Determination of Influence of Auxiliary Ingredients on Antioxidant Activity of Extract of Leaves of the Quince and Grapes Seed Meal in Phytogel with the Use of Spectrometric Method with the Dpph Indicator System

To study an impact of auxiliary substances on gel containing extracts of quince leaves and grape seed meal, which is based on polymethylsiloxane.Pharmaco - technological and physicochemical methods. In this study, a spectrophotometric method is applied to determine an antioxidant activity of the gel.We examined an impact of auxiliary substances on the gel. According to the results of studies we chose auxiliary ingredients which improve not only gustatory quality but also technological parameters. Applying spectrometric analysis, we investigated an antioxidant activity of phytogel. The gel has a structure of rigid matrix, which is built through a process of condensation of methylsilanetriol and siloxane bonds between the silicon atoms, which makes it possible to maintain and stabilize active natural ingredients. The experiment proved that the extract of leaves of quince and grape seed meal have some antioxidant activity. But, upon the introduction of stevia extract as a coregent taste, the gel that contains quince leaf extract and grape seed meal increases the antioxidant activity. Phytogel has antioxidant activity of 84% relative to the reference sample, which suggests that the gel can resist the harmful effects of free radicals, which are constantly produced in the human organismIt was confirmed that the addition of auxiliary substances into the gel with the extracts of quince leaves and grape seed meal based on polymethylsiloxane increases bioavailability and therapeutic efficiency, in particular, the antioxidant activity, of the gel.Stevia extract as an adjuvant in the phytogel, as gustatory corrector, increases the antioxidant activity of phyto pharmaceutical drugs

DETERMINATION OF INFLUENCE OF AUXILIARY INGREDIENTS ON ANTIOXIDANT ACTIVITY OF EXTRACT OF LEAVES OF THE QUINCE AND GRAPES SEED MEAL IN PHYTOGEL WITH THE USE OF SPECTROMETRIC METHOD WITH THE DPPH INDICATOR SYSTEM

To study an impact of auxiliary substances on gel containing extracts of quince leaves and grape seed meal, which is based on polymethylsiloxane. Pharmaco - technological and physicochemical methods. In this study, a spectrophotometric method is applied to determine an antioxidant activity of the gel. We examined an impact of auxiliary substances on the gel. According to the results of studies we chose auxiliary ingredients which improve not only gustatory quality but also technological parameters. Applying spectrometric analysis, we investigated an antioxidant activity of phytogel. The gel has a structure of rigid matrix, which is built through a process of condensation of methylsilanetriol and siloxane bonds between the silicon atoms, which makes it possible to maintain and stabilize active natural ingredients. The experiment proved that the extract of leaves of quince and grape seed meal have some antioxidant activity. But, upon the introduction of stevia extract as a coregent taste, the gel that contains quince leaf extract and grape seed meal increases the antioxidant activity. Phytogel has antioxidant activity of 84% relative to the reference sample, which suggests that the gel can resist the harmful effects of free radicals, which are constantly produced in the human organism It was confirmed that the addition of auxiliary substances into the gel with the extracts of quince leaves and grape seed meal based on polymethylsiloxane increases bioavailability and therapeutic efficiency, in particular, the antioxidant activity, of the gel. Stevia extract as an adjuvant in the phytogel, as gustatory corrector, increases the antioxidant activity of phyto pharmaceutical drugs

