231 research outputs found
High-Energy Cosmology: gamma rays and neutrinos from beyond the galaxy
Our knowledge of the high-energy universe is undergoing a period of rapid
change as new astronomical detectors of high-energy radiation start to operate
at their design sensitivities. Now is a boomtime for high-energy astrophysics,
with new discoveries from Swift and HESS, results from MAGIC and VERITAS
starting to be reported, the upcoming launches of the gamma-ray space
telescopes GLAST and AGILE, and anticipated data releases from IceCube and
Auger. A formalism for calculating statistical properties of cosmological
gamma-ray sources is presented. Application is made to model calculations of
the statistical distributions of gamma-ray and neutrino emission from (i)
beamed sources, specifically, long-duration GRBs, blazars, and extagalactic
microquasars, and (ii) unbeamed sources, including normal galaxies, starburst
galaxies and clusters. Expressions for the integrated intensities of faint
beamed and unbeamed high-energy radiation sources are also derived. A toy model
for the background intensity of radiation from dark-matter annihilation taking
place in the early universe is constructed. Estimates for the gamma-ray fluxes
of local group galaxies, starburst, and infrared luminous galaxies are briefly
reviewed. Because the brightest extragalactic gamma-ray sources are flaring
sources, and these are the best targets for sources of PeV -- EeV neutrinos and
ultra-high energy cosmic rays, rapidly slewing all-sky telescopes like MAGIC
and an all-sky gamma-ray observatory beyond Milagro will be crucial for optimal
science return in the multi-messenger age.Comment: 10 pages, 3 figs, accepted for publication in the Barcelona
Conference on Multimessenger Astronomy; corrected eq. 27, revised Fig. 3,
added 2 ref
Incipient Separation in Shock Wave Boundary Layer Interactions as Induced by Sharp Fin
The incipient separation induced by the shock wave turbulent boundary layer
interaction at the sharp fin is the subject of present study. Existing theories
for the prediction of incipient separation, such as those put forward by McCabe
(1966) and Dou and Deng (1992), can have thus far only predicting the direction
of surface streamline and tend to over-predict the incipient separation
condition based on the Stanbrook's criterion. In this paper, the incipient
separation is firstly predicted with Dou and Deng (1992)'s theory and then
compared with Lu and Settles (1990)' experimental data. The physical mechanism
of the incipient separation as induced by the shock wave/turbulent boundary
layer interactions at sharp fin is explained via the surface flow pattern
analysis. Furthermore, the reason for the observed discrepancy between the
predicted and experimental incipient separation conditions is clarified. It is
found that when the wall limiting streamlines behind the shock wave becomes\
aligning with one ray from the virtual origin as the strength of shock wave
increases, the incipient separation line is formed at which the wall limiting
streamline becomes perpendicular to the local pressure gradient. The formation
of this incipient separation line is the beginning of the separation process.
The effects of Reynolds number and the Mach number on incipient separation are
also discussed. Finally, a correlation for the correction of the incipient
separation angle as predicted by the theory is also given.Comment: 34 pages; 9 figure
Addition of Casein or Whey Protein to Colostrum or a Colostrum Supplement Product on Absorption of IgG in Neonatal Calves
Olber's Paradox for Superluminal Neutrinos: Constraining Extreme Neutrino Speeds at TeV-ZeV Energies with the Diffuse Neutrino Background
The only invariant speed in special relativity is c; therefore, if some
neutrinos travel at even tiny speeds above c, normal special relativity is
incomplete and any superluminal speed may be possible. I derive a limit on
superluminal neutrino speeds v >> c at high energies by noting that such speeds
would increase the size of the neutrino horizon. The increased volume of the
Universe visible leads to a brighter astrophysical neutrino background. The
nondetection of "guaranteed" neutrino backgrounds from star-forming galaxies
and ultrahigh energy cosmic rays (UHECRs) constrains v/c at TeV--ZeV energies.
