Simagan Teresa
- Simmonds Peter
- Simmons Ruth
- Skrabl-Baumgartner Andrea
- Solomon Tom
- Spencer Collette
- Sperl Matthias
- Sprenkeler Evelien
- Spyridis Nikos
- Srovin Tina Plankar
- Srpcic Anja
- Stampfer Laura
- Steele Michael
- Stevens Jake
- Stevens Molly
- Stocker Martin
- Stoiser Bianca
- Stoldere Diana
- Storey Nathaniel
- Strempfl Martina
- Strenger Volker
- Strijbosch Annelieke M.
- Strle Franc
- SuĂĄrez Carlos DurĂĄn
- Svile Dace
- Swingler Rachel
- Syggelou Kelly
- SĂĄnchez JosĂ© MarĂa MartinĂłn
- SĂ©e HĂ©lĂšne
- Tait Sarah
- Talts Tiina
- Tambouratzi Maria
- Tan Chantal
- Tappouni Luke J.
- Tauchert Maike K.
- Tavliavini Emma
- Tayler Rachel
- Tedder Richard S.
- Tempel Dennie
- Templeton Kate
- Thalassinos Konstantinos
- Thomas Daisy
- Thomson Emma
- Thomson Evelyn
- Thorson Stephen
- Tibby Shane
- Till Holger
- Tissing Wim J. E.
- Tkhayat Raja Ben
- Torres Montaguth Oscar Enrique
- Tramper-Stranders G. A.
- Trasorras Cristina Serén
- Treloar Owen
- Trobisch Andreas
- Tsolia Maria
- Turtle Lance C. W.
- Tutill Helena
- Urbane Urzula Nora
- Ushiro-Lumb Ines
- Usman Mariama
- Usuf Effua
- Valentine Lucille
- van Aerde Koen
- van de Kuip Martijn
- van den Berg J. M.
- van den Berg Merlijn
- van den Broek Bryan
- van der Flier Michiel
- van der Flier Michiel
- van der Giessen Ilona
- van der Kuip M.
- van der Velden Fabian
- van der Velden Fabian J. S.
- van der Zee Carlijn
- van Furth A. M.
- van Furth Marceline
- van Gool Alain J.
- van Hensbroek Michael Boele
- van Keulen Danielle
- van Leur M.
- van Mierlo G.
- Vastert Sebastiaan J.
- Venturini Cristina
- Vergnault Nathalie
- Verkuil Floris
- Vermont Clementien L.
- Vicente Luisa GarcĂa
- Vijlbrief Daniel C.
- Villaverde Serena
- Vincek Katarina
- Vito Ortensia
- Voice Marie
- von Both Ulrich
- VĂĄzquez Sara Rey
- Waddington Simon N.
- Wallia Diane
- Wallner Elmar
- Wang Shih-Min
- Ward Bryony
- Ward Catriona
- Watson Conall
- Weber Kathrin
- Wedderburn Catherine
- Wellings Lucy
- Wellman Paul
- Wham Murray
- White Deborah
- White Marie
- Whittaker Elizabeth
- Whittaker Paul
- Whittaker Thomas E.
- Willems Esther
- Williams Charlotte A.
- Williams Rachel
- Wilson Barbara
- Wilson Clare
- Winmill Helen
- Wolfs Tom F. W.
- Womersley Rebecca
- Wood Amanda
- Woodsford Phil
- Wright Victoria
- Wrobel Nicola
- Wyss Verena
- Wösten-van Asperen Roelie M.
- Xagorari Marietta
- Yeung Shunmay
- Zachariasse Joany
- Zaman Syed M. A.
- Zambon Maria
- Zandstra Judith
- Zavadska Dace
- Zennezini Chiozzi Riccardo
- Zenz Werner
- Zimmermann Elisa
- Zurl Christoph
- Zwerenz Manuela
- Publication venue
- Nature Research
- Publication date
- 30/03/2023
- Field of study
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children
Benchmarking plant diversity of Palaearctic grasslands and other open habitats
- Author
- Acic S. (Svetlana)
- Acosta A. T. (Alicia T. R.)
- Afif E. (Elias)
- Akasaka M. (Munemitsu)
- Alatalo J. M. (Juha M.)
