Strengthening mechanisms in thermomechanically processed NbTi-microalloyed steel

The effect of deformation temperature on microstructure and mechanical properties was investigated for thermomechanically processed NbTi-microalloyed steel with ferrite-pearlite microstructure. With a decrease in the finish deformation temperature at 1348 K to 1098 K (1075 °C to 825 °C) temperature range, the ambient temperature yield stress did not vary significantly, work hardening rate decreased, ultimate tensile strength decreased, and elongation to failure increased. These variations in mechanical properties were correlated to the variations in microstructural parameters (such as ferrite grain size, solid solution concentrations, precipitate number density and dislocation density). Calculations based on the measured microstructural parameters suggested the grain refinement, solid solution strengthening, precipitation strengthening, and work hardening contributed up to 32 pct, up to 48 pct, up to 25 pct, and less than 3 pct to the yield stress, respectively. With a decrease in the finish deformation temperature, both the grain size strengthening and solid solution strengthening increased, the precipitation strengthening decreased, and the work hardening contribution did not vary significantly

Recurrent Coding Sequence Variation Explains only A Small Fraction of the Genetic Architecture of Colorectal Cancer

Whilst common genetic variation in many non-coding genomic regulatory regions are known to impart risk of colorectal cancer (CRC), much of the heritability of CRC remains unexplained. To examine the role of recurrent coding sequence variation in CRC aetiology, we genotyped 12,638 CRCs cases and 29,045 controls from six European populations. Single-variant analysis identified a coding variant (rs3184504) in SH2B3 (12q24) associated with CRC risk (OR = 1.08, P = 3.9 × 10-7), and novel damaging coding variants in 3 genes previously tagged by GWAS efforts; rs16888728 (8q24) in UTP23 (OR = 1.15, P = 1.4 × 10-7); rs6580742 and rs12303082 (12q13) in FAM186A (OR = 1.11, P = 1.2 × 10-

Prunella vulgaris: A comprehensive review of chemical constituents, pharmacological effects and clinical applications.

Prunella vulgaris (PV) is a perennial herb belonging to the Labiate family and is widely distributed in northeastern Asian countries such as Korea, Japan, and China. It is reported to display diverse biological activities including anti-microbial, anti-cancer, and anti-inflammation as determined by in vitro or in vivo studies. So far, about 200 compounds have been isolated from PV plant and majority of these have been characterized mainly as triterpenoids, sterols and flavonoids, followed by coumarins, phenylpropanoids, polysaccharides and volatile oils. This review summarizes and analyzes the current knowledge on the chemical constituents, pharmacological activities, mechanisms of action and clinical applications of the PV plant including its potential as a future medicinal plant. Although some of the chemical constituents of the PV plant and their mechanism of action have been investigated the biological activities of many of these remain unknown and further clinical trials are required to further enhance its reputation as a medicinal plant

Projected WIMP sensitivity of the LUX-ZEPLIN dark matter experiment

LUX-ZEPLIN (LZ) is a next-generation dark matter direct detection experiment that will operate 4850 feet underground at the Sanford Underground Research Facility (SURF) in Lead, South Dakota, USA. Using a two-phase xenon detector with an active mass of 7 tonnes, LZ will search primarily for low-energy interactions with weakly interacting massive particles (WIMPs), which are hypothesized to make up the dark matter in our galactic halo. In this paper, the projected WIMP sensitivity of LZ is presented based on the latest background estimates and simulations of the detector. For a 1000 live day run using a 5.6-tonne fiducial mass, LZ is projected to exclude at 90% confidence level spin-independent WIMP-nucleon cross sections above 1.4 × 10-48cm2 for a 40 GeV/c2 mass WIMP. Additionally, a 5σ discovery potential is projected, reaching cross sections below the exclusion limits of recent experiments. For spin-dependent WIMP-neutron(-proton) scattering, a sensitivity of 2.3 × 10−43 cm2 (7.1 × 10−42 cm2) for a 40 GeV/c2 mass WIMP is expected. With underground installation well underway, LZ is on track for commissioning at SURF in 2020

Formación docente para la implementación de la plataforma virtual Moodle como recurso didáctico en educación básica secundaria

