An instantiation of the Cramer-Shoup encryption paradigm using bilinear map groups

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The security of PSEC-KEM versus ECIES-KEM

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On the Creation of Diverse Ensembles for Nonstationary Environments using Bio-inspired Heuristics

Recently the relevance of adaptive models for dynamic data environments has turned into a hot topic due to the vast number of sce- narios generating nonstationary data streams. When a change (concept drift) in data distribution occurs, the ensembles of models trained over these data sources are obsolete and do not adapt suitably to the new distribution of the data. Although most of the research on the field is focused on the detection of this drift to re-train the ensemble, it is widely known the importance of the diversity in the ensemble shortly after the drift in order to reduce the initial drop in accuracy. In a Big Data sce- nario in which data can be huge (and also the number of past models), achieving the most diverse ensemble implies the calculus of all possible combinations of models, which is not an easy task to carry out quickly in the long term. This challenge can be formulated as an optimization prob- lem, for which bio-inspired algorithms can play one of the key roles in these adaptive algorithms. Precisely this is the goal of this manuscript: to validate the relevance of the diversity right after drifts, and to un- veil how to achieve a highly diverse ensemble by using a self-learning optimization technique

Annona cherimolia Mill.: Histología e histoquímica de raíz, tallo, hoja y fruto

Se ha realizado el estudio histológico e bistoquímico de la raíz, tallo, boja y fruto de Annona cherimolia Mill. Desde el punto de vista histoquímico, cabe destacar la presencia de alcaloides, flavonoides y taminos como componentes más abundantes, existiendo también aceites esenciales.A histologic and histochemical study of roots, stems, leaves and fruits of Annona cherimolia MilI. has been carried out. From a bistochemical point of view alkaloids, flavonoids and tanins were tbe most quantitatively important compounds. Essential oil was also detected

Evaluation of turbulent dissipation rate retrievals from Doppler Cloud Radar

Turbulent dissipation rate retrievals from cloud radar Doppler velocity measurements are evaluated using independent, in situ observations in Arctic stratocumulus clouds. In situ validation data sets of dissipation rate are derived using sonic anemometer measurements from a tethered balloon and high frequency pressure variation observations from a research aircraft, both flown in proximity to stationary, ground-based radars. Modest biases are found among the data sets in particularly low- or high-turbulence regimes, but in general the radar-retrieved values correspond well with the in situ measurements. Root mean square differences are typically a factor of 4-6 relative to any given magnitude of dissipation rate. These differences are no larger than those found when comparing dissipation rates computed from tetheredballoon and meteorological tower-mounted sonic anemometer measurements made at spatial distances of a few hundred meters. Temporal lag analyses suggest that approximately half of the observed differences are due to spatial sampling considerations, such that the anticipated radar-based retrieval uncertainty is on the order of a factor of 2-3. Moreover, radar retrievals are clearly able to capture the vertical dissipation rate structure observed by the in situ sensors, while offering substantially more information on the time variability of turbulence profiles. Together these evaluations indicate that radar-based retrievals can, at a minimum, be used to determine the vertical structure of turbulence in Arctic stratocumulus clouds

Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration

The renin-angiotensin system (RAS) was initially considered as a circulating humoral system controlling blood pressure, being kidney the key control organ. In addition to the \u27classical\u27 humoral RAS, a second level in RAS, local or tissular RAS, has been identified in a variety of tissues, in which local RAS play a key role in degenerative and aging-related diseases. The local brain RAS plays a major role in brain function and neurodegeneration. It is normally assumed that the effects are mediated by the cell-surface-specific G-protein-coupled angiotensin type 1 and 2 receptors (AT1 and AT2). A combination of in vivo (rats, wild-type mice and knockout mice) and in vitro (primary mesencephalic cultures, dopaminergic neuron cell line cultures) experimental approaches (confocal microscopy, electron microscopy, laser capture microdissection, transfection of fluorescent-tagged receptors, treatments with fluorescent angiotensin, western blot, polymerase chain reaction, HPLC, mitochondrial respirometry and other functional assays) were used in the present study. We report the discovery of AT1 and AT2 receptors in brain mitochondria, particularly mitochondria of dopaminergic neurons. Activation of AT1 receptors in mitochondria regulates superoxide production, via Nox4, and increases respiration. Mitochondrial AT2 receptors are much more abundant and increase after treatment of cells with oxidative stress inducers, and produce, via nitric oxide, a decrease in mitochondrial respiration. Mitochondria from the nigral region of aged rats displayed altered expression of AT1 and AT2 receptors. AT2-mediated regulation of mitochondrial respiration represents an unrecognized primary line of defence against oxidative stress, which may be particularly important in neurons with increased levels of oxidative stress such as dopaminergic neurons. Altered expression of AT1 and AT2 receptors with aging may induce mitochondrial dysfunction, the main risk factor for neurodegeneratio

