59 research outputs found
Crystal structures and superconducting properties of metallic double-chain based cuprate Pr2Ba4Cu7O15-delta
- Author
- Publication venue
- Publication date
- 17/02/2024
- Field of study
We demonstrated the lattice structures and the superconducting phases of
metallic double-chain based cuprate Pr2Ba4Cu7O15-delta exhibiting higher Tc.
After the oxygen heat treatment on citrate pyrolysis precursors, their
reduction treatment followed by a quench procedure caused higher Tc samples
with 26.5-30 K. The crystal structural parameters for the superconducting
sample (delta = 0.81) were analyzed from the powder synchrotron X-ray
diffraction data using RIETAN-FP program. The effect of magnetic field on the
superconducting phase of these samples with different oxygen defects (delta
=0.73, 0.81 and 0.87) was examined, for our understanding of the
superconducting magnetic field-temperature phase diagram. For delta = 0.87
sample with Tc = 30 K, the resistive critical field Hc* was estimated to be 13
T at 4.2 K. The oxygen deficiency dependence on Tc,on for our samples was
compared with the data of several other groups.Comment: 8 pages, 6 figure
Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2018
- Field of study
ObjectiveRheumatoid arthritis (RA) is a chronic autoimmune disease characterized with joint destructions; environmental and genetic factors were thought to be involved in the etiology of RA. The production of anti-citrullinated peptide antibodies (ACPA) is specifically associated with RA. DRB1 is associated with the susceptibility of RA, especially ACPA-positive RA [ACPA(+)RA]. However, a few studies reported on the independent associations of DPB1 alleles with RA susceptibility. Thus, we investigated the independent association of DPB1 alleles with RA in Japanese populations.MethodsAssociation analyses of DPB1 were conducted by logistic regression analysis in 1667 RA patients and 413 controls.ResultsIn unconditioned analysis, DPB1*04:02 was nominally associated with the susceptibility of ACPA(+)RA (P = 0.0021, corrected P (Pc) = 0.0275, odds ratio [OR] 1.52, 95% confidence interval [CI] 1.16–1.99). A significant association of DPB1*02:01 with the susceptibility of ACPA(+)RA was observed, when conditioned on DRB1 (Padjusted = 0.0003, Pcadjusted = 0.0040, ORadjusted 1.47, 95%CI 1.19–1.81). DPB1*05:01 was tended to be associated with the protection against ACPA(+)RA, when conditioned on DRB1 (Padjusted = 0.0091, Pcadjusted = 0.1184, ORadjusted 0.78, 95%CI 0.65–0.94). When conditioned on DRB1, the association of DPB1*04:02 with ACPA(+)RA was disappeared. No association of DPB1 alleles with ACPA-negative RA was detected.ConclusionThe independent association of DPB1*02:01 with Japanese ACPA(+)RA was identified
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force
- Author
- Abe Ryuzo
- Abe Shinji
- Adachi Tomohiro
- Adachi Yuichi
- Ai Masumi
- Amishima Masaru
- Amiya Saori
- Anan Ryusuke
- Ando Akira
- Anzai Tatsuhiko
- Arai Daisuke
- Arai Ryosuke
- Arai Sawako
- Arakawa Kenichi
- Arimura Ken
- Asakura Takanori
- Asano Koichiro
- Awano Nobuyasu
- Azuma Masanori
- Baba Hiroaki
- Baba Rie
- Baba Tomoya
- Beppu Satoru
- Chiba Shigeru
- Chihara Yusuke
- Chubachi Shotaro
- Edahiro Ryuya
- Egi Moritoki
- Endo Akifumi
- Endo Mayu
- Enomoto Takatoshi
- Eriguchi Yoshihiro
- Fuchimoto Yasuko
- Fujii Kazuhiko
- Fujimoto Nobukazu
- Fujita Kazue
- Fujitani Shigeki
- Fujiwara Akiko
- Fuke Satoshi
- Fukui Takahiro
- Fukui Yasutaka
- Fukunaga Koichi
- Fukuta Tetsuya
- Fukuyama Satoru
- Funatsu Yohei
- Gon Yasuhiro
- Hagihara Masao
- Hagimoto Satoshi
- Hagiwara Eri
- Hagiwara Shigehiro
- Hanada Satoko
