Work integrated learning: A whole of curriculum approach

The School of Nursing and Midwifery at Edith Cowan University, Western Australia is currently developing an innovative work integrated learning masters to service the needs of students and industry. As this paper details, the program is aimed at Registered Nurses and Midwives to support and develop the skills to conceptualise and implement a work integrated program of study, the products of which are then used as recognised assessment items. Unlike many other work integrated learning initiatives, this curriculum is entirely work integrated learning based with early units of study providing students with the foundational skills and conceptual understanding required to implement a series of employment based projects and work based activities. Importantly, central to this program is the requirement for students to map their program of learning against essential and desirable criteria, congruent with an ability to frame an argument of competence, substantiated by quality evidence. During the course, students undertake a series of ‘traditionally taught’ units that are designed to support entry into clinical specialty practice areas. The largest proportion of units however, will support students to undertake project activities that address the needs of their employer, whilst also contributing to a portfolio of evidence required as part of the master’s award. The program’s philosophy is underpinned by a trilateral relationship between the student, industry and the University. The relationship developed through the implementation of the program enables capacity building, both for the student and for industry through the provision of advanced practitioners who align with the local and strategic goals of their organisation

Mars: new insights and unresolved questions

Mars exploration motivates the search for extraterrestrial life, the development of space technologies, and the design of human missions and habitations. Here, we seek new insights and pose unresolved questions relating to the natural history of Mars, habitability, robotic and human exploration, planetary protection, and the impacts on human society. Key observations and findings include: – high escape rates of early Mars’ atmosphere, including loss of water, impact present-day habitability; – putative fossils on Mars will likely be ambiguous biomarkers for life; – microbial contamination resulting from human habitation is unavoidable; and – based on Mars’ current planetary protection category, robotic payload(s) should characterize the local martian environment for any life-forms prior to human habitation.Some of the outstanding questions are:– which interpretation of the hemispheric dichotomy of the planet is correct; – to what degree did deep-penetrating faults transport subsurface liquids to Mars’ surface; – in what abundance are carbonates formed by atmospheric processes; – what properties of martian meteorites could be used to constrain their source locations; – the origin(s) of organic macromolecules; – was/is Mars inhabited; – how can missions designed to uncover microbial activity in the subsurface eliminate potential false positives caused by microbial contaminants from Earth; – how can we ensure that humans and microbes form a stable and benign biosphere; and – should humans relate to putative extraterrestrial life from a biocentric viewpoint (preservation of all biology), or anthropocentric viewpoint of expanding habitation of space?Studies of Mars’ evolution can shed light on the habitability of extrasolar planets. In addition, Mars exploration can drive future policy developments and confirm (or put into question) the feasibility and/or extent of human habitability of space

Shared heritability and functional enrichment across six solid cancers

Correction: Nature Communications 10 (2019): art. 4386 DOI: 10.1038/s41467-019-12095-8Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.Peer reviewe

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals

Copy number variants (CNV) are established risk factors for neurodevelopmental disorders with seizures or epilepsy. With the hypothesis that seizure disorders share genetic risk factors, we pooled CNV data from 10,590 individuals with seizure disorders, 16,109 individuals with clinically validated epilepsy, and 492,324 population controls and identified 25 genome-wide significant loci, 22 of which are novel for seizure disorders, such as deletions at 1p36.33, 1q44, 2p21-p16.3, 3q29, 8p23.3-p23.2, 9p24.3, 10q26.3, 15q11.2, 15q12-q13.1, 16p12.2, 17q21.31, duplications at 2q13, 9q34.3, 16p13.3, 17q12, 19p13.3, 20q13.33, and reciprocal CNVs at 16p11.2, and 22q11.21. Using genetic data from additional 248,751 individuals with 23 neuropsychiatric phenotypes, we explored the pleiotropy of these 25 loci. Finally, in a subset of individuals with epilepsy and detailed clinical data available, we performed phenome-wide association analyses between individual CNVs and clinical annotations categorized through the Human Phenotype Ontology (HPO). For six CNVs, we identified 19 significant associations with specific HPO terms and generated, for all CNVs, phenotype signatures across 17 clinical categories relevant for epileptologists. This is the most comprehensive investigation of CNVs in epilepsy and related seizure disorders, with potential implications for clinical practice

A reprodução medicamente assistida e seus aspectos jurídicos e sucessórios

O presente trabalho tem por escopo analisar o direito sucessório do filho proveniente de inseminação artificial post mortem, ou seja, como será a vocação hereditária do filho concebido por meio da técnica homóloga póstuma, quando se utiliza o material genético do pai, ora falecido, que se encontrava conservado por meio de procedimentos especiais, para inseminar a viúva. Para se verificar as conseqüências advindas dessa inseminação, é feito um apanhado geral acerca da reprodução medicamente assistida, a iniciar-se pela evolução, a qual remota há tempos antigos, passando-se a apresentar as técnicas atualmente existentes, bem como a questão da filiação provinda da utilização da reprodução medicamente assistida. Após, faz-se uma análise a respeito do instituto sucessão, esboçando-se alguns pontos de suma relevância para a compreensão do tema, como os tipos de sucessão existentes, quem está legitimado a herdar, quando a herança se considera transferida aos herdeiros e como estes são classificados no ordenamento jurídico. Por fim, será procedida a junção dos capítulos anteriores, abordando-se a vocação hereditária do filho concebido post mortem, de forma a demonstrar por meio de quais preceitos legais e constitucionais os concebidos de forma póstuma estão amparados para ocuparem o pólo passivo da sucessão, assim como quais os dispositivos que os excluem do direito a herança, situação que gera um grande debate jurídico, competindo à doutrina a busca de uma solução para o caso

From chaos to clarity: the scientometric breakthrough in covid-19 research

This review brings a broad search of scientific articles from the initial periods of the COVID-19 pandemic, verifying which direction science followed at that time

Baricitinib Treatment of Coronavirus Disease 2019 Is Associated With a Reduction in Secondary Infections

We performed a secondary analysis of the National Institutes of Health-sponsored Adaptive COVID-19 Treatment Trial (ACTT-2) randomized controlled trial and found that baricitinib was associated with a 50% reduction in secondary infections after controlling for baseline and postrandomization patient characteristics. This finding provides a novel mechanism of benefit for baricitinib and supports the safety profile of this immunomodulator for the treatment of coronavirus disease 2019