Formación Polanco: Petrografía, estructura y metamorfismo en la región de Polanco-manguera azul

La zona de Polanco-Manguera Azul, abarcada dentro de la faja de esquistos del Cinturón Dom Feliciano posee una asociación litológica conformada cominantemente por mármoles calciticos, subordinadamente dolomíticos, e intercalaciones de calcoesquistos, metaconglomerados, cuarcitas, BIF y micaesquistos. Al estudiarse en detalle los mármoles y particularmente los calcoesquistos, se encuentra que los mismos poseen una asociación mineral dada por Cal+Qtz+Ab+Tr+Phl+Ep+Op, coherente con la facies esquisto verde superior (450-500 °C y 200-600 MPa), así como microestructuras coherentes con ese grado. La estructura de la región, con rumbos dominantemente E-O de la superficie principal (S1), junto con las relaciones de esta con los cuerpos graníticos y las trasnscurrencias de la zona, señalan que dicha área se encontraba operando como un dominio de baja deformación durante el Brasiliano.The Polanco-Manguera Azul region, comprised within the schist belt of the Dom Feliciano Belt, has a lithological association mainly composed of calcitic and dolomitic marbles, with intercalations of calc-schists, metaconglomerates, quartzites, BIF and micaschists. Studying in detail the marbles and particularly the calc-schists, it is found that they have a mineral association given by Cal+Qtz+Ab+Tr+Phl+Ep+Op, consistent with the upper green schist facies (450-500 °C and 200-600 MPa), as well as coherent microstructures. The structure of the region, with main EW strikes of S1, together with the relationships with the granitic bodies and the shear zones of the region, indicate that this area was operating as a low strain domain during the Brasiliano orogeny.Fil: Silva Lara, Hernan. Universidad de la República. Facultad de Ciencias; UruguayFil: Masquelin, H.. Universidad de la República. Facultad de Ciencias; UruguayFil: Núñez Demarco, Pablo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Geológicas; Argentina. Universidad de la República. Facultad de Ciencias; Urugua

Reassessing the polyphase Neoproterozoic evolution of the Punta del Este Terrane, Dom Feliciano Belt, Uruguay

Some recent models challenge the position and extension of the assumed oceanic basins formed through the break-up of Rodinia, and the tectonic processes involved in the Gondwana assembly, making the investigation of the Early Neoproterozoic record of great relevance. Within the South-American Atlantic margin, the Punta del Este Terrane (PET) of the Dom Feliciano Belt (DFB) comprises a unique Tonian to Ediacaran record, and has a strategic position to reconstruct spatio-temporal relationships with the southern African orogenic belts. Novel zircon U–Pb and Lu–Hf data from the PET basement orthogneisses display Tonian magmatic ages (805–760 Ma) and Hf isotopic signatures indicative of mainly crustal/metasedimentary sources, (Nd TDM ages: 2.2–1.9 Ga, and εHf(t): − 12 to − 4). The basement paragneisses yielded late Paleoproterozoic to Neoproterozoic U–Pb ages, but dominantly positive εHf(t) values. The presented results confirm the correlation of the PET with the Coastal Terrane of the Kaoko Belt, and discard the idea of the Nico Pérez Terrane as a source. Detrital zircon U–Pb and Lu–Hf data from the Rocha Formation yielded a main peak at ca. 660 Ma, with the Neoproterozoic grains showing a εHf(t) between + 1 and + 14. The deposition age of the Rocha Formation is constrained by the youngest detrital zircon age peak (660 Ma), and the beginning of the deposition of the Sierra de Aguirre Formation (580 Ma). The data indicate common sources with the Marmora Terrane, and it is thus proposed that the Rocha Formation belongs to the Gariep Belt, and it was juxtaposed during the Ediacaran to the DFB.Fil: Silva Lara, Hernan. Universität Göttingen; AlemaniaFil: Siegesmund, S.. Universität Göttingen; AlemaniaFil: Oriolo, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Hueck, M.. Universidade de Sao Paulo; Brasil. Universität Göttingen; AlemaniaFil: Wemmer, K.. Universität Göttingen; AlemaniaFil: Basei, M. A. S.. Universidade de Sao Paulo; BrasilFil: Oyhantçabal, P.. Universidad de la República; Urugua

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Association between kinetics of ruminal degradation parameters and cell wall constituents of four tropical grasses Associações entre parâmetros da cinética de degradação ruminal e os constituintes da parede celular de quatro gramíneas tropicais

The association of digestible and indigestible cell wall contents, the in vitro dry mater digestibility, the digestion rate, lag phase and the relative gas volume produced from neutral detergent fiber potentially digestible were evaluated in tropical grasses samples. The samples were from setaria grass, hemarthria grass, angola grass and acroceres grass fertilized with 0, 100, 200, 300 and 400kg of N/ha and in the cutting ages of 28, 42, 56 and 70 days. The results were submitted to a factor analysis. It was opted for the adoption of three factors comprising 73,81% % of the total variation, where the first factor was strongly associated with the in vitro dry matter digestibility, neutral detergent fiber potentially digestible, lag and with relative gas volume. The second factor was connected to the indigestible neutral detergent fiber and with digestion rate, and the third factor was related to lignin. The neutral potentially digestible detergent fiber showed positive correlation (0.5294) with in vitro dry matter digestibility (P&lt;0.01), for hermarthria grass at 42 days old. This grass showed better results when compared to the other grasses, and it presented higher values for in vitro dry matter digestibility (69.39%) and neutral detergent fiber potentially digestible (57.89%) and smaller production of relative gas volume (0,186mL/mg), that means better fermentation characteristics and utilization of carbon for energy production.<br>Objetivou-se avaliar a associação entre constituintes digestíveis e indigestíveis da parede celular, a digestibilidade in vitro da matéria seca e a taxa de digestão, latência e volume relativo de gás produzido a partir da fibra em detergente neutro potencialmente digestível de amostras obtidas de capins setária, hemarthria, angola e acroceres, adubados com 0, 100, 200, 300 e 400kg de N/ha e colhidos aos 28, 42, 56 e 70 dias de idade. Os resultados foram avaliados através de análise de fatores. Optou-se pela adoção de três fatores, os quais englobaram 73,81% da variação total, em que o primeiro fator associou-se com a digestibilidade in vitro da matéria seca, com a fibra em detergente neutro potencialmente digestível, com a latência e com o volume relativo de gás. Já o segundo fator associou-se com a fibra em detergente neutro indigestível e com a taxa de digestão, e o terceiro fator associou-se à lignina. A fibra em detergente neutro potencialmente digestível apresentou correlação positiva (0,5294) com a digestibilidade in vitro da matéria seca (P&lt;0,01), o que pode ser verificado para o capim-hemarthria aos 42 dias de idade de corte, o qual se destacou por apresentar maior digestibilidade (69,39%) e maior teor de fibra em detergente potencialmente digestível (57,89%). Por outro lado, verificou-se também menor volume relativo de gás (0,186mL/mg) , em que, quanto menor o volume de g��s, pode-se inferir em melhor característica de fermentação e utilização dos carbonos para produção de energia