231 research outputs found
The relation between star formation, morphology and local density in high redshift clusters and groups
We investigate how the [OII] properties and the morphologies of galaxies in
clusters and groups at z=0.4-0.8 depend on projected local galaxy density, and
compare with the field at similar redshifts and clusters at low-z. In both
nearby and distant clusters, higher-density regions contain proportionally
fewer star-forming galaxies, and the average [OII] equivalent width of
star-forming galaxies is independent of local density. However, in distant
clusters the average current star formation rate (SFR) in star-forming galaxies
seems to peak at densities ~15-40 galaxies Mpc^{-2}. At odds with low-z
results, at high-z the relation between star-forming fraction and local density
varies from high- to low-mass clusters. Overall, our results suggest that at
high-z the current star formation (SF) activity in star-forming galaxies does
not depend strongly on global or local environment, though the possible SFR
peak seems at odds with this conclusion. We find that the cluster SFR
normalized by cluster mass anticorrelates with mass and correlates with the
star-forming fraction. These trends can be understood given a) that the average
star-forming galaxy forms about 1 Msun/yr in all clusters; b) that the total
number of galaxies scales with cluster mass and c) the dependence of
star-forming fraction on cluster mass. We present the morphology-density (MD)
relation for our z=0.4-0.8 clusters, and uncover that the decline of the spiral
fraction with density is entirely driven by galaxies of types Sc or later. For
galaxies of a given Hubble type, we see no evidence that SF properties depend
on local environment. In contrast with recent findings at low-z, in our distant
clusters the SF-density relation and the MD-relation are equivalent, suggesting
that neither of the two is more fundamental than the other.(abr.)Comment: 21 pages, 14 figures, accepted for publication in Ap
The ESO Distant Cluster Sample: galaxy evolution and environment out to z=1
The ESO Distant Cluster Survey (EDisCS, P.I. Simon D.M. White, LP 166.A-0162)
is an ESO large programme aimed at studying clusters and cluster galaxies at
z=0.4-1. How different is the evolution of the star formation activity in
clusters, in groups and in the field? Does it depend on cluster mass and/or the
local galaxy density? How relevant are starburst and post-starburst galaxies in
the different environments? Is there an evolution in the galaxies' structures,
and if so, is this related to the changes in their star formation activity?
These are some of the main questions that have been investigated using the
EDisCS dataset.Comment: to appear in The Messenger, issue June 200
The Pediatric Cell Atlas:Defining the Growth Phase of Human Development at Single-Cell Resolution
Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan
Gluons and the quark sea at high energies: distributions, polarization, tomography
This report is based on a ten-week program on "Gluons and the quark sea at
high-energies", which took place at the Institute for Nuclear Theory in Seattle
in Fall 2010. The principal aim of the program was to develop and sharpen the
science case for an Electron-Ion Collider (EIC), a facility that will be able
to collide electrons and positrons with polarized protons and with light to
heavy nuclei at high energies, offering unprecedented possibilities for
in-depth studies of quantum chromodynamics. This report is organized around
four major themes: i) the spin and flavor structure of the proton, ii)
three-dimensional structure of nucleons and nuclei in momentum and
configuration space, iii) QCD matter in nuclei, and iv) Electroweak physics and
the search for physics beyond the Standard Model. Beginning with an executive
summary, the report contains tables of key measurements, chapter overviews for
each of the major scientific themes, and detailed individual contributions on
various aspects of the scientific opportunities presented by an EIC.Comment: 547 pages, A report on the joint BNL/INT/Jlab program on the science
case for an Electron-Ion Collider, September 13 to November 19, 2010,
Institute for Nuclear Theory, Seattle; v2 with minor changes, matches printed
versio
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity
A genome-wide association study identifies risk alleles in plasminogen and P4HA2 associated with giant cell arteritis
Giant cell arteritis (GCA) is the most common form of vasculitis in individuals older than 50 years in Western countries. To shed light onto the genetic background influencing susceptibility for GCA, we performed a genome-wide association screening in a well-powered study cohort. After imputation, 1,844,133 genetic variants were analysed in 2,134 cases and 9,125 unaffected controls from ten independent populations of European ancestry. Our data confirmed HLA class II as the strongest associated region (independent signals: rs9268905, P = 1.94E-54, per-allele OR = 1.79; and rs9275592, P = 1.14E-40, OR = 2.08). Additionally, PLG and P4HA2 were identified as GCA risk genes at the genome-wide level of significance (rs4252134, P = 1.23E-10, OR = 1.28; and rs128738, P = 4.60E-09, OR = 1.32, respectively). Interestingly, we observed that the association peaks overlapped with different regulatory elements related to cell types and tissues involved in the pathophysiology of GCA. PLG and P4HA2 are involved in vascular remodelling and angiogenesis, suggesting a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis
New genetic loci link adipose and insulin biology to body fat distribution.
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
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