Characterizing uranium solubilization under natural near oxic conditions

A 782 d solubilization study using not shaken batch experiments and involving one uranium-bearing rock and three natural carbonate minerals was conducted to characterize uranium (U) leaching under oxic conditions. Results showed that aqueous U concentration increased continuously with a solubilization rate of 0.16 mgm-2h-1 for the first 564 d (1.5 y). After 1.5 y, U concentration reached a maximum value (saturation) and decreased afterwards. The saturation concentration of 54 mgL-1 (mean value) was influenced to various extent by the presence of carbonate minerals. Dissolution/precipitation, adsorption or ion exchange processes appear to control U solubilization

Beschleunigte Aushärtung von Klebverbindungen mit Curie-Partikeln

Eine große Herausforderung beim Kleben ist die Beschleunigung des Aushärteprozesses. Denn das Fixieren, zumindest bis zur Handfestigkeit, verlangsamt den Takt der Fertigung. Außerdem sind – vor allem im Bauwesen – die Umgebungsbedingungen ein Hemmnis für die sowieso schon vergleichsweise langsame Aushärtung struktureller 2K-Klebstoffe. Einen eleganten Ausweg aus dieser Situation verspricht der Einsatz ferritischer Partikel, insbesondere der sogenannten Curie‑Partikel

LIFT Deliverable D3.1 Farm technical-economic performance depending on the degree of ecological approaches

This document presents the results of Task 3.2 (farm technical-economic performance) in workpackage (WP) 3 (farm performance of ecological agriculture) of the LIFT project. The overall aim of Task 3.2 is to assess and compare technical-economic farm performance across the European Union (EU) depending on the degree of ecological approaches adopted by farms and analyse drivers, affecting their performance

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular communication is critical for metastatic progression. Here, we show that PDAC-derived exosomes induce liver pre-metastatic niche formation in naive mice and consequently increase liver metastatic burden. Uptake of PDAC-derived exosomes by Kupffer cells caused transforming growth factor β secretion and upregulation of fibronectin production by hepatic stellate cells. This fibrotic microenvironment enhanced recruitment of bone marrow-derived macrophages. We found that macrophage migration inhibitory factor (MIF) was highly expressed in PDAC-derived exosomes, and its blockade prevented liver pre-metastatic niche formation and metastasis. Compared with patients whose pancreatic tumours did not progress, MIF was markedly higher in exosomes from stage I PDAC patients who later developed liver metastasis. These findings suggest that exosomal MIF primes the liver for metastasis and may be a prognostic marker for the development of PDAC liver metastasis.We thank D. L. Bajor (Vonderheide laboratory, University of Pennsylvania) for the gift of the R6560B cells. We thank L. Bojmar for carefully reviewing the paper. We thank S. Rudchenko and M. Barbu-Stevanovic at the Hospital for Special Surgery Fannie E. Rippel Foundation Flow Cytometry Core Facility for expert flow cytometry. We are supported by grants from the Children’s Cancer and Blood Foundation (H.P., D.L.), Manning Foundation (D.L.), Hartwell Foundation (D.L.), Champalimaud Foundation (D.L.), Fundacao para a Ciencia e a Tecnologia (D.L.), Nancy C and Daniel P Paduano Foundation (H.P., D.L.), Mary Kay Foundation (D.L.), Pediatric Oncology Experimental Therapeutic Investigator Consortium (D.L.), James Paduano Foundation (D.L., H.P.), Melanoma Research Alliance (H.P.), Sohn Conference Foundation (H.P.), Beth Tortolani Foundation (D.L., J.B.), Malcolm Hewitt Weiner Foundation (D.L.), Jose Carreras Leukemia Foundation (B.K.T.), Theodore Rapp Foundation (D.L.), American Hellenic Educational Progressive Association 5th District Cancer Research Foundation (D.L.), Charles and Marjorie Holloway Foundation (J.B.), Sussman Family Fund (J.B.), Lerner Foundation (J.B.), Breast Cancer Alliance (J.B.), and Manhasset Women’s Coalition Against Breast Cancer (J.B.).S