155 research outputs found
Analyse et création d'une plateforme de crowdfunding
Le crowdfunding est un moyen alternatif qui permet non seulement le financement de projets mais qui peut Ă©galement faciliter la rĂ©colte de dons. Actuellement, le contexte Ă©conomique a en partie poussĂ© le mouvement et grĂące Ă lâexpansion des blogs, il a pu s'accroitre. Aujourd'hui, de plus en plus de plateformes qui proposent ce type de financement se crĂ©ent sur la toile. GrĂące au crowdfunding, de nombreux artistes ont pu produire leur album et de nombreuses causes humanitaires ont bĂ©nĂ©ficiĂ© des avantages du service du web pour obtenir plus de dons. Ce travail comprend tout dâabord une analyse dĂ©taillĂ©e des diffĂ©rentes plateformes de crowdfunding disponibles dans le monde et en Suisse. On y parlera des particularitĂ©s de chacune, ce quâelles reprĂ©sentent et comment elles fonctionnent. On Ă©voquera Ă©galement le problĂšme des fraudes faites par des porteurs de projet peu scrupuleux et ce qui se passe pour le donateur qui a perdu son argent. Dâautre part, le document retranscrit une Ă©tude du projet qui explique lâobjectif de la plateforme. Elle dĂ©finit les buts Ă atteindre et le cahier des charges Ă fournir. Par la suite, on trouve un petit descriptif des outils qui mâont aidĂ© dans lâĂ©laboration du projet. Ceci sera suivi par les multiples phases de dĂ©veloppement qui ont permis au projet dâexister. Jâexpliquerai en dĂ©tail les diffĂ©rentes Ă©tapes de la crĂ©ation. Dans ce travail, on trouve Ă©galement un explicatif dĂ©taillĂ© de chacune des fonctionnalitĂ©s implĂ©mentĂ©es par la plateforme. Il sâagit dâune description prĂ©cise de chaque Ă©lĂ©ment important du site. Finalement, le document contient un petit guide permettant aux futurs utilisateurs dâavoir une meilleure comprĂ©hension du projet et de son dĂ©veloppement
Functional Diversification of Fungal Glutathione Transferases from the Ure2p Class
The glutathione-S-transferase (GST) proteins represent an extended family involved in detoxification processes. They are divided into various classes with high diversity in various organisms. The Ure2p class is especially expanded in saprophytic fungi compared to other fungi. This class is subdivided into two subclasses named Ure2pA and Ure2pB, which have rapidly diversified among fungal phyla. We have focused our analysis on Basidiomycetes and used Phanerochaete chrysosporium as a model to correlate the sequence diversity with the functional diversity of these glutathione transferases. The results show that among the nine isoforms found in P. chrysosporium, two belonging to Ure2pA subclass are exclusively expressed at the transcriptional level in presence of polycyclic aromatic compounds. Moreover, we have highlighted differential catalytic activities and substrate specificities between Ure2pA and Ure2pB isoforms. This diversity of sequence and function suggests that fungal Ure2p sequences have evolved rapidly in response to environmental constraints
A Wearable Camera Detects Gaze Peculiarities during Social Interactions in Young Children with Pervasive Developmental Disorders
A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection.
One of the largest single sources of epilepsy in the world is produced as a neurological sequela in survivors of cerebral malaria. Nevertheless, the pathophysiological mechanisms of such epileptogenesis remain unknown and no adjunctive therapy during cerebral malaria has been shown to reduce the rate of subsequent epilepsy. There is no existing animal model of postmalarial epilepsy. In this technical report we demonstrate the first such animal models. These models were created from multiple mouse and parasite strain combinations, so that the epilepsy observed retained universality with respect to genetic background. We also discovered spontaneous sudden unexpected death in epilepsy (SUDEP) in two of our strain combinations. These models offer a platform to enable new preclinical research into mechanisms and prevention of epilepsy and SUDEP
Alzheimerâs disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression
Characterization of an AP-1-like transcription factor that mediates an oxidative stress response in Kluyveromyces lactis
International audienc
Nouvelles approches en chirurgie mini-invasive (chirurgie endoscopique transluminale et chirurgie laparo-endoscopique transombilicale. Avenir Ă court terme en chirurgie digestive)
DIJON-BU MĂ©decine Pharmacie (212312103) / SudocSudocFranceF
Bioluminescence-Based Assays for Detection and Characterization of Bacteria and Chemicals in Clinical Laboratories
International audienc
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