Prevalence and profile of depressive mixed state in patients with autism spectrum disorder

Purpose: The present study aimed to clarify prevalence and profile of depressive mixed state (DMX) in depressed individuals with autism spectrum disorder (ASD). Patients and methods: The Quick Inventory of Depressive Symptomatology Self-Report Japanese version (QIDS-SR-J) and global assessment of functioning (GAF) were administered to 182 consecutive patients (36 ASD and 146 non-ASD subjects) with a major depressive episode (MDE). DMX was categorically diagnosed according to the criteria for mixed depression (MD) by Benazzi and mixed features (MF) specifier by DSM-5. Severity of DMX was assessed by the self-administered 12-item questionnaire for DMX (DMX-12). Clinical backgrounds and incidence/severity of DMX were compared between the ASD and non-ASD groups. Results: ASD patients showed higher prevalence of MD than non-ASD patients (36.1% versus 18.5%). Mood lability, distractibility, impulsivity, aggression, irritability, dysphoria and risk-taking behavior as mixed symptoms were more prevalent in ASD patients than those in non-ASD patients, together with higher scores of total DMX-12 and its disruptive emotion/behavior cluster. Multiple regression analysis revealed significant contribution of ASD to the disruptive emotion/behavior symptoms. Conclusion: Careful monitoring and management of potential DMX are warranted in depressed ASD individuals

The 12-Item Self-Rating Questionnaire for Depressive Mixed State (DMX-12) for Screening of Mixed Depression and Mixed Features

For simultaneous screening of mixed features (MF) by DSM-5 and mixed depression (MD) by Benazzi, useful symptoms were extracted from our 12-item dimensional scale for depressive mixed state (DMX-12). Subjects were 190 consecutive cases with major depressive episode (MDE) who visited our clinic. Associations between symptomatological combinations of the DMX-12 and MF or MD were analyzed using receiver operating characteristic (ROC). The rate of MF was 4.2% while that of MD was 22.6%. Eight symptoms (overreactivity, inner tension, racing/crowded thought, impulsivity, irritability, aggression, risk-taking behavior, and dysphoria) with their AUC > 0.6 for ROC curves were specially focused on distinguishing patients with MF or MD from non-mixed patients. By using these 8 symptoms, 40.5% of the overall patients were screened as positive at the same cut-off value (≥13) for both MD and MF. The AUC of ROC curve and sensitivity/specificity were well balanced together with sufficient negative predictive values. The abovementioned 8 symptoms seem to be helpful for primary screening and negative check of DMX with considerable severity during MDE

The application of Dohsa-hou to the mothers who have the child with physically handicapped

要約 Ⅰ.問題 Ⅱ.本研究の目的 Ⅲ.活動の概要 Ⅳ.事例経過 Ⅴ.考察 Ⅵ.今後の課題 引用文献本稿では，肢体不自由の子どもを持つ親の会のメンバーからの相談に基づいた健康動作法の実践（生涯発達支援部門）について報告し同時にその意義を考えることを目的とする。来談者は、肢体不自由の子どもを持つ保護者（母親） 9名である。参加者は主として成人した肢体不自由の子どもを持ち， 日常生活における介護，家事，仕事の疲労などから身体の痛みや硬さなどの訴えが主なもので、あった。来談者は，動作法については子どもへの実践によってリラクセイション効果なとさについては知っているため動作法を受ける ことを希望しそれに基づいて月約2回の割合で3年間継続した。その健康動作法の実施の結果，身体的な不具合と身体・生活の不安の軽減などが本稿では，肢体不自由の子どもを持つ親の会のメンバーからの相談に基づいた健康動作法の実践（生涯発達支援部門）について報告し同時にその意義を考えることを目的とする。来談者は、肢体不自由の子どもを持つ保護者（母親） 9名である。参加者は主として成人した肢体不自由の子どもを持ち， 日常生活における介護，家事，仕事の疲労などから身体の痛みや硬さなどの訴えが主なもので、あった。来談者は，動作法については子どもへの実践によってリラクセイション効果などついては知っているため動作法を受けることを希望しそれに基づいて月約2回の割合で3年間継続した。その健康動作法の実施の結果，身体的な不具合と身体・生活の不安の軽減などが実感され，日常生活において肢体不自由を持つ子どもに対しての介助や世話にもゆとりが感じられるようになったなどの感想が述べられるようになった。これらのことから健康動作法を実施することは，肢体不自由の子どもを持つ親の日常を支えることにつながることが示唆された。The purpose of this study is to discuss the effects of Dohsa-hou to the mothers who had the son or daughter with physically handicapped causing cerebral palsy. Their child became to be adult who had continued to undergo Dohsa-hou therapy. They, however, had stiffness at any parts of body and they needed supports from the parents in daily life. The parents, especially mothers were hard to take care of their child, so they felt tired and had stiffness at their body like as the son and daughter. They knew very well the effect of Dohsa-hou, because they had own experience of Dousa-hou practice to their child. So, they applied the Dousa-hou to the Center, Kyushu University. They had been taken Dohsa-hou therapy twice a month for 3 years. Each session is 1 hour. The results of the therapy were the following. The clients described and reported that their stiffness and pain ant the body has been weakened and their anxiety of body or the behaviors of daily life have been reduced. And then, they reported that they felt easy and relaxed to take care of the child in daily life. These clients reports and descriptions suggest that Dohsa-hou could be effective as the support method for the parents who should be take care of their child with physically handicapped