- Hara Reina
- Harada Masahiro
- Harada Norihiro
- Harada Sonoko
- Harada Yuko
- Haruta Yuki
- Hase Isano
- Hasegawa Naoki
- Hasegawa Takanori
- Hasegawa Yoshinori
- Hashiguchi Mizuha
- Hashimoto Naozumi
- Hashimoto Satoru
- Hashino Takuya
- Hattori Takeshi
- Hayashi Kentaro
- Hayashi Reina
- Hayashi Shinichi
- Hida Naoya
- Hiki Makoto
- Hirai Yoshihiro
- Hiramatsu Yuji
- Hirano Toshiyuki
- Hiranuma Hisato
- Hirata Haruhiko
- Hirouchi Takatomo
- Honda Takayuki
- Horinouchi Hirohisa
- Hoshino Kota
- Hosoda Chiaki
- Hyugaji Takayoshi
- Ichikado Kazuya
- Ichikawa Masako
- Ichimura Naoya
- Igarashi Akira
- Ihara Shoichi
- Ikemura Shinnosuke
- Imamura Tomonori
- Imoto Seiya
- Inomata Minoru
- Inoue Sumito
- Inoue Takashi
- Inoue Takuya
- Inoue Yoshiaki
- Ishiguro Takashri
- Ishihara Sayoko
- Ishihara Shoichiro
- Ishii Makoto
- Ishii Tomoo
- Ishikawa Motonao
- Ishikura Hiroyasu
- Ishioka Kota
- Isogai Susumu
- Isono Taisuke
- Ito Akihiro
- Ito Fumimaro
- Ito Kazuto
- Ito Satoshi
- Ito Yoko
- Iwagoe Hajime
- Iwamura Hiromu
- Izumi Namiki
- Izumo Takehiro
- Kabata Hiroki
- Kagaya Takashi
- Kagyo Junko
- Kai Hirayasu
- Kamata Hirofumi
- Kamimaki Isamu
- Kamiya Akane
- Kan-o Keiko
- Kanai Masahiro
- Kanai Masayuki
- Kanai Takanori
- Kanaoka Kensuke
- Kanayama Syuji
- Kanda Hidenori
- Kanehiro Arihiko
- Kaneko Yutaro
- Kaneyama Yasunari
- Kasamatsu Yu
- Kashiwada Takeru
- Katayama Kazuhiko
- Katayama Kotoe
- Kato Kazuto
- Kato Yasuhiro
- Kawada Miki
- Kawamura Kodai
- Kawana Akihiko
- Kawana Masatoshi
- Kawashima Hidetoshi
- Kikuchi Ryota
- Kimizuka Yoshifumi
- Kimura Akinori
- Kimura Nozomu
- Kimura Tomoki
- Kimura Tomoyuki
- Kimura Yasuhiro
- Kishi Hiroto
- Kita Toshiyuki
- Kitagawa Yuichiro
- Kitagawa Yuko
- Kitamura Hideya
- Kobayashi Keigo
- Kobayashi Yoichi
- Kodaka Norio
- Kodama Nobuhiro
- Koh Hidefumi
- Kohashi Sumiko
- Koike Ryuji
- Koji Sakamoto
- Kojima Mitsuaki
- Kokuto Hiroyuki
- Komase Yuko
- Komuta Kiyoshi
- Konishi Shunichiro
- Kono Yuta
- Koshida Kiyoshi
- Kozu Yutaka
- Kuge Tomoki
- Kumanogoh Atsushi
- Kuraki Takashige
- Kuramochi Mizuki
- Kurihara Yuko
- Kusaka Yu
- Kuse Naoyuki
- Kuwahara Naota
- Lee Ho
- Maeda Shunsuke
- Maeno Toshitaka
- Makino Shohei
- Makino Yasushi
- Manabe Tadashi
- Maruyama Junichi
- Maruyama Shuhei
- Masaki Katsunori
- Mashimo Shuko
- Masuda Makoto
- Masuzawa Keita
- Matsui Yuma
- Matsumoto Kinnosuke
- Matsumoto Koichiro
- Matsumoto Shuichiro
- Matsumoto Takemasa
- Matsunaga Tomohiro
- Matsuse Hiroto
- Matsushita Yasushi
- Minemura Hiroyuki
- Mitamura Keiko
- Miyagawa Kazuya
- Miyake Takahito
- Miyano Satoru
- Miyawaki Masayoshi
- Miyazaki Masatoshi
- Miyazaki Yasunari
- Miyazaki Yoshimune
- Miyazawa Naoki
- Mochimaru Takao
- Mori Nobuaki
- Morikawa Daiki
- Morisaki Hiroshi
- Morita Atsuho
- Morita Takayoshi
- Motegi Mitsuru
- Murakami Koji
- Murakami Teruaki
- Muranaka Hiroyuki
- Murohashi Kota
- Mutoh Yoshikazu
- Nagai Hideaki
- Nagao Genta
- Nagasaka Tomoki
- Nagasaki Tadao
- Nagasaki Yoji
- Nagata Kaoru
- Naito Tatsuhiko
- Naito Toshio
- Nakachi Ichiro
- Nakada Taka-Aki
- Nakajima Jun
- Nakajima Yukiko
- Nakamori Yasushi
- Nakamura Ai
- Nakamura Kazunori
- Nakamura Morio
- Nakamura Yoshihiko
- Nakano Chihiro
- Nakano Yasushi
- Nakatsumi Hiroki
- Nakayama Sohei
- Namba Shinichi
- Namkoong Ho
- Nanki Kosaku
- Nannya Yasuhito
- Narita Atsuya
- Narumoto Osamu
- Niitsu Takayuki
- Nikaido Takefumi
- Nishi Koichi
- Nishida Takashi
- Nishikawa Masanori
- Nishimura Tomoyasu
- Nishio Kazumi
- Nishitsuji Masaru
- Nishiyama Kei
- Nishiyama Kenta
- Niwa Kazuki
- Noda Yoshimi
- Noguchi Yoichiro
- Nukaga Shigenari
- Ochi Junichi
- Odani Toshio
- Odate Mitsuru
- Ogata Hideo
- Ogata Tomouki
- Ogawa Aki