I find that v/c <= 820 at 60 TeV from the nondetection of neutrinos from
star-forming galaxies. The nondetection of neutrinos from UHECRs constrains v/c
to be less than 2500 at 0.1 EeV in a pessimistic model and less than 4.6 at 4
EeV in an optimistic model. The UHECR neutrino background nondetection is
strongly inconsistent with a naive quadratic extrapolation of the OPERA results
to EeV energies. The limits apply subject to some caveats, particularly that
the expected pionic neutrino backgrounds exist and that neutrinos travel faster
than c when they pass the detector. They could be improved substantially as the
expected neutrino backgrounds are better understood and with new experimental
neutrino background limits. I also point out that extremely subluminal speeds
would result in a much smaller neutrino background intensity than expected.Comment: 13 pages, 2 figures, fixed titl
Spatially clustered resources increase male aggregation and mating duration in Drosophila melanogaster
In environments where females mate multiply, males should adjust their behaviour and physiology in response to the perceived level of sperm competition to maximize their fitness. Evidence of such plasticity has been found in several laboratory and field studies, but little is known about the cues stimulating these responses in natural populations. One way in which males appear to assess sperm competition risk is through encounter rates with conspecific males. Such encounter rates may be driven by the spatial distribution of resources required by males (i.e. food patches or potential mates), which in turn affects local density. However, explicit links between resource distribution, male encounter rates and shifts in behaviour related to sperm competition have not been demonstrated. We found that when group size of Drosophila melanogaster males was held constant, a small decrease in the distance between patches of food resources had striking effects on male behaviour. Compared to those from dispersed resources, males on clustered resources had a significantly reduced intermale distance (and hence encounter rate) and subsequently a longer noncompetitive copulation duration, previously shown to be a reliable indicator of male perception of sperm competition risk. The aggregation of resources, operating via increased encounter rate, can stimulate shifts in behaviour affecting male sperm competition performance. Given that the spatial distribution of resources is typically variable in natural populations (and often unpredictable), selection is likely to favour the evolution of plasticity in sexual behaviour where resource aggregation increases the probability of sperm competition
Regulation of phosphorylase kinase by low concentrations of Ca ions upon muscle contraction: the connection between metabolism and muscle contraction and the connection between muscle physiology and Ca-dependent signal transduction
It had long been one of the crucial questions in muscle physiology how glycogenolysis is regulated in connection with muscle contraction, when we found the answer to this question in the last half of the 1960s. By that time, the two principal currents of muscle physiology, namely, the metabolic flow starting from glycogen and the mechanisms of muscle contraction, had already been clarified at the molecular level thanks to our senior researchers. Thus, the final question we had to answer was how to connect these two currents. We found that low concentrations of Ca ions (10−7–10−4 M) released from the sarcoplasmic reticulum for the regulation of muscle contraction simultaneously reversibly activate phosphorylase kinase, the enzyme regulating glycogenolysis. Moreover, we found that adenosine 3′,5′-monophosphate (cyclic AMP), which is already known to activate muscle phosphorylase kinase, is not effective in the absence of such concentrations of Ca ions. Thus, cyclic AMP is not effective by itself alone and only modifies the activation process in the presence of Ca ions (at that time, cyclic AMP-dependent protein kinase had not yet been identified). After a while, it turned out that our works have not only provided the solution to the above problem on muscle physiology, but have also been considered as the first report of Ca-dependent protein phosphorylation, which is one of the central problems in current cell biology. Phosphorylase kinase is the first protein kinase to phosphorylate a protein resulting in the change in the function of the phosphorylated protein, as shown by Krebs and Fischer. Our works further showed that this protein kinase is regulated in a Ca-dependent manner. Accordingly, our works introduced the concept of low concentrations of Ca ions, which were first identified as the regulatory substance of muscle contraction, to the vast field of Ca biology including signal transduction
Alterações do pH, da P O2 e da P CO2 arteriais e da concentração de lactato sangüíneo de cavalos da raça Árabe durante exercício em esteira de alta velocidade
COVID-19: Rapid antigen detection for SARS-CoV-2 by lateral flow assay: A national systematic evaluation of sensitivity and specificity for mass-testing
Background
Lateral flow device (LFD) viral antigen immunoassays have been developed around the world as diagnostic tests for SARS-CoV-2 infection. They have been proposed to deliver an infrastructure-light, cost-economical solution giving results within half an hour.