- Aleffi M. (Michele)
- Aleksanyan A. (Alla)
- Ali A. (Arshad)
- Apostolova I. (Iva)
- Ashouri P. (Parvaneh)
- Axmanova I. (Irena)
- Bartha S. (Sandor)
- Batori Z. (Zoltan)
- Baumann E. (Esther)
- Becker T. (Thomas)
- Bello F. (Francesco)
- Belonovskaya E. (Elena)
- Benito Alonso J. L. (Jose Luis)
- Berastegi A. (Asun)
- Bergamini A. (Ariel)
- Bhatta K. P. (Kuber Prasad)
- Biurrun I. (Idoia)
- Boch S. (Steffen)
- Bonini I. (Ilaria)
- Bruun H. H. (Hans Henrik)
- Buchler M.-O. (Marc-Olivier)
- Budzhak V. (Vasyl)
- Bueno A. (Alvaro)
- Buldrini F. (Fabrizio)
- Burrascano S. (Sabina)
- Campos J. A. (Juan Antonio)
- Cancellieri L. (Laura)
- Carboni M. (Marta)
- Ceulemans T. (Tobias)
- Chiarucci A. (Alessandro)
- Chocarro C. (Cristina)
- Chytry M. (Milan)
- Conradi T. (Timo)
- Conti L. (Luisa)
- Csergo A. M. (Anna Maria)
- Cykowska-Marzencka B. (Beata)
- Czarniecka-Wiera M. (Marta)
- Czarnocka-Cieciura M. (Marta)
- Czortek P. (Patryk)
- Danihelka J. (Jiri)
- De Frenne P. (Pieter)
- Deak B. (Balazs)
- del Galdo G. P. (Gian Pietro Giusso)
- Dembicz I. (Iwona)
- Demeter L. (Laszlo)
- Deng L. (Lei)
- Dengler J. (Jurgen)
- Diekmann M. (Martin)
- Dolezal J. (Jiri)
- Dolnik C. (Christian)
- Drevojan P. (Pavel)
- Dupre C. (Cecilia)
- Ecker K. (Klaus)
- Ejtehadi H. (Hamid)
- Erschbamer B. (Brigitta)
- Essl F. (Franz)
- Etayo J. (Javier)
- Etzold J. (Jonathan)
- Farkas T. (Tunde)
- Farzam M. (Mohammad)
- Fayvush G. (George)
- Fernandez Calzado M. R. (Maria Rosa)
- Filibeck G. (Goffredo)
- Finckh M. (Manfred)
- Fjellstad W. (Wendy)
- Fotiadis G. (Georgios)
- Garcia-Magro D. (Daniel)
- Garcia-Mijangos I. (Itziar)
- Gavilan R. G. (Rosario G.)
- Germany M. (Markus)
- Ghafari S. (Sahar)
- Gillet F. (Francois)
- Grytnes J.-A. (John-Arvid)
- Guarino R. (Riccardo)
- Guler B. (Behlul)
- Gutierrez-Giron A. (Alba)
- Hajek M. (Michal)
- Helm A. (Aveliina)
- Herrera M. (Mercedes)
- Hullbusch E. M. (Elisabeth M.)
- Ingerpuu N. (Nele)
- Jaegerbrand A. K. (Annika K.)
- Jandt U. (Ute)
- Janisova M. (Monika)
- Jeanneret P. (Philippe)
- Jeltsch F. (Florian)
- Jensen K. (Kai)
- Jentsch A. (Anke)
- Jimenez-Alfaro B. (Borja)
- Kacki Z. (Zygmunt)
- Kakinuma K. (Kaoru)
- Kapfer J. (Jutta)
- Kargar M. (Mansoureh)
- Kelemen A. (Andras)
- Kiehl K. (Kathrin)
- Kirschner P. (Philipp)
- Koyama A. (Asuka)
- Kozub L. (Lukasz)
- Kuzemko A. (Anna)
- Langer N. (Nancy)
- Lazzaro L. (Lorenzo)
- Leps J. (Jan)
- Li C.-F. (Ching-Feng)
- Li F. Y. (Frank Yonghong)
- Liendo D. (Diego)
- Lindborg R. (Regina)
- Loebel S. (Swantje)
- Lomba A. (Angela)
- Lososova Z. (Zdenka)
- Lustyk P. (Pavel)
- Luzuriaga A. L. (Arantzazu L.)
- Ma W. (Wenhong)
- Maccherini S. (Simona)
- Magnes M. (Martin)
- Malicki M. (Marek)
- Manthey M. (Michael)
- Marceno C. (Corrado)
- Mardari C. (Constantin)
- May F. (Felix)
- Mayrhofer H. (Helmut)
- Meier E. S. (Eliane Seraina)
- Memariani F. (Farshid)
- Merunkova K. (Kristina)
- Michelsen O. (Ottar)
- Molero Mesa J. (Joaquin)
- Molnar Z. (Zsolt)
- Moradi H. (Halime)
- Moysiyenko I. (Ivan)
- Mugnai M. (Michele)
- Naqinezhad A. (Alireza)
- Natcheva R. (Rayna)
- Ninot J. M. (Josep M.)
