598 research outputs found
Thermal and chemical unfolding and refolding of a eukaryotic sodium channel
Voltage-gated sodium channels are dynamic membrane proteins essential for signaling in nervous and muscular systems. They undergo substantial conformational changes associated with the closed, open and inactivated states. However, little information is available regarding their conformational stability. In this study circular dichroism spectroscopy was used to investigate the changes in secondary structure accompanying chemical and thermal denaturation of detergent-solubilised sodium channels isolated from Electrophorus electricus electroplax. The proteins appear to be remarkably resistant to either type of treatment, with "denatured" channels, retaining significant helical secondary structure even at 77 degrees C or in 10% SDS. Further retention of helical secondary structure at high temperature was observed in the presence of the channel-blocking tetrodotoxin. It was possible to refold the thermally-denatured (but not chemically-denatured) channels in vitro. The correctly refolded channels were capable of undergoing the toxin-induced conformational change indicative of ligand binding. In addition, flux measurements in liposomes showed that the thermally-denatured (but not chemically-denatured) proteins were able to re-adopt native, active conformations. These studies suggest that whilst sodium channels must be sufficiently flexible to undergo major conformational changes during their functional cycle, the proteins are highly resistant to unfolding, a feature that is important for maintaining structural integrity during dynamic processes. (c) 2009 Elsevier B.V. All rights reserved
High Precision Mass Measurements in and Families Revisited
High precision mass measurements in and families performed
in 1980-1984 at the VEPP-4 collider with OLYA and MD-1 detectors are revisited.
The corrections for the new value of the electron mass are presented. The
effect of the updated radiative corrections has been calculated for the
and mass measurements.Comment: 5 pages, 1 table, submitted to Phys. Lett.
Measurement of and between 3.12 and 3.72 GeV at the KEDR detector
Using the KEDR detector at the VEPP-4M collider, we have measured
the values of and at seven points of the center-of-mass
energy between 3.12 and 3.72 GeV. The total achieved accuracy is about or
better than at most of energy points with a systematic uncertainty of
about . At the moment it is the most accurate measurement of in
this energy range
Towards Formalizing Non-monotonic Reasoning in Physics: Logical Approach Based on Physical Induction and Its Relation to Kolmogorov Complexity
To formalize some types of non-monotonic reasoning in physics, researchers have proposed an approach based on Kolmogorov complexity. Inspired by Vladimir Lifschitz\u27s belief that many features of reasoning can be described on a purely logical level, we show that an equivalent formalization can be described in purely logical terms: namely, in terms of physical induction.
One of the consequences of this formalization is that the set of not-abnormal states is (pre-)compact. We can therefore use Lifschitz\u27s result that when there is only one state that satisfies a given equation (or system of equations), then we can algorithmically find this state. In this paper, we show that this result can be extended to the case of approximate uniqueness
New precise determination of the \tau lepton mass at KEDR detector
The status of the experiment on the precise lepton mass measurement
running at the VEPP-4M collider with the KEDR detector is reported. The mass
value is evaluated from the cross section behaviour around the
production threshold. The preliminary result based on 6.7 pb of data is
MeV. Using 0.8 pb of data
collected at the peak the preliminary result is also obtained:
eV.Comment: 6 pages, 8 figures; The 9th International Workshop on Tau-Lepton
Physics, Tau0
Measurement of \Gamma_{ee}(J/\psi)*Br(J/\psi->e^+e^-) and \Gamma_{ee}(J/\psi)*Br(J/\psi->\mu^+\mu^-)
The products of the electron width of the J/\psi meson and the branching
fraction of its decays to the lepton pairs were measured using data from the
KEDR experiment at the VEPP-4M electron-positron collider. The results are
\Gamma_{ee}(J/\psi)*Br(J/\psi->e^+e^-)=(0.3323\pm0.0064\pm0.0048) keV,
\Gamma_{ee}(J/\psi)*Br(J/\psi->\mu^+\mu^-)=(0.3318\pm0.0052\pm0.0063) keV.
