Lithium enhancement in X-ray binaries due to stellar rotation

We discuss the high lithium abundances in the secondary stars of X-ray binaries. We show that no lithium production in these stars is necessary, and that the abundances can be explained simply due to the tidally locked rotation of the stars, which lead naturally to slower lithium destruction rates. The differences in abundances of CVs' secondaries from those of LMXBs had previously been put forth as evidence that the compact object was related to the lithium abundance, but this scenario also accounts for the lower lithium abundances in the secondary stars in cataclysmic variable systems (CVs) than in low mass X-ray binaries (LMXBs), since these stars have typically lived much longer before becoming tidally locked short period systems. We point out that if this scenario is correct, then the globular cluster X-ray binaries' donor stars should, as a class, show less lithium enhancement relative to other stars of the same spectral type in the clusters than the field X-ray binaries' donor stars show.Comment: 5 pages, accepted to A&A research note

Early career resilience: interdisciplinary insights to support professional education of Radiation Therapists

Background : A number of studies across a range of countries have indicated a proportion of the radiotherapy workforce maybe experiencing burnout. Furthermore, current national attrition from UK radiotherapy training programmes is approximately 36%. The consequence is a potential shortfall in qualifying practitioners. The loss of skilled practitioners from the workplace through burnout and a reduction in the numbers qualifying at a time of rising cancer referrals has implications on the ability of radiotherapy services to keep pace with demand. A report from the College of Radiographers on the factors affecting attrition from UK training programmes recommends the development of emotional resilience as part of the educational preparation for Therapists, but failed to identify specific interventions that may help. Radiation Therapists (RTTs) are not unique in terms of their exposure to the potential of burnout and other professionals share similar concerns. In this paper we report on an interdisciplinary study of professional resilience, which indicates that there is much we can learn from other professions that are engaged in emotional labour. The concept of ‘resilience’ is important in retention studies but research in this field is limited by a lack of detailed accounts of resilience in specific professional contexts; with few accounts of strategies in professional education to develop resilience. Aim : To identify: what supports and hinders the development of professional resilience in early career professionals, in professions involving emotional and moral challenge, such as radiation therapy; what creative pedagogical approaches may help to develop resilience. Method : Using a mixed method design over 50 participants were invited to participate from radiotherapy, social work and teacher education. A combination of survey research, interpretative interviews and innovative group activities were used across four key groups; early career professionals, current students, Higher Education lecturers and work based professionals who support students. Purposive sampling was undertaken with codes, themes and texts used iteratively to develop understanding of professional resilience. Coding was informed by principles of constructivist grounded theory to allow for the identification of themes. Peer debriefing was used to agree the coding structure and member checking was used to confirm identified themes with research participants. Results : Emergent themes indicate resilience is dependent on a complex interplay between individual and organisational (or situated) characteristics. Key concepts were: Transitions- new identity demands Organisational and systemic issues- being treated unfairly, team culture, difficult cases, feedback and support, professional demands Personal Characteristics – personal actions, personal qualities (accepting, confidence, forms of reflection, interpersonal skills and positive psychology) Professionality- agency, commitment, moral purpose and value Conclusion : By addressing issues of resilience course credibility is enhanced as a preparation for professional life; with a subsequent corollary of reduced attrition. The data from this study can be used to inform a creative curriculum to enhance professional resilience in students and early career professionals.</p

A grounded theory of psychological resilience in Olympic champions

Objective: Although it is well-established that the ability to manage stress is a prerequisite of sporting excellence, the construct of psychological resilience has yet to be systematically examined in athletic performers. The study reported here sought to explore and explain the relationship between psychological resilience and optimal sport performance. Design and Method: Twelve Olympic champions (8 men and 4 women) from a range of sports were interviewed regarding their experiences of withstanding pressure during their sporting careers. A grounded theory approach was employed throughout the data collection and analysis, and interview transcripts were analyzed using open, axial and selective coding. Methodological rigor was established by incorporating various verification strategies into the research process, and the resultant grounded theory was also judged using the quality criteria of fit, work, relevance, and modifiability. Results and Conclusions: Results indicate that numerous psychological factors (relating to a positive personality, motivation, confidence, focus, and perceived social support) protect the world’s best athletes from the potential negative effect of stressors by influencing their challenge appraisal and meta-cognitions. These processes promote facilitative responses that precede optimal sport performance. The emergent theory provides sport psychologists, coaches and national sport organizations with an understanding of the role of resilience in athletes’ lives and the attainment of optimal sport performance