- Nobis M. (Marcin)
- Noroozi J. (Jalil)
- Nowak A. (Arkadiusz)
- Onipchenko V. (Vladimir)
- Pakeman R. J. (Robin J.)
- Palpurina S. (Salza)
- Partel M. (Meelis)
- Patsch R. (Ricarda)
- Pauli H. (Harald)
- Pedashenko H. (Hristo)
- Pedersen C. (Christian)
- Peet R. K. (Robert K.)
- Perez-Haase A. (Aaron)
- Peters J. (Jan)
- Pielech R. (Remigiusz)
- Pipenbaher N. (Natasa)
- Pirini C. (Chrisoula)
- Pladevall-Izard E. (Eulalia)
- Pleskova Z. (Zuzana)
- Potenza G. (Giovanna)
- Preislerova Z. (Zdenka)
- Prentice H. C. (Honor C.)
- Rahmanian S. (Soroor)
- Reitalu T. (Triin)
- Rodriguez-Rojo M. P. (Maria Pilar)
- Rolecek J. (Jan)
- Ronkin V. (Vladimir)
- Rosati L. (Leonardo)
- Ruprecht E. (Eszter)
- Rusina S. (Solvita)
- Sabovljevic M. (Marko)
- Sanaei A. (Anvar)
- Sanchez A. M. (Ana M.)
- Santi F. (Francesco)
- Savchenko G. (Galina)
- Shyriaieva D. (Dariia)
- Silva V. (Vasco)
- Skornik S. (Sonja)
- Smerdova E. (Eva)
- Sonkoly J. (Judit)
- Sperandii M. G. (Marta Gaia)
- Staniaszek-Kik M. (Monika)
- Stevens C. (Carly)
- Stifter S. (Simon)
- Suchrow S. (Sigrid)
- Sutcliffe L. M. (Laura M. E.)
- Swacha G. (Grzegorz)
- Swierszcz S. (Sebastian)
- Talebi A. (Amir)
- Teleki B. (Balazs)
- Teresa Sebastia M. (Maria)
- Terzi M. (Massimo)
- Tichy L. (Lubomir)
- Tolgyesi C. (Csaba)
- Torca M. (Marta)
- Torok P. (Peter)
- Tsarevskaya N. (Nadezda)
- Tsiripidis I. (Ioannis)
- Turisova I. (Ingrid)
- Ushimaru A. (Atushi)
- Valko O. (Orsolya)
- Van Mechelen C. (Carmen)
- Van Meerbeek K. (Koenraad)
- Vanneste T. (Thomas)
- Vasheniak I. (Iuliia)
- Vassilev K. (Kiril)
- Viciani D. (Daniele)
- Villar L. (Luis)
- Virtanen R. (Risto)
- Vitasovic-Kosic I. (Ivana)
- Vojtko A. (Andras)
- Vynokurov D. (Denys)
- Walden E. (Emelie)
- Wang Y. (Yun)
- Weiser F. (Frank)
- Wen L. (Lu)
- Wesche K. (Karsten)
- White H. (Hannah)
- Widmer S. (Stefan)
- Winkler M. (Manuela)
- Wolfrum S. (Sebastian)
- Wrobel A. (Anna)
- Wu J. (Jianshuang)
- Yuan Z. (Zuoqiang)
- Zeleny D. (David)
- Zhao L. (Liqing)
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Abstract
Aims: Understanding fine-grain diversity patterns across large spatial extents is fundamental for macroecological research and biodiversity conservation. Using the GrassPlot database, we provide benchmarks of fine-grain richness values of Palaearctic open habitats for vascular plants, bryophytes, lichens and complete vegetation (i.e., the sum of the former three groups).
Location: Palaearctic biogeographic realm.
Methods: We used 126,524 plots of eight standard grain sizes from the GrassPlot database: 0.0001, 0.001, 0.01, 0.1, 1, 10, 100 and 1,000 mÂČ and calculated the mean richness and standard deviations, as well as maximum, minimum, median, and first and third quartiles for each combination of grain size, taxonomic group, biome, region, vegetation type and phytosociological class.
Results: Patterns of plant diversity in vegetation types and biomes differ across grain sizes and taxonomic groups. Overall, secondary (mostly semi-natural) grasslands and natural grasslands are the richest vegetation type. The open-access file âGrassPlot Diversity Benchmarksâ and the web tool âGrassPlot Diversity Explorerâ are now available online (https://edgg.org/databases/GrasslandDiversityExplorer) and provide more insights into species richness patterns in the Palaearctic open habitats.