- Ogawa Seishi
- Ogawa Shinichi
- Oguma Tsuyoshi
- Ogura Shinji
- Ogura Takashi
- Ogura Takayuki
- Ohba Takehiko
- Ohira Yoshiyuki
- Ohta Kazuhide
- Ohta Ken
- Ohta Shin
- Okabayashi Hiroko
- Okada Takenori
- Okada Yukinori
- Okamori Satoshi
- Okamoto Masaki
- Omae Yosuke
- Omote Norihito
- Ono Akihiro
- Ono Hiroshi
- Ono Yoshinao
- Onoi Keisuke
- Ooshima Nobuharu
- Osawa Takeshi
- Oshima Taku
- Oshio Takeshi
- Ota Sho
- Oyama Baku
- Oyamada Yoshitaka
- Ozaki Shinji
- Sado Reiko
- Sado Toshikatsu
- Sagara Hironori
- Sageshima Hisako
- Saiki Ryunosuke
- Saito Fukuki
- Saito Fumitake
- Saito Hiroshi
- Saito Ryuichi
- Saito Yoshinobu
- Sakagami Satoru
- Sakurai Toshihiro
- Sandhu Yuuki
- Sano Hirohito
- Sano Tomoya
- Sasa Noah
- Sasaki Junichi
- Sasaki Kana
- Sasano Hajime
- Sassa Chihiro Tani
- Sato Masamichi
- Sato Ryuichi
- Sato Tomonori
- Sato Toshiro
- Sato Yoko
- Sato Yuki
- Satomi Ryosuke
- Seike Masahiro
- Sekikawa Yoshiyuki
- Shibata Shun
- Shibata Yoko
- Shibusawa Takayuki
- Shichinohe Yasuo
- Shimada Hisato
- Shimada Tadanaga
- Shimizu Eigo
- Shimizu Tetsuo
- Shimo Masatoshi
- Shimoda Masafumi
- Shinoki Masato
- Shinozuka Jun
- Shinozuka Keisuke
- Shiomi Tetsuya
- Shirai Yuya
- Shiroyama Takayuki
- Shoko Tomohisa
- Sonehara Kyuto
- Sonobe Kazunari
- Suematsu Ryohei
- Sueyoshi Atsushi
- Sugimoto Hideyasu
- Sugiura Hisatoshi
- Suzuki Junya
- Suzuki Shoji
- Suzuki Yusuke
- Tada Ai
- Tagaya Etsuko
- Takada Minoru
- Takagi Haruhi
- Takahashi Hidenori
- Takahashi Hiroshi
- Takahashi Kazuhisa
- Takahashi Kenichiro
- Takahashi Kunihiko
- Takahashi Mai
- Takahashi Saeko
- Takahashi Takeshi
- Takaku Yotaro
- Takano Kenji
- Takano Tomomi
- Takaoka Hatsuyo
- Takata Tohru
- Takayanagi Noboru
- Takeda Yoshito
- Takei Reoto
- Takeuchi Mayumi
- Taki Reiko
- Takita Mumon
- Takoi Hiroyuki
- Tanaka Akihiko
- Tanaka Hiromu
- Tanaka Toru
- Tanaka Yoshiaki
- Tani Mayuko
- Tanino Yoshinori
- Tateishi Tomoya
- Tateno Hiroki
- Terai Hideki
- Terashima Mariko
- Togashi Yuki
- Tohda Shuji
- Tokunaga Katsushi
- Tokunaga Yoshihisa
- Tominaga Yoshiteru
- Tomono Kazunori
- Tone Mari
- Tsuburai Takahiro
- Tsuchida Tomoya
- Uchida Sho
- Uchida Tomoyuki
- Uchimura Yuji
- Ueda Ken
- Ueda Soichiro
- Ueda Suguru
- Ueda Tetsuya
- Ueno Takafumi
- Umeda Akira
- Uno Shunsuke
- Utsugi Mitsuyoshi
- Uwamino Yoshifumi
- Wada Daiki
- Wada Sae
- Wakabayashi Aya
- Wakahara Keiko
- Wang Qingbo S.
- Watanabe Chie
- Watanabe Hiroki
- Watanabe Hiroko
- Watanabe Kazuyoshi
- Watanabe Masafumi
- Yagi Kazuma
- Yamada Mitsuhiro
- Yamada Yuichiro
- Yamagata Kunihiro
- Yamaguchi Yuta
- Yamamoto Kenichi
- Yamamoto Makoto
- Yamamoto Masaomi
- Yamamoto Yuji
- Yamano Yasuhiko
- Yamasaki Masaki
- Yamashita Tatsuya
- Yasui Yoshinori
- Yatomi Masakiyo
- Yokote Koutaro
- Yoneda Midori
- Yonekawa Akiko
- Yoshida Eriko
- Yoshida Kosuke
- Yoshida Shozo
- Yoshida Shuichi
- Yoshida Toru
- Yoshifuji Ayumi
- Yoshihara Tomoyuki
- Yoshiya Kazuhisa
- Yoshiyama Takashi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection
DOCK2 is involved in the host genetics and biology of severe COVID-19
- Author
- Abe Ryuzo
- Abe Shinji
- Adachi Tomohiro
- Adachi Yuichi
- Ai Masumi
- Amishima Masaru
- Amiya Saori
- Anan Ryusuke
- Ando Akira
- Anzai Tatsuhiko
- Aoki Ryousuke
- Arai Daisuke
- Arai Ryosuke
- Arai Sawako
- Arakawa Kenichi
- Arimura Ken
- Asai Satoshi
- Asakura Takanori
- Asano Koichiro
- Awano Nobuyasu
- Azekawa Shuhei
- Azuma Masanori
- Baba Hiroaki
- Baba Rie
- Baba Tomoya
- Beppu Satoru
- Chiba Shigeru
- Chihara Yusuke
- Chubachi Shotaro
- Edahiro Ryuya
- Egi Moritoki
- Eguchi Hirotaka
- Endo Akifumi
- Endo Mayu
- Enomoto Takatoshi
- Eriguchi Yoshihiro
- Fuchimoto Yasuko