4. HYBAM: un observatorio para medir el impacto del Cambio Climático sobre la erosión y los flujos de sedimentos en la zona Andino-Amazónica

La cuenca Amazónica es la más grande del mundo. La instalación del observatorio HYBAM con una amplia red de estaciones hidrológicas ubicadas desde el piedemonte andino hasta el océano Atlántico permite, desde el 2003, la generación de registros periódicos y confiables (nivel del agua, caudal, concentración de sedimentos y otros parámetros físico-químicos de la calidad del agua) a lo largo de toda la cuenca. Hoy en día, el desarrollo de técnicas satelitales, como la altimetría, permite completar eficientemente los datos obtenidos por las redes de medición en los ríos. El recrudecimiento de eventos extremos en la Amazonia (Inundaciones, sequias,) por efecto del cambio climático actual asociado a un cambio acelerado de ocupación de los suelos (deforestación, prácticas agrícolas), tiene una incidencia directa sobre la producción sedimentarla. Conocer los flujos de materiales transportados por los ríos es esencial tanto para la navegación fluvial como para guiar la explotación de los recursos naturales (agua, petróleo, minerales), para conocer el transporte de partículas contaminantes o para diseñar infraestructuras.Le bassin de l’Amazone est le plus grand du monde. La mise en œuvre de l’observatoire HYBAM avec un vaste réseau de stations hydrologiques situées sur les contreforts des Andes jusqu’á l’océan Atlantique permet de générer, depuis 2003, des données régulières et fiables tout le long du bassin (hauteur d’eau, débit, concentration de sédiments et d’autres paramètres physico-chimiques de qualité de l’eau). De nos jours, la mise au point des techniques par satellite, tels que l’altimétrie, permet de compléter efficacement les données obtenues par les réseaux de mesure dans les rivières. L’intensification des événements extrêmes dans la région amazonienne (inondations, sécheresses), liés au changement climatique actuel associé á un changement rapide de l’utilisation des terres (déforestation, pratiques agricoles), ont un impact direct sur la production de sédiments. Connaître les flux de matières transportés par les rivières est essentiel pour la navigation fluviale ainsi que pour guider l’exploitation des ressources naturelles (eau, pétrole, minéraux), connaître le trajet de particules polluantes ou concevoir des infrastructures.The Amazon basin is the largest basin in the world. The implementation of the HYBAM observatory, which has installed a large network of hydrological stations located from the Andean foothills down to the Atlantic Ocean, allows since 2003, generate periodical and reliable records (such as water level, flow, sediment concentration and other physicochemical parameters of water quality) along the entire basin. Nowadays, the development of satellite techniques, (such as altimetry), makes it possible to efficiently complete the data obtained by the measurement networks in rivers. The intensification of extreme events in the Amazon region (floods, droughts) occurred as a result of the current Climate Change associated with a more rapid change of land use (deforestation, agricultural practices) have a direct impact on sediment production. It is essential to know the flows of the materials transported by rivers, both for river navigation as well as to guide the exploitation of natural resources (water, oil, minerals), to know the transport of particulate pollutants, or to design infrastructures

Anisotropic flow of charged hadrons, pions and (anti-)protons measured at high transverse momentum in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}=2.76 TeV