Conclusions: The GrassPlot Diversity Benchmarks provide high-quality data on species richness in open habitat types across the Palaearctic. These benchmark data can be used in vegetation ecology, macroecology, biodiversity conservation and data quality checking. While the amount of data in the underlying GrassPlot database and their spatial coverage are smaller than in other extensive vegetation-plot databases, species recordings in GrassPlot are on average more complete, making it a valuable complementary data source in macroecology
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Author
- A David Smith
- Aaltonen L.
- Aaltonen V.
- Aarno Palotie
- Aarsland D.
- Aavikko M.
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- Warner N.
- Warren J. D.
- Waterworth D.
- Wayne C McCormick
- Wayne W Poon
- Weber H.
- Wei Gu
- Wei Zhou
- Weinhold L.
- Weinstein G.
- Weintraub S.
- Welsh-Bohmer K. A.
- Whelan C.
- Whitehead P. L.
- Wichmann H. -E.
- Wigmore E.
- Wijsman E. M.
- Wilcock G.
- Wilhelmsen K. C.
- Will S Bush
- William Kremen
- William Nash
- William W Seeley
- Williams A.
- Williams B.
- Williams D.
- Williams J.
- Williamson J.
- Wilms H.
- Wiltfang J.
- Windle G.
- Wingo T. S.
- Wisniewski T.
- Wittfeld K.
- Woltjer R. L.
- Wong R.
- Woods B.
- Woon M.
- Wright C. B.
- Wu C. -K.
- Wu Y.
- Xia T. -H.
- Xing Chen
- Xinli Hu
- Xiongwei Zhu
- Xu E.
- Xu F.
- Xuan Liu
- Yanbing Wang
- Yanek L.
- Yang Q.
- Yang Y.
- Yannakoulia M.
- Yaqub A.
- Yasaman Saba
- Yash Patel
- Yeunjoo E Song
- Yi Zhao
- Ying Wu
- Yoav Ben-Shlomo
- Yogen Patel
- Younkin S. G.
- Yu C. -E.
- Yu L.
- Yuanchao Zhang
- Yuk Yee Leung
- Yunfeng Huang
- Yunju Yang
- Zare H.
- Zdenka Pausova
- Zhang X.
- Zhang Y.
- Zhao Y.
- Zhao Y.
- Zhou W.
- Zhu C.
- Zhu X.
- Ziemann A.
- Zoia C. P.
- Zompo M. D.
- Zulaica M.
- Zulma Sevillano
- Ălvarez V.
- Ă sa Hedman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
Clinical manifestations of intermediate allele carriers in Huntington disease
- Author
- A Marit de Weert
- Aakta Patel
- Abigail Wright
- Abigail Wright
- Adriana Prundean
- Adrien Come
- Adrienne Curtis
- Agata Stenwak
- Agnieszka Gorzkowska
- Agnieszka Konkel
- Aicha Ghenam
- Alain Kaelin
- Aleksandra Kaczmarczyk
- Alessandro Roca
- Alexander MĂŒnchau
- Alexandra Ure
- Alexandre Eusebio
- Alice Seris
- Alison Kraus
- Alma Sikiric
- Alyson Andrew
- Alyson Bradbury
- Alzbeta MĂŒhlbĂ€ck
- Amaia GonzĂĄlez
- Amy Palmer
- Ana Calado
- Ana GarcĂa
- Ana Maria Finisterra
- Ana Maria Finisterra
- Ana Rojo SebastiĂĄn
- Ana Rojo SebastiĂĄn
- Ana Salgueiro
- Anabela Valadas
- Andrea Buck
- Andrea Ginestroni
- Andrea H Nemeth
- Andrea Horta-Barba
- Andrea Kesse
- Andrea Sollom
- Andrew Parkinson
- Andrzej Szczudlik
- Aneta Klimberg
- Angel MartĂnez Pueyo
- Anke Niess
- Anna Ciesielska
- Anna Gogol
- Anna Kaminska
- Anna Maria Romoli
- Anna Rita Bentivoglio
- Anna Rita Dellomonaco
- Anna SuĆek
- Anna Wasielewska
- Anne Kampstra
- Anne Rosser
- Anne Schoonderbeek
- Anne-Catherine Bachoud-LĂ©vi
- Annunziata De Nicola
- Antonella Muroni
- Antonia Campolongo
- Antonio Herranz BĂĄrcenas
- Antonio Villa Riballo
- Ariane Schneider
- Artur Dziadkiewicz
- Arvid Heiberg
- Arvid Heiberg
- ArĂĄnzazu Gorospe
- Ashok Krishnamoorthy
- Ashok Raman
- AsunciĂłn MartĂnez Descals
- AsunciĂłn MartĂnez-Descals
- Audrey Olivier
- Baldev Singh
- Barbara D'Alessio
- Barbara JasiĆska-Myga
- Barbara Kaminski
- Barbara Vives Pastor
- BartĆomiej WiĆniewski
- Beate Rindal
- Beatriz Tijero Merino
- Beatriz Udaeta
- Belén Frades
- Bernhard Landwehrmeyer
- Beverley Hayward
- Beverley Soltysiak
- Bianca Kramer
- Blandine Babiloni
- Bénédicte Gohier
- Calvo S.