- Fujii Kazuhiko
- Fujimoto Nobukazu
- Fujita Kazue
- Fujitani Shigeki
- Fujiwara Akiko
- Fuke Satoshi
- Fukui Takahiro
- Fukui Yasutaka
- Fukui Yoshinori
- Fukunaga Koichi
- Fukushima Munehisa
- Fukusumi Takahito
- Fukuta Tetsuya
- Fukuyama Satoru
- Funatsu Yohei
- Furukawa Yoichi
- Gon Yasuhiro
- Hagihara Masao
- Hagimoto Satoshi
- Hagiwara Eri
- Hagiwara Shigehiro
- Hamamoto Junko
- Hanada Satoko
- Hara Reina
- Harada Masahiro
- Harada Norihiro
- Harada Sonoko
- Harada Yuko
- Haruta Yuki
- Hase Isano
- Hasegawa Naoki
- Hasegawa Takanori
- Hasegawa Yoshinori
- Hashiguchi Mizuha
- Hashimoto Naozumi
- Hashimoto Satoru
- Hashino Takuya
- Hattori Takeshi
- Hayashi Hiroyuki
- Hayashi Kentaro
- Hayashi Reina
- Hayashi Shinichi
- Hida Naoya
- Higashiyama Masahiko
- Hiki Makoto
- Hirai Yoshihiro
- Hiramatsu Yuji
- Hirano Toshiyuki
- Hiranuma Hisato
- Hirata Haruhiko
- Hirouchi Takatomo
- Hizawa Nobuyuki
- Honda Takayuki
- Horinouchi Hirohisa
- Hoshino Kota
- Hosoda Chiaki
- Hyugaji Takayoshi
- Ichikado Kazuya
- Ichimura Naoya
- Igarashi Akira
- Ihara Shoichi
- Ikemura Shinnosuke
- Imai Takao
- Imamura Tomonori
- Imoto Seiya
- Inohara Hidenori
- Inomata Minoru
- Inoue Sumito
- Inoue Takashi
- Inoue Takuya
- Inoue Yoshiaki
- Ishiguro Takashi
- Ishihara Rino
- Ishihara Sayoko
- Ishihara Shoichiro
- Ishii Makoto
- Ishii Tomoo
- Ishikawa Motonao
- Ishikura Hiroyasu
- Ishioka Kota
- Isogai Susumu
- Isono Taisuke
- Ito Akihiro
- Ito Fumimaro
- Ito Kazuto
- Ito Satoshi
- Ito Yoko
- Iwagoe Hajime
- Iwamura Hiromu
- Izumi Namiki
- Izumo Takehiro
- Kabata Hiroki
- Kagaya Takashi
- Kagyo Junko
- Kai Hirayasu
- Kamata Hirofumi
- Kamatani Yoichiro
- Kamimaki Isamu
- Kamiya Akane
- Kan-o Keiko
- Kanai Masahiro
- Kanai Masayuki
- Kanai Takanori
- Kanaoka Kensuke
- Kanayama Syuji
- Kanda Hidenori
- Kanehiro Arihiko
- Kaneko Yutaro
- Kaneyama Yasunari
- Kasamatsu Yu
- Kashiwada Takeru
- Katayama Kazuhiko
- Katayama Kotoe
- Kato Kazuto
- Kato Yasuhiro
- Kawabata Shuhei
- Kawada Miki
- Kawamura Kodai
- Kawamura Yusuke
- Kawana Akihiko
- Kawana Masatoshi
- Kawashima Hidetoshi
- Kijima Noriyuki
- Kikuchi Ryota
- Kimizuka Yoshifumi
- Kimura Akinori
- Kimura Nozomu
- Kimura Tomoki
- Kimura Tomoyuki
- Kimura Yasuhiro
- Kishi Hiroto
- Kishikawa Toshihiro
- Kishima Haruhiko
- Kita Toshiyuki
- Kitagawa Yuichiro
- Kitagawa Yuko
- Kitamura Hideya
- Kobayashi Keigo
- Kobayashi Yoichi
- Kodaka Norio
- Kodama Nobuhiro
- Koh Hidefumi
- Kohashi Sumiko
- Koike Ryuji
- Koji Sakamoto
- Kojima Mitsuaki
- Kokuto Hiroyuki
- Komase Yuko
- Komuta Kiyoshi
- Konishi Shunichiro
- Kono Yuta
- Koretsune Yukihiro
- Koshida Kiyoshi
- Kozu Yutaka
- Kuge Tomoki
- Kumanogoh Atsushi
- Kuraki Takashige
- Kuramochi Mizuki
- Kurihara Yuko
- Kusaka Yu
- Kuse Naoyuki
- Kuwahara Naota
- Lee Ho
- Liu Yu-Chen
- Maeda Shunsuke
- Maeda Yuichi
- Maeno Toshitaka
- Makino Shohei
- Makino Yasushi
- Manabe Tadashi
- Maruyama Junichi
- Maruyama Shuhei
- Masaki Katsunori
- Mashimo Shuko
- Masuda Makoto
- Masumoto Akihide
- Masuzawa Keita
- Matsubara Yuta
- Matsuda Fumihiko
- Matsuda Koichi
- Matsui Yuma
- Matsumoto Kinnosuke
- Matsumoto Koichiro
- Matsumoto Shuichiro
- Matsumoto Takemasa
- Matsunaga Tomohiro
- Matsuo Hirotaka
- Matsuse Hiroto
- Matsushita Yasushi
- Mikami Yohei
- Minami Shiro
- Minemura Hiroyuki
- Mitamura Keiko
- Miyagawa Kazuya
- Miyake Takahito
- Miyano Satoru
- Miyawaki Masayoshi
- Miyawaki Satoru
- Miyazaki Masatoshi
- Miyazaki Yasunari
- Miyazaki Yoshimune
- Miyazawa Naoki
- Mochimaru Takao
- Mori Nobuaki
- Morikawa Daiki
- Morisaki Hiroshi
- Morisaki Takayuki
- Morita Atsuho
- Morita Takayoshi
- Motegi Mitsuru
- Motooka Daisuke
- Murakami Koji
- Murakami Teruaki