Methods
LFDs were initially reviewed by a Department of Health and Social Care team, part of the UK government, from which 64 were selected for further evaluation from 1st August to 15th December 2020. Standardised laboratory evaluations, and for those that met the published criteria, field testing in the Falcon-C19 research study and UK pilots were performed (UK COVID-19 testing centres, hospital, schools, armed forces).
Findings
4/64 LFDs so far have desirable performance characteristics (orient Gene, Deepblue, Abbott and Innova SARS-CoV-2 Antigen Rapid Qualitative Test). All these LFDs have a viral antigen detection of >90% at 100,000 RNA copies/ml. 8951 Innova LFD tests were performed with a kit failure rate of 5.6% (502/8951, 95% CI: 5.1–6.1), false positive rate of 0.32% (22/6954, 95% CI: 0.20–0.48). Viral antigen detection/sensitivity across the sampling cohort when performed by laboratory scientists was 78.8% (156/198, 95% CI 72.4–84.3).
Interpretation
Our results suggest LFDs have promising performance characteristics for mass population testing and can be used to identify infectious positive individuals. The Innova LFD shows good viral antigen detection/sensitivity with excellent specificity, although kit failure rates and the impact of training are potential issues. These results support the expanded evaluation of LFDs, and assessment of greater access to testing on COVID-19 transmission.
Funding
Department of Health and Social Care. University of Oxford. Public Health England Porton Down, Manchester University NHS Foundation Trust, National Institute of Health Research
Combination of searches for Higgs boson pairs in pp collisions at \sqrts = 13 TeV with the ATLAS detector
This letter presents a combination of searches for Higgs boson pair production using up to 36.1 fb(-1) of proton-proton collision data at a centre-of-mass energy root s = 13 TeV recorded with the ATLAS detector at the LHC. The combination is performed using six analyses searching for Higgs boson pairs decaying into the b (b) over barb (b) over bar, b (b) over barW(+)W(-), b (b) over bar tau(+)tau(-), W+W-W+W-, b (b) over bar gamma gamma and W+W-gamma gamma final states. Results are presented for non-resonant and resonant Higgs boson pair production modes. No statistically significant excess in data above the Standard Model predictions is found. The combined observed (expected) limit at 95% confidence level on the non-resonant Higgs boson pair production cross-section is 6.9 (10) times the predicted Standard Model cross-section. Limits are also set on the ratio (kappa(lambda)) of the Higgs boson self-coupling to its Standard Model value. This ratio is constrained at 95% confidence level in observation (expectation) to -5.0 < kappa(lambda) < 12.0 (-5.8 < kappa(lambda) < 12.0). In addition, limits are set on the production of narrow scalar resonances and spin-2 Kaluza-Klein Randall-Sundrum gravitons. Exclusion regions are also provided in the parameter space of the habemus Minimal Supersymmetric Standard Model and the Electroweak Singlet Model. For complete list of authors see http://dx.doi.org/10.1016/j.physletb.2019.135103</p
Searches for lepton-flavour-violating decays of the Higgs boson in TeV collisions with the ATLAS detector
This Letter presents direct searches for lepton flavour violation in Higgs boson decays, H → eτ and
H → μτ , performed with the ATLAS detector at the LHC. The searches are based on a data sample
of proton–proton collisions at a centre-of-mass energy √s = 13 TeV, corresponding to an integrated
luminosity of 36.1 fb−1. No significant excess is observed above the expected background from Standard
Model processes. The observed (median expected) 95% confidence-level upper limits on the leptonflavour-violating branching ratios are 0.47% (0.34+0.13−0.10%) and 0.28% (0.37+0.14−0.10%) for H → eτ and H → μτ , respectively.publishedVersio
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