Estrategia did?ctica para el fortalecimiento del pensamiento matem?tico del grado 1? del colegio "San Sim?n" sede Montealegre jornada ma?ana Ibague - Tolima

111 p. Recurso Electr?nicoEl presente proyecto pretende fomentar participativamente el pensamiento matem?tico por medio de actividades l?dicas e innovadoras en estudiantes del grado 1? del colegio ?San Sim?n?. Por este hecho, se quiere dejar establecido un camino de apoyo a futuros docentes para transformar las competencias matem?ticas con un soporte fijado a partir del juego. Para los antecedentes, se tuvieron en cuenta algunas investigaciones y tesis realizadas en M?xico y Colombia de acuerdo a la problem?tica vista desde diferentes contextos educativos que llevan como punto central la ense?anza-aprendizaje en las matem?ticas de primaria. As? mismo, se retroaliment? significativamente con te?ricos contempor?neos para conocer, indagar y ampliar otros trabajos investigativos. Adicionalmente, este proyecto est? basado en el modelo de investigaci?n-acci?n en el aula con enfoque cualitativo; la poblaci?n objeto de estudio son aproximadamente 42 estudiantes, cuatro docentes de la instituci?n donde se llev? a cabo e trabajo investigativo y un docente de la Universidad del Tolima a los cuales se les aplic? instrumentos de dicho enfoque como lo son: gu?a de observaci?n, pre-test, ficha de redacci?n, unidad did?ctica y pos-test. Para el an?lisis de la informaci?n se realizar? un cruce de informaci?n recolectada (contraste), espec?ficamente de los grupos focales de estudiantes y profesores con el fin de obtener informaci?n concreta del problema de investigaci?n. Los datos obtenidos ser?n analizados con la finalidad de crear categor?as y subcategor?as para, despu?s redactar el informe final detallado. Los resultados que se esperan con este proyecto investigativo son, en primera instancia despertar el inter?s a los estudiantes por las matem?ticas usando actividades l?dicas e innovadoras dentro y fuera del aula y en segundo lugar dejar establecido un camino de apoyo a futuros docentes para transformar la visi?n de la ense?anza-aprendizaje de las matem?ticas en primaria.This project aims to encourage participatory mathematical thinking through playful and innovative activities in 1st grade students of the school "San Simon". Because of this, you want to leave in place a way to support future teachers to transform math skills with a bracket from the game. For background, some research and thesis made in Mexico and Colombia, according to the problems seen from different educational contexts that take as a central point of teaching and learning in primary mathematics were considered. He also fed back significantly to contemporary to know, explore and expand other theoretical research work. Additionally, this project is based on the model of action research in the classroom with a qualitative approach; the study population are about 42 students, four teachers from the institution where he was held and research work and teaching at the University of Tolima to which we applied instruments of this approach as they are: observation guide, pre -test, record of writing, teaching unit and post-test. For the analysis of the information collected a cross information (contrast) will be held, specifically in the focus groups of students and teachers in order to obtain specific information research problem. The data obtained will be analyzed in order to create categories and subcategories to then draft the detailed final report. The results are expected with this research project are, firstly arouse interest students in mathematics using playful and innovative activities within and outside the classroom and secondly let established a way to support future teachers to transform the vision the teaching and learning of mathematics in primary school. Keywords: encouraging, teaching and learning, class, fun, math, teaching strategy

The Role of the Unfolded Protein Response on Renal Lipogenesis in C57BL/6 Mice.

Renal injury observed in several pathologies has been associated with lipid accumulation in the kidney. While it has been suggested that the accumulation of renal lipids depends on free fatty acids released from adipose tissue, it is not known whether in situ renal lipogenesis due to endoplasmic reticulum (ER) stress contributes to kidney injury. The aim of the present study was to elucidate the role of pharmacological ER stress in renal structure and function and its effect on renal lipid metabolism of C57BL/6 mice. ER stress increased serum creatinine and induced kidney structural abnormalities. Tunicamycin-administered mice developed hyperinsulinemia, augmented lipolysis and increased circulating leptin and adiponectin. Renal unfolded protein response (UPR) gene expression markers, the lipogenic transcription factor SREBP1 and the phosphorylation of eIF2α increased 8 h after tunicamycin administration. At 24 h, an increase in BiP protein content was accompanied by a reduction in p-eIF2α and increased SREBP-1 and FASn protein content, in addition to a significant increase in triglyceride content and a reduction in AMPK. Thus, ER stress induces in situ lipid synthesis, leading to renal lipid accumulation and functional alterations. Future pharmacological and/or dietary strategies must target renal ER stress to prevent kidney damage and the progression of metabolic diseases

Validation of a Latin-American Spanish version of the Body Esteem Scale for Adolescents and Adults (BESAA-LA) in Colombian and Nicaraguan adults