The stroke oxygen pilot study: a randomized control trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months

Introduction: Post-stroke hypoxia is common, and may adversely affect outcome. We have recently shown that oxygen supplementation may improve early neurological recovery. Here, we report the six-month outcomes of this pilot study. Methods: Patients with a clinical diagnosis of acute stroke were randomized within 24 h of admission to oxygen supplementation at 2 or 3 L/min for 72 h or to control treatment (room air). Outcomes (see below) were assessed by postal questionnaire at 6 months. Analysis was by intention-to-treat, and statistical significance was set at p#0.05. Results: Out of 301 patients randomized two refused/withdrew consent and 289 (148 in the oxygen and 141 in the control group) were included in the analysis: males 44%, 51%; mean (SD) age 73 (12), 71 (12); median (IQR) National Institutes of Health Stroke Scale score 6 (3, 10), 5 (3, 10) for the two groups respectively. At six months 22 (15%) patients in the oxygen group and 20 (14%) in the control group had died; mean survival in both groups was 162 days (p= 0.99). Median (IQR) scores for the primary outcome, the modified Rankin Scale, were 3 (1, 5) and 3 (1, 4) for the oxygen and control groups respectively. The covariate-adjusted odds ratio was 1.04 (95% CI 0.67, 1.60), indicating that the odds of a lower (i.e. better) score were non-significantly higher in the oxygen group (p= 0.86). The mean differences in the ability to perform basic (Barthel Index) and extended activities of daily living (NEADL), and quality of life (EuroQol) were also non-significant. Conclusions: None of the key outcomes differed at 6 months between the groups. Although not statistically significant and generally of small magnitude, the effects were predominantly in favour of the oxygen group; a larger trial, powered to show differences in longer-term functional outcomes, is now on-going. Trial Registration: Controlled-Trials.com ISRCTN12362720; Eudract.ema.europa.eu 2004-001866-4

The Academic Resilience Scale (ARS-30) : a new multidimensional construct measure

Resilience is a psychological construct observed in some individuals that accounts for success despite adversity. Resilience reflects the ability to bounce back, to beat the odds and is considered an asset in human characteristic terms. Academic resilience contextualises the resilience construct and reflects an increased likelihood of educational success despite adversity. The paper provides an account of the development of a new multidimensional construct measure of academic resilience. The 30 item Academic Resilience Scale (ARS-30) explores process—as opposed to outcome—aspects of resilience, providing a measure of academic resilience based on students’ specific adaptive cognitive-affective and behavioural responses to academic adversity. Findings from the study involving a sample of undergraduate students (N=532) demonstrate that the ARS-30 has good internal reliability and construct validity. It is suggested that a measure such as the ARS-30, which is based on adaptive responses, aligns more closely with the conceptualisation of resilience and provides a valid construct measure of academic resilience relevant for research and practice in university student populations

Science and economics in the management of an invasive species

Author Posting. © American Institute of Biological Sciences, 2006. This article is posted here by permission of American Institute of Biological Sciences for personal use, not for redistribution. The definitive version was published in BioScience 56 (2006): 931-935, doi: 10.1641/0006-3568(2006)56[931:SAEITM]2.0.CO;2Estimates of the economic impacts of nonnative nuisance ("invasive") species must rely on both a sound ecological understanding and the proper application of economic methods. Focusing on the example of the invasive European green crab (Carcinus maenas), we show that the crab's estimated economic impact—which has been used to help justify recent public policy—is based on data taken from the wrong geographic location. Furthermore, the predictions of ecological effects appear to rest on loose footing, and economic methods have been misapplied in constructing the estimate. Our purpose is to call attention to the need for the more careful application of science and economics in managing this pressing environmental issue.This work was supported by a research grant from the US Department of Commerce,National Oceanic and Atmospheric Administration, Project no. NA16RG1698