- Camille Genoves
- Carina Hvalstedt
- Carlo Rinaldi
- Carlos Salvador
- Carmen AntĂșnez Almagro
- Carmen DurĂĄn Herrera
- Carole Clayton
- Carolin Geitner
- Carolina Mendez Lucena
- Carolina Villa
- Caroline Hallam
- Caroline Peacy
- Carsten Saft
- Cat Taylor
- Caterina Bartoli
- Catherine Bourdet
- Catherine Clenaghan
- Catherine Taylor
- Cecilie Haggag Johannessen
- Charlotte Duché
- Charlotte Eddy
- Charlotte Golding
- Cheryl Stopford
- Chiara Esposito
- Christelle Chabot
- Christian Sass
- Christian Sass
- Christiane Schlangen
- Christina Vangsted-Hansen
- Christine Garreau
- Christine Held
- Christine Held
- Christine Leypold
- Christine Verellen-Dumoulin
- Christine Verellen-Dumoulin
- Christoph Michael Kosinski
- Christoph Schrader
- Christophe Verny
- Christos Ganos
- Cici Feliz Feliz
- Cinzia Valeria Russo
- Claire Thiriez
- Clara Villanueva
- Clarisse Scherer-Gagou
- Claudia Cormio
- Claudia Lamanna
- Claudia Mechi
- Claudia Serpino
- Cornelius J Werner
- Cristina JanuĂĄrio
- Cristina Melgar Fernandez
- Cristina Semedo
- Cubo E.
- Cynthia Butcher
- Cyril Goizet
- CĂšlia Mareca Viladrich
- CĂ©cile Focseneanu
- CĂ©cile Minet
- Daniel Ecker
- Daniel Ecker
- Daniel Stompel
- Daniel Zielonka
- Daniel Zielonka
- Daniela Monza
- Daniela Probst
- Daniela Rae
- Daniela Schwenk
- Danielle LafoucriĂšre
- Danuta Ryglewicz
- David Craufurd
- David Harrison
- Davina Hensman
- Dawn Freire- Patino
- Dawn Rogers
- Dawn Rogers
- Deena Gallantree
- Dirk Dressler
- Dolors Badenes Guia
- Dominique Bonneau Marie Bost
- Dominique Van Paemel
- Dorota BoÄwiĆska
- Edward Wild
- Elena Bellosta Diago
- Elena Ghelli
- Elena LĂłpez
- Elena Salvatore
- Elisabeth Dramstad
- Elisabeth Rosser
- Elisabetta Bertini
- Elizabeth Coulthard
- Elizaveta Yudina
- Ellen P 't Hart
- Elvina Chu
- Elvira Roca
- Elzbieta Zdzienicka
- ElĆŒbieta SzczygieĆ
- Emilia Sitek
- Emma Hobson
- Emma Oughton
- Erika Timewell
- Esther Cubo
- Eugeniusz Zielonka
- Eva Hölzner
- Eva Milkereit
- Eva Pacheco Cortegana
- Eve M Dumas
- Ewa NaroĆŒaĆska
- Ewelina Ciach-Wysocka
- Ewelina Kubowicz
- Fabienne Calvas
- Farideh Badei
- Ferdinando Squitieri
- Fernanda Fortunato
- Fernando Alonso Frech
- Fernando Alonso-Frech
- Filipa JĂșlio
- Fiona Summers
- Flverly Francis
- Francesca De Gregorio
- Francesca Elifani
- Francesca Lovo
- Francesco Marrosu
- Francisco Castera Brugada Carmen PeirĂł Vilaplana
- Franziska Lezius
- Frédérique Fluchere
- Fuensanta Noguera Perea
- FĂĄtima Damas Hermoso
- G Bernhard Landwehrmeyer
- Gabriela KĆodowska-Duda
- Gabriele Diercks
- Gareth Thomas
- Gemma Tome Carruesco
- Gil-Polo CAnne-Catherine Bachoud-LĂ©vi
- Gill Siuda
- Ginette Cass
- Gioia Jacopini
- Giovanni Franco
- Giovanni Ristori
- Gisa Ellrichmann
- Giulia Coarelli
- Giuseppe De Michele
- Graça Morgado
- Grzegorz Opala
- Grzegorz Witkowski
- Grzegorz Witkowski
- Guillermo GarcĂa Ribas
- Gunnel Fredlund
- Halina Sienkiewicz-Jarosz
- Hanan Khalil
- Hannah Musgrave
- Hannele Hypponen
- Heather Dipple
- Heike Beckmann