- Murakami Yoshinori
- Muranaka Hiroyuki
- Murayama Shigeo
- Murohashi Kota
- Muto Kaori
- Mutoh Yoshikazu
- Nagai Akiko
- Nagai Hideaki
- Nagao Genta
- Nagasaka Tomoki
- Nagasaki Tadao
- Nagasaki Yoji
- Nagata Kaoru
- Nagayama Satoshi
- Naito Tatsuhiko
- Naito Toshio
- Naito Yoko
- Nakachi Ichiro
- Nakada Taka-Aki
- Nakajima Jun
- Nakajima Yukiko
- Nakamori Yasushi
- Nakamura Ai
- Nakamura Kazunori
- Nakamura Morio
- Nakamura Yoshihiko
- Nakano Chihiro
- Nakano Yasushi
- Nakatsumi Hiroki
- Nakayama Akiyoshi
- Nakayama Sohei
- Namba Shinichi
- Namkoong Ho
- Nanki Kosaku
- Nannya Yasuhito
- Narita Atsuya
- Narumoto Osamu
- Nii Takuro
- Niitsu Takayuki
- Nikaido Takefumi
- Nishi Koichi
- Nishida Takashi
- Nishihara Hiroshi
- Nishikawa Masanori
- Nishimura Tomoyasu
- Nishio Kazumi
- Nishitsuji Masaru
- Nishiyama Kei
- Nishiyama Kenta
- Niwa Kazuki
- Noda Yoshimi
- Noguchi Yoichiro
- Nukaga Shigenari
- Obara Wataru
- Obata Daisuke
- Ochi Junichi
- Odani Toshio
- Odate Mitsuru
- Ogata Hideo
- Ogata Tomouki
- Ogawa Aki
- Ogawa Seishi
- Ogawa Shinichi
- Oguma Tsuyoshi
- Ogura Shinji
- Ogura Takashi
- Ogura Takayuki
- Ohba Takehiko
- Ohira Yoshiyuki
- Ohta Kazuhide
- Ohta Ken
- Ohta Shin
- Okabayashi Hiroko
- Okada Takenori
- Okada Yukinori
- Okamori Satoshi
- Okamoto Masaki
- Okudela Koji
- Okuzaki Daisuke
- Omae Yosuke
- Omote Norihito
- Ono Akihiro
- Ono Hiroshi
- Ono Yoshinao
- Onoi Keisuke
- Ooshima Nobuharu
- Osawa Takeshi
- Oshima Taku
- Oshio Takeshi
- Ota Sho
- Oyama Baku
- Oyamada Yoshitaka
- Ozaki Shinji
- Sado Reiko
- Sado Toshikatsu
- Sagara Hironori
- Sageshima Hisako
- Saiki Ryunosuke
- Saito Fukuki
- Saito Fumitake
- Saito Hiroshi
- Saito Ryuichi
- Saito Yoshinobu
- Sakagami Satoru
- Sakakibara Shuhei
- Sakurai Toshihiro
- Sano Hirohito
- Sano Tomoya
- Sasa Noah
- Sasaki Junichi
- Sasaki Kana
- Sasano Hajime
- Sasano Hitoshi
- Sassa Chihiro Tani
- Sato Masamichi
- Sato Ryuichi
- Sato Tomonori
- Sato Toshiro
- Sato Yoko
- Sato Yuki
- Satomi Ryosuke
- Seike Masahiro
- Sekikawa Yoshiyuki
- Shibata Shun
- Shibata Yoko
- Shibusawa Takayuki
- Shichinohe Yasuo
- Shimada Hisato
- Shimada Tadanaga
- Shimizu Eigo
- Shimizu Tetsuo
- Shimo Masatoshi
- Shimoda Masafumi
- Shinoki Masato
- Shinozuka Jun
- Shinozuka Keisuke
- Shiomi Tetsuya
- Shirai Yuya
- Shiroyama Takayuki
- Shoko Tomohisa
- Sinozaki Nobuaki
- Sonehara Kyuto
- Sonobe Kazunari
- Suematsu Ryohei
- Sueyoshi Atsushi
- Sugihara Fuminori
- Sugimoto Hideyasu
- Sugiura Hisatoshi
- Suzuki Junya
- Suzuki Ken
- Suzuki Motoyuki
- Suzuki Shoji
- Suzuki Takao
- Suzuki Yusuke
- Tachikawa Natsuo
- Tada Ai
- Tagaya Etsuko
- Takada Minoru
- Takagaki Masatoshi
- Takagi Haruhi
- Takahashi Hidenori
- Takahashi Hiroshi
- Takahashi Kazuhisa
- Takahashi Kenichiro
- Takahashi Kunihiko
- Takahashi Mai
- Takahashi Meiko
- Takahashi Saeko
- Takahashi Takeshi
- Takahashi Yasuo
- Takaku Yotaro
- Takano Kenji
- Takano Tomomi
- Takaoka Hatsuyo
- Takata Tohru
- Takayanagi Noboru
- Takeda Yoshito
- Takei Reoto
- Takemoto Norihiko
- Takeuchi Mayumi
- Taki Reiko
- Takita Mumon
- Takoi Hiroyuki
- Takuwa Ayako
- Tanaka Akihiko
- Tanaka Hiromu
- Tanaka Toru
- Tanaka Yoshiaki
- Tani Mayuko
- Tanino Yoshinori
- Tateishi Tomoya
- Tateno Hiroki
- Terai Hideki
- Terashima Mariko
- Togashi Yuki
- Tohda Shuji
- Tokunaga Katsushi
- Tokunaga Yoshihisa
- Tominaga Yoshiteru
- Tomono Kazunori
- Tone Mari
- Tsuburai Takahiro
- Tsuchida Tomoya
- Uchida Sho
- Uchida Tomoyuki
- Uchimura Yuji
- Ueda Ken
- Ueda Soichiro
- Ueda Suguru
- Ueda Tetsuya
- Ueno Takafumi
- Ueno Yuya
- Umeda Akira
- Uno Shunsuke
- Utsugi Mitsuyoshi
- Uwamino Yoshifumi
- Wada Daiki
- Wada Sae
- Wakabayashi Aya
- Wakahara Keiko
- Wang Qingbo S.