The elliptic, $v_2$, triangular, $v_3$, and quadrangular, $v_4$, azimuthal anisotropic flow coefficients are measured for unidentified charged particles, pions and (anti-)protons in Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV with the ALICE detector at the Large Hadron Collider. Results obtained with the event plane and four-particle cumulant methods are reported for the pseudo-rapidity range $|\eta|<0.8$ at different collision centralities and as a function of transverse momentum, $p_{\rm T}$, out to $p_{\rm T}=20$ GeV/$c$. The observed non-zero elliptic and triangular flow depends only weakly on transverse momentum for $p_{\rm T}>8$ GeV/$c$. The small $p_{\rm T}$ dependence of the difference between elliptic flow results obtained from the event plane and four-particle cumulant methods suggests a common origin of flow fluctuations up to $p_{\rm T}=8$ GeV/$c$. The magnitude of the (anti-)proton elliptic and triangular flow is larger than that of pions out to at least $p_{\rm T}=8$ GeV/$c$ indicating that the particle type dependence persists out to high $p_{\rm T}$.Comment: 16 pages, 5 captioned figures, authors from page 11, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/186

Efficacy and safety of preoperative preparation with Lugol''s iodine solution in euthyroid patients with Graves’ disease (LIGRADIS Trial): Study protocol for a multicenter randomized trial

Background: Currently, both the American Thyroid Association and the European Thyroid Association recommend preoperative preparation with Lugol''s Solution (LS) for patients undergoing thyroidectomy for Graves’ Disease (GD), but their recommendations are based on low-quality evidence. The LIGRADIS trial aims to provide evidence either to support or refute the systematic use of LS in euthyroid patients undergoing thyroidectomy for GD. Methods: A multicenter randomized controlled trial will be performed. Patients =18 years of age, diagnosed with GD, treated with antithyroid drugs, euthyroid and proposed for total thyroidectomy will be eligible for inclusion. Exclusion criteria will be prior thyroid or parathyroid surgery, hyperparathyroidism that requires associated parathyroidectomy, thyroid cancer that requires adding a lymph node dissection, iodine allergy, consumption of lithium or amiodarone, medically unfit patients (ASA-IV), breastfeeding women, preoperative vocal cord palsy and planned endoscopic, video-assisted or remote access surgery. Between January 2020 and January 2022, 270 patients will be randomized for either receiving or not preoperative preparation with LS. Researchers will be blinded to treatment assignment. The primary outcome will be the rate of postoperative complications: hypoparathyroidism, recurrent laryngeal nerve injury, hematoma, surgical site infection or death. Secondary outcomes will be intraoperative events (Thyroidectomy Difficulty Scale score, blood loss, recurrent laryngeal nerve neuromonitoring signal loss), operative time, postoperative length of stay, hospital readmissions, permanent complications and adverse events associated to LS. Conclusions: There is no conclusive evidence supporting the benefits of preoperative treatment with LS in this setting. This trial aims to provide new insights into future Clinical Practice Guidelines recommendations. Trial registration: ClinicalTrials.gov identifier: NCT03980132. © 202

Centrality dependence of charged particle production at large transverse momentum in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm{NN}}} = 2.76 TeV

The inclusive transverse momentum ($p_{\rm T}$) distributions of primary charged particles are measured in the pseudo-rapidity range $|\eta|<0.8$ as a function of event centrality in Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}=2.76$ TeV with ALICE at the LHC. The data are presented in the $p_{\rm T}$ range $0.15<p_{\rm T}<50$ GeV/$c$ for nine centrality intervals from 70-80% to 0-5%. The Pb-Pb spectra are presented in terms of the nuclear modification factor $R_{\rm{AA}}$ using a pp reference spectrum measured at the same collision energy. We observe that the suppression of high-$p_{\rm T}$ particles strongly depends on event centrality. In central collisions (0-5%) the yield is most suppressed with $R_{\rm{AA}}\approx0.13$ at $p_{\rm T}=6$-7 GeV/$c$. Above $p_{\rm T}=7$ GeV/$c$, there is a significant rise in the nuclear modification factor, which reaches $R_{\rm{AA}} \approx0.4$ for $p_{\rm T}>30$ GeV/$c$. In peripheral collisions (70-80%), the suppression is weaker with $R_{\rm{AA}} \approx 0.7$ almost independently of $p_{\rm T}$. The measured nuclear modification factors are compared to other measurements and model calculations.Comment: 17 pages, 4 captioned figures, 2 tables, authors from page 12, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/284