The SOS Pilot Study: a RCT of routine oxygen supplementation early after acute stroke—effect on recovery of neurological function at one week

Mild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12 months. This pilot study reports the effects of routine oxygen supplementation for 72 hours on oxygen saturation and neurological outcomes at 1 week after a stroke

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need. There is evidence that neuroinflammation plays a pathogenic role in drug-resistant epilepsy. The high-mobility group box 1 (HMGB1)/TLR4 axis is a key initiator of neuroinflammation following epileptogenic injuries, and its activation contributes to seizure generation in animal models. However, further work is required to understand the role of HMGB1 and its isoforms in epileptogenesis and drug resistance. Using a combination of animal models and sera from clinically well-characterized patients, we have demonstrated that there are dynamic changes in HMGB1 isoforms in the brain and blood of animals undergoing epileptogenesis. The pathologic disulfide HMGB1 isoform progressively increased in blood before epilepsy onset and prospectively identified animals that developed the disease. Consistent with animal data, we observed early expression of disulfide HMGB1 in patients with newly diagnosed epilepsy, and its persistence was associated with subsequent seizures. In contrast with patients with well-controlled epilepsy, patients with chronic, drug-refractory epilepsy persistently expressed the acetylated, disulfide HMGB1 isoforms. Moreover, treatment of animals with antiinflammatory drugs during epileptogenesis prevented both disease progression and blood increase in HMGB1 isoforms. Our data suggest that HMGB1 isoforms are mechanistic biomarkers for epileptogenesis and drug-resistant epilepsy in humans, necessitating evaluation in larger-scale prospective studies

Development and Validation of the Behavioral Tendencies Questionnaire

At a fundamental level, taxonomy of behavior and behavioral tendencies can be described in terms of approach, avoid, or equivocate (i.e., neither approach nor avoid). While there are numerous theories of personality, temperament, and character, few seem to take advantage of parsimonious taxonomy. The present study sought to implement this taxonomy by creating a questionnaire based on a categorization of behavioral temperaments/tendencies first identified in Buddhist accounts over fifteen hundred years ago. Items were developed using historical and contemporary texts of the behavioral temperaments, described as “Greedy/Faithful”, “Aversive/Discerning”, and “Deluded/Speculative”. To both maintain this categorical typology and benefit from the advantageous properties of forced-choice response format (e.g., reduction of response biases), binary pairwise preferences for items were modeled using Latent Class Analysis (LCA). One sample (n1 = 394) was used to estimate the item parameters, and the second sample (n2 = 504) was used to classify the participants using the established parameters and cross-validate the classification against multiple other measures. The cross-validated measure exhibited good nomothetic span (construct-consistent relationships with related measures) that seemed to corroborate the ideas present in the original Buddhist source documents. The final 13-block questionnaire created from the best performing items (the Behavioral Tendencies Questionnaire or BTQ) is a psychometrically valid questionnaire that is historically consistent, based in behavioral tendencies, and promises practical and clinical utility particularly in settings that teach and study meditation practices such as Mindfulness Based Stress Reduction (MBSR)

The research and practice of integrating conservation and development: Self-reflections by researchers on methodologies, objectives and influence

This study examines the application of mixed-method and participatory approaches to conservation and development research. Both approaches were applied in a research project on the relationship between ecosystem governance and the wellbeing of local communities adjacent to a protected area in Laos. By encouraging four of the involved field researchers to reflect upon and expose their practical approaches as scientific experts (in terms of methodologies, objectives, reliability of results and research influence), this article aims to improve our learning from research practice and to promote reflexivity in research. The reflexive study presented here emphasizes the social and political context or real world situation against which research outputs can and should be evaluated, and retrospectively sheds light on the barriers to reach research objectives. In essence, the article addresses the relation between science and policy, and underlines the political undercurrent of conservation and development research in facilitating institutional change. The article outlines the very role of researchers in developing conservation policies, and provides a foundation for institutions and individual researchers to promote critical and constructive self-reflections in scientific practices