- Heike Gorzolla
- Helen Fairtlough
- Helen Gundersen
- Helen Murphy
- Helene Padieu
- Heli Hiivola
- Herwig Lange
- Hubert Kwiecinski
- Hugh Rickards
- Husam Samara
- HĂ©lĂšne Grosjean
- Ida Biunno
- Ida Unmack Larsen
- Idaira MartĂn
- Ines Goerendt
- Inés Legarda Ramirez
- Irene Mazzante
- Irene Romero
- Iris Trender-Gerhard
- Isabella Foustanos
- Itziar Gaston
- Ivana Markova
- Iwona StÄpniak
- Jacek AnioĆa Anna Bryl
- Jacek Zaremba
- Jacek Zaremba
- Jaime Kulisevsky Bojarsky
- Jakub Antczak
- Jamie Levey
- Jan Coebergh
- Jan Frich
- Jan Lewerenz
- Jan Lewerenz
- Jan Wahlström
- Jan Wahlström
- Jan Wright
- Jaroslaw Slawek
- Javier Del Val Fernandez
- Javier LĂłpez Del Val
- Javier Pagonabarraga
- Jean Rothery
- Jean Toscano
- Jean-Marc Burgunder
- Jean-Marc Burgunder
- Jean-Philippe Azulay
- Jennifer Thompson
- Jenny Callaghan
- Jenny Callaghan
- Jenny Callaghan
- Jenny Crooks
- Jenny de Souza
- Jenny Schmalfeld
- Jenny Townhill
- Jenny Townhill
- Jeremy Cosgrove
- Jeroen P P van Vugt
- Jerzy Marcinkowski
- Jesus Perez Perez
- JesĂșs Miguel Ruiz Idiago
- Jette Stockholm
- Jill Davison
- Jillian Foster
- Joana Morgado
- Joaquim J Ferreira
- Joaquim J Ferreira
- Johannes Schiefer
- John O Donovan
- John Piedad
- Jordi Bas
- Josh Williams
- Josh Wood
- José Chacón Peña
- José Luis López-Sendón Moreno
- JosĂ© Manuel GarcĂa Moreno
- JosĂ© MatĂas Arbelo
- Joy Read
- Juan Andres Burguera
- Juan Carlos Gomez Esteban
- Juan GarcĂa Caldentey
- Juan GarcĂa Caldentey
- Juan GarcĂa Caldentey
- Juan Manuel Periañez
- Juan MarĂn Muñoz
- Juan Pablo Tartari DĂaz-Zorita
- Judit LĂłpez Catena
- Judith Bek
- Julia Connemann
- Julia Middleton
- Julie Frost
- Julie Prouzet
- Julie Snowden
- Justo GarcĂa de YĂ©benes
- Justyna SempoĆowicz
- Jutta Rummel
- Jérémie Pariente
- JĂžrgen E Nielsen
- JĂžrgen Nielsen
- Kai Boelmans
- Kamila Bojakowska-Jaremek
- Karen Doherty
- Karen Morgan
- Karolina Ziora-Jakutowicz
- Kasia Sieradzan
- Katarzyna Jachinska
- Katherine Tidswell
- Kathleen Fuller
- Kathleen Price
- Kathrin Reetz
- Kathrine BjĂžrgo
- Kathrine Haggag
- Kathryn Dixon
- Katia Youssov
- Katri Tuuha
- Katrin Barth
- Katrin Barth
- Katrina Holmes
- Kay Fillingham
- Kerstin Koppers
- Kerstin Nöth
- Kingsley Powell
- Kirsti Martikainen
- Kirsty Matheson
- Kirsty O'Donovan
- Kirsty O'Donovan
- Koldo Berganzo Corrales
- Krzysztof Banaszkiewicz
- Laetitia Jameau
- Laetitia Vervoitte
- Lars RetterstĂžl
- Lars Stubbe
- Laura Casas Hernanz
- Laura Martinez Martinez
- Laura Mundler
- Laura Vivancos Moreau
- Laurent Cléret
- Laurent Marquine
- Laurent Paterski
- Laurie Lemoine
- Leann Westmoreland
- Leanne Timings
- Lena Hjermind
- Lennard Herrmann
- Leonor Correia Guedes
- Leonor Correia Guedes
- Lesley Gowers
- Lesley Jones
- Lisanne MĂŒtze
- Lisbeth Regeur
- Liselotte Neleborn-LingefjÀrd
- Liv Barnett
- Liz Howard
- Liz Johnson
- Liz Rowett
- Lois Savage
- Lorna Downie
- Lotfi Boudali
- Louise Gethin
- Louise Nevitt
- Lucy Partington-Jones
- Luigi Di Maio
- Luis Menéndez Guisasola
- Luis Redondo
- Lynn Davidson
- Madeleine Fannemel
- Magdalena Boczarska-Jedynak
- Magdalena BĆaszczyk
- Magdalena WĂłjcik
- Maite Paredes Mata
- Malgorzata Krawczyk
- Malgorzata Nowak
- Mandy Longthorpe
- Manuel Almeida
- Marco Massarelli
- Marco Paganini
- Margarida Dias
- Maria Angeles Acera Gil
- Maria Antonia Ramos-Arroyo
- Maria Ascension Zea Sevilla
- Maria Bosca
- Maria Dolores Martinez-Jaurrieta
- Maria Dolores Romero Lemos
- Maria Peterson
- Maria Ramos-Arroyo
- Maria Simonelli
- Marianne Hare
- Marianne Novak
- Marie Delfini
- Marie-Anne Guérid
- Marie-Noelle Witjes-Ané
- Marielle Nowak
- Marina de Tommaso
- Marina Frontali
- Marina Ăvila Villanueva
- Markku PÀivÀrinta
- Marleen R van Walsem
- Marleen van Walsem
- Marloes Verhoeven
- Marta FatĂĄs Ventura
- Marta Para Prieto
- Martin Oehmen
- Martina Di Renzo
- Martina Petrollini
- Martinez-Descalls A.
- Martinez-Horta S.
- Mary Jones
- Maryla Rakowicz
- Maryline Couette
- MarĂa Del Mar Fenollar
- MarĂa JosĂ© Sainz Artiga
- MarĂa Martirio Antequera Torres
- Matilde Calopa
- Matilde LaurĂ
- Matthias Dose
- Maurizio Vezza
- Max Hughes
- Maïté Bertrand
- MaĆgorzata Dec
- Mbombe Kazoka
- Mehdi Sebaiti
- Melisa Vacca
- Meriel McEntagart
- Mette Gilling
- Michael Bachmeier
- Michael Orth
- Michael Orth
- Michael Owen
- Michael Patton
- Michael SchĂŒpbach
- Michal Szinwelski
- Michalina Malec-Litwinowicz
- MichaĆ Arkuszewski
- Michela Ferraldeschi
- Michela Figorilli
- Michelle Phillips
- MichĂšle Pierre
- Miguel Coelho
- Milena Cannella
- Milou Jacobs
- Miquel Aguilar Barbera
- Misericordia Floriach Robert
- Monica Bascuñana Garde
- Monica Busse
- Monica Lewis
- Monica Rodriguez Lopera
- Monika RudziĆska
- Monika RudziĆska
- Monique S E van Hout
- MĂĄrio Miguel Rosa
- Mónica Bascuñana
- Nadia Peppa
- Nadia Peppa
- Nadia RodrĂguez DedichĂĄ
- Nancy BorgerĂžd
- Natalia Grabska
- Natalie Arran
- Natalie Bechtel
- Nathalia Weber
- Natividad Mariscal
- Nayana Lahiri
- Nayana Lahiri
- Neil Fullerton
- Nichola Verstraelen
- Nicola Johns
- Nicola Robertson
- Nicole Göpfert
- Niini RĂžren
- Nils Olav Aanonsen
- Nina Hofstetter
- Noelia RodrĂguez MartĂnez
- Noemi Calzado
- NĂșria Busquets
- Oda Jacobsen
- Oddveig Rosby
- Olaf Aaserud
- Olga Solberg
- Olimpia Difruscolo
- Oliver Bandmann
- Oliver Quarrell
- Olivia J Handley
- Olivia J Handley
- Pablo SĂĄnchez Lozano
- Pam Yardumian
- Pamela Bethwaite
- Paola Zinzi
- Paola Zinzi
- Pascale RibaĂŻ
- Patricia Trigo Cubillo
- Patricia Trigo Cubillo
- Patrick Weydt
- Patrocinio Garcia Moreno
- Paul Gill
- Pavla Ć aĆĄinkovĂĄ
- Pawel Tacik
- Pedro JosĂ© GarcĂa RuĂz
- Penelope Navas Arques
- Per GĂžrvell
- Peter Berglund
- Peter Brockie
- Philippe Allain
- Pia Eklund
- Pierpaolo Sorrentino
- Pilar Quiléz Ferrer
- Piotr Janik
- Piotr Robowski
- Przemyslaw Richter
- Rachel Edwards
- Rachel Taylor
- Radu Constantinescu
- Rafal Rola
- Ragnhild Wehus
- Rainer Hoffmann
- Ralf Marquard
- Ralf Reilmann
- Ramon Fernandez de Bobadilla
- Ramos-Arroyo M. A.
