SZZ Unleashed: An Open Implementation of the SZZ Algorithm -- Featuring Example Usage in a Study of Just-in-Time Bug Prediction for the Jenkins Project

Numerous empirical software engineering studies rely on detailed information about bugs. While issue trackers often contain information about when bugs were fixed, details about when they were introduced to the system are often absent. As a remedy, researchers often rely on the SZZ algorithm as a heuristic approach to identify bug-introducing software changes. Unfortunately, as reported in a recent systematic literature review, few researchers have made their SZZ implementations publicly available. Consequently, there is a risk that research effort is wasted as new projects based on SZZ output need to initially reimplement the approach. Furthermore, there is a risk that newly developed (closed source) SZZ implementations have not been properly tested, thus conducting research based on their output might introduce threats to validity. We present SZZ Unleashed, an open implementation of the SZZ algorithm for git repositories. This paper describes our implementation along with a usage example for the Jenkins project, and conclude with an illustrative study on just-in-time bug prediction. We hope to continue evolving SZZ Unleashed on GitHub, and warmly invite the community to contribute

Mycobacterium bovis bacilli Calmette-Guerin regulates leukocyte recruitment by modulating alveolar inflammatory responses.

Leukocyte migration into the epithelial compartment is an important feature in the active phase of mycobacterial infections. In this study, we used the Transwell model to investigate the mechanisms behind mycobacteria-induced leukocyte recruitment and investigated the role of TLR2 and TLR4 in this process. Infection of epithelial cells resulted in significantly increased secretion of the neutrophil chemotactic CXCL8 and IL-6, but no secretion of monocyte chemotactic CCL2 or TNF-α was observed. In contrast to epithelial response, mycobacteria-infected neutrophils and monocytes secreted all these cytokines. Corresponding with epithelial cytokine response, mycobacterial infection of the epithelial cells increased neutrophil diapedesis, but decreased monocyte recruitment. However, monocyte recruitment towards mycobacteria infected epithelial cells significantly increased following addition of neutrophil pre-conditioned medium. Mycobacterial infection also increases alveolar epithelial expression of TLR2, but not TLR4, as analyzed by flow cytometry, Western blotting and visualized by confocal microscopy. Blocking of TLR2 inhibited neutrophil recruitment and cytokine secretion, while blocking of TLR4 had a lesser effect. To summarize, we found that primary alveolar epithelial cells produced a selective TLR2-dependent cytokine secretion upon mycobacterial infection. Furthermore, we found that cooperation between cells of the innate immunity is required in mounting proper antimicrobial defence

A just transition towards a coal-free steel industry: perspectives from labour

Limiting global warming to ‘safe’ levels will require rapid and radical reductions of greenhouse gas emissions across all sectors of the global economy. The discontinuation of incumbent industrial structures, that will be an unavoidable part of such sustainability transitions, will disproportionally burden certain groups. Recent events including the social and political unrest linked to the imminent deterioration of coal communities and the fuel tax protests of the ’Gilets Jaunes’ have loudly shown that distributional effects of climate transitions cannot be ignored. Trade unions and NGOs have for some time called for an inclusive transition and brought increased attention to the justice dimension of energy transitions. In this paper, we analyse potential social impacts in a concrete case: the planned transition from coal to hydrogen-based steelmaking in the Swedish steel industry. To this end, we conduct a series of semi-structured interviews to examine the role of trade unions and the national trade union federation in re-orienting the industry. By doing so we aim to widen the scope of the just transitions debate to include process industries and to explore the concrete meaning of a just transition in the case of the planned transition of the Swedish steel industry.We analyse, on the one hand, the capacity of trade unions to influence the transition process, and, on the other hand, the potential social impacts of the transition on the labour force and local communities. As the transition of the Swedish steel sector kicks into gear, we highlight a number of social issues that should be addressed both within industry and through policy. We conclude that it is important to early on: include stakeholders in the process, bring up social and political aspects of the transition, and acknowledge and address potential conflicting interests associated with it

Näthat och demokratiskt deltagande – en kunskapsöversikt

Rätten att uttrycka åsikter, att kritisera och att ifrågasätta är en del av enlevande demokrati. Ett demokratiskt samhälle måste vara öppet för olikaröster och ge alla möjlighet att komma till tals. Demokratin är beroendeav att människor deltar och engagerar sig i samhällsfrågor. Med rättentill yttrandefrihet kommer också ett ansvar. Var och en bör skydda, värnaoch bevara yttrandefriheten genom att respektera andra och bidra till ensamhällsdebatt fri från hot och hat. Tystas människor tystnar demokratin.Den digitala utvecklingen gör det möjligt för fler att göra sin röst hörd. Det ärpositivt men för också med sig utmaningar. Att föra fram och sprida hot ochhat har blivit enklare. Uttalanden kan få snabb spridning i sociala medier ochpå så sätt få större genomslagskraft i dag än tidigare. Det kan missbrukas avpersoner som inte vill bevara det demokratiska samhället.Personer som engagerar sig i samhällsfrågor är särskilt utsatta för hotoch hat. Det gäller till exempel förtroendevalda, journalister, konstnärer,opinionsbildare, forskare och representanter för det civila samhället. Utsatthetkan också vara kopplat till exempelvis en persons kön, könsidentitet, hudfärg,sexuella läggning eller ålder. När kvinnor och hbtqi-personer får hot och hatriktat mot sig har det ofta att göra med kön och sexualitet.På uppdrag av Brottsoffermyndigheten har forskare vid Lunds universitetoch Högskolan i Halmstad genomfört en enkätundersökning som visadeatt mer än hälften av de tillfrågade har känt sig kränkta av sådant som andraskriver om dem på nätet. Särskilt utsatta är unga och personer med utländskbakgrund, och följden blir omfattande nivåer av självcensur bland dessagrupper. Det innebär att de anpassar hur de uttrycker sig för att undvika hotoch hat, eller helt avstår från att publicera och delta i samhällsdebatten. Detdemokratiska samtalet begränsas och viktiga röster riskerar att tystna.Även denna kunskapsöversikt är ett resultat av samarbetet mellan Brottsoffer- myndigheten, Lunds universitet och Högskolan i Halmstad. Den belyser olika frågor om näthat och demokratiskt deltagande, såsom vilka områden som genererar hot och hat, vilka samhälls- och yrkesgrupper som är särskilt utsatta och vilka konsekvenser näthat leder till

