Propuesta de un Modelo Multidimensional para un Datawarehouse sobre pacientes diabéticos

Se sabe que la tecnología Datawarehousing debido a su orientación analítica, impone un procesamiento y pensamiento distinto, la cual se sustenta por un modelado de Bases de Datos propio, conocido como Modelado Multidimensional. Su objetivo es ofrecer al usuario información integral que le permita visualizar la operación del negocio. Se propone en este trabajo formalizar un modelo lógico de la solución, planteando una primera definición de las posibles tablas del modelo Multidimensional con sus atributos y dimensiones, definiendo una primera versión del modelo de un DW para pacientes diabéticos. Para su elaboración se definen cuales son los elementos necesarios para el logro del objetivo planteado, y para el tema en estudio, el criterio de selección de los mismos. Los resultados obtenidos están basados en el análisis de los requerimientos a satisfacer y la fuente de información seleccionada.Eje: Bases de Datos y Minería de DatosRed de Universidades con Carreras en Informática (RedUNCI

Propuesta de un Modelo Multidimensional para un Datawarehouse sobre pacientes diabéticos

Se sabe que la tecnología Datawarehousing debido a su orientación analítica, impone un procesamiento y pensamiento distinto, la cual se sustenta por un modelado de Bases de Datos propio, conocido como Modelado Multidimensional. Su objetivo es ofrecer al usuario información integral que le permita visualizar la operación del negocio. Se propone en este trabajo formalizar un modelo lógico de la solución, planteando una primera definición de las posibles tablas del modelo Multidimensional con sus atributos y dimensiones, definiendo una primera versión del modelo de un DW para pacientes diabéticos. Para su elaboración se definen cuales son los elementos necesarios para el logro del objetivo planteado, y para el tema en estudio, el criterio de selección de los mismos. Los resultados obtenidos están basados en el análisis de los requerimientos a satisfacer y la fuente de información seleccionada.Eje: Bases de Datos y Minería de DatosRed de Universidades con Carreras en Informática (RedUNCI

Imago. Sensory diversity project

Imago. Proyecto de diversidad sensorial se ha centrado en el estudio y la accesibilidad de las imágenes artísticas desde la perspectiva y experiencia de personas con diversidad sensorial. Nuestro punto de partida quedaba así fijado por la idea de que las personas con diversidad sensorial nos ofrecen una apertura para el estudio ampliado de las imágenes en función de la facultad de imaginar. Se trataba, pues, de elaborar un material audiovisual adecuado que prestase atención a la amplitud sensorial, esto es, sinestésica, de la imagen. Con tal planteamiento, este proyecto se proponía desarrollar tanto una dimensión teórica como una práctica para el estudio de las imágenes. De una parte se trataba de trabajar a partir de autores (artistas y teóricos) de distintas épocas que permitieran un acercamiento a la concepción ampliada de las imágenes desde perspectivas integradoras. De otra, se trataba de realizar una serie de videos en colaboración con personas con diversidad sensorial que nos permitieran un estudio crítico de las posibilidades de este formato en Internet.Depto. de Historia del ArteFac. de Geografía e HistoriaFALSEsubmitte

Imago 2. Proyecto de diversidad sensorial

Proyecto de innovación docente dedicado a la relación entre la imaginación y los sentidos desde la diversidad sensorial

Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

<p>Abstract</p> <p>Background</p> <p>One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples.</p> <p>Methods</p> <p>The mRNA levels were measured by quantitative real-time PCR and hybridization of a tumor tissue cDNA array; and the protein levels and distribution by immunostaining of a custom tissue array containing a set of paraffin-embedded samples of different tumor and normal tissues followed by statistical analysis.</p> <p>Results</p> <p>We show that the expression of two mRNP factors, THOC1 and ALY are altered in several tumor tissues. THOC1 mRNA and protein levels are up-regulated in ovarian and lung tumors and down-regulated in those of testis and skin, whereas ALY is altered in a wide variety of tumors. In contrast to THOC1, ALY protein is highly detected in normal proliferative cells, but poorly in high-grade cancers.</p> <p>Conclusions</p> <p>These results suggest a differential connection between tumorogenesis and the expression levels of human THO and ALY. This study opens the possibility of defining mRNP biogenesis factors as putative players in cell proliferation that could contribute to tumor development.</p

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake