Molecular ratchets - verification of the principle of detailed balance

We argue that the recent experiments of Kelly et. al.(Angew. Chem. Int. Ed. Engl. 36, 1866 (1997)) on molecular ratchets, in addition to being in agreement with the second law of thermodynamics, is a test of the principle of detailed balance for the ratchet. We suggest new experiments, using an asymmetric ratchet, to further test the principle. We also point out methods involving a time variation of the temperature to to give it a directional motion

Benthic biomass size spectra in shelf and deep-sea sediments

The biomass distributions of marine benthic metazoans (meio- to macro-fauna, 1 ?g–32 mg wet weight) across three contrasting sites were investigated to test the hypothesis that allometry can consistently explain observed trends in biomass spectra. Biomass (and abundance) size spectra were determined from observations made at the Faroe–Shetland Channel (FSC) in the Northeast Atlantic (water depth 1600 m), the Fladen Ground (FG) in the North Sea (150 m), and the hypoxic Oman Margin (OM) in the Arabian Sea (500 m). Observed biomass increased with body size as a power law at FG (scaling exponent, b = 0.16) and FSC (b = 0.32), but less convincingly at OM (b = 0.12 but not significantly different from 0). A simple model was constructed to represent the same 16 metazoan size classes used for the observed spectra, all reliant on a common detrital food pool, and allowing the three key processes of ingestion, respiration and mortality to scale with body size. A micro-genetic algorithm was used to fit the model to observations at the sites. The model accurately reproduces the observed scaling without needing to include the effects of local influences such as hypoxia. Our results suggest that the size-scaling of mortality and ingestion are dominant factors determining the distribution of biomass across the meio- to macrofaunal size range in contrasting marine sediment communities. Both the observations and the model results are broadly in agreement with the "metabolic theory of ecology" in predicting a quarter power scaling of biomass across geometric body size classes

Breaking of general rotational symmetries by multi-dimensional classical ratchets

We demonstrate that a particle driven by a set of spatially uncorrelated, independent colored noise forces in a bounded, multidimensional potential exhibits rotations that are independent of the initial conditions. We calculate the particle currents in terms of the noise statistics and the potential asymmetries by deriving an n-dimensional Fokker-Planck equation in the small correlation time limit. We analyze a variety of flow patterns for various potential structures, generating various combinations of laminar and rotational flows.Comment: Accepted, Physical Review

Hadron Structure on the Lattice

A few chosen nucleon properties are described from a lattice QCD perspective: the nucleon sigma term and the scalar strangeness in the nucleon; the vector form factors in the nucleon, including the vector strangeness contribution, as well as parity breaking effects like the anapole and electric dipole moment; and finally the axial and tensor charges of the nucleon. The status of the lattice calculations is presented and their potential impact on phenomenology is discussed.Comment: 17 pages, 9 figures; proceedings of the Conclusive Symposium of the Collaborative Research Center 443 "Many-body structure of strongly interacting systems", Mainz, February 23-25, 201

A new measurement of the structure functions PLL−PTT/epsilonP_{LL}-P_{TT}/epsilon and PLTP_{LT} in virtual Compton scattering at Q2=Q^2= 0.33 (GeV/c)2^2

The cross section of the $ep \to e' p' \gamma$ reaction has been measured at $Q^2 = 0.33$ (GeV/c)$^2$. The experiment was performed using the electron beam of the MAMI accelerator and the standard detector setup of the A1 Collaboration. The cross section is analyzed using the low-energy theorem for virtual Compton scattering, yielding a new determination of the two structure functions P_LL}-P_{TT}/epsilon and $P_{LT}$ which are linear combinations of the generalized polarizabilities of the proton. We find somewhat larger values than in the previous investigation at the same $Q^2$. This difference, however, is purely due to our more refined analysis of the data. The results tend to confirm the non-trivial $Q^2$-evolution of the generalized polarizabilities and call for more measurements in the low-$Q^2$ region ($\le$ 1 (GeV/c)$^2$).Comment: 9 pages, 10 figures. EPJA version. slight revisions in the text and figure

Evaluation of Effect of Taxus baccata Leaves Extract on Bronchoconstriction and Bronchial Hyperreactivity in Experimental Animals

The present investigation was undertaken to evaluate the bronchodilating effect and bronchial hyperreactivity of alcoholic extract of Taxus baccata Linn. (AET) leaves in experimental animals. Bronchodilator activity of AET was studied on the histamine and acetylcholine aerosol induced bronchospasm in guinea pigs and bronchial hyperreactivity was studied on bronchoalveolar lavage fluid (BALF) in the egg albumin sensitized guinea pigs and by histopathological studies. In vitro mast cell stabilizing activity was studied using compound 48/80 as a degranulating agent. Treatment with AET (200 and 400 mg/kg, p.o., for 7 days) showed significant protection against histamine and acetylcholine aerosol induced bronchospasm in guinea pigs. Significant decrease in the total leukocyte and differential leukocyte count in the BALF of the egg albumin sensitized guinea pigs was observed by administration of AET (200 and 400 mg/kg, p.o., for 15 days). AET dose dependently protected the mast cell disruption induced by compound 48/80. These results suggest that AET not only has bronchodilating activity but also decreases bronchial hyperreactivity by decreasing the infiltration of inflammatory cells in the airway and inhibiting the release of histamine like mediators from the mast cell by stabilizing it

Early- Onset Stroke and Vasculopathy Associated with Mutations in ADA2

Adenosine deaminase 2 (ADA2) is an enzyme involved in purine metabolism and a growth factor that influences the development of endothelial cells and leukocytes. This study shows that defects in ADA2 cause recurrent fevers, vascular pathologic features, and mild immunodeficiency. Patients with autoinflammatory disease sometimes present with clinical findings that encompass multiple organ systems.(1) Three unrelated children presented to the National Institutes of Health (NIH) Clinical Center with intermittent fevers, recurrent lacunar strokes, elevated levels of acute-phase reactants, livedoid rash, hepatosplenomegaly, and hypogammaglobulinemia. Collectively, these findings do not easily fit with any of the known inherited autoinflammatory diseases. Hereditary or acquired vascular disorders can have protean manifestations yet be caused by mutations in a single gene. Diseases such as the Aicardi-Goutieres syndrome,(2),(3) polypoidal choroidal vasculopathy,(4) sickle cell anemia,(5) livedoid vasculopathy,(6) and the small-vessel vasculitides(7),(8) are examples of systemic ...</p