The effect of hydrogen on the breakdown of the protective oxide scale in solid oxide fuel cell interconnects

In this study, the effect of hydrogen, on the degradation of AISI 441 interconnect, under solid oxide fuel cell operating conditions was investigated between 500−800 \ub0C for 336 h. As a new hypothesis, it is concluded that, hydrogen impedes Cr diffusion, probably in the grain boundaries, leading to the breakdown of the protective oxide scale. This effect is most severe at 600 \ub0C, while at lower or higher temperatures the effect is attenuated. Cr diffusion is enhanced at high temperatures, whereas protective scales can be obtained at low temperatures with a lower amount of Cr

A Novel Porous Ti-Squarate as Efficient Photocatalyst in the Overall Water Splitting Reaction under Simulated Sunlight Irradiation

[EN] A new porous titanium(IV) squarate metal¿organic framework (MOF), denoted as IEF-11, having a never reported titanium secondary building unit, is successfully synthesized and fully characterized. IEF-11 not only exhibits a permanent porosity but also an outstanding chemical stability. Further, as a consequence of combining the photoactive Ti(IV) and the electroactive squarate, IEF-11 presents relevant optoelectronic properties, applied here to the photocatalytic overall water splitting reaction. Remarkably, IEF-11 as a photocatalyst is able to produce record H2 amounts for MOF-based materials under simulated sunlight (up to 672 µmol gcatalyst in 22 h) without any activity loss during at least 10 d.P.S.-A. and A.A.B. contributed equally to this work. The authors acknowledge the Ramón Areces Foundation project H+MOFs, the M-ERA-NET C-MOF-cell (grant PCI2020-111998 funded by MCIN/AEI/10.13039/501100011033 and European Union NextGenerationEU/ PRTR) project, and Retos Investigación MOFSEIDON (grant PID2019-104228RB-I00 funded by MCIN/AEI/10.13039/501100011033) project. S.N. thanks financial support by Ministerio de Ciencia, Innovatión y Universidades RTI2018-099482-A-I00 project and Agència Valenciana de la Innovació (AVI, INNEST/2020/111) project. H.G. thanks financial support to the Spanish Ministry of Science and Innovation (Severo Ochoa and RTI2018-098237-CO21) and Generalitat Valenciana (Prometeo2017/083). T.W. acknowledges financial support from the Swedish Research Council (VR, 2019-05465). Parts of this research were carried out at ¿CRISTAL¿ at SOLEIL. P.S. and A.A.B. sincerely thank to the project CALIPSOplus under the Grant Agreement 730872 from the EU Framework Programme for Research and Innovation HORIZON 2020 for the support of the synchrotron experiment.Salcedo-Abraira, P.; Babaryk, AA.; Montero-Lanzuela, E.; Contreras Almengor, OR.; Cabrero-Antonino, M.; Svensson, E.; Willhammar, T.... (2021). A Novel Porous Ti-Squarate as Efficient Photocatalyst in the Overall Water Splitting Reaction under Simulated Sunlight Irradiation. Advanced Materials. 33(52):1-9. https://doi.org/10.1002/adma.20210662719335

Cystatin C and Cardiovascular Disease

Background Epidemiological studies show that high circulating cystatin C is associated with risk of cardiovascular disease (CVD), independent of creatinine-based renal function measurements. It is unclear whether this relationship is causal, arises from residual confounding, and/or is a consequence of reverse causation. Objectives The aim of this study was to use Mendelian randomization to investigate whether cystatin C is causally related to CVD in the general population. Methods We incorporated participant data from 16 prospective cohorts (n = 76,481) with 37,126 measures of cystatin C and added genetic data from 43 studies (n = 252,216) with 63,292 CVD events. We used the common variant rs911119 in CST3 as an instrumental variable to investigate the causal role of cystatin C in CVD, including coronary heart disease, ischemic stroke, and heart failure. Results Cystatin C concentrations were associated with CVD risk after adjusting for age, sex, and traditional risk factors (relative risk: 1.82 per doubling of cystatin C; 95% confidence interval [CI]: 1.56 to 2.13; p = 2.12 × 10−14). The minor allele of rs911119 was associated with decreased serum cystatin C (6.13% per allele; 95% CI: 5.75 to 6.50; p = 5.95 × 10−211), explaining 2.8% of the observed variation in cystatin C. Mendelian randomization analysis did not provide evidence for a causal role of cystatin C, with a causal relative risk for CVD of 1.00 per doubling cystatin C (95% CI: 0.82 to 1.22; p = 0.994), which was statistically different from the observational estimate (p = 1.6 × 10−5). A causal effect of cystatin C was not detected for any individual component of CVD. Conclusions Mendelian randomization analyses did not support a causal role of cystatin C in the etiology of CVD. As such, therapeutics targeted at lowering circulating cystatin C are unlikely to be effective in preventing CVD

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms