84 research outputs found
Demonstration of fine pitch FCOB (Flip Chip on Board) assembly based on solder bumps at Fermilab
Bump bonding is a superior assembly alternative compared to conventional wire
bond techniques. It offers a highly reliable connection with greatly reduced
parasitic properties. The Flip Chip on Board (FCOB) procedure is an especially
attractive packaging method for applications requiring a large number of
connections at moderate pitch. This paper reports on the successful
demonstration of FCOB assembly based on solder bumps down to 250um pitch using
a SUESS MA8 flip chip bonder at Fermilab. The assembly procedure will be
described, microscopic cross sections of the connections are shown, and first
measurements on the contact resistance are presented.Comment: 4 pages, 8 figure
Status of a DEPFET pixel system for the ILC vertex detector
We have developed a prototype system for the ILC vertex detector based on
DEPFET pixels. The system operates a 128x64 matrix (with ~35x25 square micron
large pixels) and uses two dedicated microchips, the SWITCHER II chip for
matrix steering and the CURO II chip for readout. The system development has
been driven by the final ILC requirements which above all demand a detector
thinned to 50 micron and a row wise read out with line rates of 20MHz and more.
The targeted noise performance for the DEPFET technology is in the range of
ENC=100 e-. The functionality of the system has been demonstrated using
different radioactive sources in an energy range from 6 to 40keV. In recent
test beam experiments using 6GeV electrons, a signal-to-noise ratio of S/N~120
has been achieved with present sensors being 450 micron thick. For improved
DEPFET systems using 50 micron thin sensors in future, a signal-to-noise of 40
is expected.Comment: Invited poster at the International Symposium on the Development of
Detectors for Particle, AstroParticle and Synchrotron Radiation Experiments,
Stanford CA (SNIC06) 6 pages, 12 eps figure
Readout Concepts for DEPFET Pixel Arrays
Field effect transistors embedded into a depleted silicon bulk (DEPFETs) can
be used as the first amplifying element for the detection of small signal
charges deposited in the bulk by ionizing particles, X-ray photons or visible
light. Very good noise performance at room temperature due to the low
capacitance of the collecting electrode has been demonstrated. Regular two
dimensional arrangements of DEPFETs can be read out by turning on individual
rows and reading currents or voltages in the columns. Such arrangements allow
the fast, low power readout of larger arrays with the possibility of random
access to selected pixels. In this paper, different readout concepts are
discussed as they are required for arrays with incomplete or complete clear and
for readout at the source or the drain. Examples of VLSI chips for the steering
of the gate and clear rows and for reading out the columns are presented.Comment: 8 pages, 9 figures, submitted to Nucl. Instr. and Methods as
proceedings of the 9th European Symposium on Semiconductor Detectors, Elmau,
June 23-27, 200
Die prognostische Relevanz des Nachweises disseminierter Tumorzellen im Knochenmark und in Lymphknoten Level I nodal-negativer Mammakarzinompatientinnen
Fragestellung: Der Nachweis von CK+-KMM ist ein unabhängiger Prognosefaktor, der das primär auf den LK_Status ausgerichtete, aktuelle Tumorstaging beeinflussen könnte. In der vorliegenden Studie wurde untersucht, ob CK+-KMM und LKM parallel nachweisbar und jeweils prognostisch Relevant sind.
Methode: 300 KM-Aspirate und 1590 axilläre Level I LK von 150 nodal-negativer Patientinnen wurden mit monoklonalen anti-CK Antikörpern (A45-B/B3 und NCL-5D3) prospektiv analysiert und mit etablierten Prognosefaktoren verglichen. Die mediane Beobachtungszeit betrug 39 Monate
Ergebnisse: CK+-KMM fanden sich bei 44/150 (29%)und CK+-LKM bei 13/150 (9%) Patientinnen. ein CK+-Befund korrelierte nicht mit den etablierten Prognosefaktoren. Der Nachweis von CK+-KMM war nicht mit locoregionären Rezidiven aber mit Fernmetastasierung und tumorabhängigen Tod assoziiert. Der immunzytochemische LKM-Nachweis hatte keine prognostische Bedeutung. In der multiarianten Analyse blieb die CK-Positivität des KM ein unabhängiger Prognosefaktor mit einer Hazard-Ratio von 6,1 für ein verkürztes Gesamtüberleben.
Schlussfolgerung: Hämatogene, nicht jedoch lymphogene Mikrometastasierung scheint ein unabhängiger Prognosefaktor für nodal-negative Patientinnen zu sein. Dies könnte als Stratifizierungskriterium in adjuvanten Therapiestudien eingesetzt werden und zukünftige chirurgische Strategien beeinflussen
Die prognostische Relevanz des Nachweises disseminierter Tumorzellen im Knochenmark und in Lymphknoten Level I nodal-negativer Mammakarzinompatientinnen
Fragestellung: Der Nachweis von CK+-KMM ist ein unabhängiger Prognosefaktor, der das primär auf den LK_Status ausgerichtete, aktuelle Tumorstaging beeinflussen könnte. In der vorliegenden Studie wurde untersucht, ob CK+-KMM und LKM parallel nachweisbar und jeweils prognostisch Relevant sind.
