1,053 research outputs found
Jogos digitais educacionais como uma proposta de trabalho em educação ambiental
Pereira, R.; Gouveia, L. e Dinis, A. (2021). Jogos digitais educacionais como uma proposta de trabalho em Educação Ambiental. Seminário Doutoramento em Ciência da Informação, especialidade Sistemas, Tecnologias e Gestão da Informação (SITEGI). 16 de Julho. Universidade Fernando Pessoa. Porto.info:eu-repo/semantics/publishedVersio
Right of the Citizen and Evaluation of Health Services: theoretical-Practical Approaches
Making the invisible visible: searching for human T-cell lymphotropic virus types 1 and 2 (HTLV-1 and HTLV-2) in Brazilian patients with viral hepatitis B and C
Nursing ethical processes in the State of Santa Catarina: characterization of factual elements
Differentials in risk factors for chronic non-communicable diseases from the race/color standpoint
Linguagem oral de adolescentes deficientes auditivos: avaliação fonoaudiológica e relato dos professores
Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points
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