- Watanabe Chie
- Watanabe Hiroki
- Watanabe Hiroko
- Watanabe Kazuyoshi
- Watanabe Masafumi
- Wing James B.
- Yagi Kazuma
- Yamada Mitsuhiro
- Yamada Shuhei
- Yamada Yuichiro
- Yamagata Kunihiro
- Yamaguchi Hiroki
- Yamaguchi Yuta
- Yamaji Ken
- Yamamoto Kenichi
- Yamamoto Makoto
- Yamamoto Masaomi
- Yamamoto Yuji
- Yamanashi Yuji
- Yamano Yasuhiko
- Yamasaki Masaki
- Yamashita Tatsuya
- Yanagita Emmy
- Yasui Yoshinori
- Yatomi Masakiyo
- Yokote Koutaro
- Yoneda Midori
- Yonekawa Akiko
- Yoshida Eriko
- Yoshida Kosuke
- Yoshida Shozo
- Yoshida Shuichi
- Yoshida Toru
- Yoshifuji Ayumi
- Yoshihara Tomoyuki
- Yoshimori Kozo
- Yoshimura Yukihiro
- Yoshiya Kazuhisa
- Yoshiyama Takashi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target
Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad
- Azuelos Georges
- Baas Alessandra
- Baca Matthew
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Bagnaia Paolo
- Bahmani Marzieh
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver
- Bakker Pepijn
- Baldin Evgenii
- Balek Petr
- Balli Fabrice
- Balunas William
- Banas Elzbieta
- Bandyopadhyay Anjishnu
- Banerjee Swagato
- Bannoura Arwa
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Stefan
- Barkeloo Jason
- Barklow Timothy
- Barlow Nick
- Barnes Sarah
- Barnett Bruce
- Barnett Michael
- Barnovska-Blenessy Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Barros Vale Maria
- Bartoldus Rainer
- Barton Adam
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Bates Richard
- Batista Santiago
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder
- Beacham James
- Beattie Michael
- Beau Tristan
- Beauchemin Pierre-Hugues
- Bechtle Philip
- Beck Hans~Peter
- Beck Helge
- Becker Kathrin
- Becker Maurice
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bedognetti Matteo
- Bee Christopher
- Beermann Thomas
- Begalli Marcia
- Begel Michael
- Behr Janna
- Bell Andrew
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimiliano
- Belotskiy Konstantin
- Beltramello Olga
- Belyaev Nikita
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Benekos Nektarios
- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Jose
- Benjamin Douglas
- Benoit Mathieu
- Bensinger James
- Bentvelsen Stan
- Beresford Lydia
- Beretta Matteo
- Berge David
- Bergeaas Kuutmann Elin
- Berger Nicolas
- Bergsten Laura
- Beringer Jürg
- Berlendis Simon
- Bernard Nathan
- Bernardi Gregorio
- Bernius Catrin
- Bernlochner Florian
- Berry Tracey
- Berta Peter
- Bertella Claudia
- Bertoli Gabriele
- Bertram Iain
- Bertsche Carolyn
- Besjes Geert-Jan
- Bessidskaia Bylund Olga
- Bessner Martin
- Besson Nathalie
- Bethani Agni
- Bethke Siegfried
- Betti Alessandra
- Bevan Adrian
- Beyer Julien-christopher
- Bianchi Riccardo-Maria
- Biebel Otmar
- Biedermann Dustin
- Bielski Rafal
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- Biglietti Michela
- Billoud Thomas
- Bilokon Halina
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- Bittrich Carsten
- Bjergaard David
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- Black Kevin
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- Blocker Craig
- Blue Andrew
- Blumenschein Ulrike
- Blunier Sylvain
- Bobbink Gerjan
- Bobrovnikov Victor
- Bocchetta Simona
- Bocci Andrea
- Bock Christopher
- Boehler Michael
- Boerner Daniela
- Bogavac Danijela
- Bogdanchikov Alexander
- Bohm Christian
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- Boldyrev Alexey
- Bolz Arthur
- Bomben Marco
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- Boonekamp Maarten
- Borisov Anatoly
- Borissov Guennadi
- Bortfeldt Jonathan
- Bortoletto Daniela
- Bortolotto Valerio
- Boscherini Davide
- Bosman Martine
- Bossio Sola Jonathan
- Boudreau Joseph
- Bouhova-Thacker Evelina
- Boumediene Djamel
- Bourdarios Claire
- Boutle Sarah
- Boveia Antonio
- Boyd James
- Boyko Igor
- Bozson Adam
- Bracinik Juraj
- Brandt Andrew
- Brandt Gerhard
- Brandt Oleg
- Braren Frued
- Bratzler Uwe
- Brau Benjamin
- Brau James
- Breaden Madden William
- Brendlinger Kurt
- Brennan Amelia
- Brenner Lydia
- Brenner Richard
- Bressler Shikma
- Briglin Daniel
- Bristow Timothy
- Britton Dave
- Britzger Daniel
- Brochu Frederic
- Brock Ian
- Brock Raymond
- Brooijmans Gustaaf
- Brooks Timothy
- Brooks William
- Brosamer Jacquelyn
- Brost Elizabeth
- Broughton James
- Bruckman de Renstrom Pawel
- Bruncko Dusan
- Bruni Alessia
- Bruni Graziano
- Bruni Lucrezia
- Bruno Salvatore
- Brunt Benjamin
- Bruschi Marco
- Bruscino Nello
- Bryant Patrick
- Bryngemark Lene
- Buanes Trygve
- Buat Quentin
- Buchholz Peter
- Buckley Andrew
- Budagov Ioulian
- Buehrer Felix
- Bugge Magnar
- Bulekov Oleg
- Bullock Daniel
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- Buttinger William