MYOPATHY AS A DESTABILIZING FACTOR OF MEAT QUALITY FORMATION

This review paper is devoted to myopathy of slaughter animals and poultry, and examines a relationship between fast growth of muscle tissue in hybrid pigs, broiler chickens and turkey, and high frequency of detection of spontaneous or idiopathic myopathies. The development of myopathy reduces consumer and technological properties of meat, and leads to emergence of different pathological conditions (PSE or RSE meat, «destructured meat», «white» or «green» meat, punctate hemorrhage, «wooden breast» and others). Two types of myopathic conditions are examined: myopathies caused by stress in animals and nutritional myopathies, which contribution to meat quality deterioration seems to be determinative. It is shown that the basis of the mechanism of the myopathy development is the mechanism of the successive changes in muscle tissue: damage of cell membranes and release of mitochondrial calcium, which causes hypercontraction, dystrophic changes, atrophy and necrosis of muscle fibers. To alleviate the damaging effect of two types of myopathies, different substances-adaptogens (selenium, vitamin E, flavonoids and others) can be used. It is stated that the requirements of animals in adaptogens change with an increase in the indicators of their productivity.This review paper is devoted to myopathy of slaughter animals and poultry, and examines a relationship between fast growth of muscle tissue in hybrid pigs, broiler chickens and turkey, and high frequency of detection of spontaneous or idiopathic myopathies. The development of myopathy reduces consumer and technological properties of meat, and leads to emergence of different pathological conditions (PSE or RSE meat, «destructured meat», «white» or «green» meat, punctate hemorrhage, «wooden breast» and others). Two types of myopathic conditions are examined: myopathies caused by stress in animals and nutritional myopathies, which contribution to meat quality deterioration seems to be determinative. It is shown that the basis of the mechanism of the myopathy development is the mechanism of the successive changes in muscle tissue: damage of cell membranes and release of mitochondrial calcium, which causes hypercontraction, dystrophic changes, atrophy and necrosis of muscle fibers. To alleviate the damaging effect of two types of myopathies, different substances-adaptogens (selenium, vitamin E, flavonoids and others) can be used. It is stated that the requirements of animals in adaptogens change with an increase in the indicators of their productivity

Managing art projects with societal impact : study book for students, stakeholders and researchers

This publication is an outcome of a joint co-writing effort created together with several researchers: Riikka Anttonen, Victoria Ateca-Amestoy, Kaisa Holopainen, Tanja Johansson, Annukka Jyrämä, Anne Karkkunen, Kaari-Kiitsak Prikk, Kristina Kuznetsova-Bogdanovitš, Mervi Luonila, Juko-Mart Kõlar, Beatriz Plaza, Kätlin Pulk, Tiina Pusa, Anna Ranczakowska-Ljutjuk, Marge Sassi, Ira Stiller and Anne Äyväri. We have each contributed to the building and commenting on the chapters, not only within our fields of expertise but conjointly and collectively throughout the Study Book. The book is based on our joint activities within Managing Art Projects with Societal Impact (MAPSI) – project in EU Erasmus+ Lifelong learning –programme (201-32016). MAPSI joins five organizations that each bring into the project their special expertise; Estonian Academy of Theatre and Music, Estonian Business School, Laurea University of Applied Sciences, Sibelius Academy of the University of the Arts Helsinki and Universidad del País Vasco / Euskal Herriko Unibertsitatea UPV/EHU (for more information about the project please see http://www.mapsi.eu/). During the project we have learnt to question each other, reflect together, and jointly create new knowledge across the different fields of experiences. The Study Book highlights this process way of working. The aims of MAPSI project were: • To create a specialization module in master programs in management of artistic projects with societal impact • To create an international network focusing on educating cultural managers and facilitators to manage and mediate artistic and cultural projects with societal impact. • Create an innovative field of specialization in the context of art/cultural management master’s programmes that train the future managers and mediators for artistic projects with societal impact • Develop new teaching materials and content of high quality that contribute to the European arts/cultural management education • Build up a conception of new integrated models for interactive study and internships This Study Book is one way to respond to these aims. The book is particularly called a ‘study book’, aiming not to give direct answers, but to open avenues for students and practitioners to reflect and learn to create their own way of managing art project with societal impact. The book provides analysis of the current practices, skills and the competences need for successful interaction between art and society. It contains multiple cases and examples as well as theoretical perspectives and tools for managers to build up their knowledge, competences and skills to manage art projects with societal impact. Yet, as we firmly believe that there is never only one right way to do 4 this, we do not provide only one way or a model to apply, but various perspectives to create one’s own model or models that could work in some specific contexts and circumstances. The key target group of the Study Book is students in arts management, social studies, arts, or economics interested in the field where art is used for societal engagement. We also believe that it contributes to the people already working or aiming to work in art projects or organizations with societal impact. We hope that our readers will not only acquire answers but also new questions; new knowledge and new perspectives building further the content of the book

Mechanical and biocompatible properties of the poly(lactide-co-glycolide) matrices produced by antisolvent 3D printing

Three-dimensional scaffolds were made from a solution of poly(lactide-co-glycolide) mixed with tetraglycol using antisolvent 3D printing. The elastic properties and the structure of the obtained matrices were studied. MTT-test and staining with PKH-26, Calcein-AM, DAPI with subsequent fluorescence microscopy were used to study biological properties. The three-dimensional scaffolds had good mechanical properties. Young’s modulus value was 18±2 MPa, tensile strength was 0.43±0.05 MPa. The relative survival rate of cells after the first day was 99.58±2.28%, on the 14th day – 98.14±2.22%. The structure of the scaffold promoted cell adhesion and spreading on its surface. The poly(lactide-co-glycolide) matrices produced by antisolvent printing have high porosity, biocompatibility and good mechanical properties. It is allowed to use them in the future as a basis for personalized constructions for the replacement of extensive bone defects

Perspectives on Mentorship – Reinventing Mentoring in Arts and Creative Industries Management.