Their combinations
\Gamma_{ee}\times(\Gamma_{ee}+\Gamma_{\mu\mu})/\Gamma=(0.6641\pm0.0082\pm0.0100)
keV,
\Gamma_{ee}/\Gamma_{\mu\mu}=1.002\pm0.021\pm0.013 can be used to improve
theaccuracy of the leptonic and full widths and test leptonic universality.
Assuming e\mu universality and using the world average value of the lepton
branching fraction, we also determine the leptonic \Gamma_{ll}=5.59\pm0.12 keV
and total \Gamma=94.1\pm2.7 keV widths of the J/\psi meson.Comment: 7 pages, 6 figure
Search for narrow resonances in e+ e- annihilation between 1.85 and 3.1 GeV with the KEDR Detector
We report results of a search for narrow resonances in e+ e- annihilation at
center-of-mass energies between 1.85 and 3.1 GeV performed with the KEDR
detector at the VEPP-4M e+ e- collider. The upper limit on the leptonic width
of a narrow resonance Gamma(R -> ee) Br(R -> hadr) < 120 eV has been obtained
(at 90 % C.L.)
Measurement of main parameters of the \psi(2S) resonance
A high-precision determination of the main parameters of the \psi(2S)
resonance has been performed with the KEDR detector at the VEPP-4M e^{+}e^{-}
collider in three scans of the \psi(2S) -- \psi(3770) energy range. Fitting the
energy dependence of the multihadron cross section in the vicinity of the
\psi(2S) we obtained the mass value
M = 3686.114 +- 0.007 +- 0.011 ^{+0.002}_{-0.012} MeV and the product of the
electron partial width by the branching fraction into hadrons \Gamma_{ee}*B_{h}
= 2.233 +- 0.015 +- 0.037 +- 0.020 keV.
The third error quoted is an estimate of the model dependence of the result
due to assumptions on the interference effects in the cross section of the
single-photon e^{+}e^{-} annihilation to hadrons explicitly considered in this
work.
Implicitly, the same assumptions were employed to obtain the charmonium
leptonic width and the absolute branching fractions in many experiments.
Using the result presented and the world average values of the electron and
hadron branching fractions, one obtains the electron partial width and the
total width of the \psi(2S):
\Gamma_{ee} =2.282 +- 0.015 +- 0.038 +- 0.021 keV,
\Gamma = 296 +- 2 +- 8 +- 3 keV.
These results are consistent with and more than two times more precise than
any of the previous experiments
Low Complexity Regularization of Linear Inverse Problems
Inverse problems and regularization theory is a central theme in contemporary
signal processing, where the goal is to reconstruct an unknown signal from
partial indirect, and possibly noisy, measurements of it. A now standard method
for recovering the unknown signal is to solve a convex optimization problem
that enforces some prior knowledge about its structure. This has proved
efficient in many problems routinely encountered in imaging sciences,
statistics and machine learning. This chapter delivers a review of recent
advances in the field where the regularization prior promotes solutions
conforming to some notion of simplicity/low-complexity. These priors encompass
as popular examples sparsity and group sparsity (to capture the compressibility
of natural signals and images), total variation and analysis sparsity (to
promote piecewise regularity), and low-rank (as natural extension of sparsity
to matrix-valued data). Our aim is to provide a unified treatment of all these
regularizations under a single umbrella, namely the theory of partial
smoothness. This framework is very general and accommodates all low-complexity
regularizers just mentioned, as well as many others. Partial smoothness turns
out to be the canonical way to encode low-dimensional models that can be linear
spaces or more general smooth manifolds. This review is intended to serve as a
one stop shop toward the understanding of the theoretical properties of the
so-regularized solutions. It covers a large spectrum including: (i) recovery
guarantees and stability to noise, both in terms of -stability and
model (manifold) identification; (ii) sensitivity analysis to perturbations of
the parameters involved (in particular the observations), with applications to
unbiased risk estimation ; (iii) convergence properties of the forward-backward
proximal splitting scheme, that is particularly well suited to solve the
corresponding large-scale regularized optimization problem
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
- …