Background: Body dissatisfaction (BD) is a growing concern in Latin America; reliable and culturally appropriate scales are necessary to support body image research in Spanish speaking Latin American countries. We sought to validate a Latin-American Spanish version of the Body Esteem Scale for Adolescents and Adults (BESAA; Mendelson et al. 2001). Methods: The BESAA was translated, culturally adapted, and validated in a sample of adults in Colombia (N = 525, 65% women, Mage 24.4, SD = 9.28). We assessed factor structure (using confirmatory factor analysis (CFA), exploratory factor analysis (EFA) and exploratory structural equation model (ESEM)), internal reliability (using Cronbach’s alpha and omega), validity (using the Body Appreciation Scale BAS and Sociocultural Attitudes Towards Appearance Questionnaire SATAQ), test–retest stability in a small subsample (N = 84, using Intraclass correlations ICC) and measurement invariance across gender. To evaluate the generalizability of the scale, we assessed reliability, validity, and factor structure in a second sample from rural Nicaragua (N = 102, 73% women, Mage 22.2, SD = 4.72), and assessed measurement invariance across Nicaraguan and Colombian participants. Results: The scale showed good internal reliability and validity in both samples, and there was evidence of adequate test–retest stability in the Colombian sample. EFA showed a three-factor structure with subscales we labelled ‘appearance-positive’, ‘appearance-negative’ and ‘weight’, that was confirmed using CFA and ESEM in the Colombian sample. Measurement invariance was confirmed across the Colombian and Nicaraguan samples, and across gender within the Colombian sample. Conclusion: The Latin-American Spanish version of the BESAA (BESAA-LA) appears to be a psychometrically sound measure with good reliability, validity and invariance across gender and countries. These results support the use of this scale to measure body satisfaction/dissatisfaction in Latin American adult populations

Depressive symptoms and inflammatory biomarkers in patients with heart failure

Inflammation may be a link between depressive symptoms and outcomes in patients with heart failure (HF). It is not clear whether inflammatory markers are independently related to depressive symptoms in this population

Cluster K Mycobacteriophages: Insights into the Evolutionary Origins of Mycobacteriophage TM4

Five newly isolated mycobacteriophages –Angelica, CrimD, Adephagia, Anaya, and Pixie – have similar genomic architectures to mycobacteriophage TM4, a previously characterized phage that is widely used in mycobacterial genetics. The nucleotide sequence similarities warrant grouping these into Cluster K, with subdivision into three subclusters: K1, K2, and K3. Although the overall genome architectures of these phages are similar, TM4 appears to have lost at least two segments of its genome, a central region containing the integration apparatus, and a segment at the right end. This suggests that TM4 is a recent derivative of a temperate parent, resolving a long-standing conundrum about its biology, in that it was reportedly recovered from a lysogenic strain of Mycobacterium avium, but it is not capable of forming lysogens in any mycobacterial host. Like TM4, all of the Cluster K phages infect both fast- and slow-growing mycobacteria, and all of them – with the exception of TM4 – form stable lysogens in both Mycobacterium smegmatis and Mycobacterium tuberculosis; immunity assays show that all five of these phages share the same immune specificity. TM4 infects these lysogens suggesting that it was either derived from a heteroimmune temperate parent or that it has acquired a virulent phenotype. We have also characterized a widely-used conditionally replicating derivative of TM4 and identified mutations conferring the temperature-sensitive phenotype. All of the Cluster K phages contain a series of well conserved 13 bp repeats associated with the translation initiation sites of a subset of the genes; approximately one half of these contain an additional sequence feature composed of imperfectly conserved 17 bp inverted repeats separated by a variable spacer. The K1 phages integrate into the host tmRNA and the Cluster K phages represent potential new tools for the genetics of M. tuberculosis and related species

Salud de los trabajadores

Actividad física y su relación con los factores de riesgo cardiovascular de carteros chilenosAnálisis de resultados: riesgos psicosociales en el trabajo Suceso-Istas 21 en Cesfam QuellónAusentismo laboral por enfermedades oftalmológicas, Chile 2009Brote de diarreas por norovirus, posterremoto-tsunami, Constitución, Región del MauleCalidad de vida en profesionales de la salud pública chilenaCaracterización del reposo laboral en personal del SSMN durante el primer semestre de 2010Concentración de nicotina en pelo en trabajadores no fumadores expuestos a humo de tabaco ambientalCondiciones de trabajo y bienestar/malestar docente en profesores de enseñanza media de SantiagoDisfunción auditiva inducida por exposición a xilenoErgonomía aplicada al estudio del síndrome de dolor lumbar en el trabajoEstimación de la frecuencia de factores de riesgo cardiovascular en trabajadores de una empresa mineraExposición a plaguicidas inhibidores de la acetilcolinesterasa en Colombia, 2006-2009Factores de riesgo y daños de salud en conductores de una empresa peruana de transporte terrestre, 2009Las consecuencias de la cultura en salud y seguridad ocupacional en una empresa mineraPercepción de cambios en la práctica médica y estrategias de afrontamientoPercepción de la calidad de vida en la Universidad del BiobíoPesos máximos aceptables para tareas de levantamiento manual de carga en población laboral femeninaRiesgo coronario en trabajadores mineros según la función de Framingham adaptada para la población chilenaTrastornos emocionales y riesgo cardiovascular en trabajadores de la salu

National identity predicts public health support during a global pandemic (vol 13, 517, 2022) : National identity predicts public health support during a global pandemic (Nature Communications, (2022), 13, 1, (517), 10.1038/s41467-021-27668-9)

Publisher Copyright: © The Author(s) 2022.In this article the author name ‘Agustin Ibanez’ was incorrectly written as ‘Augustin Ibanez’. The original article has been corrected.Peer reviewe

National identity predicts public health support during a global pandemic.

Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = -0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics

National identity predicts public health support during a global pandemic

Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.publishedVersio