The book Perspectives on Mentorship – Reinventing Mentoring in Arts and Creative Industries Management offers a holistic view with multiple perspectives to the topic of mentorship in arts and cultural context. It can be used as a course book for mentorship programmes, providing further knowledge for anyone working in mentorship or planning to build a mentorship programme in the context of arts management education within art or cultural institutions. It provides a unique exploration of this subject by presenting different perspectives, raising thought provoking questions, and examining ways to manage a mentoring programme. It is important to remember that mentoring does not happen by itself, and that it requires management and intervention in order to be sustainable. University students interested in arts management will find the book invaluable in obtaining a better understanding of how mentoring could be approached and help them in the development of their professional identity. It does not present one universal truth or method, but instead is about sharing experiences. From the academic perspective, the book encourages readers to approach mentoring with an open mind, offering tools to reflect on the process of building programmes around the core of mentoring – a dynamic human relationship which affects the identity of both parties – and then to build on the different layers around that foundation. The book seeks to provide insights into the different layers that are created during the mentoring process. It poses a variety of questions that can apply to specific programmes and helps readers understand how to effectively manage and sustain mentorship relationships.EUROPEAN COMMISSION–EACEA 2020: Ref. 2020-1-EE01-KA203-078003. Reinventing Mentoring in Arts Management. (2020-2023

Escaping a migrant metropolis: Post-Soviet urbanization through the art project Nasreddin in Russia

This article narrates the politics of escape from borders and labour discipline in a post-Soviet migrant metropolis drawing on the art-activism project Nasreddin in Russia. It explores the relation between control and autonomy in urban migrations through a trans-aesthetics: a set of visual and verbal stories weaving together experiences and outcomes of the art project with academic debates on late capitalist urbanization. The encounter of artistic practices and migrants’ embodied, everyday struggles to inhabit the city, it is suggested, has potential for disrupting the disciplinary and exclusionary effects of capitalist transformations and migration enforcement. This is made visible through transient spaces of escape in which the everyday lives and social worlds of migrants, constrained by the precarization of labour and by the multiplication and diversification of bordering practices, are reclaimed through laughter, mobility and care. This point is illustrated by focusing on three such spaces and practices: trickster politics in the housing market, acts of disidentification and care work on the city ‘as a body.’ The article offers a methodologically innovative contribution to ongoing debates on aesthetic political economy, cities and borders and artistic and activist interventions in global cities.Peer reviewe

Multiple Myeloma Treatment in Real-world Clinical Practice : Results of a Prospective, Multinational, Noninterventional Study