- Raphael M Bonelli
- Raymund A C Roos
- Raymund A C Roos
- Rebecca Minschke
- Reineke Bos
- Reineke Bos
- René Ribacoba
- Richard Armstrong
- RocĂo GarcĂa-Ramos GarcĂa
- RocĂo Malo de Molina
- Roisin Jack
- Roland Raseta
- Rosa Guerrero LĂłpez
- Rupert Noad
- Ruth Fullam
- Ruth Fullam
- Ruth Fullam
- Ruth Valentine
- Sabine Gayde-Stephan
- Sabine Weber Zaugg
- Sabrina Betz
- Sabrina Debruxelles
- Salman Haider
- Salvadora Manzanares
- Samia Cheriet
- Sandra Gutierrez Romero
- Sandra Large
- Sandrine Rolland
- Sandro Sorbi
- Sara Minster
- Sara Minster
- Sarah Hunt
- Sarah J Tabrizi
- Sarah Rose
- Sarah Tabrizi
- Saul Martinez-Horta
- Saul Martinez-Horta
- Selene Capodarca
- Serge JaumĂ Classen
- Shahbana Akhtar
- Sharon McDonnell
- Sheila A Simpson
- Shona Yates
- Sigrun Schepers
- Sigurd SĂŒssmuth
- Silke Rumpf
- Silvia Piacentini
- Silvia Pradella
- Silvia Romano
- Silvio Peluso
- Simon J A van den Bogaard
- Simone Zittel
- Solveig Nepper
- Sonia Arribas Pardo
- Sonia GonzĂĄlez
- Sonja Trautmann
- Stefan Bohlen
- Stefania Bruno
- Stefanie Brown
- Stefanie Rohm
- Stephan Klebe
- Stephanie Hamer
- Stephen B Dunnett
- Stephen Dunnett
- Stuart Jamieson
- Sue McKenzie
- Sue Wild
- Suresh Komati
- Susan Huson
- Susana Pro Koivisto
- Susana Pro Koivisto
- Suzanne Lindquist
- SĂ©bastien Charpentier
- Tecla Tucci
- Tereza Uhrova
- Thomas Musacchio
- Thomas Warner
- Thomasin Andrews
- Tiago Mendes
- Tiago Mestre
- Tiago Mestre
- Tiziana Martino
- Torsten Illmann
- Tua Vinther-Jensen
- Ulrika HĂžsterey-Ugander
- Umberto Spampinato
- Una Jones
- Uruj Anjum
- Ute Hidding
- Valentina Codella
- Valeria Piras
- Valérie Vaquie
- Verena Baake
- Verena Baake
- Veronica Puertas Martin
- Verónica Mañanes Barral
- Vicenta SĂĄnchez
- Vittorio Sciruicchio
- Vivien Vaughn
- Walburgis Heinicke
- Wildson Vieira da Silva
- Wim Vandenberghe
- Wioletta Krysa
- Witold Soltan
- Yanik Stebler
- Yuri Seliverstov
- Zeid Mohammed
- Zosia Miedzybrodzka
- Zygmunt Jamrozik
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2016
- Field of study
Objective: There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. Methods: We assessed a cohort of participants at risk with <36 CAG repeats of the huntingtin (HTT) gene. Outcome measures were the Unified Huntington's Disease Rating Scale (UHDRS) motor, cognitive, and behavior domains, Total Functional Capacity (TFC), and quality of life (Short Form-36 [SF-36]). This cohort was subdivided into IA carriers (27-35 CAG) and controls (<27 CAG) and younger vs older participants. IA carriers and controls were compared for sociodemographic, environmental, and outcome measures. We used regression analysis to estimate the association of age and CAG repeats on the UHDRS scores. Results: Of 12,190 participants, 657 (5.38%) with <36 CAG repeats were identified: 76 IA carriers (11.56%) and 581 controls (88.44%). After correcting for multiple comparisons, at baseline, we found no significant differences between IA carriers and controls for total UHDRS motor, SF-36, behavioral, cognitive, or TFC scores. However, older participants with IAs had higher chorea scores compared to controls (p 0.001). Linear regression analysis showed that aging was the most contributing factor to increased UHDRS motor scores (p 0.002). On the other hand, 1-year follow-up data analysis showed IA carriers had greater cognitive decline compared to controls (p 0.002). Conclusions: Although aging worsened the UHDRS scores independently of the genetic status, IAs might confer a late-onset abnormal motor and cognitive phenotype. These results might have important implications for genetic counseling. ClinicalTrials.gov identifier: NCT01590589