1 recurso en línea (288 páginas) : ilustraciones color, tablas.Este estudio describe una experiencia llevada a cabo en entornos virtuales de aprendizaje Moodle, donde se planteó la utilización de la Educación Virtual como recurso didáctico educativo. A partir de un proceso de formación docente para la implementación de la plataforma virtual Moodle como recurso didáctico de enseñanza, se analizó si se presentaron cambios significativos en las competencias digitales: Pedagógica, tecnológica, comunicativa y de gestión, y a partir de ello se mejoró el desempeño pedagógico de los educadores; de igual forma se indago sobre la posibilidad de que las plataformas virtuales como Moodle puedan convertirse en una alternativa viable que pueda dar respuesta a los nuevos retos educativos relacionados con los ambientes virtuales de aprendizaje para dinamizar el proceso educativo. Como objetivo general del estudio se planteó Identificar las competencias digitales que poseen los docentes para el uso y administración de la plataforma Moodle, en el nivel de educación básica secundaria y media de la Institución Educativa Técnica de Monguí, para implementar un programa de formación encaminado a fortalecer dichas competencias. La metodología empleada en el estudio fue de tipo mixto, porque involucra aspectos cuantitativos como la medición de las variable competencias digitales desarrolladas por los docentes para el empleo de la plataforma virtual Moodle, desde el paradigma cualitativo se tuvieron en cuenta las opiniones y conceptos de los sujetos participantes en el estudio; de los resultados obtenidos se encontró que los programas de formación docente para el uso didáctico de las TIC en entornos de aprendizaje virtual como la plataforma Moodle, cuando son orientados con un modelo pedagógico activo diferente al catedrático, permiten que los educadores apropien el uso de estas tecnologías y sean gestores de proyectos que dinamizan el proceso enseñanza – aprendizaje, al brindar al estudiante la posibilidad de ser un agente participativo y por su puesto al educador ser guía y orientador en el proceso educativo.This study describes an experience carried out in Moodle virtual learning environments, where the use of Virtual Education as an educational didactic resource was proposed. From a process of teacher training for the implementation of the Moodle virtual platform as a didactic teaching resource, it was analyzed if there were significant changes in the digital competences: Pedagogical, technological, communicative and management, and from this the pedagogical performance of educators; In the same way, I inquired about the possibility that virtual platforms such as Moodle could become a viable alternative that could respond to new educational challenges related to virtual learning environments to boost the educational process. The general objective of the study was to identify the digital competences that teachers possess for the use and administration of the Moodle platform, at the level of secondary and secondary education of the Technical Educational Institution of Monguí, to implement a training program aimed at strengthen these competences The methodology used in the study was of mixed type, because it involved quantitative aspects such as the measurement of the variable digital competences developed by teachers for the use of the Moodle virtual platform, from the qualitative paradigm the opinions and concepts of the subjects participating in the study; From the results obtained it was found that the teacher training programs for the didactic use of ICT in virtual learning environments such as the Moodle platform, when they are oriented with an active pedagogical model different from the professor, allow educators to appropriate the use of these technologies and managers of projects that dynamize the teaching - learning process, giving the student the possibility of being a participative agent and of course the educator being a guide and guidance in the educational process.Bibliografía y webgrafía: páginas 196-205MaestríaMagíster en TIC Aplicadas a las Ciencias de la Educació

Transverse momentum spectra of charged particles in proton-proton collisions at s=900\sqrt{s} = 900 GeV with ALICE at the LHC

The inclusive charged particle transverse momentum distribution is measured in proton-proton collisions at $\sqrt{s} = 900$ GeV at the LHC using the ALICE detector. The measurement is performed in the central pseudorapidity region $(|\eta|<0.8)$ over the transverse momentum range $0.15<p_{\rm T}<10$ GeV/$c$. The correlation between transverse momentum and particle multiplicity is also studied. Results are presented for inelastic (INEL) and non-single-diffractive (NSD) events. The average transverse momentum for $|\eta|<0.8$ is $\left<p_{\rm T}\right>_{\rm INEL}=0.483\pm0.001$ (stat.) $\pm0.007$ (syst.) GeV/$c$ and \left_{\rm NSD}=0.489\pm0.001 (stat.) $\pm0.007$ (syst.) GeV/$c$, respectively. The data exhibit a slightly larger $\left<p_{\rm T}\right>$ than measurements in wider pseudorapidity intervals. The results are compared to simulations with the Monte Carlo event generators PYTHIA and PHOJET.Comment: 20 pages, 8 figures, 2 tables, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/390