The demands on detectors for particle detection as well as for medical and
astronomical X-ray imaging are continuously pushing the development of novel
pixel detectors. The state of the art in pixel detector technology to date are
hybrid pixel detectors in which sensor and read-out integrated circuits are
processed on different substrates and connected via high density interconnect
structures. While these detectors are technologically mastered such that large
scale particle detectors can be and are being built, the demands for improved
performance for the next generation particle detectors ask for the development
of monolithic or semi-monolithic approaches. Given the fact that the demands
for medical imaging are different in some key aspects, developments for these
applications, which started as particle physics spin-off, are becomming rather
independent. New approaches are leading to novel signal processing concepts and
interconnect technologies to satisfy the need for very high dynamic range and
large area detectors. The present state in hybrid and (semi-)monolithic pixel
detector development and their different approaches for particle physics and
imaging application is reviewed