- Buzatu Adrian
- Buzykaev Aleksey
- Büscher Daniel
- Büscher Volker
- C-Q Changqiao
- Cabrera Urbán Susana
- Caforio Davide
- Cai Huacheng
- Cairo Valentina
- Cakir Orhan
- Calace Noemi
- Calafiura Paolo
- Calandri Alessandro
- Calderini Giovanni
- Calfayan Philippe
- Callea Giuseppe
- Caloba Luiz
- Calvente Lopez Sergio
- Calvet David
- Calvet Samuel
- Calvet Thomas
- Camacho Toro Reina
- Camarda Stefano
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- Cameron David
- Caminal Armadans Roger
- Camincher Clement
- Campana Simone
- Campanelli Mario
- Camplani Alessandra
- Campoverde Angel
- Canale Vincenzo
- Cano Bret Marc
- Cantero Josu
- Cao Tingting
- Capeans Garrido Maria
- Caprini Irinel
- Caprini Mihai
- Capua Marcella
- Carbone Ryne
- Cardarelli Roberto
- Cardillo Fabio
- Carli Ina
- Carli Tancredi
- Carlino Gianpaolo
- Carlson Benjamin
- Carminati Leonardo
- Carney Rebecca
- Caron Sascha
- Carquin Edson
- Carrillo-Montoya German
- Carrá Sonia
- Casadei Diego
- Casado Maria
- Casha Albert
- Casolino Mirkoantonio
- Casper David
- Castelijn Remco
- Castillo Gimenez Victoria
- Castro Nuno
- Catinaccio Andrea
- Catmore James
- Cattai Ariella
- Caudron Julien
- Cavaliere Viviana
- Cavallaro Emanuele
- Cavalli Donatella
- Cavalli-Sforza Matteo
- Cavasinni Vincenzo
- Celebi Emre
- Ceradini Filippo
- Cerda Alberich Leonor
- Cerri Alessandro
- Cerrito Lucio
- Cerutti Fabio
- Cervelli Alberto
- Cetin Serkant
- Chafaq Aziz
- Chakraborty Dhiman
- Chan Stephen
- Chan Wing
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- Chang Philip
- Chapman John
- Charlton Dave
- Chau Chav
- Chavez Barajas Carlos
- Che Siinn
- Cheatham Susan
- Chegwidden Andrew
- Chekanov Sergei
- Chekulaev Sergey
- Chelkov Gueorgui
- Chelstowska Magda
- Chen Cheng
- Chen Chunhui
- Chen Hucheng
- Chen Jing
- Chen Shenjian
- Chen Shion
- Chen Xin
- Chen Ye
- Cheng Hok
- Cheng Huajie
- Cheplakov Alexander
- Cheremushkina Evgeniya
- Cherkaoui El Moursli Rajaa
- Cheu Elliott
- Cheung Kingman
- Chevalier Laurent
- Chiarella Vitaliano
- Chiarelli Giorgio
- Chiodini Gabriele
- Chisholm Andrew
- Chitan Adrian
- Chiu Yu
- Chizhov Mihail
- Choi Kyungeon
- Chomont Arthur
- Chouridou Sofia
- Chow Yun
- Christodoulou Valentinos
- Chu Ming
- Chudoba Jiri
- Chuinard Annabelle
- Chwastowski Janusz
- Chytka Ladislav
- Ciftci Abbas
- Cinca Diane
- Cindro Vladimir
- Cioara Irina
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- Citron Zvi
- Citterio Mauro
- Ciubancan Mihai
- Clark Allan
- Clark Brian
- Clark Michael
- Clark Philip
- Clarke Robert
- Clement Christophe
- Coadou Yann
- Cobal Marina
- Coccaro Andrea
- Cochran James
- Colasurdo Luca
- Cole Brian
- Colijn Auke-Pieter
- Collot Johann
- Colombo Tommaso
- Conde Muiño Patricia
- Coniavitis Elias
- Connell Simon
- Connelly Ian
- Constantinescu Serban
- Conti Geraldine
- Conventi Francesco
- Cooke Mark
- Cooper-Sarkar Amanda
- Cormier Felix
- Cormier Kyle
- Corradi Massimo
- Corriveau Francois
- Cortes-Gonzalez Arely
- Costa Giuseppe
- Costa María
- Costanzo Davide
- Cottin Giovanna
- Cowan Glen
- Cox Brian
- Cranmer Kyle
- Crawley Samuel
- Creager Rachael
- Cree Graham
- Crescioli Francesco
- Cribbs Wayne
- Cristinziani Markus
- Croft Vince
- Crosetti Giovanni
- Crépé-Renaudin Sabine
- Cueto Ana
- Cuhadar Donszelmann Tulay
- Cukierman Aviv
- Cummings Jane
- Curatolo Maria
- Czekierda Sabina
- Czodrowski Patrick
- Cúth Jakub
- D'amen Gabriele
- D'Auria Saverio
- D'Eramo Louis
- D'Onofrio Monica
- Da Cunha Sargedas De Sousa Mario
- Da Via Cinzia
- Dabrowski Wladyslaw
- Dado Tomas
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- Dandoy Jeffrey
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- de Asmundis Riccardo
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- De Vasconcelos Corga Kevin
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- Filipčič Andrej
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- Frost James
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- Yamanaka Takashi
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- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
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- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten
- Šfiligoj Tina
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- Antón Z
- Anwar T
- Apetoh L
- Apostolova N
- Araki T
- Araki Y
- Arasaki K
- Araya J
- Araújo WL
- Arden C
- Arguelles S
- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
- Aurelian L
- Autelli R
- Avagliano L
- Aveic S
- Aveleira CA
- Avin-Wittenberg T
- Aydin Y
- Ayton S
- Ayyadevara S
- Azzopardi M
- Baba M
- Backer JM
- Backues SK
- Bae D-H
- Bae O-N
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
- Abudu Y. P.
- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
- Adolph T. E.
- Adornetto A.
- Aflaki E.
- Agam G.
- Agarwal A.
- Aggarwal B. B.
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- Agrotis A.
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- Aits S.
- Aizawa S.
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- Al-Abd A. M.
- Al-Akra L.
- Al-Gharaibeh A.
- Alaoui-Jamali M. A.
- Alberti S.
- Alcocer-Gomez E.
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- Ali M.
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- Alizadeh J.
- Almacellas E.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Effect of endoscopic transpapillary biliary drainage with/without endoscopic sphincterotomy on post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with biliary stricture (E-BEST) : a protocol for a multicentre randomised controlled trial
- Publication venue
- 'BMJ'
- Publication date
- 01/08/2017
- Field of study
Introduction: The effect of endoscopic sphincterotomy prior to endoscopic biliary stenting to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis remains to be fully elucidated. The aim of this study is to prospectively evaluate the non-inferiority of non-endoscopic sphincterotomy prior to stenting for naive major duodenal papilla compared with endoscopic sphincterotomy prior to stenting in patients with biliary stricture. Methods and analysis: We designed a multicentre randomised controlled trial, for which we will recruit 370 patients with biliary stricture requiring endoscopic biliary stenting from 26 high-volume institutions in Japan. Patients will be randomly allocated to the endoscopic sphincterotomy group or the non-endoscopic sphincterotomy group. The main outcome measure is the incidence of pancreatitis within 2 days of initial transpapillary biliary drainage. Data will be analysed on completion of the study. We will calculate the 95% confidence intervals (CIs) of the incidence of pancreatitis in each group and analyse weather the difference in both groups with 95% CIs is within the non-inferiority margin (6%) using the Wald method. Ethics and dissemination: This study has been approved by the institutional review board of Hokkaido University Hospital (IRB: 016-0181). Results will be submitted for presentation at an international medical conference and published in a peer-reviewed journal. Trial registration number: The University Hospital Medical Information Network ID: UMIN000025727 Pre-results
Oral appliance therapy for obstructive sleep apnea: a retrospective study in a psychiatric sleep clinic
- Publication venue
- Fujita Medical Society
- Publication date
- 01/01/2023
- Field of study
journal articl
Nanosized Authigenic Magnetite and Hematite Particles in Mature‐Paleosol Phyllosilicates: New Evidence for a Magnetic Enhancement Mechanism in Loess Sequences of China
- Author
- Publication venue
- 'American Geophysical Union (AGU)'
- Publication date
- 05/03/2020
- Field of study
Magnetic enhancement of Chinese loess‐paleosol sequences has been used extensively as a proxy for East Asian summer monsoon variations. However, the pedogenic magnetic particles contributing to this magnetic enhancement are difficult to extract, so it is not clear how they formed. In this study, we reveal pedogenic magnetite and hematite using electron microscopy, synchrotron radiation X‐ray diffraction, and rock magnetic methods. First‐order reversal curves indicate that superparamagnetic/single domain/vortex state magnetic properties dominated both loess and paleosol samples. Samples of muscovite and chlorite, which are paramagnetic, have weak spontaneous magnetization. The 1‐ to 10‐μm‐sized fraction of host silicatesis responsible for most of the magnetic enhancement of paleosols. In the paleosol fraction, we found weathered phyllosilicates (muscovite/chlorite), including many elongated submicron to a few microns authigenic magnetite and hematite particles between layers; however, few such interlayer particles were found in phyllosilicates of the loess fraction. The concentration of magnetite/hematite particles within paleosol muscovite/chlorite grains and in aggregates of phyllosilicate fragments is much higher than that of the submicron iron oxides found on silicate surfaces. Interlayer magnetite particles are dominantly prism‐shaped with aspect ratios >~4. The authigenic magnetite must be mainly responsible for the spontaneous magnetization of the muscovites and chlorites and the paleosol magnetic properties. The protective silicates account for the low extraction efficiency and also the near absence of surface oxidation of pedogenic magnetite. Based on our results, we suggest that magnetite/hematite in weathered phyllosilicates contribute significantly to the magnetic enhancement of mature paleosols
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