Methode: 300 KM-Aspirate und 1590 axilläre Level I LK von 150 nodal-negativer Patientinnen wurden mit monoklonalen anti-CK Antikörpern (A45-B/B3 und NCL-5D3) prospektiv analysiert und mit etablierten Prognosefaktoren verglichen. Die mediane Beobachtungszeit betrug 39 Monate
Ergebnisse: CK+-KMM fanden sich bei 44/150 (29%)und CK+-LKM bei 13/150 (9%) Patientinnen. ein CK+-Befund korrelierte nicht mit den etablierten Prognosefaktoren. Der Nachweis von CK+-KMM war nicht mit locoregionären Rezidiven aber mit Fernmetastasierung und tumorabhängigen Tod assoziiert. Der immunzytochemische LKM-Nachweis hatte keine prognostische Bedeutung. In der multiarianten Analyse blieb die CK-Positivität des KM ein unabhängiger Prognosefaktor mit einer Hazard-Ratio von 6,1 für ein verkürztes Gesamtüberleben.
Schlussfolgerung: Hämatogene, nicht jedoch lymphogene Mikrometastasierung scheint ein unabhängiger Prognosefaktor für nodal-negative Patientinnen zu sein. Dies könnte als Stratifizierungskriterium in adjuvanten Therapiestudien eingesetzt werden und zukünftige chirurgische Strategien beeinflussen
2D Detectors for Particle Physics and for Imaging Applications
The demands on detectors for particle detection as well as for medical and
astronomical X-ray imaging are continuously pushing the development of novel
pixel detectors. The state of the art in pixel detector technology to date are
hybrid pixel detectors in which sensor and read-out integrated circuits are
processed on different substrates and connected via high density interconnect
structures. While these detectors are technologically mastered such that large
scale particle detectors can be and are being built, the demands for improved
performance for the next generation particle detectors ask for the development
of monolithic or semi-monolithic approaches. Given the fact that the demands
for medical imaging are different in some key aspects, developments for these
applications, which started as particle physics spin-off, are becomming rather
independent. New approaches are leading to novel signal processing concepts and
interconnect technologies to satisfy the need for very high dynamic range and
large area detectors. The present state in hybrid and (semi-)monolithic pixel
detector development and their different approaches for particle physics and
imaging application is reviewed
News, intelligence and 'little lies' : rumours between the Cherokees and the British 1740-1785
Rumour and information are one of the most fundamental ways in which people engage
with one another. Rumours can change the way that individuals and groups see each other
and the actions that they take. Sociologists and anthropologists have long used rumour as a
way to explore the experiences of their subjects. Historians of early America have, in recent
years, begun to make use of rumour as a way of examining the, often hidden, world of
interactions between American Indians and white Europeans. This thesis will expand upon
this work by exploring the changing role of rumour within an intercultural relationship over
several decades. This thesis will focus on rumour in the relationship between the Cherokee
Nation and the colonists of the British Empire. It will explore the ways that rumour
influenced these interactions and the impact of the rapidly changing backcountry
environment of the latter eighteenth century, both on rumour and on the wider Cherokee-
British relationship. This thesis will argue that rumour shifted in the course of the
eighteenth century from being a diplomatic tool which could be used- either to create
further panic and confusion or to calm and smooth over problems- to an uncontrollable
force which would deepen and exacerbate the divisions between Cherokees and the
British. Rumour played an important role in politics and society in the eighteenth century
backcountry and its changing function offers a way to better understand the shifting
currents of life in early America
Design and technology of DEPFET pixel sensors for linear collider applications
Abstract The performance requirements of vertex detectors for future linear collider experiments is very challenging, especially for the detector's innermost sensor layers. The DEPleted Field Effect Transistor (DEPFET), combining detector and amplifier operation, is capable to meet these requirements. A silicon technology is presented which allows production of large sensor arrays consisting of linear DEPFET detector structures. The envisaged pixel array offers low noise and low power operation. To ensure a high radiation length a thinning technology based on direct wafer bonding is proposed
Description and performance of track and primary-vertex reconstruction with the CMS tracker
A description is provided of the software algorithms developed for the CMS tracker both for reconstructing charged-particle trajectories in proton-proton interactions and for using the resulting tracks to estimate the positions of the LHC luminous region and individual primary-interaction vertices. Despite the very hostile environment at the LHC, the performance obtained with these algorithms is found to be excellent. For tbar t events under typical 2011 pileup conditions, the average track-reconstruction efficiency for promptly-produced charged particles with transverse momenta of pT > 0.9GeV is 94% for pseudorapidities of |η| < 0.9 and 85% for 0.9 < |η| < 2.5. The inefficiency is caused mainly by hadrons that undergo nuclear interactions in the tracker material. For isolated muons, the corresponding efficiencies are essentially 100%. For isolated muons of pT = 100GeV emitted at |η| < 1.4, the resolutions are approximately 2.8% in pT, and respectively, 10μm and 30μm in the transverse and longitudinal impact parameters. The position resolution achieved for reconstructed primary vertices that correspond to interesting pp collisions is 10–12μm in each of the three spatial dimensions. The tracking and vertexing software is fast and flexible, and easily adaptable to other functions, such as fast tracking for the trigger, or dedicated tracking for electrons that takes into account bremsstrahlung
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