Funding Information: The authors would like to thank all patients and their families and all the EMMOS investigators for their valuable contributions to the study. The authors would like to acknowledge Robert Olie for his significant contribution to the EMMOS study. Writing support during the development of our report was provided by Laura Mulcahy and Catherine Crookes of FireKite, an Ashfield company, a part of UDG Healthcare plc, which was funded by Millennium Pharmaceuticals, Inc, and Janssen Global Services, LLC. The EMMOS study was supported by research funding from Janssen Pharmaceutical NV and Millennium Pharmaceuticals, Inc. Funding Information: The authors would like to thank all patients and their families and all the EMMOS investigators for their valuable contributions to the study. The authors would like to acknowledge Robert Olie for his significant contribution to the EMMOS study. Writing support during the development of our report was provided by Laura Mulcahy and Catherine Crookes of FireKite, an Ashfield company, a part of UDG Healthcare plc, which was funded by Millennium Pharmaceuticals, Inc, and Janssen Global Services, LLC. The EMMOS study was supported by research funding from Janssen Pharmaceutical NV and Millennium Pharmaceuticals, Inc. Funding Information: M.M. has received personal fees from Janssen, Celgene, Amgen, Bristol-Myers Squibb, Sanofi, Novartis, and Takeda and grants from Janssen and Sanofi during the conduct of the study. E.T. has received grants from Janssen and personal fees from Janssen and Takeda during the conduct of the study, and grants from Amgen, Celgene/Genesis, personal fees from Amgen, Celgene/Genesis, Bristol-Myers Squibb, Novartis, and Glaxo-Smith Kline outside the submitted work. M.V.M. has received personal fees from Janssen, Celgene, Amgen, and Takeda outside the submitted work. M.C. reports honoraria from Janssen, outside the submitted work. M. B. reports grants from Janssen Cilag during the conduct of the study. M.D. has received honoraria for participation on advisory boards for Janssen, Celgene, Takeda, Amgen, and Novartis. H.S. has received honoraria from Janssen-Cilag, Celgene, Amgen, Bristol-Myers Squibb, Novartis, and Takeda outside the submitted work. V.P. reports personal fees from Janssen during the conduct of the study and grants, personal fees, and nonfinancial support from Amgen, grants and personal fees from Sanofi, and personal fees from Takeda outside the submitted work. W.W. has received personal fees and grants from Amgen, Celgene, Novartis, Roche, Takeda, Gilead, and Janssen and nonfinancial support from Roche outside the submitted work. J.S. reports grants and nonfinancial support from Janssen Pharmaceutical during the conduct of the study. V.L. reports funding from Janssen Global Services LLC during the conduct of the study and study support from Janssen-Cilag and Pharmion outside the submitted work. A.P. reports employment and shareholding of Janssen (Johnson & Johnson) during the conduct of the study. C.C. reports employment at Janssen-Cilag during the conduct of the study. C.F. reports employment at Janssen Research and Development during the conduct of the study. F.T.B. reports employment at Janssen-Cilag during the conduct of the study. The remaining authors have stated that they have no conflicts of interest. Publisher Copyright: © 2018 The AuthorsMultiple myeloma (MM) remains an incurable disease, with little information available on its management in real-world clinical practice. The results of the present prospective, noninterventional observational study revealed great diversity in the treatment regimens used to treat MM. Our results also provide data to inform health economic, pharmacoepidemiologic, and outcomes research, providing a framework for the design of protocols to improve the outcomes of patients with MM. Background: The present prospective, multinational, noninterventional study aimed to document and describe real-world treatment regimens and disease progression in multiple myeloma (MM) patients. Patients and Methods: Adult patients initiating any new MM therapy from October 2010 to October 2012 were eligible. A multistage patient/site recruitment model was applied to minimize the selection bias; enrollment was stratified by country, region, and practice type. The patient medical and disease features, treatment history, and remission status were recorded at baseline, and prospective data on treatment, efficacy, and safety were collected electronically every 3 months. Results: A total of 2358 patients were enrolled. Of these patients, 775 and 1583 did and did not undergo stem cell transplantation (SCT) at any time during treatment, respectively. Of the patients in the SCT and non-SCT groups, 49%, 21%, 14%, and 15% and 57%, 20%, 12% and 10% were enrolled at treatment line 1, 2, 3, and ≥ 4, respectively. In the SCT and non-SCT groups, 45% and 54% of the patients had received bortezomib-based therapy without thalidomide/lenalidomide, 12% and 18% had received thalidomide/lenalidomide-based therapy without bortezomib, and 30% and 4% had received bortezomib plus thalidomide/lenalidomide-based therapy as frontline treatment, respectively. The corresponding proportions of SCT and non-SCT patients in lines 2, 3, and ≥ 4 were 45% and 37%, 30% and 37%, and 12% and 3%, 33% and 27%, 35% and 32%, and 8% and 2%, and 27% and 27%, 27% and 23%, and 6% and 4%, respectively. In the SCT and non-SCT patients, the overall response rate was 86% to 97% and 64% to 85% in line 1, 74% to 78% and 59% to 68% in line 2, 55% to 83% and 48% to 60% in line 3, and 49% to 65% and 36% and 45% in line 4, respectively, for regimens that included bortezomib and/or thalidomide/lenalidomide. Conclusion: The results of our prospective study have revealed great diversity in the treatment regimens used to manage MM in real-life practice. This diversity was linked to factors such as novel agent accessibility and evolving treatment recommendations. Our results provide insight into associated clinical benefits.publishersversionPeer reviewe

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio